Clinical trials: Spondylitis
Inflammatory Disease, Crohn Disease
Monitoring of Inflammatory Conditions
People with inflammatory diseases treated with immune-suppressing medication are recommended to have regular blood-tests to monitor for potential side-effects of this treatment on their blood count, liver and kidneys.
- Conditions
- Inflammatory Disease, Crohn Disease, Ulcerative Colitis, Rheumatoid Arthritis
- Trial name
- NCT05458531
- Testing
- Questionnaire, Semi-structured interview
- Where
- United Kingdom
- Volunteers
- 664 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Osteoarthritis, Knee, Rheumatoid Arthritis
Early Biomarkers for ARthritic PAIN to Guide Improved Treatments for Arthritis
Osteoarthritis (OA) is a condition affecting the whole joint and is a major cause of pain and disability worldwide. Although OA is very common, the initial steps which lead to the development of pain and tissue damage are not…
- Conditions
- Osteoarthritis, Knee, Rheumatoid Arthritis, Spondyloarthritis, Psoriatic Arthritis
- Trial name
- ARPAIN (NCT03533569)
- Testing
- Intra-articular corticosteroid injection
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- St George's, University of London
Psoriasis, Arthritic Psoriasis
Evaluation of Adipokines and Fat Tissue in Psoriasis and Psoriatic Arthritis
Body composition analysis and especially body fat distribution in regions of interest (android and in particular intra-abdominal region) provides some information on the risk of cardiovascular disease.
- Trial name
- ADIPSO (NCT02849795)
- Testing
- bone densitometry, questionnaires, biological analyses
- Where
- France
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Spondyloarthritis, Rheumatoid Arthritis
Characterisation of Intestinal Microbiota of Patients With Spondyloarthritis or Rheumatoid Arthritis
The primary objective of the study aims to compare the biodiversity of intestinal microbiota between spondylarthritis (SPA) or rheumatoid arthritis (RA) patients and healthy volunteers, by microbiota DNA sequencing in order to…
- Trial name
- MICROBIART (NCT04292067)
- Testing
- Faecal sampling, Blood sampling
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Arthritis, Rheumatoid, Spondylarthritis
Immunogenicity and Safety of Vaccinations in Immunocompromised Persons
Backgound and relevance of the project: Patients with autoimmune inflammatory rheumatic diseases (AIIRD) are at increased risk of contracting infections.
- Conditions
- Arthritis, Rheumatoid, Spondylarthritis, Vasculitis
- Trial name
- NCT01947465
- Testing
- Hepatitis A vaccine and tetanus vaccine
- Where
- 10 sites in Switzerland
- Volunteers
- 645 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Inflammatory Disease, Rheumatoid Arthritis
Prospective Follow-up of Patients With Chronic Inflammatory Rheumatism
It is a prospective follow-up. The aim is to study the maintenance of therapeutic at 10 years and 20 years of inflammatory rheumatism (rheumatoid arthritis and spondyloarthritis)
- Conditions
- Inflammatory Disease, Rheumatoid Arthritis, Spondyloarthritis
- Trial name
- PPCRNice (NCT03076866)
- Testing
- observational follow-up:clinical, radiological et biological
- Where
- France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Systemic Lupus Erythematosus, Arthritic Psoriasis
The Effect of BMS-986165 Combined With an Oral Contraceptive (Ethinyl Estradiol/Norethindrone) in Healthy Female Patients
The purpose of this study is to investigate the effect of BMS-986165 in combination with an oral contraceptive in healthy female patients.
- Conditions
- Systemic Lupus Erythematosus, Arthritic Psoriasis, Psoriasis, Inflammatory Bowel Diseases
- Trial name
- NCT03262727
- Testing
- BMS-986165, Loestrin 1.5/30 (1.5 mg norethindrone acetate/30 μg ethinyl estradiol)
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Ankylosing Spondylitis
An Open-Label, Multicentre, Long-Term Extension Study of Etanercept in Ankylosing Spondylitis
The primary objective of this study was to determine the long-term safety of etanercept in adults with AS who had completed study 0881A3-311-EU.
- Trial name
- NCT00421980
- Testing
- Etanercept
- Where
- Belgium
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Axial Spondyloarthritis, Arthritis, Rheumatoid
The Role of Microbiome on Biological Therapy Efficacy in axSpA and RA
Spondyloarthritis (SpA) and Rheumatoid arthritis (RA) are among the most common chronic inflammatory rheumatic diseases. Introduction of Tumor Necrosis Factor alpha inhibitors (TNFi) to the therapeutic strategy improved acute…
- Trial name
- MicroSpA & RA (NCT04973787)
- Testing
- biological disease-modifying antirheumatic drugs (bDMARDs)
- Where
- 10 sites in Portugal
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universidade Nova de Lisboa
Psoriatic Arthritis
Treatment With Apremilast in Patients With Psoriatic Arthritis
Apremilast (Otezla®) is a Federal Drug Administration (FDA)-approved treatment for psoriatic arthritis and psoriasis. Although there are a lot of data demonstrating how apremilast works in the laboratory, there are very few…
- Trial name
- NCT02558361
- Testing
- Treatment with Apremilast
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of South Florida
Arthritis, Spondylitis, Ankylosing
Natural History and Development of Spondyloarthritis
Background: Spondyloarthritis (SpA) is a group of bone and joint disorders that may cause back and joint pain and stiffness. In some cases, SpA can lead to abnormal bone growth affecting the joints and spine.
- Trial name
- NCT01422694
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Rheumatoid Arthritis (RA, Ankylosing Spondylitis
Skin Autofluorescence Assessment of Advanced Glycation End Products in Rheumatic Diseases
Rheumatic diseases are chronic inflammatory conditions that can lead to long-term tissue damage and increased cardiovascular and metabolic risk.
- Conditions
- Rheumatoid Arthritis (RA, Ankylosing Spondylitis, Psoriatic Arthritis, Reactive Arthritis (ReA)
- Trial name
- NCT07329556
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Bursa City Hospital
Ankylosing Spondylitis and Psoriatic Arthritis Patients
TNFAIP3 Gene Expression in Ankylosing Spondylitis and Psoriatic Arthritis Patients and Its Relation to Disease Activity
1. Identify gene expression of TNFAIP3 in ankylosing spondylitis and psoriatic arthritis patients. 2. Detect relation between TNFAIP3 and disease activity. Inclusion criteria: 1.
- Trial name
- NCT07507487
- Testing
- Detection of TNFAIP3 gene expression by real time PCR.
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Asmaa Hassan mohamed Abdel Mawjoud
Inflammatory Bowel Disease
Analysis of Birth Outcomes of Swedish, Danish and Finnish Women Exposed to Remicade With Inflammatory Bowel Disease, Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, and Psoriasis
The purpose of this study is collection and analysis of information pertaining to pregnancy outcomes in women exposed to infliximab during pregnancy, relative to the background risk in similar but non-biologic exposed patients…
- Trial name
- NCT00658827
- Testing
- No intervention
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Janssen Biotech, Inc.
Ankylosing Spondylitis
Inturlekin L33 in Ankylosing Spondylities Patients and Its Relation to Subclinical Atherosclerosis
detect level of Inturlekin 33 in ankylosing spondyilits patient measure CIMT (carotid intima media thickness ) by carotid duplex to detect subclinical atherosclerosis in ankylosing spondyitis patients detect the relation between…
- Trial name
- NCT06564155
- Testing
- carotid duplex
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Assiut University
Psoriasis, Psoriasis Arthritis
A Multi-center RCT Clinical Trial on Personalized Precision Medicine for Patients With Psoriasis and Psoriatic Arthritis and Investigation on Cardiovascular Biomarkers
The inclusion criteria for this study were patients aged 18 to 75 years with a confirmed diagnosis of psoriasis by a dermatologist or psoriatic arthritis by a rheumatologist.
- Conditions
- Psoriasis, Psoriasis Arthritis, Biologics
- Trial name
- SMILE (NCT07149792)
- Testing
- Prescreen platform, biologics treatment
- Where
- 2 sites in Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Taichung Veterans General Hospital
Enthesopathy
Comparation of Ultrasonic Imaging of Enthesopathy in Patients With Psoriatic Arthritis and Psoriasis
Psoriatic arthritis(PsA) and psoriasis(Ps) are two systemic inflammatory diseases linked with rash of psoriasis, but there's still great controversy regarding the exact relationship between them.
- Trial name
- NCT02962271
- Testing
- Musculoskeletal Ultrasound
- Where
- China
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Rheumatoid Arthritis, Polyarticular Juvenile Idiopathic Arthritis
Comparison of PK and Tolerability of MSB11022 Administered by AI or PFS
The primary objective of this study is to demonstrate equivalence of the pharmacokinetic (PK) profile of MSB11022 administered by either an auto-injector (AI) or a pre-filled syringe (PFS) as single subcutaneous (s.c.) injection…
- Conditions
- Rheumatoid Arthritis, Polyarticular Juvenile Idiopathic Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis
- Trial name
- NCT04018599
- Testing
- 40 mg MSB11022
- Where
- 2 sites in United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Fresenius Kabi SwissBioSim GmbH
Systemic Lupus, Rheumatoid Arthritis
Yellow Fever Vaccine in Patients With Rheumatic Diseases
According to World Health Organization (WHO), since December 2016, Brazil is showing a significant increase in cases of yellow fever in humans.
- Conditions
- Systemic Lupus, Rheumatoid Arthritis, Spondyloarthritis, Inflammatory Myopathy
- Trial name
- NCT03430388
- Testing
- Yellow Fever vaccine (17D)
- Where
- Brazil
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Axial Spondyloarthritis, Ankylosing Spondylitis
Is the Human Microbiome Altered in Patients With Axial Spondyloarthritis?
This study aims to compare biological communities in stool samples obtained from age, diet and BMI-matched subjects in five study groups: subjects with ankylosing spondylitis (AS) never treated with tumor necrosing factor (TNF)…
- Trial name
- NCT02962479
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Eyal Kedar