Clinical trials: Spontaneously Breathing
Neonatal Respiratory Distress
Aerosolized Infasurf Treatment Protocol: Aerosolized Infasurf for Spontaneously Breathing Patients With Early RDS (AERO-03)
Surfactant replacement therapy can be life-saving for newborn infants born with symptomatic lung surfactant deficiency causing Respiratory Distress Syndrome (RDS).
- Trial name
- NCT03582930
- Testing
- Infasurf Aero
- Where
- 5 sites in United States
- Sponsor
- ONY
Invasive Mechanical Ventilation, Ventilator-Induced Lung Injury
Effects of Large Tidal Volumes Despite Minimal Inspiratory Support in Spontaneously Ventilated Intubated Resuscitation Patients. Pathophysiological Exploratory Study.
Some ICU ventilated patients might present with large tidal volume despite very low or inexistant presser support. Patient-Self Inflicted Lung Injury (P-SILI) might appear related with large alveolar stretch an distension.
- Conditions
- Invasive Mechanical Ventilation, Ventilator-Induced Lung Injury, Patient-Self Inflicted Lung Injury, Encephalopathy
- Trial name
- InLarge (NCT05056961)
- Testing
- Multiparametric mesurements
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Clermont-Ferrand
Sepsis
Infraclavicular Axillary Vein Collapsibility Index as a Predictor of Fluid Responsiveness
Fluid responsiveness refers to the ability of the left ventricle to significantly increase stroke volume following fluid administration, and its assessment is critical in managing acute circulatory failure while avoiding fluid…
- Trial name
- NCT07507877
- Testing
- Infraclavicular axillary vein collapsibility index
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Sepsis, Circulatory Failure
Respiratory Variations For Predicting Fluid Responsiveness 2
Objectives: To investigate whether respiratory variations of inferior vena cava diameters (cIVC) predict fluid responsiveness in spontaneously breathing patients with septic acute circulatory failure and irregular heartbeats.
- Conditions
- Sepsis, Circulatory Failure, Respiratory Physiological Phenomena
- Trial name
- ReVaPreF2 (NCT03066375)
- Testing
- Echocardiography-Doppler
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Lille
Ventilatory Depression
Correlation of ETCO2 to PaCO2 Measured by Sentri Nasal Cannula
Sampling end tidal gas via nasal prong has been shown to be a noninvasive and reliable method of monitoring end-tidal CO2 in spontaneously breathing patients.
- Trial name
- NCT03374644
- Testing
- SentriTM ETCO2 adult nasal cannula
- Volunteers
- 40 people
- Sponsor
- University of Malaya
Circulatory Failure
Simplified Inferior Vena Cava Collapsiblity
Fluid administration is a cornerstone therapy in critically ill patient. Fluid restriction or overload can therefore change patient's outcome and mortality.
- Trial name
- CVCISIMPLIFIEE (NCT06921642)
- Testing
- Echocardiography images
- Where
- France
- Volunteers
- 74 people
- Sponsor
- University Hospital, Lille
Acute Respiratory Distress Syndrome
5-HT3 Receptor Antagonist and Respiratory Drive in Patients With ARDS
This is a pilot study aimed at acquiring primary physiological data, describing and estimating the effects of a 5-HT3 receptor antagonist (ondansetron) on respiratory drive in patients with acute respiratory distress syndrome…
- Trial name
- DRIVE (NCT05514483)
- Testing
- Ondansetron
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Breathing
Diagnostic Accuracy of the Central Venous Pressure (CVP) Variation to Predict Fluid Responsiveness in Spontaneously Breathing Patients
Volume expansion (VE) is often administered in intensive care (ICU)-patient to improve arterial oxygen delivery. Such effect is secondary to an increase in stroke volume and cardiac output.
- Trial name
- VPVC (NCT03780660)
- Where
- France
- Volunteers
- 68 people
- Sponsor
- University Hospital, Lille
Pulmonary Disease, Chronic Obstructive
Six-Minute Walk Test Comparing Helium/Oxygen to Nitrogen/Oxygen for COPD Rehabilitation
The purpose of this study is to evaluate effects of inspired gas mixtures on the distance walked by patients with severe Chronic Obstructive Pulmonary Disease (COPD) during a Six-Minute Walk test.
- Trial name
- rehabilitate (NCT01355809)
- Testing
- Inhalation gas, Inhalation Nitrogen/Oxygen, Inhalation Helium/Oxygen
- Where
- Germany
- Volunteers
- 3 people
- Sponsor
- Air Liquide SA
Tracheostomized Patients
Influence of Tracheostomy on Lung Deposition in Spontaneously Breathing Patient
To compare lung deposition of amikacin in two settings: spontaneously breathing through a tracheostomy cannula and through the mouth.
- Trial name
- NCT01882595
- Testing
- Nebulization through the tracheostomy, Nebulization through the mouth
- Where
- Belgium
- Volunteers
- 9 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Pulmonary Perfusion, Ventilation-Perfusion Ratio
Non-apnea Electrical Impedance Tomography for Bedside Ventilation-Perfusion Assessment: a Prospective Cross-over Validation Study
Title: Validating the Accuracy of Lung Blood Flow Monitoring Without Breath-Holding Under Spontaneous Breathing Support Purpose: The purpose of this study is to evaluate the accuracy of a new Electrical Impedance Tomography (EIT)…
- Conditions
- Pulmonary Perfusion, Ventilation-Perfusion Ratio, Respiratory Insufficiency, Critical Illness
- Trial name
- NELSB (NCT07489950)
- Testing
- Saline-contrast EIT with a non-apnea algorithm
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Ruijin Hospital
Medical Device Complication
Comparative Study of Baska & I-gel for Ventilation of Female Patients During Minor Procedures
The study aimed to compare safety of the 3rd generation Supra-glottic airway device (SAD) "Baska" to the I-Gel , regarding seal pressure, fitting on the larynx (detected by Fiberoptic) \& complications.
- Trial name
- NCT03140215
- Testing
- laryngeal mask insertion (Baska), laryngeal mask insertion (I-gel )
- Volunteers
- 60 people
- Sponsor
- Cairo University
Healthy, Blood Pressure
Capnogram and Fluid Responsiveness
Predicting fluid responsiveness in critically ill patients is of paramount importance. It can help define an adequate fluid balance.
- Trial name
- NCT03788707
- Testing
- Passive leg raising
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Augusta University
Respiratory Distress Syndrome (RDS)
A Study in Preterm Neonates With Respiratory Distress Syndrome (RDS) Comparing CUROSURF® Administration Through Less Invasive Surfactant Administration (LISA) and Conventional Administration
This study compared the administration of porcine surfactant (poractant alfa, Curosurf®) through a less invasive method (LISA), using a thin catheter, CHF 6440 (LISACATH®), during non-invasive ventilation (CPAP, NIPPV, BiPAP)…
- Trial name
- LISPAP (NCT02772081)
- Testing
- LISA combination product (Curosurf+catheter CHF6440), Curosurf through conventional administration (endotracheal tube)
- Where
- 26 sites in United States
- Volunteers
- 33 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Respiratory Insufficiency
Pathophysiology of Gas Exchange and Time Course Changes in Spontaneously Breathing Patients With Acute Respiratory Failure Due to COVID-19. A Multicenter Prospective Study.
The pathophysiology of SARS-COV-2 related respiratory disease is still poorly understood, especially in its most severe form called acute respiratory distress syndrome (ARDS).
- Trial name
- COVAQ (NCT05392062)
- Testing
- Pathophysiology of gas exchange
- Where
- France
- Volunteers
- 59 people
- Sponsor
- CHU de Reims
Acute Respiratory Failure, Acute Respiratory Distress Syndrome
Closed-loop syncHronization vErsuS convenTional Synchronization in sPontaneously Breathing Adult Nonivasive ventilationPatients
The study is a multicentric prospective randomised cross-over study. It evaluates the compatibility of patients with the device without altering the routine treatment applied.
- Conditions
- Acute Respiratory Failure, Acute Respiratory Distress Syndrome, Chronic Respiratory Failure
- Trial name
- CHESTSPAN (NCT06357780)
- Testing
- close-loop synchronization controller with spontaneous mode, Conventional
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Hypoxemic Without Hypercapnia Acute Respiratory Failure
Pronostic Value of Fluid Responsiveness Evaluated by Inferior Vena Cava Collapsibility Index in Patients Admitted in ICU With Acute Respiratory Failure
Acute respiratory failure represents a frequent cause of admission to intensive care units (ICUs). In the absence of tailored interventions, it poses an imminent threat to patients' lives.
- Trial name
- PRIVACY (NCT06286306)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Lille
Neonatal Respiratory Distress Syndrome
A Study To InvestigateThe Safety, Tolerability And Efficacy Of Nebulised Curosurf® In Preterm Neonates With Respiratory Distress Syndrome (RDS)
The present study will mainly aim at investigating the safety, tolerability and efficacy of different escalating single doses administration of nebulised Curosurf®, in preterm neonates with RDS (Respiratory Distress Syndrome)…
- Trial name
- NCT03235986
- Testing
- nCPAP (nasal Continuous Positive Airway Pressure) + Nebulised Curosurf® (Part I), nCPAP (nasal Continuous Positive Airway Pressure) + Nebulised Curosurf® (Part II), nCPAP (nasal Continuous Positive Airway Pressure) alone (Part I)
- Where
- Italy
- Volunteers
- 166 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Laryngeal Masks
Comparative Evaluation of Ambu AuraGain Laryngeal Mask and Proseal Laryngeal Mask Airway
Comparison of two different supraglottic airway devices i.e., the ProSeal Laryngeal Mask Airway (PLMA) and Ambu AuraGain, a third generation laryngeal mask Airway.
- Trial name
- NCT03139292
- Testing
- ProSeal Laryngeal Mask Airway, AmbuAuraGain Laryngeal Mask Airway
- Where
- India
- Volunteers
- 160 people
- Sponsor
- Tata Main Hospital
Respiratory Insufficiency, Shock, Septic
Fluid Responsiveness in HFNC Patients
The plethysmographic variation index (PVi) is a measure of the respiratory-induced variations in the plethysmographic waveform. Interestingly, in mechanically ventilated patients and under certain conditions, PVi may reflect…
- Conditions
- Respiratory Insufficiency, Shock, Septic, Sepsis
- Trial name
- HIDRATE (NCT03817996)
- Testing
- Fluid challenge
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute