Clinical trials: Stenosis of Bile Duct
Inoperable Tumors of the Bile Duct
A Trial Comparing the Uncovered to the Covered Wallstent in the Palliation of Malignant Bile Duct Strictures
The purpose of the study is to determine the best management of bile duct narrowing (stricture) due to inoperable tumors. The bile duct is a tube that carries bile formed in the liver to the small bowel to digest fats.
- Trial name
- Wallstent (NCT01047332)
- Testing
- Partially Covered Wallstent, Uncovered Wallstent
- Volunteers
- 129 people
- Sponsor
- Brigham and Women's Hospital
Benign Biliary Stricture, Biliary Stricture
Kaffes Stent in the Management of Post-surgical Biliary Strictures
Post-surgical biliary strictures are common especially after cholecystectomy. Standard treatment involves the performance of multiple procedures over a 1 year period at least using several plastic stents to achieve permanent…
- Conditions
- Benign Biliary Stricture, Biliary Stricture, Cholangitis, Bile Duct Stricture
- Trial name
- NCT03716232
- Testing
- Metallic stent, Multiple plastic stents
- Where
- 3 sites in Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Alagille Syndrome
Characterization of Pulmonary Artery Stenoses in Alagille Syndrome - a Medical Record Review
Patients who have Alagille Syndrome (AGS) also frequently have blockages (or "stenoses") of their pulmonary arteries. Little is known about the degree or variability of these stenoses, or the effect of this disease on the right…
- Trial name
- NCT01515631
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Stanford University
Bile Duct Stricture, Bile Duct Cancer
Metal Stents (Moving Cell Stent) for Inoperable Tumors of the Bile Duct Tract
In this feasibility study (non-randomized), the applicability of a new "moving cell" biliary stents (by HILZO) in Klatskin tumors (bile duct obstruction) will be investigated.
- Trial name
- NCT03788655
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Johannes Vermehren
Stenosis of Bile Duct, Endoscopic Retrograde Cholangiopancreatography
Artificial Intelligence-assisted Common Bile Duct Stent Selection in Endoscopic Retrograde Cholangiopancreatography
Common bile duct stenosis is an important indication for endoscopic retrograde cholangiopancreatography(ERCP). Appropriate selection of bile duct stent size is not only conducive to successful stent implantation but also to…
- Trial name
- NCT05321472
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Shandong University
Bile Duct Stricture, Bile Duct Cancer
PTFE Stents for Treatment of Malignant Biliary Strictures
In this randomized trial two two self-expanding metal stents (SEMS) for treatment of malignant biliary strictures are investigated.
- Conditions
- Bile Duct Stricture, Bile Duct Cancer, Pancreas Cancer
- Trial name
- NCT03763214
- Testing
- Stenting with PTFE-coated stent (HILZO)
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- Johannes Vermehren
Biliary Stricture, Biliary Tract Diseases
Percutaneous Biodegradable Biliary Stents for the Treatment of Benign Biliary Strictures.
To assess safety and effectiveness in the long term of percutaneous insertion of Biodegradable (BD) Biliary Stents for the treatment of benign biliary strictures, in a single center experience.
- Conditions
- Biliary Stricture, Biliary Tract Diseases, Bile Duct Stricture, Bile Duct Injury
- Trial name
- NCT05556668
- Testing
- Percutaneous placement of biodegradable biliary stents
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Corporacion Parc Tauli
Biliary Stricture, Bile Duct Stenosi
Biliary Complications in Live Donor Liver Transplantation
The study was designed as a prospective cohort study. The effects of hot and cold ischemic times during live donor liver transplantation on postoperative 1-3 and 6 month follow up biliary complications will be investigated.
- Conditions
- Biliary Stricture, Bile Duct Stenosi, Bile Leak, Bile Duct Injury
- Trial name
- NCT03673033
- Testing
- liver transplantation
- Where
- Turkey (Türkiye)
- Volunteers
- 99 people
- Sponsor
- Inonu University
Bile Duct Stricture
Prospective Evaluation of Stent Patency in Patients With Benign Biliary Obstruction of the Wing Biliary Stent (Viaduct™)
Endoscopic retrograde cholangiopancreatography (ERCP) with plastic stent placement for resolution of biliary obstruction has been the method of choice for many years.
- Trial name
- NCT01818050
- Testing
- Liver Function Tests
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stanford University
Choledocholithiasis, Papillary Stenosis
Endoscopic Antegrade Sphincterotomy (ASD) Versus Standard Sphincterotomy
This study compares endoscopic transpapillary antegrade sphincterotomy developed by Dr. Dovbenko (Antegrade Sphincterotomy Dovbenko, ASD) with conventional pull-type endoscopic sphincterotomy (EST) in patients undergoing…
- Conditions
- Choledocholithiasis, Papillary Stenosis, Biliary Obstruction, Gallstone Disease
- Trial name
- ASD (NCT04406961)
- Testing
- Endoscopic transpapillary antegrade sphincterotomy developed by Dr. Dovbenko., The antegrade sphincterotome developed by Dr. Dovbenko., Endoscopic sphincterotomy.
- Where
- Ukraine
- Volunteers
- 1,521 people
- Sponsor
- Military Medical Clinical Center of the Southern Region, Ukraine
Common Bile Duct Stone, Malignant Hepatobiliary Neoplasm
Primary Needle Knife Fistulotomy Versus Conventional Cannulation Method
The aim of this study are to evaluate the feasibility of needle knife fistulotomy (NKF) as an initial procedure for biliary access in patients with biliary disease who are at increased risk for post-endoscopic retrograde…
- Conditions
- Common Bile Duct Stone, Malignant Hepatobiliary Neoplasm, Biliary Stricture, Pancreatic Diseases
- Trial name
- NCT02916199
- Testing
- cannulation of ampulla of Vater
- Where
- 7 sites in South Korea
- Volunteers
- 207 people
- Sponsor
- Gangnam Severance Hospital
Cholangiocarcinoma, Biliary Stenosis
Contribution of the EyeMAX™ 11Fr (Micro-Tech) Digital Single-Operator Cholangioscope With a Wide Working Channel
Background and aims Digital single-operator cholangioscopy (DSOC) enhances biliary stricture diagnosis, but the collection of quality samples can be difficult due to the small diameter of the working channel.
- Conditions
- Cholangiocarcinoma, Biliary Stenosis, Bile Duct Stones, Bile Duct Stenosis
- Trial name
- EyeMAX-CREGG (NCT06933576)
- Testing
- DSOC EyeMAX 11Fr
- Where
- 5 sites in France
- Volunteers
- 28 people
- Sponsor
- Clinique Paris-Bercy
Common Bile Duct Stricture
Covered Metallic Stents for First-Line Treatment of Benign Bile Duct Strictures
The current standard of care for benign bile duct strictures involves placement of multiple plastic stents under endoscopic and fluoroscopic guidance to progressively dilate or stretch it open.
- Trial name
- NCT01221311
- Testing
- Fully covered Metallic Stent, Plastic Stent
- Where
- 8 sites in United States, United Kingdom
- Volunteers
- 112 people
- Sponsor
- Medical University of South Carolina
Primary Sclerosing Cholangitis
Mitomycin C Therapy for Patients With Primary Sclerosing Cholangitis
The purpose of this study is to determine the effectiveness and safety of mitomycin C in the treatment of primary sclerosing cholangitis (PSC).
- Trial name
- NCT01688024
- Testing
- Mitomycin C, Normal saline
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Li, Zhiping, M.D.
Obstructive Jaundice, Biliary Stricture
Evaluation of the Use of a Biodegradable Endoprothesis in the Prevention of Post-Endoscopic Retrograde CholoangioPancreatography Pancreatitis
The use of an endoprothesis in a pancreatic duct is a measure to minimize the incidence and severity of Post-Endoscopic Retrograde CholoangioPancreatography Pancreatitis.
- Conditions
- Obstructive Jaundice, Biliary Stricture, Sphincter of Oddi Dysfunction
- Trial name
- ARCHIMEDE (NCT03977779)
- Testing
- Placement of ARCHIMEDES fast biodegradable stent during the Endoscopic Retrograde CholoangioPancreatography
- Where
- 2 sites in France
- Volunteers
- 46 people
- Sponsor
- Institut Paoli-Calmettes
Acute Cholangitis, Biliary Tract Infection
Comparative Efficacy Of Intraductal Antibiotic During ERCP In Acute Cholangitis
Does intraductal administration of antibiotics during endoscopic retrograde cholangiopancreatography (ERCP), in addition to standard systemic antibiotic therapy, improve clinical outcomes in patients with acute cholangitis…
- Conditions
- Acute Cholangitis, Biliary Tract Infection, Biliary Obstruction, Choledocholithiasis
- Trial name
- NCT07407491
- Testing
- Gentamicin - single dose, Distilled water
- Where
- Malaysia
- Volunteers
- 172 people
- Sponsor
- National University of Malaysia
Common Bile Duct Stricture, Jaundice; Malignant
Efficacy and Safety of Plastic, Covered and Uncovered Self-expandable Metal Stents in the Treatment of Malignant Biliary Obstructions (NEOSTENT)
The aim of the study is to evaluate the efficacy and safety of the various types of stents available for biliary drainage in patients with neoplastic stenosis of the common bile duct and to evaluate the adherence to the current…
- Trial name
- NEOSTENT (NCT05395013)
- Where
- Italy
- Volunteers
- 3,149 people
- Sponsor
- Azienda Unità Sanitaria Locale della Romagna
Extrahepatic Cholangiocarcinoma
Repeated Endobiliary Radiofrequency Ablation Plus Durvalumab, Gemcitabine, and Cisplatin for Unresectable Extrahepatic Cholangiocarcinoma
This international, multicenter, open-label randomized controlled trial evaluates whether repeated endobiliary radiofrequency ablation (EB-RFA) improves overall survival in patients with unresectable extrahepatic…
- Trial name
- BRAVE (NCT07235007)
- Testing
- Endobiliary Radiofrequency Ablation (EB-RFA), Plastic Biliary Stent
- Where
- 8 sites in Japan, South Korea
- Volunteers
- 120 people
- Sponsor
- Aichi Medical University
Bile Duct Stricture
Comparison of On-Site Versus Off-Site Evaluation of Cholangioscopy-Guided Biopsies of the Bile Duct
This study will test two different methods for processing biopsy specimens taken from the bile duct. Patient;s who are asked to participate int his study have a stricture in the bile duct that needs a single operator…
- Trial name
- NCT01815619
- Testing
- on-site specimen evaluation, off-site specimen evaluation
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- AdventHealth
Bile Duct Stricture, Malignancy
Performance of FISH for the Diagnosis of Malignant Biliary Strictures in Thai Patients
Fluorescence in situ hybridization (FISH) has improved the diagnostic performance of cytology for evaluation of malignant biliary strictures in the US and Europe.
- Trial name
- NCT02442167
- Volunteers
- 101 people
- Sponsor
- Mayo Clinic