Clinical trials: Stratification
Clinical Pharmacology
Study on the Safety of BAY 63-2521, How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Drug Given as a Single Oral Dose of 1 mg Tablet in Participants With Renal Impairment and Healthy Participants Matched for Age-, Gender-, and Weight
BAY 63-2521 is intended to be used for a disease that affects the blood flow through the lungs. Renal impairment is a common condition in patients with this disease.
- Trial name
- NCT04364464
- Testing
- Riociguat (Adempas, BAY 63-2521)
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bayer
Head Pain
Copeptin for Risk Stratification in Non-traumatic Headache in the Emergency Setting - The CoHead Study
Headache is a common symptom, and patients often seek medical attention at emergency departments due to headaches. The aim of the CoHead Study is to find out if it is possible by measuring copeptin, a marker of stress in the…
- Trial name
- CoHead (NCT01174901)
- Where
- 2 sites in Switzerland
- Volunteers
- 400 people
- Sponsor
- University Hospital, Basel, Switzerland
Lung; Disease, Interstitial, With Fibrosis, Pulmonary Disease, Chronic Obstructive
Deep Learning Diagnostic and Risk-stratification for IPF and COPD
Idiopathic pulmonary fibrosis (IPF), non-specific interstitial pneumonia (NSIP), and chronic obstructive pulmonary disease (COPD) are severe, progressive, irreversibly incapacitating pulmonary disorders with modest response to…
- Conditions
- Lung; Disease, Interstitial, With Fibrosis, Pulmonary Disease, Chronic Obstructive, Artificial Intelligence
- Trial name
- DeepBreath (NCT05318599)
- Testing
- Lung auscultation, Lung ultrasound, Quality of Life's questionnaires
- Where
- Switzerland
- Volunteers
- 160 people
- Sponsor
- Pediatric Clinical Research Platform
Lung Neoplasms
Risk Stratification of Patients Using the Lung Cancer Biomarker Panel in China
The purpose of this study is to verify clinical utility of a simple blood test comprising of four protein- based markers for risk stratification of patients presenting symptoms related to lung cancer.
- Trial name
- LCBP (NCT01928836)
- Where
- 6 sites in China
- Volunteers
- 764 people
- Sponsor
- Bai Chunxue
Head Injury Trauma
Study Evaluating the Potential Impact of a Hemorrhagic Risk Stratification Score in Patients With Mild Head Trauma
Head injuries are a common reason for consultation in emergency departments. The clinical severity of head injury is assessed using the Glasgow Coma Scale (GCS).
- Trial name
- TCL (NCT04993495)
- Where
- France
- Volunteers
- 470 people
- Sponsor
- University Hospital, Angers
Chronic Liver Disease, HepatoCellular Carcinoma
Stratification of Patients With Chronic Liver Disease Using Multi Spectral CT
The purpose of this study is to evaluate the feasibility to stratify liver fibrosis in patients with chronic liver disease through non-invasive, spectral CT.
- Conditions
- Chronic Liver Disease, HepatoCellular Carcinoma, Liver Fibrosis
- Trial name
- NCT01825213
- Testing
- Multispectral CT of the liver
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Genomics, Thyroid Cancer
Integrating Tumor Genomics and Urinary Exosomal Proteomics to Establish a Multi-Layer Biomarker Framework for Early Risk Stratification and Post-Treatment Surveillance in Fresh Thyroid Cancer Patients
Thyroid cancer is the most common endocrine malignancy, and although differentiated thyroid cancer (DTC) generally confers favorable outcomes, 10-20% of patients still face substantial postoperative risks, including local…
- Conditions
- Genomics, Thyroid Cancer, NGS
- Trial name
- NCT07532356
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Anemia
Single Dose Group Stratified Study in Renal Impaired and Healthy Aged and Gender Matched Subjects
Safety, tolerability, pharmacokinetics and pharmacodynamics will be investigated in a single dose group stratified study in renal impaired and healthy subjects.
- Trial name
- NCT01318551
- Testing
- BAY85-3934
- Where
- Germany
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Bayer
Osteoporosis
Changes in Bone Mineral Density and Fracture Risk in Patients Receiving Androgen Deprivation Therapy for Prostate Cancer
The aim of this study is to determine the long term effects of two types of hormonal treatment for advanced prostate cancer (LHRH agonists and the antiandrogen bicalutamide)on the bone mineral density of patients.
- Trial name
- NCT00536653
- Testing
- Bicalutamide and Calcium/ Vitamin D supplementation, LHRH agonists (Goserelin acetate) and Calcium/ Vitamin D supplementation, LHRH agonists (Goserelin acetate)
- Where
- United Kingdom
- Volunteers
- 618 people
- Sponsor
- Wirral University Teaching Hospital NHS Trust
Pulmonary Tuberculosis, Tuberculosis (TB)
Artificial Intelligence-driven Tuberculosis Landscape Analysis & Stratification Research
The goal of this observational study is to establish and validate a comprehensive AI-driven clinical decision support system (AI-CDSS) in whole-chain management for pulmonary tuberculosis (TB) patients.
- Conditions
- Pulmonary Tuberculosis, Tuberculosis (TB), Tuberculosis Active
- Trial name
- TB-ATLAS (NCT07611695)
- Where
- 2 sites in China
- Volunteers
- 31,600 people
- Sponsor
- Huashan Hospital
Heart Transplantation, Rejection Heart Transplant
Evaluation of the Added Clinical Value of Donor-derived Cell-free DNA for the Monitoring of Cardiac Allograft Rejection.
The goal of this observational study is to assess the clinical added value of donor-derived cell-free DNA (dd-cfDNA) to monitor cardiac allograft rejection.
- Trial name
- HEART-FREE (NCT06740578)
- Where
- 2 sites in France
- Volunteers
- 320 people
- Sponsor
- Paris Translational Research Center for Organ Transplantation
Obese Adults, BMI/Body Composition
Precision Lifestyle Medicine Program for IFHAS Participants
The goal of this clinical trial is to evaluate whether a precision lifestyle medicine intervention can improve cardiometabolic health in Emirati adults aged 25 to 50 years living in Abu Dhabi with obesity (BMI 30-35 kg/m²) who…
- Conditions
- Obese Adults, BMI/Body Composition, Cardiometabolic Risk, Cardiovascular Disease Risk
- Trial name
- NCT07742917
- Testing
- Precision Lifestyle Medicine Program, Standard IFHAS Care
- Where
- United Arab Emirates
- Volunteers
- 150 people
- Sponsor
- Institute for Healthier Living Abu Dhabi
Acute Respiratory Distress Syndrome (ARDS)
Stratification of the Acute Respiratory Distress Syndrome
The American-European Consensus Conference (AECC) and the Berlin definitions of the Acute Respiratory Distress Syndrome (ARDS) could be adequate for epidemiologic studies, but it is not adequate for inclusion of patients into…
- Trial name
- STANDARDS (NCT02288949)
- Testing
- stratification
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Hospital Universitario de Gran Canaria Doctor Negrín
Cardiovascular Diseases, Cardiovascular Risk Factor
Elaboration and Analysis of a New Cardiac Risk Stratification Protocol Based on Clinical and Physical Variables
This research project has as objective the elaboration and analysis of a new cardiac risk stratification protocol based on clinical and physical variables to predict the occurrence of signs and symptoms during a cardiac…
- Trial name
- NCT04790643
- Testing
- Exercise-based cardiac rehabilitation program (Stage 1), Exercise-based cardiac rehabilitation program (Stage 2)
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Pulmonary Embolism
Artificial Intelligence to Improve Detection and Risk Stratification of Acute Pulmonary Embolism (AID-PE)
The goal of this exploratory observational study is to assess the feasibility and real-world clinical impact of implementing Artificial Intelligence (AI) software for the detection of acute Pulmonary Embolism (PE) in patients who…
- Trial name
- AID-PE (NCT06093217)
- Testing
- Artificial Intelligence
- Where
- United Kingdom
- Volunteers
- 3,872 people
- Sponsor
- Royal United Hospitals Bath NHS Foundation Trust
Crohn's Disease
Risk Stratification of Rapid Disease Progression in Children With Crohn's Disease
The purpose of this study for children with a new diagnosis of Crohn's disease is to identify biomarkers found in the blood or stool to help predict which children are at risk of developing complications.
- Trial name
- RS (NCT00790543)
- Where
- 28 sites in United States, Canada
- Volunteers
- 1,813 people
- Sponsor
- Emory University
Colon Cancer Stage III
Lymph Node Ratio and Kras Mutation in R Colon Cancer
clinical impact of LN ratio with Kras expression in colon cancer
- Trial name
- NCT04342676
- Testing
- k ras, Panitumumab
- Where
- Egypt
- Volunteers
- 433 people
- Sponsor
- Mansoura University
Euthyroid Sick Syndromes, Non-thyroidal Illness Syndrome
Approach to a Quantitative Follow-up of Non-thyroidal Illness Syndrome
AQUA FONTIS is a unicentric, multidisciplinary, prospective cross-section and longitudinal study that aims at the development of a more clear-cut diagnostic definition and classification of non-thyroidal illness syndrome (NTIS).
- Conditions
- Euthyroid Sick Syndromes, Non-thyroidal Illness Syndrome, Low T3 Syndrome, TACITUS
- Trial name
- AQUA FONTIS (NCT00591032)
- Where
- 6 sites in Germany
- Volunteers
- 590 people
- Sponsor
- Ruhr University of Bochum
Heart Failure With Reduced Ejection Fraction
Improving the Criteria for Selecting Patients for Primary Prevention of Sudden Cardiac Death by Arrhythmic Risk Stratification
A number of large randomized studies have demonstrated the importance of left ventricle ejection fraction (LV EF) for ventrucular tachyarhrythmia's (VT) prediction.
- Trial name
- PERFECT (NCT05539898)
- Testing
- ICD implantation
- Where
- Russia
- Volunteers
- 450 people
- Sponsor
- Astrakhan Federal Centre For Cardiac Surgery
Acute Pancreatitis (AP), News-2
Predictive Performance of NEWS-2 and NEWS-Calcium Scores for In-Hospital Mortality in Older Patients With Acute Pancreatitis
Acute pancreatitis is an important gastrointestinal emergency that may lead to mortality, particularly in older patients. This retrospective, single-center observational prognostic validation study aims to compare the predictive…
- Conditions
- Acute Pancreatitis (AP), News-2, Prediction of In-Hospital Mortality in Older Patients With Acute Pancreatitis
- Trial name
- NEWS (NCT07640971)
- Testing
- Retrospective Calculation of NEWS-2 Score
- Where
- Turkey (Türkiye)
- Volunteers
- 350 people
- Sponsor
- Antalya Health Sciences University