Clinical trials: Stress
Family Relationship, Stress
Impact of Increased Parent Presence in the Neonatal Intensive Care Unit on Parent & Infant Outcomes
The purpose of this pilot study is to compare parent and infant outcomes and unit outcomes pre and post a planned unit-wide intervention aimed at increasing parent presence in the Neonatal Intensive Care Unit (NICU).
- Conditions
- Family Relationship, Stress, Breastfeeding, Bottle Feeding
- Trial name
- NCT02901665
- Testing
- FCC intervention
- Where
- 2 sites in United States
- Volunteers
- 191 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Homocystinuria
Oxidative Stress Markers In Inherited Homocystinuria And The Impact Of Taurine
Cystathionine beta-synthase deficiency is an inherited disease that results in elevation of a substance called homocysteine (Hcy) in blood and urine.
- Trial name
- NCT01192828
- Testing
- taurine
- Where
- 4 sites in United States
- Volunteers
- 15 people
- Sponsor
- University of Colorado, Denver
Depression, Anxiety
Mechanisms of Mindfulness-based Interventions
Mindfulness-based Interventions (MBIs) are a family of standardized cognitive and behavioral therapies that focus on cultivating mindfulness-related skills for improving maladaptive cognitive, emotional, and behavioral processes.
- Conditions
- Depression, Anxiety, Stress
- Trial name
- MBI (NCT03571386)
- Testing
- Mindfulness-based Cognitive Therapy (MBCT), Mindfulness-based Stress Reduction (MBSR)
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Vanderbilt University Medical Center
Caregiver Burden
Building a Bridge (BAB) Between Clinical and Community Care
Dementia diagnosis triggers a transitional phase for the individuals and their families, often causing emotional distress and family conflicts due to the ambiguity of the illness and future trajectories.
- Trial name
- BAB (NCT03932812)
- Testing
- Options Counselor Health Educator (OC-HE) Intervention
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Sato Ashida
Oxidative Stress, Anesthesia
Comparison of Total Oxidant and Total Antioxidant Capacities in Low-Flow and High-Flow General Anesthesia
The goal of this observational study is to determine whether low-flow anesthesia has a positive contribution to the total oxidant/antioxidant balance.
- Trial name
- NCT05590312
- Testing
- general anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Duzce University
Substance Use Disorder, Post-traumatic Stress Disorder
Mindful Self Compassion for Combat Deployed Veterans With Moral Injury and Co-occurring PTSD-SUD
Veterans with co-occurring Posttraumatic Stress Disorder and Substance Use Disorder (PTSD-SUD) experience more severe symptomatology and poorer response to existing treatments than Veterans with either disorder alone.
- Conditions
- Substance Use Disorder, Post-traumatic Stress Disorder, Moral Injury
- Trial name
- NCT03681288
- Testing
- Mindful Self-Compassion
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- VA Office of Research and Development
Carpal Tunnel Syndrome
Study Protocol for CTS and Keyboard Controlled Randomized Trial
The study hypothesis is that there is a relationship between the keyboard layout and carpal tunnel syndrome (CTS). Specifically, use of the standard QWERTY keyboard increases the risk of symptoms of carpal tunnel syndrome.
- Trial name
- NCT02101294
- Testing
- Interossei Lumbricals Neuro Interface, Standard QWERTY keyboard
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Finger Relief
Stress Urinary Incontinence
Voiding Function After Mid-Urethral Slings With and Without Local Anesthetic: Randomized Controlled Trial
The purpose of this study is to determine if there is a difference in post-operative voiding function between subjects receiving local anesthetic and those receiving placebo at the time of mid-urethral sling placement.
- Trial name
- URINE&ME (NCT01583166)
- Testing
- Bupivacaine, Saline, Epinephrine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Massachusetts, Worcester
Posttraumatic Stress Disorders
Eszopiclone for the Treatment of Posttraumatic Stress Disorder
The purpose of this study is to determine if eszopiclone relative to placebo (sugar pill) is effective and tolerable for people with posttraumatic stress disorder (PTSD)-related sleep disturbance.
- Trial name
- NCT01605253
- Testing
- Eszopiclone
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Rush University Medical Center
Cardiac Arrest, Post Traumatic Stress Syndrome
Family-Authored ICU Diaries to Reduce Fear in Patients Experiencing a Cardiac Arrest (FAID Fear)
The present study will: Aim 1: Enroll 15 family members of CA patients to (a) pilot recruitment procedures, (b) estimate retention, and (c) assess acceptability of study procedures.
- Trial name
- FAID Fear (NCT05144477)
- Testing
- FAID Fear Intervention
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Columbia University
Mental Health Wellness 1
The Momba Mobile Application-based Community
The investigators' mobile application-based community, termed Momba, will provide a bi-directional flow of information on maternal and infant mental health to traditionally underrepresented groups of mothers and their infants.
- Trial name
- MOMBA (NCT01816945)
- Testing
- MOMBA web-based application
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Yale University
Stroke, Acute, Hyperglycemia
Pioglitazone Treatment for Hyperglycemic Acute Ischemic Stroke
Study objective is to determine whether Pioglitazone (PGZ) can improve clinical outcomes in hyperglycemic acute ischemic stroke (IS).
- Conditions
- Stroke, Acute, Hyperglycemia, Diabetes
- Trial name
- NCT04123067
- Testing
- Pioglitazone 45 mg
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Milton S. Hershey Medical Center
Depression, Inflammation
Stress and Inflammation in Late-Life Depression
Over 18% of Americans aged 65 years and older have depression. Recent evidence suggests that there is a link between depression and inflammatory disease.
- Trial name
- S&I (NCT02389465)
- Testing
- Escitalopram + Celecoxib
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
PTSD, Posttraumatic Stress Disorder
CAP-Ketamine for Antidepressant Resistant PTSD
The purpose of this study is to test the safety and efficacy of repeated doses of ketamine as compared to placebo, in reducing symptoms of Posttraumatic Stress Disorder (PTSD) in an active duty military and Veteran population.
- Trial name
- NCT02655692
- Testing
- Ketamine
- Where
- 3 sites in United States
- Volunteers
- 163 people
- Sponsor
- VA Office of Research and Development
Advanced Solid Tumors or Non-Hodgkin's Lymphoma (NHL)
A Phase 1/2 Trial of SRA737 in Subjects With Advanced Cancer
The purpose of this clinical study is to establish the safety profile, determine the maximum tolerated dose (MTD) and recommend a Phase 2 dose and schedule of SRA737; and to evaluate the efficacy of SRA737 in…
- Trial name
- NCT02797964
- Testing
- SRA737
- Where
- 15 sites in United Kingdom
- Volunteers
- 107 people
- Sponsor
- Sierra Oncology LLC - a GSK company
Alzheimer's Disease, Dementia
Webnovela for Hispanic Dementia Family Caregivers
Photozig and Stanford University are creating a new program for Hispanic dementia caregivers to help cope with caregiving, alleviate related stress, and enhance quality of life for caregivers, with funding from the National…
- Trial name
- NCT02489110
- Testing
- Webnovela, Information
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Photozig, Inc.
PTSD
Safety and Efficacy Study of TNX-102 SL in Patients With Military-related PTSD
This is a 12-week, multicenter, randomized, double-blind, placebo-controlled, fixed-dose study that will investigate the efficacy and safety of 5.6 mg TNX-102 SL (2 x 2.8 mg tablets)-a sublingual formulation of cyclobenzaprine.
- Trial name
- HONOR (NCT03062540)
- Testing
- TNX-102 SL
- Where
- 44 sites in United States
- Volunteers
- 358 people
- Sponsor
- Tonix Pharmaceuticals, Inc.
Psychosis;Schizophrenic, Personality Disorders
The Impact of the COVID-19 (SARS-CoV-2 Disease) on Psychopathology
The outbreak of the SARS-CoV-2 pandemic may be considered a traumatic phenomenon. In a sample of subjects suffering from different psychiatric disorders, psychopathological status and Post-Traumatic Stress Disorder (PTSD)…
- Conditions
- Psychosis;Schizophrenic, Personality Disorders, Mood Disorders, Anxiety Disorders
- Trial name
- NCT04694482
- Testing
- Psychometric scale administration
- Where
- Italy
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- University of Milano Bicocca
Stress, Cancer Diagnosis
Building Resiliency Among Caregivers of Curvivors and Metavivors
The main purpose of this research study is to assess the feasibility and participants' satisfaction of the Stress Management and Resiliency - Relaxation Response Resiliency Program (SMART-3RP) and compare this treatment with…
- Conditions
- Stress, Cancer Diagnosis, Distress, Emotional
- Trial name
- ForTe (NCT05702723)
- Testing
- Smart-3RP, Enhanced Usual Care
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Massachusetts General Hospital
Sedation, Critical Illness
Musical Intervention and Physiological Stress and Inflammatory Biomarkers in Mechanically Ventilated ICU Patients
This randomized clinical trial evaluates the effects of a musical intervention on hormonal and inflammatory biomarkers in sedated adult patients undergoing invasive mechanical ventilation in an intensive care unit.
- Conditions
- Sedation, Critical Illness, Respiration, Artificial, Inflammation
- Trial name
- NCT06120660
- Testing
- Music Therapy
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- University of Oviedo
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