Clinical trials: Stroke, Acute Ischemic
Stroke, Transient Ischemic Attack
Copeptin for Risk Stratification in Acute Stroke Patients: the CoRisk Study
Prospective observational multicenter study to evaluate copeptin as a prognostic marker in patients with an acute cerebrovascular event.
- Trial name
- CoRisk (NCT00878813)
- Testing
- Sampling of 15ml blood, Blood-Sampling
- Where
- 4 sites in Germany, Switzerland
- Volunteers
- 1,102 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Acute Stroke
Evaluating the Therapeutic Effect of Acupuncture on Acute Ischemic Stroke Patients
The investigators design a randomized, single blinded, control study to evaluate the therapeutic effect of acupuncture in acute ischemic stroke patients:
- Trial name
- NCT02210988
- Testing
- acupuncture
- Volunteers
- 38 people
- Sponsor
- Cathay General Hospital
Acute Ischaemic Stroke
Study of rhPro-UK in Patients With Acute Ischaemic Stroke in 4.5 Hours After Stroke Onset(PROST)
This is a randomized, rt-PA controlled, open-label phase 3 clinical study to evaluate the efficacy and safety of recombinant human urokinase(rhPro-UK) versus rt-PA thrombolysis for patients with acute ischaemic stroke in 4.5…
- Trial name
- NCT03541668
- Testing
- Recombinant human urokinase, Alteplase
- Where
- 35 sites in China
- Volunteers
- 674 people
- Sponsor
- Tasly Biopharmaceuticals Co., Ltd.
Ischemic Stroke
Clopidogrel Response in Acute Ischemic Stroke. The Bochumer CRISP Study
The aim of this study was to determine the prevalence rate and risk factors for chemical laboratory clopidogrel low-response (CLR) in the acute phase after an ischemic stroke.
- Trial name
- Bo-CRISP (NCT01843361)
- Where
- Germany
- Volunteers
- 159 people
- Sponsor
- Ruhr University of Bochum
Acute Ischemic Stroke
Effect of Ginkgo Biloba Extract on Cognitive Function in Acute Ischemic Stroke
The purpose of this study is to determine the effect of ginkgo biloba extract on cognitive function in acute ischemic stroke.
- Trial name
- NCT06140888
- Testing
- Ginkgo Biloba Extract
- Volunteers
- 356 people
- Sponsor
- Yi Yang
Stroke, Acute
Normobaric Hyperoxia Combined With Reperfusion for Acute Ischemic Stroke
NBO is a nonpharmacological measure of neuroprotection. The purpose of our study is to evaluate the safety and efficiency of NBO（Normobaric hyperoxia) in the acute ischemic stroke patients who received endovascular treatment.
- Trial name
- NCT03620370
- Testing
- Normobaric oxygen therapy
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Capital Medical University
Ischemic Cerebrovascular Accident
Interest of Direct Aspiration First Pass Technique (ADAPT) for Thrombectomy Revascularisation of Large Vessel Occlusion in Acute Ischaemic Stroke
Mechanical thrombectomy (TM) is now validated through 4 randomized controlled trials of high scientific level as the reference treatment of cerebral infarction associated with proximal cerebral occlusion (MR CLEAN, ESCAPE 2014…
- Trial name
- ASTER (NCT02523261)
- Testing
- direct aspiration procedure, stent retriever procedure
- Where
- 8 sites in France
- Volunteers
- 381 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Brain Diseases, Cardiovascular Diseases
pRESET for Occlusive Stroke Treatment
Compare the safety and effectiveness of pRESET to Solitaire in the treatment of stroke related to large vessel occlusion
- Conditions
- Brain Diseases, Cardiovascular Diseases, Central Nervous System Diseases, Cerebrovascular Disorders
- Trial name
- PROST (NCT03994822)
- Testing
- Mechanical Thrombectomy using the pRESET Thrombectomy device, Mechanical Thrombectomy using the Solitaire Revascularization Device
- Where
- 24 sites in United States, Germany
- Volunteers
- 340 people
- Sponsor
- phenox Inc.
Acute Ischemic Stroke, Atrial Fibrillation
Registration Study of Acute Ischemic Stroke/Transient Ischemic Attack (TIA) With Atrial Fibrillation
Patient Registration Study of Acute Ischemic Stroke/transient ischemic attack(TIA) With Atrial Fibrillation (AISWAF) is a single-center prospective, consecutively, observational study, was conducted in patients with acute…
- Trial name
- AISWAF (NCT04080830)
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Xuanwu Hospital, Beijing
Stroke, Acute
Perfusion and Antihypertensive Therapy in Acute Ischemic Stroke
The purpose of this study is to provide a description of blood flow changes in the brain after blood pressure lowering drugs are given.
- Trial name
- PATIS (NCT02327793)
- Testing
- Nitroglycerin, Labetalol
- Where
- Canada
- Volunteers
- 65 people
- Sponsor
- University of Alberta
Stroke
Micro-embolic Signals Detection With Transcranial HOLter in Acute Ischemic STroke
In acute ischemic stroke, the identification of an etiology is of major importance to prevent recurrence by providing the best treatment.
- Trial name
- HOLISTER (NCT02762552)
- Testing
- Transcranial-holter monitoring
- Where
- France
- Volunteers
- 244 people
- Sponsor
- University Hospital, Bordeaux
Ischemic Stroke
The Prevalence of a Low Ankle-Brachial Index in Acute Cerebral Ischemia.
Aim of the study is assessment the prevalence of the low ankle-brachial index (ABI) defined less than or equal 0.9 in patients with acute cerebral ischemic event (stroke or transient ischemic attack) and determinate the…
- Trial name
- NCT03948399
- Testing
- Duplex scanning of carotid arteries, ABI measurement
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Jan Biziel University Hospital No 2 in Bydgoszcz
Acute Ischemic Stroke
A Phase 1b Study to Assess the Safety and Tolerability of AB126 Neural Exosomes in Patients With Moderate to Severe Acute Ischemic Stroke
The goal of this clinical trial is to learn if AB126, an investigational treatment made from neural exosomes, is safe and well tolerated when given to adults with moderate to severe acute ischemic stroke (AIS) who have undergone…
- Trial name
- NEXIS (NCT07813130)
- Testing
- AB126 Neural Exosomes Intravenous Injection
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Aruna Bio, Inc.
Acute Ischemic Stroke
Dose Finding Study of MCI-186 in Acute Ischemic Stroke
To investigate the efficacy and safety of MCI-186 (bolus followed by continuous infusion) in acute ischemic stroke patients through a double-blind, parallel-group comparison with the existing MCI-186 dosing regimen…
- Trial name
- NCT03346538
- Testing
- Continuous infusion high-dose MCI-186, Continuous infusion low-dose MCI-186, Approved dosing regimen MCI-186
- Where
- 45 sites in Japan
- Volunteers
- 17 people
- Sponsor
- Shionogi
Acute Ischemic Stroke, rhTNK-tPA
Observational Study to Assess the Safety of rhTNK-tPA (Mingfule®) vs. Rt-PA (Actilyse®) in Treating Acute Ischemic Stroke
This is a multicenter, prospective, non-randomized, post-marketing safety surveillance cohort study with rt-PA (Actilyse®) as the control.
- Trial name
- NCT07519889
- Testing
- rhTNK-tPA, rt-PA
- Volunteers
- 4,500 people
- Sponsor
- CSPC Mingfule Pharmaceutical (Guangzhou) Co., Ltd.
Brain Ischemia, Acute Stroke
Heart and Ischemic STrOke Relationship studY
Although cardio-embolic etiology of ischemic stroke (IS) is largely respected, there is still no clear recommendation for routine complex cardiological examination in all IS patients.
- Conditions
- Brain Ischemia, Acute Stroke, Heart Diseases
- Trial name
- HISTORY (NCT01541163)
- Where
- Czechia
- Volunteers
- 500 people
- Sponsor
- University Hospital Olomouc
Acute Ischemic Stroke
Intravenous Tirofiban After Delayed Thrombolysis in Stroke
A multicenter, double-blind, double-dummy, randomized trial evaluating the efficacy and safety of intravenous tirofiban in acute ischemic stroke (AIS) patients without large/medium vessel occlusion, who presented 4.5-24 hours…
- Trial name
- PEARL-TIRO (NCT07111806)
- Testing
- Tirofiban
- Where
- China
- Volunteers
- 852 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Ischemic Stroke
Normobaric Oxygen Therapy in Acute Ischemic Stroke Trial
The purpose of this study is to compare the safety and efficacy of treating individuals with acute ischemic stroke with normobaric oxygen therapy (NBO, given within 9 hours of symptom onset), to standard medical treatment.
- Trial name
- NCT00414726
- Testing
- NBO (Normobaric Oxygen), Room Air
- Where
- 2 sites in United States
- Volunteers
- 85 people
- Sponsor
- Massachusetts General Hospital
Stroke, Stroke, Acute
Glucagon-like Peptide 1 Receptor Agonist in Acute Large Vessel Occlusion Stroke Treated by Reperfusion Therapies
Endovascular thrombectomy (EVT) is a highly effective therapy for acute ischemic stroke with large vessel occlusion (LVO). EVT was proven efficacious in selected patients with symptoms onset or last-known-well time of up to 24…
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic, Brain Diseases
- Trial name
- GALLOP (NCT05920889)
- Testing
- Semaglutide
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 140 people
- Sponsor
- Chinese University of Hong Kong
Acute Ischemic Stroke
Effects of Cerebrospinal Fluid Drainage on Cerebral Hemodynamics
This pilot interventional study investigates whether continuous cerebrospinal fluid (CSF) drainage via lumbar drain can improve cerebrovascular reactivity (CVR) in patients with acute ischemic stroke and hemodynamic failure, as…
- Trial name
- NCT07056907
- Testing
- Lumbar drain placement
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich