Clinical trials: Subjective Cognitive Decline (SCD)
Neurologically Unimpaired Elderly Participants, Subjective Cognitive Decline (SCD)
Italian Adaptation and Validation of Functional and Behavioural Scales for Subjective Cognitive Decline, Mild Cognitive Impairment and Mild Dementia.
The first aim of the observational study is the translation, cross-cultural adaptation and validation of functional and behavioral scales used in the diagnosis of neurodegenerative diseases, for which a formal version in Italian…
- Conditions
- Neurologically Unimpaired Elderly Participants, Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI), Major Neurocognitive Disorder
- Trial name
- ITA-VALI-DEM (NCT06701630)
- Where
- Italy
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- Casa di Cura IGEA
Subjective Cognitive Decline (SCD), Subjective Cognitive Decline
Chinese Classics Recitation Training in Subjective Cognitive Decline
Subjective cognitive decline (SCD) is considered a preclinical condition associated with an increased risk of dementia and Alzheimer's disease.
- Trial name
- NCT07463391
- Testing
- Memory training by Chinese Classics recitation
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- China Medical University Hospital
Subjective Cognitive Decline (SCD), Alzheimer's Disease
Art of Memory for Cognitive Enhancement in the Monza Brain Health Service
The goal of this pilot interventional clinical trial (non-drug study) is to learn whether memory techniques (mnemonics) can improve cognitive performance in adults over 50 years old with subjective cognitive decline who are…
- Conditions
- Subjective Cognitive Decline (SCD), Alzheimer's Disease, Cognitive Enhancement
- Trial name
- MEMO (NCT07479914)
- Testing
- Art of memory classes, General information on art of memory
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- University of Milano Bicocca
Subjective Cognitive Decline (SCD)
Cog-Fun Ageing Participation-centered, Health Promotion for Older Adults
The goal of this feasibility study is to test the feasibility of a group intervention program based on health management principles for older adults with Subjective Cognitive Decline (SCD).
- Trial name
- NCT06632145
- Testing
- Cog Fun Ageing intervention
- Where
- Israel
- Volunteers
- 11 people
- Sponsor
- Hebrew University of Jerusalem
Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI)
Study of Bedroom Environment Sleep Intervention at Home for Older Adults Living Alone With Memory Concerns
This is an eight-week pilot research study designed to test whether simple changes to the bedroom environment along with brief sleep hygiene strategies, can improve sleep in older adults who live alone, have memory concerns, and…
- Conditions
- Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI), Insomnia
- Trial name
- NCT07440498
- Testing
- Bedroom Environment Tailoring, Sleep Health Education
- Volunteers
- 40 people
- Sponsor
- Johns Hopkins University
Subjective Cognitive Decline (SCD), Healthy Subjects
High Frequency Stimulation to Improve Cognition, Mobility, and Affect in Individuals With and Without Subjective Cognitive Decline
The goal is to determine whether three months of at least three times / week of sensory flicker stimulation improves cognition, mobility, and affect in healthy older adults and older adults with and without Subjective Cognitive…
- Trial name
- NCT07395609
- Testing
- Experimental -- 16.67 Hz Visual Occlusion, Control - 1Hz Visual Occlusion
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Florida
Alzheimer Disease, Subjective Cognitive Decline
dTMS for Subjective Cognitive Decline
Deep transcranial magnetic stimulation (dTMS) is a brain stimulation technique that involves generating a brief magnetic field in a coil that is placed on the scalp.
- Trial name
- NCT06095063
- Testing
- Active Brainsway H7-Coil Deep TMS System, Cognitive Training
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Rotman Research Institute at Baycrest
Mild Cognitive Impairment (MCI), Alzheimer's Dementia (AD)
Expanding Access to Cognitive Health Biomarker Testing at Home
The goal of this observational study is to learn whether at-home blood biomarker testing for Alzheimer's disease risk is feasible and acceptable in older adults with cognitive concerns.
- Conditions
- Mild Cognitive Impairment (MCI), Alzheimer's Dementia (AD), Subjective Cognitive Decline (SCD), Cognitive Aging
- Trial name
- NCT07594665
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Virginia
MCI, Subjective Cognitive Decline (SCD)
FACE Phase II (a Stage II Trial)
How to ensure adherence to computerized cognitive training in unsupervised circumstances (e.g., at-home, self-administered) in older adults at risk for Alzheimer's disease (AD) or AD related dementia (AD/ADRD) is understudied.
- Conditions
- MCI, Subjective Cognitive Decline (SCD), Mild Behavioral Impairment
- Trial name
- NCT07130669
- Testing
- Cognitive Remediation, Cognitive Remediation II
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Stanford University
Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)
LETHE-AT: a Personalized Multidomain Lifestyle Intervention for Individuals at Increased Risk of Memory Impairment.
The goal of this clinical trial is to learn whether a hybrid multidomain lifestyle program can prevent cognitive decline and reduce dementia risk in community-dwelling adults in mid- to late life who are at increased risk of…
- Trial name
- LETHE-AT (NCT07376135)
- Testing
- A tailored hybrid multidomain lifestyle intervention group, Self-guided multimodal lifestyle advice group
- Where
- 3 sites in Austria
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Mild Cognitive Impairment, Dementia
Korean Joint Registry for Alzheimer's Treatment and Diagnostics (JOY-ALZ)
The purpose of this research is to investigate the long-term effectiveness and safety of new Alzheimer's disease treatments, particularly monoclonal antibody therapies like lecanemab and donanemab, as well as to enhance…
- Conditions
- Mild Cognitive Impairment, Dementia, Subjective Cognitive Decline (SCD), Alzheimer Disease
- Trial name
- JOY-ALZ (NCT06889818)
- Where
- 3 sites in South Korea
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Ewha Womans University Mokdong Hospital
Subjective Cognitive Decline (SCD), Olfactory Dysfunction
The Efficacy of Modified Olfactory Training for MCI High-Risk Individuals
The goal of this clinical trial is to validate the effectiveness of the modified olfactory training device, the main questions it aims to answer are: Is it possible that the device can delay the progression of MCI in older…
- Conditions
- Subjective Cognitive Decline (SCD), Olfactory Dysfunction, Mild Cognitive Impairment (MCI), ELDERLY PEOPLE
- Trial name
- NCT06821828
- Testing
- Modified olfactory training device, Conventional olfactory training device
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Peking University Third Hospital
Alzheimer Disease, Subjective Cognitive Decline
Early Diagnosis of SCD Based on Radiogenomics
The incidence of AD dementia is increasing due to the aging population, putting a heavy burden on our society and economics. Exploring the mechanisms underlying SCD due to preclinical AD has scientific and clinical significance.
- Conditions
- Alzheimer Disease, Subjective Cognitive Decline, Neuroimaging, Gene
- Trial name
- NCT04696315
- Testing
- Multiple features extraction
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Ying Han
Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI)
Positive Psychology for Early Cognitive Decline: Effects on Cognitive and Brain Function
This randomized study tests whether a new multicomponent Positive Psychology program can improve cognition and wellbeing in older adults at the earliest stages of dementia-related decline.
- Conditions
- Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI), Alzheimer Dementia (AD)
- Trial name
- NCT07289061
- Testing
- Positive Psychology Intervention, Treatment as usual (TAU)
- Where
- Greece
- Volunteers
- 128 people
- Sponsor
- Aristotle University Of Thessaloniki
Mild Cognitive Impairment, Alzheimer Disease
A Feasiblity Study of Green Activity Program for People Living With Memory Challenges
The purpose of this study is to test the Green Activity Program that was designed with people living with memory challenges and their study partners to see if it can be done and if they enjoy the program.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Subjective Cognitive Decline (SCD)
- Trial name
- GAP (NCT06403345)
- Testing
- Green Activity Program
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Indiana University
Biomarkers, Cognitive Assessment
Neuropsychological Indicators of SCD Progression
Some patients with subjective cognitive decline (SCD) progress to neurocognitive disorders (NCD), whereas others remain stable; however, the neuropsychological determinants of this progression have not been identified.
- Conditions
- Biomarkers, Cognitive Assessment, Cognitive Decline, Neurocognitive Disorders
- Trial name
- SCD-CI (NCT04880252)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Subjective Cognitive Decline (SCD)
An Open Label Trial Evaluating the Efficacy of Lacticaseibacillus Paracasei PS23 on Cognition
This open label study aims to evaluate whether the consumption of probiotics can improve symptoms and overall quality of life in individuals experiencing cognitive decline symptoms, as well as to evaluate the effects of…
- Trial name
- NCT07168824
- Testing
- Lacticaseibacillus paracasei
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chi-Chang Huang
Feasibility Randomized Control Trial
Mindfulness-Based Stress Reduction With Older Adults Living With Cognitive Impairment in Primary Care.
People living with subjective cognitive decline (SCD) or mild cognitive impairment (MCI) experience less efficiency in performing complex everyday tasks, which may result in a general sense of discontentment and decreased…
- Trial name
- NCT03867474
- Testing
- Mindfulness-Based Stress Reduction (MBSR)
- Where
- 2 sites in Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Women's College Hospital
Subjective Cognitive Decline (SCD), Depression Disorder
Electro-acupuncture for SCD With Depression
The goal of this clinical trial is to evaluate the efficacy and safety of electroacupuncture in treating adults with subjective cognitive decline accompanied by depression.
- Trial name
- NCT07350226
- Testing
- "TXJN" electro-acupuncture
- Where
- China
- Volunteers
- 86 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Subjective Cognitive Decline
Attentional Mechanisms in SCD
This study will use an anticholinergic pharmacological probe to examine attention network function in SCD using EEG. The overall hypothesis is that in older adults with SCD, normal cognitive performance is maintained by…
- Trial name
- AMoCC-SCD (NCT06002477)
- Testing
- Mecamylamine Challenge
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center