Clinical trials: Submucosal Tumor
Submucosal Tumor of Stomach
Endoscopic Full Thickness Resection Without Exposure to Peritoneum
This study evaluates the feasibility of endo-laparoscopic full-thickness resection with simple suturing technique which did not expose gastric mucosa to peritoneum (simple non-exposure EFTR) in patients with gastric tumor.
- Trial name
- NCT02764944
- Testing
- simple non-exposure EFTR
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- National Cancer Center, Korea
Early Gastric Cancer, Gastric Adenoma
Performance of Endoscopic Submucosal Dissection According to the Sedation Method
Although proper sedation is mandatory for endoscopic procedures such as endoscopic submucosal dissection, the effects of sedation on ESD performance and complications have not been fully evaluated.
- Trial name
- NCT01806753
- Testing
- Intermittent midazolam/propofol injection controlled by endoscopist, Continuous propofol infusion with opioid administration
- Where
- South Korea
- Volunteers
- 157 people
- Sponsor
- Yonsei University
Stomach Neoplasm, Intestinal Neoplasm
Multicentric Study an Endoscopic Treatment of Digestive Neoplasia by Submucosal Dissection Evaluation of a New Water Jet System
safety evaluation of endoscopic sub-mucosal dissection with nestis enki2 system. This system is a new water jet system which allows to perform Endoscopic submucosal dissection with a bifunctional catheter (injection and cutting).
- Conditions
- Stomach Neoplasm, Intestinal Neoplasm, Rectal Neoplasm
- Trial name
- NCT01910974
- Testing
- endoscopic sub-mucosal dissection
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Hôpital Edouard Herriot
Neoplasm, Stomach, Neoplasm, Colorectal
Endoscopic Submucosal Dissection Registry
This is a patient registry for all cases of pre-neoplastic or early neoplastic digestive tract lesions treated with curative intention by endoscopic submucosal dissection (ESD) technique.
- Conditions
- Neoplasm, Stomach, Neoplasm, Colorectal, Neoplasm, Esophagus, Neoplasm, Duodenal
- Trial name
- ESDREG (NCT06033976)
- Testing
- Endoscopic submucosal dissection (ESD)
- Where
- Romania
- Volunteers
- 200 people
- Sponsor
- Carol Davila University of Medicine and Pharmacy
Colorectal Neoplasms
EMR Versus ESD for Resection of Large Distal Non-pedunculated Colorectal Adenomas
Endoscopic resection of adenomas in the colon is the cornerstone of effective colorectal cancer prevention. Endoscopic mucosal resection (EMR) is currently the most used technique for resection of large distal colorectal…
- Trial name
- MATILDA (NCT02657044)
- Testing
- EMR, ESD
- Where
- Netherlands
- Volunteers
- 212 people
- Sponsor
- UMC Utrecht
Esophageal Stenosis Acquired
Mixed Gel of Hydrocortisone and Aluminium Phosphate Preventing Endoscopic Submucosal Dissection Postoperative Stenosis for Patients With Large Esophageal Carcinoma
Endoscopic submucosal dissection as the fastest growing endoscopic treatment technology in the past decade has been widely used in the treatment of early esophageal cancer and gastric cancer without local lymph node metastasis.
- Trial name
- NCT03165344
- Testing
- Hydrocortisone sodium succinate mixed with Aluminium Phosphate gel (route of administration), Triamcinolone Acetonide (route of administration), Prednisone (route of administration)
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Peking University Third Hospital
Rectal Cancer, Colo-rectal Cancer
Pre-therapeutic MRI Assessment of Early-Stage Rectal Cancer and Significant Rectal Polyps to Avoid Major Resectional Surgery
When a patient is diagnosed with a rectal (bowel) polyp or cancer, radiology doctors read MRI scans to describe how deeply the cancer invades into the bowel wall (this is the 'stage' of the cancer).
- Trial name
- PRESERVE (NCT04103372)
- Testing
- MRI scan, Radiologist training
- Where
- 23 sites in United Kingdom
- Volunteers
- 200 people
- Sponsor
- Imperial College London
Gastric Dysplasia
Endoscopic Submucosal Dissection Using a Thulium Laser
We aim to evaluate safety and feasibility of a thulium laser system in performing endoscopic submucosal dissection of gastric neoplasia.
- Trial name
- NCT01753544
- Where
- South Korea
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Soonchunhyang University Hospital
Rectal Neuroendocrine Tumor
Traction-Assisted Versus Conventional Endoscopic Submucosal Dissection for Rectal Neuroendocrine Tumors
This prospective, randomized pilot study will compare traction-assisted endoscopic submucosal dissection (T-ESD) with conventional endoscopic submucosal dissection (C-ESD) for the treatment of rectal neuroendocrine tumors.
- Trial name
- TRACE-NET (NCT07848360)
- Testing
- Traction-Assisted Endoscopic Submucosal Dissection, Conventional Endoscopic Submucosal Dissection
- Volunteers
- 66 people
- Sponsor
- Pusan National University Hospital
Early Gastric Cancer, Gastric Adenoma
Fibrin Glue After ESD for High Risk Patients of Bleeding
It is a prospective randomized controlled study to look for effectiveness of fibrin glue to prevent bleeding in high-risk patients after endoscopic submucosal dissection in gastric neoplasm.
- Trial name
- NCT04602689
- Testing
- Human fibrinogen concentrate
- Where
- South Korea
- Volunteers
- 134 people
- Sponsor
- Seoul National University Hospital
Early Gastric Cancer or Gastric Adenoma
Pilot Trial on Efficacy of Single Dose Perioperative Intravenous Dexamethasone for Pain Relief After Endoscopic Submucosal Dissection
Besides major ESD-related complications, minor adverse events after ESD are also commonly noticed. Pain is one of minor ESD-related complications. .
- Trial name
- NCT02037399
- Testing
- intravenous dexamethasone, intravenous normal saline
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yonsei University
Gastric Cancer
Magnetic Anchoring Guided Endoscopic Submucosal Dissection for Early Gastric Caner
This study uses magnetic anchored guidance system to treat early gastric cancer by endoscopic mucosal dissection to test the advantages of magnetically anchored guidance system for surgical field exposure during endoscopic…
- Trial name
- MAGESD (NCT04327050)
- Testing
- Magnetic anchored guided endoscopic submucosal dissection
- Volunteers
- 30 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Colonic Polyp, Colonic Neoplasms
Additive Hemostatic Efficacy of EndoClot After EMR or ESD in the Gastrointestinal Tract
The investigators want to verify in a randomised trial, the effectiveness of EndoClotTM in preventing post-procedural bleeding after EMR (Endoscopic Mucosal Resection) or ESD (Endoscopic Submucosal Dissection) for sessile lesions…
- Conditions
- Colonic Polyp, Colonic Neoplasms, Colonic Dysplasia
- Trial name
- NCT02688699
- Testing
- EndoClot
- Volunteers
- 288 people
- Sponsor
- University of Turin, Italy
Superficial Esophageal Cancer
Human (Autologous) Oral Mucosal Cell Sheet Transplantation After ESD in Patients With Superficial Esophageal Cancer
The purpose of this study is to evaluate the efficacy and safety of esophageal epithelial regenerative treatment by the transplantation of the product, CLS2702C, to the esophageal wound site after extensive ESD for superficial…
- Trial name
- NCT02866019
- Testing
- CLS2702C/CLS2702D
- Where
- 3 sites in Japan
- Volunteers
- 10 people
- Sponsor
- CellSeed Inc.
Esophageal Cancer
Endoscopic Submucosal Dissection Versus Esophagectomy for Early Esophageal Carcinoma
Endoscopic submucosal dissection (ESD) is a minimally invasive alternative to esophagectomy for early esophageal squamous cell carcinoma (EESCC), The data of EESCC patients who received ESD or esophagectomy were retrospectively…
- Trial name
- NCT06060106
- Testing
- Endoscopic submucosal dissection, Esophagectomy
- Where
- China
- Volunteers
- 191 people
- Sponsor
- Changhai Hospital
Submucosal Tumor of Gastrointestinal Tract
Hydrogel Injection to Assist Endoscopic Submucosal Dissection
The aim of the investigators' study is to evaluate the mucosa-elevating capacity and clinical safety of Sodium Alginate (SA) mixed with Calcium Lactate in assisting Endoscopic Submucosal Dissection/Endoscopic Mucosal Resection.
- Trial name
- NCT03321396
- Testing
- sodium alginate mixed with calcium lactate
- Where
- Taiwan
- Volunteers
- 13 people
- Sponsor
- National Cheng-Kung University Hospital
Colo-rectal Cancer
Efficacy of a Hemostatic Agent (PuraStat®) in Reducing Delayed Bleeding After Endoscopic Submucosal Dissection
The problem of delayed bleeding after endoscopic resection is becoming important due to the growing number of indications for anti-aggregation or anticoagulant treatment for cardiovascular reasons in the aging populations.
- Trial name
- NCT05031325
- Testing
- Endoscopic submucosal dissection with Purastat
- Where
- France
- Volunteers
- 288 people
- Sponsor
- Mathieu Pioche
Gastric Adenoma, Early Gastric Cancer
The Effect of Proton Pump Inhibitor and Polaprezinc Combination Therapy for Healing of Endoscopic Submucosal Dissection-induced Ulcer
Endoscopic submucosal dissection (ESD) is an advanced technique that enables en bloc resection of superficial tumors in the gastrointestinal tract.
- Trial name
- NCT02243618
- Testing
- Polaprezinc, Rebamipide
- Where
- South Korea
- Volunteers
- 153 people
- Sponsor
- Yonsei University
Gastric Neoplasm
The Effect of Perioperative Intravenous Magnesium on Pain After Endoscopic Submucosal Dissection for Gastric Neoplasm: Prospective Randomized Double-blind Placebo Controlled Study
Endoscopic submucosal dissection (ESD) is an effective treatment for early gastric cancer or premalignant lesions in the stomach.
- Trial name
- NCT02235246
- Testing
- Magnesium Sulfate, Normal saline
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Early Gastric Cancer, Endoscopic Submucosal Dissection
The Relationship Between Scar Formation and ESD Depth in Therapy for Gastric Carcinoma
This study is a single-center, prospective, group-controlled clinical trial, aiming to clarify the relationship between the depth of dissection and scar formation in the treatment of early gastric cancer by ESD, and to provide…
- Trial name
- NCT05323929
- Testing
- ESD
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine