Clinical trials: Surgery of Breast Cancer
Breast Cancer, Drug/Agent Toxicity by Tissue/Organ
Combination Chemotherapy After Surgery With or Without Chinese Herbal Therapy to Treat Symptoms in Women With Breast Cancer
RATIONALE: Herbs used in traditional Chinese medicine may decrease the side effects of chemotherapy. PURPOSE: Randomized phase I/II trial to study the effectiveness of herbs used in traditional Chinese medicine in decreasing the…
- Trial name
- NCT00028964
- Testing
- Chinese herbs, cyclophosphamide, doxorubicin hydrochloride
- Where
- United States
- Sponsor
- University of California, San Francisco
Female Breast Carcinoma
Effect of Yoga on Life Quality and Immunity in Breast Cancer Patients After Operation and or Chemotherapy
The purpose of study is to investigate if yoga exercise improve life quality and immune status in breast cancer patients after complete treatment (including surgery and / or radiotherapy and / or chemotherapy)
- Trial name
- NCT02243163
- Testing
- Yoga exercise
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Chang Bing Show Chwan Memorial Hospital
Other Reconstructive Surgery, Failure of Muscle Graft
Robotic Harvest of the Latissimus Dorsi (LD) Muscles
The goal of this clinical research study is to learn more about the safety and feasibility of using the Da Vinci Robotic Surgical system in procedures that harvest the latissimus dorsi muscle (a back muscle below your shoulder)…
- Conditions
- Other Reconstructive Surgery, Failure of Muscle Graft, Cancer, Complications
- Trial name
- NCT02274493
- Testing
- da Vinci® Robotic Surgical System, LD muscle flap harvest procedure, Reconstructive surgery
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer Surgery, Locoregional Anaesthesia
Feasibility of a Standardized Fascial Plane Block Protocol for Breast Cancer Surgery
The goal of this observational study is to evaluate the feasibility of a standardized locoregional anesthesia protocol for patients undergoing breast cancer surgery under procedural sedation or adjunctive hypnosis.
- Conditions
- Breast Cancer Surgery, Locoregional Anaesthesia, Hypnosis, Fascial Plane Block
- Trial name
- FASTBREAST2026 (NCT07877740)
- Testing
- Standardized locoregional anesthesia protocol for breast cancer surgery
- Where
- Switzerland
- Volunteers
- 65 people
- Sponsor
- Hôpital Fribourgeois
Breast Carcinoma, Breast Carcinoma in Situ
Postoperative Pain After Breast Surgery Under Tumescent Local Anaesthesia Versus General Anaesthesia ( TLA-001 )
The present study aims to investigate the impact of Tumescent Local Anesthesia (TLA) on pain perception following surgeries typical for breast cancer.
- Trial name
- NCT06335108
- Testing
- General Anaesthesia, Local tumescent anaesthesia
- Where
- Germany
- Volunteers
- 349 people
- Sponsor
- University Hospital Tuebingen
Early-stage Breast Cancer, Estrogen-receptor-positive Breast Cancer
Ketorolac and Pregabalin Effects on breaSt Cancer (KePreSt)
Out of all proportion to its short duration, the perioperative period is critical in determining the long-term outcome of cancer.
- Trial name
- KePreSt (NCT06150898)
- Testing
- Prospective data and sample collection, Ketorolac 10 Mg Oral Tablet, Pregabalin 75mg
- Where
- Belgium
- Volunteers
- 112 people
- Sponsor
- Jules Bordet Institute
Pleural Metastases, Breast Cancer
Heated Chemotherapy for Cancers That Have Spread to the Chest Cavity
Cancers that have spread to the inner lining of the chest are classified as Stage IV and bear a poor prognosis. Surgery is rarely an option, with palliative chemotherapy and/or radiation therapy the only treatment options.
- Conditions
- Pleural Metastases, Breast Cancer, Colon Cancer, Ovarian Cancer
- Trial name
- NCT01163552
- Testing
- Surgical debulking and Intrathoracic Hyperthermic Chemotherapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Breast Carcinoma, Colon Carcinoma
Biospecimen Collection in Identifying Genetic Changes in Patients With Breast, Prostate, Colorectal, Liver, or Kidney Cancer or Multiple Myeloma Undergoing Surgery
This research trial studies how well biospecimen collection works in identifying genetic changes in patients with breast, prostate, colorectal, liver, or kidney cancer or multiple myeloma undergoing surgery.
- Conditions
- Breast Carcinoma, Colon Carcinoma, Invasive Carcinoma, Kidney Carcinoma
- Trial name
- NCT04955808
- Testing
- Biospecimen Collection, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 2,400 people
- Sponsor
- National Cancer Institute (NCI)
Breast Cancer
A Study of Dato-DXd With or Without Durvalumab Versus Investigator's Choice of Therapy in Patients With Stage I-III Triple-negative Breast Cancer Without Pathological Complete Response Following Neoadjuvant Therapy (TROPION-Breast03)
This is a Phase III, randomized, open-label, 3-arm, multicenter, international study assessing the efficacy and safety of Dato-DXd with or without durvalumab compared with ICT in participants with stage I to III TNBC with…
- Trial name
- NCT05629585
- Testing
- Dato-DXd, Durvalumab, Capecitabine
- Where
- 276 sites in United States, Belgium and 15 more
- Volunteers
- 1,174 people
- Sponsor
- AstraZeneca
Breast Cancer, Breast Surgery
Hemodynamic Effects of Intradermal Methylene Blue During Breast Surgery Under General Anesthesia
This prospective observational study aims to evaluate the effects of intradermal methylene blue injection on intraoperative hemodynamic stability in patients undergoing breast surgery under general anesthesia.
- Conditions
- Breast Cancer, Breast Surgery, Sentinel Lymph Node Biopsy, Methylene Blue
- Trial name
- NCT07040540
- Testing
- Methylene Blue, Standard Surgical Care Without Dye
- Where
- Turkey (Türkiye)
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Seroma, Breast Cancer
The Effect of Thoracal Paravertebral Block on Seroma Reduction in Breast Surgery
Thoracal paravertebral block (TPVB) is a commonly prefferred regional anesthesia technique to provide postoperative analgesia. In addition, the successful use of TPVB is reported for some seroma related pain cases.
- Trial name
- NCT03650868
- Testing
- Thoracal paravertebral block
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Gynecologic Cancer, Gynecologic Neoplasms
Intravenous and Intraperitoneal Paclitaxel and Oral Nilotinib for Peritoneal Carcinomatosis
Background: Tumors that have spread to the lining of the abdomen from other cancers, such as cancer of the appendix, colon, or ovary, are called peritoneal carcinomatosis. In most cases, outcomes are poor.
- Conditions
- Gynecologic Cancer, Gynecologic Neoplasms, Peritoneal Carcinomatosis, Peritoneal Neoplasms
- Trial name
- NCT05185947
- Testing
- Paclitaxel, Nilotinib, ECG
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Cancer Institute (NCI)
Breast Cancer Surgery, Young Adult Females
Sexual Functıon in Young Women After Breast Cancer Surgery
The aim of this observational study was to analyse sexual function in young women after breast cancer surgery. The main question it aims to answer is Sexual function in young women after breast cancer surgery changes during the…
- Trial name
- NCT06966791
- Testing
- No intervention will be performed as part of this study. However, regardless of the study, all participants will have breast cancer surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- ATİYE KAŞ ÖZDEMİR
Breast Fibroadenoma, Atypical Ductal Hyperplasia
Comparing Vacuum-Assisted Percutaneous Excision to Open Surgical Excision for Borderline or High-Risk Breast Lesions
This randomized controlled trial compares vacuum-assisted percutaneous excision to open standard surgical excision in women who have high-risk or borderline, non-malignant breast lesions with respect to efficacy, safety, cosmesis…
- Conditions
- Breast Fibroadenoma, Atypical Ductal Hyperplasia, Atypical Lobular Hyperplasia, Lobular Carcinoma in Situ
- Trial name
- VAPEX (NCT03868475)
- Testing
- Vacuum-assisted percutaneous excision, Open surgical excision
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Breast Neoplasms
The Significance of Radiologically Detected Intramammary Lymph Nodes in Prediction of Axillary Lymph Nodes Status in Breast Cancer Patients
Breast cancer is a major cause of mortality among women if not treated in early stages. Early screening and diagnosis have a lot to do with the therapeutic effect of prognosis .
- Trial name
- NCT05214781
- Testing
- modified radical mastectomy
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Breast Cancer
Establishment and Clinical Application of Precise SLNB System in Breast Cancer: a Randomized, Multicenter, Controlled Study
The investigatorsconduct the precise sentinel lymph node biopsy using preoperative computed tomographic lymphography in breast cancer.
- Trial name
- NCT03857932
- Testing
- Participants receive SLNB as well as non SLNs resection
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Shandong University
Breast Cancer
Cyclophosphamide, Methotrexate, and Fluorouracil, With or Without Epirubicin Hydrochloride, in Treating Women Who Have Undergone Surgery for Breast Cancer (Group III Closed to New Patients as of 12/7/2009)
RATIONALE: Drugs used in chemotherapy, such as cyclophosphamide, methotrexate, fluorouracil, and epirubicin hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them…
- Trial name
- NCT01031030
- Testing
- cyclophosphamide, epirubicin hydrochloride, fluorouracil
- Volunteers
- 800 people
- Sponsor
- Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
Breast Cancer
Combination Chemotherapy Before Surgery in Treating Women With Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells and shrink tumors so they can be removed during…
- Trial name
- NCT00008034
- Testing
- capecitabine, cyclophosphamide, epirubicin hydrochloride
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Breast Cancer, Mastectomy
Same-Day Awake Mastectomy With Immediate Breast Reconstruction for Patients With Breast Cancer
The goal of this clinical trial is to learn if the AMADeuS care pathway is as safe as usual hospital care and works as well for pain control in women having mastectomy with immediate prepectoral breast reconstruction.
- Conditions
- Breast Cancer, Mastectomy, Prepectoral Breast Reconstruction, ERAS Programmes
- Trial name
- AMADeuS (NCT07510698)
- Testing
- AMADeuS Perioperative Pathway, Usual Perioperative Care
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Rome Tor Vergata
Human Epidermal Growth Factor 2 Negative Carcinoma of Breast, HER2-positive Breast Cancer
Assessing the Efficacy and Safety of Anti-HER2 Therapy in Nigerian Women With HER2+ Breast Cancer Before and After Surgery
Doctors leading this study would like to learn about providing cancer treatment/therapies to Nigerian women with breast cancer based on their human epidermal growth factor receptor 2 (HER2) status.
- Conditions
- Human Epidermal Growth Factor 2 Negative Carcinoma of Breast, HER2-positive Breast Cancer, Breast Cancer
- Trial name
- NCT06348134
- Testing
- Trastuzumab emtansine, Pertuzumab Injection, Docetaxel
- Where
- 4 sites in Nigeria
- Volunteers
- 74 people
- Sponsor
- University of Chicago