Clinical trials: Suspected Lung Cancer, active
Lung Nodules, Lung Cancer Screening
ctDNA Mutations and Methylation Status for Early Detection of Lung Cancer in Patients With Suspicious Lung Nodules
Lung Cancer is common in Asia and is different from lung cancer from Western countries in terms of lung cancer epidemiology and management.
- Conditions
- Lung Nodules, Lung Cancer Screening, Suspected Lung Cancer
- Trial name
- NCT07615556
- Testing
- ctDNA mutations and methylation with SPOTMAS Lung assays, Non-contrast LDCT Thorax scans
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- The University of Hong Kong
Lung Neoplasm Malignant
Benefit of Spectral Information in Patients Suspected for Lung Cancer
Purpose The aim of the study is to investigate the utilization of photon counting CT (PCCT) and the spectral information provided to determine the impact of spectral information on follow-up examinations.
- Trial name
- NCT06440616
- Testing
- Spectral CT images generated by a photon counting CT scanner
- Where
- Denmark
- Volunteers
- 1,000 people
- Sponsor
- Copenhagen University Hospital at Herlev
Lung Carcinoma, Metastatic Malignant Neoplasm in the Lung
Molecular Analysis of Suspected or High-Risk Lung Cancer to Drive Individualized Care
This study evaluates the effectiveness of tumor samples in providing information about hereditary or cancer specific genetic variants that may have a role in diagnosis of cancer and to develop genetic results and medical record…
- Trial name
- NCT06482073
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Mayo Clinic
Lung Cancer (Diagnosis), Lung Cancer (Suspected or Confirmed)
A Study Measuring Markers of Airway Inflammation in Breath Samples From People With Respiratory Diseases and Healthy Volunteers.
Lung cancer remains the leading cause of cancer-related death in the UK, with over 35,000 deaths annually and most cases diagnosed at a late stage.
- Conditions
- Lung Cancer (Diagnosis), Lung Cancer (Suspected or Confirmed), Healthy, Pneumonia
- Trial name
- VICTORY 2 (NCT07426718)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Portsmouth Hospitals NHS Trust
Indeterminate Pulmonary Nodule
Nodify Lung Testing for Pulmonary Nodules
The STRATIFY Study is an observational study for adults age 40 or older who have a lung nodule that is not clearly benign or cancerous. The study will enroll up to 1,000 participants at about 10-12 U.S.
- Trial name
- STRATIFY (NCT07858552)
- Volunteers
- 1,000 people
- Sponsor
- Biodesix, Inc.
Small Pulmonary Nodules, Pulmonary Nodule Localization
Monarch Robotic Bronchoscopy for Lung Nodule ICG Dye Marking Before VATS
This is a single-center, prospective, single-arm clinical study conducted at Beijing Cancer Hospital to evaluate the effectiveness, safety, and learning curve of preoperative indocyanine green (ICG) dye marking mixed with…
- Conditions
- Small Pulmonary Nodules, Pulmonary Nodule Localization, Lung Cancer (Suspected or Confirmed), Video-assisted Thoracoscopic Surgery (VATS)
- Trial name
- REALM (NCT07177924)
- Testing
- Monarch RAB with CBCT-guided ICG Dye Marking
- Volunteers
- 50 people
- Sponsor
- Peking University Cancer Hospital & Institute
Lung Cancer (Suspected or Confirmed), Thoracoscopic Lobectomy
Right Ventricular Afterload Indices in Lung Surgery
Lung cancer is a leading cause of cancer death in Scotland and the UK. Surgery, typically using a keyhole approach, provides the best chance of cure.
- Conditions
- Lung Cancer (Suspected or Confirmed), Thoracoscopic Lobectomy, One Lung Ventillation (OLV)
- Trial name
- RAILS (NCT07812207)
- Testing
- Contrast cardiac magnetic resonance imaging, Right heart catheterisation, Perioperative plasma sampling
- Volunteers
- 15 people
- Sponsor
- University of Glasgow
Lung Cancer (Diagnosis), Biopsy, Fine-Needle/Methods
Accuracy Between Transthoracal Needle Aspiration (TTNA) Techniques in Suspected Lung Cancer Patients
The objective of this research is to determine the accuracy of different types of lung transthoracal needle aspiration (TTNA) i.e.
- Trial name
- NCT07255950
- Testing
- Jabbing-then-Suction, Suction-with-Jabbing, and Suction-only Transthoracal Needle Aspiration (TTNA) Techniques
- Where
- Indonesia
- Volunteers
- 54 people
- Sponsor
- Gadjah Mada University
Patients With Suspected Non-small Cell Lung Cancer (NSCLC) at Clinical Stage T1
Anesthesia Comparison in Early-stage Small NSCLC: A Multicenter RCT
This study is a prospective, randomized, controlled study, which intends to enroll patients with suspected early-stage NSCLC (non-small cell lung cancer) with a diameter of ≤ 3 cm as research subjects.
- Trial name
- NCT07327736
- Testing
- Non-intubated video-assisted thoracic surgery with spontaneous breathing (NIVATS)
- Volunteers
- 410 people
- Sponsor
- Tang-Du Hospital
Lung Cancer, Mesothelioma
Implantable Microdevices for in Situ Evaluation of Drug Responses in Lung Cancer
This research is being done to study the safety and feasibility of implanting and retrieving a microdevice that releases microdoses of 20 specific drugs or drug combinations as a possible tool to evaluate the effectiveness of…
- Conditions
- Lung Cancer, Mesothelioma, Suspected Lung Cancer, Suspected Mesothelioma
- Trial name
- NCT07892300
- Testing
- Implantable Micro- drug delivery Microdevice (IMD)
- Volunteers
- 20 people
- Sponsor
- Oliver Jonas
Lung Diseases
PET/CT GUIDED BIOPSY VERSUS CT GUIDED BIOPSY IN EVALUATION OF SUSPECTED LUNG NEOPLASMS
Percutaneous CT guided biopsy is a well-established, standard sampling technique for suspected neoplastic lesions located in peripheral region in lung parenchyma.
- Trial name
- NCT06923098
- Testing
- PET-CT guided biopsy, CT guided biopsy
- Where
- India
- Volunteers
- 108 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Lung Cancer, Non Small Cell Lung Cancer
Optimizing Endobronchial Ultrasound Sampling for Molecular Markers for NSCLC
In this monocentric randomized controlled trial, 120 potential non small cell lung cancer (NSCLC) patients for which tissue diagnosis and material for next generation sequencing (NGS) is required for clinical management will be…
- Conditions
- Lung Cancer, Non Small Cell Lung Cancer, Circulating Tumor Cell
- Trial name
- OPTIMAL (NCT05560776)
- Testing
- Endobronchial ultrasound
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Lung Cancer (Suspected or Confirmed), Cryoablation
One-stop Diagnosis and Treatment for Suspected Lung Cancer: Combined RBS, nClE, OBCT and Ablation
Using RBS as the navigation and treatment platform, precisely navigate to the target lesion. Utilize r-EUBS and nCLE to identify the lesion, and when the confocal AI model recognizes the lesion as malignant, perform a biopsy.
- Conditions
- Lung Cancer (Suspected or Confirmed), Cryoablation, Robotic Bronchoscopy System, Confocal Laser Endomicroscopy
- Trial name
- One-stop (NCT07521618)
- Testing
- Ablation
- Volunteers
- 30 people
- Sponsor
- Guangzhou Medical University
Lung Cancer (Suspected or Confirmed)
Effect of a Music Intervention in Reducing Distress and Pain in Patients With Lung Cancer Undergoing Mini-invasive Surgery
This study aims at evaluating whether music therapy intervention is effective in decreasing psychological (distress) and physical symptoms (pain) in patients with suspected or diagnosed lung cancer undergoing minimally invasive…
- Trial name
- NCT07235098
- Testing
- Music therapy intervention
- Where
- Switzerland
- Volunteers
- 74 people
- Sponsor
- Oncology Institute of Southern Switzerland
Pulmonary Nodule, Suspected Lung Cancer
Preoperative Decision-Making in Patients With Pulmonary Nodules Suspected of Lung Cancer
Patients with pulmonary nodules that are highly suspected to be lung cancer often need to make important treatment decisions before a definite pathological diagnosis is available.
- Conditions
- Pulmonary Nodule, Suspected Lung Cancer, Preoperative Decision-Making
- Trial name
- NCT07590596
- Testing
- Questionnaire-Based Decision-Making Assessment
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Suspected Malignant Lung Neoplasm, Pleural Effusion
First Local Anaesthesia Thoracoscopy for Pleural Effusion Diagnosis.
Non randomized study with two groups. The study group includes patients with suspected malignant pleural effusion, in whom the investigation of pleural effusion begins directly with pleural biopsy by Local Anesthesia Thoracoscopy…
- Conditions
- Suspected Malignant Lung Neoplasm, Pleural Effusion, Pleural Effusion, Malignant, Mesothelioma, Malignant
- Trial name
- FLAT (NCT06946498)
- Testing
- Local Anesthesia Thoracoscopy, Pleuroscopy with Rigid Thoracoscope and Forceps biopsies
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- National and Kapodistrian University of Athens
COPD (Chronic Obstructive Pulmonary Disease), Lung Cancer (Diagnosis)
Enhanced COPD Management in Suspected Lung Cancer Patients
Identifying and treating COPD in patients undergoing lung cancer evaluation is crucial. Early intervention could lead to better management of both diseases, improving health status, reducing healthcare costs, and potentially…
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Lung Cancer (Diagnosis), Lung Neoplasm Malignant, Lung Carcinoma
- Trial name
- ECHELON (NCT07543601)
- Testing
- Tailored COPD consultations
- Where
- Denmark
- Volunteers
- 280 people
- Sponsor
- Ditte Krag-Hansen
Cancer in the Lung, Ovarian Cancer
CYTALUX Dose Extension Study
The goal of this clinical trial is to learn whether giving Cytalux™ (pafolacianine) injection several days before surgery works as well as giving it closer to the time of surgery for helping surgeons see lesions during an…
- Trial name
- NCT07469202
- Testing
- CYTALUX (pafolacianine) injection
- Volunteers
- 106 people
- Sponsor
- On Target Laboratories, LLC