Clinical trials: Symptoms and Signs
Pulmonary Disease, Chronic Obstructive
Tiotropium Once Daily 18 Mcg Versus Salmeterol Twice Daily 50 Mcg on Time to First Exacerbation in COPD Patients.
This is a randomised, double-blind, double-dummy, multinational, multicentre, parallel group trial comparing tiotropium (18 mcg) inhalation capsule via HandiHaler and salmeterol (50 mcg) via MDI in patients with COPD.
- Trial name
- NCT00563381
- Testing
- Tiotropium bromide, Salmeterol
- Where
- 752 sites in Austria, Belgium and 23 more
- Volunteers
- 7,376 people
- Sponsor
- Boehringer Ingelheim
Malignant Melanoma
PET Imaging of the Immune System Using Analog Probes
The goal of this proposal is to assess the biodistribution of 18F-Clofarabine, a new tracer developed for use in PET/CT scans. The investigator's hypothesis is this tracer will allow for imaging immune activation in patients with…
- Trial name
- NCT03409419
- Testing
- [18F] CFA
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Pain, Apnea
Could Apnea Induce Hypoalgesia?
A randomized controlled trial (RCT) in healthy subjects will be conducted with the following aims: (1) Explore the effect of low pulmonary volume dynamic apnoea bouts on Pressure Pain Threshold (PPT) and conditioned pain…
- Trial name
- NCT05991141
- Testing
- Apnea, Control Intervention
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centro Universitario La Salle
Fluid Overload
Body Composition Monitoring(BCM) for Determination of the Fluid Status in Patients Undergoing General Anesthesia
The purpose of this study is to evaluate a recently developed device, which measures body composition (i.e. the water content of the body) in the perioperative setting.
- Trial name
- BCM (NCT01945541)
- Testing
- Body Composition Monitoring
- Where
- Austria
- Volunteers
- 73 people
- Sponsor
- Medical University of Vienna
Childhood Obesity, Insulin Resistance
Leipzig Adipose Tissue Childhood Cohort
In this study the investigators hypothesize that pathological alterations in adipose tissue biology already occur during the development and progression of obesity in children and adolescents.
- Trial name
- NCT02208141
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Angina Pectoris
Spinal Cord Stimulation (SCS) in Refractory Angina
The study aims at assessing safety and efficacy of Spinal Cord Stimulation (SCS) for the treatment of refractory angina pectoris in a single blind, prospective, multicenter study.
- Trial name
- NCT00121654
- Testing
- Spinal cord stimulation
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Catholic University of the Sacred Heart
Pain, Vaginal Hysterectomy
0.05 Versus 0.1 mg Spinal Morphine for Reducing Morphine Requirement After Vaginal Hysterectomy
This study aims to compare the efficacy of 0.05 mg and 0.1 mg spinal morphine in reducing postoperative morphine requirement in patients undergoing vaginal hysterectomy with/without anterior and posterior vaginoplasty.
- Trial name
- NCT01079754
- Testing
- Spinal morphine 0.05 mg, Spinal morphine 0.1 mg
- Where
- Thailand
- Volunteers
- 72 people
- Sponsor
- Mahidol University
Pain, Post Operative
Pectointercostal Fascial Plane Block Versus Transversus Thoracic Plane Block In Adult Cardiac Surgery Patients
The study will be designed to compare the analgesic effect of ultrasound-guided pectointercostal fascial plane block versus tansversus thoracic plane block in adult cardiac surgery.
- Trial name
- NCT05323305
- Testing
- ultrasound guided regional block
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Granuloma, Granulomatous Disease, Chronic
Recruitment and Apheresis Collection of Peripheral Blood Hematopoietic Stem Cells, Mononuclear Cells and Granulocytes
The research goal of this study is to obtain CD34+ hematopoietic stem cells (HSC) from peripheral blood and/or bone marrow, and Mononuclear Cells (lymphocytes and monocytes), and granulocytes (grans) from peripheral blood that…
- Conditions
- Granuloma, Granulomatous Disease, Chronic, Leukocyte Disease, Genetic Disease, X-Linked
- Trial name
- NCT00001405
- Where
- United States
- Volunteers
- 850 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pneumonia
Nebulized Ceftazidime and Amikacin in Ventilator Associated Pneumonia
Pseudomonas aeruginosa is one of the major causative microorganisms of ventilator-associated pneumonia often resistant to antibiotics.
- Trial name
- NCT00786305
- Testing
- ceftazidime and amikacin
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Leukemia, Myelodysplastic Syndromes
Reduced-Intensity Regimen Before Donor Bone Marrow Transplant in Treating Patients With Myelodysplastic Syndromes
RATIONALE: Photopheresis treats the patient's blood with drugs and ultraviolet light outside the body and kills the white blood cells.
- Conditions
- Leukemia, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms
- Trial name
- NCT00045305
- Testing
- Cyclosporine, Methotrexate, Photopheresis
- Where
- 6 sites in United States
- Volunteers
- 17 people
- Sponsor
- Eastern Cooperative Oncology Group
Noise-induced Hearing Loss and Tinnitus
TUNE! Teaching the UK About Noise Exposure: A Pilot Study
In 1986 The Medical Research Council estimated that 4 million UK adolescents were at risk of hearing damage from over-exposure to loud music from personal audio players (PAPs), gigs, clubs, pubs and festivals.
- Trial name
- gildeaf1 (NCT00916305)
- Testing
- Modified Audio video, Unmodified audio video
- Where
- United Kingdom
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Intraarticular, Ozone
Effect of Intraarticular Ozone, Prolotherapy or Dexmedetomidine in Pain Limitation in Knee Osteoarthritis
This study aimed to compare intraarticular ozone injection, prolotherapy, or dexmedetomidine effectiveness in knee osteoarthritis patients.
- Conditions
- Intraarticular, Ozone, Prolotherapy, Dexmedetomidine
- Trial name
- NCT06909305
- Testing
- Ozone, Dextrose prolotherapy, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Right Bundle-Branch Block
Adaptive Cardiac Resynchronization Therapy in Patients With RBBB
This study will address whether acute adaptive RV pacing in sinus rhythm patients with severe LV systolic dysfunction and RBBB is superior to no ventricular pacing, and is as effective as echocardiographically optimized…
- Trial name
- NCT05936294
- Testing
- Optimization of CRT Device
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Henry Ford Health System
Cold Agglutinin Disease
Therapy for Chronic Cold Agglutinin Disease
Chronic cold agglutinin disease (CAD) is a type of autoimmune hemolytic anemia (anemia due to destruction of red blood cells by abnormal antibodies).
- Trial name
- NCT00373594
- Testing
- Rituximab, Fludarabine
- Where
- 6 sites in Norway, Russia
- Volunteers
- 30 people
- Sponsor
- University of Bergen
Chronic Kidney Disease, Polycystic Kidney, Autosomal Dominant
Pilot Study of RNA as a Biomarker for Autosomal Dominant Polycystic Kidney Disease
The aim of this pilot project is to assess the potential of urine micro-RNAs (miRNA) as biomarkers for characterizing patients with autosomal dominant polycystic kidney disease (ADPKD) compared with patients with other causes of…
- Trial name
- NCT01114594
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- The Rogosin Institute
Depression, Anxiety
Caregiver Burden and Distress in Hematopoeitic Stem Cell Transplant
The purpose of this study is to examine the impact that serving as a caregiver for a patient undergoing hematopoietic stem cell transplant has on the caregiver.
- Conditions
- Depression, Anxiety, Fatigue, Distress
- Trial name
- NCT01084694
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Northside Hospital, Inc.
Relative Afferent Pupil Defect (RAPD)
Measuring Relative Afferent Pupillary Defect
The goal of this prospective reliability study is to test the effectiveness of a commercially available, off-the-shelf virtual reality head-mounted display (VR HMD) and machine learning (ML) algorithms in detecting Relative…
- Trial name
- RAPD (NCT05799066)
- Testing
- Swinging Light test, Virtual Reality Head-Mounted Display (VR HMD)
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Anemia Associated With Chronic Kidney Disease
Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of Vadadustat in Hemodialysis Subjects With Anemia Associated With Chronic Kidney Disease
This study will be conducted to assess the pharmacokinetics of vadadustat 600, 750, and 900 milligrams daily, and intravenous erythropoiesis-stimulating agent (darbepoetin alfa or epoetin alfa), in hemodialysis participants with…
- Trial name
- NCT03992066
- Testing
- Vadadustat, Darbepoetin alfa, Epoetin alfa
- Where
- 10 sites in United States
- Volunteers
- 46 people
- Sponsor
- Akebia Therapeutics
Pelvic Organ Prolapse
Comparison of Vaginal Axis on MRI in Alternative Apical Prolapse Surgeries to Sacrocolpopexy
Sacrocolpopexy remains the preeminent modality in addressing apical prolapse surgically. Nevertheless, amplified morbidity rates within cohorts characterized by obesity and advanced age constrain the advantages conferred by the…
- Trial name
- NCT06072456
- Testing
- laparoscopic lateral suspension, laparoscopic pectopexy, Sacrospinous ligament fixation
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
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