Clinical trials: Systemic Infection
Sepsis, Length of Stay
Limited Versus Extended Trophic Feeding (LET-FEED) Trial
Study Hypothesis/Question In infants born very preterm, advancing enteral feeds after 24 hours from birth (limited trophic feeds) versus after 72 hours (extended trophic feeds) reduces the risk of all-cause late onset sepsis…
- Conditions
- Sepsis, Length of Stay, Mortality, Neurodevelopmental Delay
- Trial name
- LET-FEED (NCT06893939)
- Testing
- Limited Trophic Feeds (1 day of trophic feeds), Extended Trophic Feeds (3 days of trophics)
- Where
- 6 sites in United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Washington
Burns
Relationship Between Neutrophil Function and Sepsis in Adults and Children With Severe Thermal Injuries
The study aims to validate neutrophil function, immature granulocyte and plasma free DNA levels as predictive diagnostic biomarkers of sepsis in burn patients.
- Trial name
- SIFTI-2 (NCT04693442)
- Testing
- taking of blood, urine and blood samples and objective scar assessment
- Where
- United Kingdom
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Sepsis, Septic Shock
IL-40 and IL-41 Levels in Sepsis, Septic Shock, and Healthy Individuals
This study aims to investigate the blood levels of two recently identified immune-related proteins, Interleukin-40 (IL-40) and Interleukin-41 (IL-41), in patients with sepsis and its more severe form, septic shock.
- Conditions
- Sepsis, Septic Shock, Inflammation, Biomarkers
- Trial name
- NCT06963541
- Testing
- No intervention; Observational study
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Melahat Yalcin Solak
Obesity, Endotoxemia
Dietary Green Tea Confection For Resolving Gut Permeability-Induced Metabolic Endotoxemia In Obese Adults
This study is focused on assessing gastrointestinal-level improvements by which green tea limits metabolic endotoxemia. It is completed in two phases.
- Conditions
- Obesity, Endotoxemia, Inflammation
- Trial name
- NCT03413735
- Testing
- Green Tea Extract
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Neutropenia, Neutropenia, Febrile
Investigation of the Usability of Neutrocheck Amongst Healthy Volunteers and Healthcare Professionals.
This study proposes to assess the usability of the Neutrocheck device and test kit amongst healthy volunteers and healthcare professionals (HCPs).
- Conditions
- Neutropenia, Neutropenia, Febrile, Neutropenic Sepsis (Disorder)
- Trial name
- NeutroUSE (NCT05852249)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- 52 North Health Ltd
Pneumonia, Meningitis
Safety and Immunogenicity of 10-valent and 13-valent Pneumococcal Conjugate Vaccines in Papua New Guinean Children
The study aims to evaluate the safety and immunogenicity of the 10-valent and 13-valent pneumococcal conjugate vaccines when administered in an accelerated schedule in Papua New Guinean children, who experience early dense upper…
- Conditions
- Pneumonia, Meningitis, Bacteraemia, Sepsis
- Trial name
- PCV1103 (NCT01619462)
- Testing
- Prevenar 13 and Synflorix
- Where
- Papua New Guinea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Papua New Guinea Institute of Medical Research
Sepsis
TRIM25 in Septic Patients
Sepsis is a life-threatening condition caused by the body's overwhelming response to infection, which can lead to organ damage and failure.
- Trial name
- NCT07320638
- Testing
- Gene and Inflammatory Marker Analysis in Sepsis
- Where
- China
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Sepsis, Cardiopulmonary Bypass
Multi-omics Study on Gut Microbiota in Critical Ill Patients After Cardiopulmonary Bypass
Using metagenomics as well as metabolomics, the variation of the gut microbiota and host metabolite profiles of patient after undergoing CPB were explored.
- Trial name
- CPB-MUL-GM (NCT04032938)
- Testing
- extracorporeal circulation during cardiac surgery
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Sepsis, Septic Cardiomyopathy
Identification of Cardiovascular and Molecular Prognostic Factors for the Mid- and Long-term Outcome of Sepsis
Sepsis is a life-threatening condition which can affect people of any age. An infection triggers a host response resulting in organ failure.
- Conditions
- Sepsis, Septic Cardiomyopathy, Cardiomyopathies
- Trial name
- ICROS (NCT03620409)
- Where
- Germany
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- Jena University Hospital
Overweight, Microtia
Demonstration of the Prebiotic-like Effects of Camu-camu Consumption Against Obesity-related Disorders in Humans
Previous work of the investigators demonstrated the anti-obesity and anti-steatosis potential of the Amazonian fruit camu-camu (CC) in a mouse model of diet-induced obesity [1].
- Conditions
- Overweight, Microtia, Endotoxemia, Metabolic Syndrome
- Trial name
- NCT04130321
- Testing
- Camu camu
- Where
- Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Laval University
Hemolytic Disease of Newborn, Anemia of Neonates
Risk Factors and Clinical Outcomes of Neonatal Anemia in NICU
Risk Factors, and Clinical Outcomes of Neonatal Anemia in the NICU of a Tertiary Care Hospital
- Conditions
- Hemolytic Disease of Newborn, Anemia of Neonates, Sepsis
- Trial name
- NCT07188298
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Anogenital Warts
Systemic Exposure of Catechins From Veregen 15% Ointment in Patients With External Anogenital Warts and From Oral Intake of Green Tea Beverage in Healthy Volunteers
Investigation of systemic catechin exposure following topically administered Veregen® 15% ointment in patients with external genital and perianal warts and following oral intake of a standardized green tea beverage in healthy…
- Trial name
- NCT01490008
- Testing
- Veregen, Green Tea
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- MediGene
Sepsis
Circulating microRNAs as Biomarkers of Sepsis
MicroRNA has been demonstrated to play a crucial role in regulating cell processes. Recently, microRNA was identified to exist in human serum or plasma, and it might be related to certain diseases.
- Trial name
- NCT00862290
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Sepsis
Effect of Lipopolysaccharide on Skeletal Muscle Functions
The investigators aim to examine how the skeletal muscles of the human volunteers respond to experimental septic conditions to aid understanding of muscle wasting and its biology..
- Trial name
- LPS (NCT01423968)
- Testing
- Lipopolysaccharide infusion, saline
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Sepsis, ARDS
Early Severe Illness TrAnslational BioLogy InformaticS in Humans
Advanced stages of the response to life-threatening infection, severe trauma, or other physiological insults often lead to exhaustion of the homeostatic mechanisms that sustain normal blood pressure and oxygenation.
- Conditions
- Sepsis, ARDS, Critical Illness, Neurocognitive Dysfunction
- Trial name
- ESTABLISH (NCT05591924)
- Testing
- Phelebotomy, Broncheoalveolar Lavage, Tracheal Aspirate
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Sepsis
Association Between cd163 Gene Polymorphisms and Sepsis Among Chinese Han Population
CD163 is a member of the scavenger receptor cysteine-rich family (SRCR) is exclusively expressed on cells of the monocyte lineage.CD163 acts to amplify inflammation and serves as a critical mediator of inflammatory response in…
- Trial name
- NCT01504243
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Cytomegalovirus Infections
gB/MF59 Vaccine in Preventing Cytomegalovirus Infection in Healthy Adolescent Females
The purpose of this research study is to test the safety of and the body's response to an experimental cytomegalovirus (CMV) vaccine (called gB/MF59 vaccine).
- Trial name
- NCT00133497
- Testing
- MF-59, CMV gB vaccine
- Where
- 5 sites in United States
- Volunteers
- 409 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Endotoxemia
Anti-Inflammatory Effect of Statins in the Human Endotoxin Model
The purpose of this study is to determine the effects of HMG-CoA reductase inhibitor pretreatment on inflammation and coagulation activation in human endotoxemia.
- Trial name
- NCT00309374
- Testing
- LPS 2ng/kg intravenous bolus, Simvastatin 80mg; administered daily p.o. over 5 days, Rosuvastatin 40mg; administered daily p.o. over 5 days
- Where
- Austria
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Sepsis
Effects of BCG on Immune Response
In the present study, we want to investigate whether BCG-vaccination enhances the innate immune response in humans in vivo during (single) human endotoxemia.
- Trial name
- NCT02085590
- Testing
- BCG vaccine, Lipopolysaccharide (LPS) E. Coli 1 ng/kg intravenously
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Meningococcal Infections, Neisseria Meningitis Sepsis
The Long-term Impact of Invasive Meningococcal Disease in Australian Adolescents and Young Adults
Survivors of invasive meningococcal disease (IMD) experience a range of mild to severe sequelae that impact upon their quality of life.
- Conditions
- Meningococcal Infections, Neisseria Meningitis Sepsis, Neisseria Infection
- Trial name
- AMEND (NCT03798574)
- Where
- 4 sites in Australia
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University of Adelaide