Clinical trials: TKA
Knee Arthropathy
Comparison of Accuracy and Functional Outcome Between Robotic and Gyroscopic Assisted Surgery in Primary TKA
A randomized controlled trial was conducted with 72 participants who had moderate knee osteoarthritis (Kellgren and Lawrence grade 2-3).
- Trial name
- NCT06321952
- Testing
- ROSA robotic assist TKA, iassist TKA
- Where
- Thailand
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Osteoarthritis Of Knee
Short-term Efficacy of Antidepressant in Patients Underwent TKA
By taking certain antidepressant in early postoperative period，which is supposed to improve the psychological status of patients with osteoarthritis, explore the effect of certain antidepressant on the recovery of the early stage…
- Trial name
- NCT03110172
- Testing
- Duloxetine Hydrochloride
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Dalian Municipal Central Hospital
Post Operative Nausea and Vomiting
Effects of Preoperative Carbohydrate Rich Drinks on Immediate Postoperative Outcome in Total Knee Arthroplasty
The aim of this study is to investigate the effect of preoperative carbohydrate rich drinks on postoperative nausea and vomiting in total knee arthroplasty. This is a prospective, double blinded, randomized controlled trial.
- Trial name
- PONV (NCT03380754)
- Testing
- Nutricia preOp
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Total Knee Arthroplasty (TKA), Total Knee Arthroplasty \(TKA\)
Suzetrigine in TKA
Total knee replacements are among the most common and painful orthopedic procedures performed worldwide, often requiring intensive analgesia to support early ambulation and recovery.
- Conditions
- Total Knee Arthroplasty (TKA), Total Knee Arthroplasty \(TKA\), Total Knee Replacement, Total Knee Replacement Surgery
- Trial name
- NCT07864896
- Testing
- Suzetrigine
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Osteoarthritis, Knee
Comparison of Mobile-Bearing and Fixed-Bearing All-Polyethylene Tibia Total Knee Designs
This study will be designed to compare prospectively, in a randomized fashion, the clinical, functional, and radiographic results of a nonmodular (all-polyethylene tibi/AP) fixed-bearing posterior cruciate substituting design…
- Trial name
- NCT00894361
- Testing
- TKA surgery with the rotating platform mobile-bearing knee design, TKA surgery with the all-polyethylene tibia knee design
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Osteo Arthritis Knee, Insomnia
Improving Sleep After TKA Using Mirtazapine and Quetiapine
Use of mirtazapine and quetiapine for improvement of sleep quality after TKA
- Trial name
- NCT04728581
- Testing
- Mirtazapine, Quetiapine
- Where
- 2 sites in Netherlands
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- St. Anna Ziekenhuis, Geldrop, Netherlands
Chronic Post-Surgical Pain
Pre-op Cognitive Behavior Therapy to Decrease Chronic Post-Surgical Pain in TKA
A significant number of patients develop chronic post-surgical pain (CPSP) following knee replacement surgery. Proposed is the testing of a novel computer-assisted behavioral intervention integrating motivational interviewing in…
- Trial name
- NCT04814992
- Testing
- Computer-Assisted Preoperative CBT Intervention (PAINTrainer)
- Where
- 4 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Osteoarthritis, Knee, Inflammation Knees
How TKA Implants Affect Muscle Quality and Activity During Daily Living and Immunological Response
This study compares two total knee replacement implants to asses muscle function and quality, and the immune response to the implants.
- Trial name
- NCT04105179
- Testing
- Zimmer NexGen LPS-Flex, Smith & Nephew Journey II
- Where
- Canada
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Knee Osteoarthritis
Comparison of Functional Outcomes of Three Surgical Approaches in Knee Arthroplasty
A functional outcomes comparison study of three surgical techniques using minimally invasive surgery mini-incision (MIS) for total knee arthroplasty (TKA), standard para-patellar TKA and the unicompartmental knee arthroplasty…
- Trial name
- NCT00983762
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Arthritis Knee, Blood Loss
Blood Loss Assessment in the Limited Application of Tourniquet During Primary Unilateral TKA
Tourniquet application in total knee arthroplasty has many benefits and might have a role in the incidence of peri-operative complications the aim of this research: is to look into the effectiveness of the limited application of…
- Conditions
- Arthritis Knee, Blood Loss, Arthroplasty Complications
- Trial name
- NCT05691751
- Testing
- primary unilateral total knee arthroplasty with limited application of tourniquet, primary unilateral total knee arthroplasty with full application of tourniquet
- Where
- Syria
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Damascus University
Postoperative Wound Care After TKA
Evaluation of Ioband Coverage Waterproof Dressing Versus Isolated Waterproof Dressing After Primary Total Knee Arthroplasty
Title: Evaluation of Ioband® Coverage Waterproof Dressing in Post-Operative Total Knee Arthroplasty (TKA) Goal: To evaluate the effectiveness of Ioband® coverage waterproof dressing compared to standard waterproof dressing in…
- Trial name
- Wound coverage (NCT06943053)
- Testing
- Isolate waterproof dressing (Opsite), Ioban coverage group
- Where
- 2 sites in Thailand
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Thammasat University Hospital
Revision Total Knee Arthroplasty Because of, Loosening
Joint Line Reconstruction in Navigated Total Knee Arthroplasty Revision
Hypothesis: navigated revision total knee arthroplasty results in a more precise reconstruction of preoperatively planned joint line than conventional revision total knee arthroplasty (rTKA).
- Conditions
- Revision Total Knee Arthroplasty Because of, Loosening, Instability, Impingement
- Trial name
- NavRevKnie (NCT01601756)
- Testing
- navigated revision knee arthroplasty, conventional revision knee arthroplasty
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Knee Arthropathy, Arthroplasty Complications
l Investigation of Robotic-assisted TKA (RA-TKA) With Skywalker and Evolution Medial Pivot Knee (eMP Knee)
This is a prospective trial that attempts to develop evidence on the safety and performance of RA-TKA (Robotic-assisted total knee arthroplasty) with Skywalker and eMP (Evolution Medial Pivot) knee.
- Conditions
- Knee Arthropathy, Arthroplasty Complications, Robotic Assisted Arthroplasty, TKA Outcomes
- Trial name
- NCT06969222
- Testing
- Robotic TKA, Conventional TKA
- Where
- Greece
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Orthopaedic Department of General University Hospital of Laria
Knee Replacement
Total Knee Replacement With Tourniquet or Aquamantys
The purpose of this study is to compare quadriceps muscle strength, pain, opioid consumption and patient function during the first three months after short-stay total knee replacement between patients treated with short-duration…
- Trial name
- NCT04016285
- Testing
- Aquamantys, Tourniquet
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Stephen Duncan
TKA Outcomes
Exploring the Benefits of a 3D Patient-specific Alignment in Total Knee Arthroplasty
General Aim: to explore the iKA in TKA related to clinical, biomechanical, and functional outcomes.
- Trial name
- iKA (NCT07367802)
- Testing
- iKA
- Where
- Belgium
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Osteo Arthritis Knee, Central Nervous System Sensitization
Pregabalin for Central Sensitization in TKA
The study purpose is to determine if giving pregabalin before and after total knee arthroplasty (TKA) can improve pain and meaningful function after surgery in patients that have central sensitization (CS).
- Trial name
- NCT05460871
- Testing
- Pregabalin 75mg
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Blood Loss
Clinical Trial Comparing Tranexamic Acid (TXA) With Aquamantys Sealer in Total Knee Arthroplasty (TKA)
The aim of the study is to determine if the use of iv TXA or Aquamantys system improve the postoperative hemoglobin and hematocrit after primary TKA and what is the effect of the simultaneous use of iv TXA and Aquamantys on the…
- Trial name
- NCT02374398
- Testing
- Tranexamic Acid, Aquamantys System, Control
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Eastern Maine Medical Center
Knee Replacement, Total Knee Arthroplasty
Trial of Liposomal Bupivacaine for TKA
Total knee arthroplasty (TKA), also known as a knee replacement, is a procedure performed to reduce severe pain and improve function of the joint.
- Conditions
- Knee Replacement, Total Knee Arthroplasty, Post-Operative Pain
- Trial name
- NCT05635916
- Testing
- Liposomal bupivacaine, Bupivacaine
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Northern Light Mercy Hospital
Cryotherapy Effect
Cryocompression After Total Knee Arthroplasty
The overall aim of this study is to evaluate the effectiveness of a cryocompression device after total knee arthroplasty (TKA) compared to standard therapy.
- Trial name
- NCT05395273
- Testing
- Game Ready cryocompression
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Applied Sciences and Arts of Southern Switzerland
Arthritis Knee, Pain
The Efficiency of Periarticular Multimodal Drug Injection in Pain Management Following Primary Unilateral TKA
This interventional study aims to compare the effectiveness of local multimodal drug periarticular injection in TKA patients with the standard pain control regime that includes opioids, NSAIDs, and other analgesics.
- Conditions
- Arthritis Knee, Pain, Arthroplasty Complications
- Trial name
- NCT06112548
- Testing
- primary unilateral TKA, Bupivacain, ketorolac
- Where
- Syria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Damascus University