Clinical trials: Therapy Strategies
Cancer, Solid Tumor
Clinical Study Comparing Different Strategies to Increase Adherence to Oral Therapies in Oncohematology
This is a multicenter, interventional, non-pharmacological study on a app for oral anticancer therapy management. A total of 124 patients will be considered.
- Conditions
- Cancer, Solid Tumor, Hematologic Malignancy, Oral Drug Administration
- Trial name
- NCT04826458
- Testing
- TreC-Onco, Paper diary
- Where
- 2 sites in Italy
- Volunteers
- 124 people
- Sponsor
- Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
Gout
Immediate Prescription of a Hypouricemic Treatment, Febuxostat, Compared to Its Delayed Administration
Gout, the most common inflammatory rheumatism in France, is a complication of chronic hyperuricemia (> 360umol / l). The resulting urate crystals are deposited in many tissues, especially the skeletal or kidneys.
- Trial name
- FEFACRIGOU (NCT05109936)
- Testing
- Adenuric
- Where
- 6 sites in France
- Volunteers
- 128 people
- Sponsor
- University Hospital, Rouen
Knee Osteoarthritis, Knee Osteoarthritis (Knee OA)
Home-Based Strategies for Knee Osteoarthritis
Knee osteoarthritis (KOA) is a common chronic joint condition leading to pain, functional limitations, and reduced quality of life.
- Trial name
- NCT07212647
- Testing
- Home Exercise Group, Topical Therapy Group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 83 people
- Sponsor
- Istanbul University - Cerrahpasa
HIV
Targeted Clinical Strategies and Low Level Viraemia (LLV) in Boosted Protease Inhibitor Therapy
The purpose of the study is to look at possible reasons why some HIV positive people who take their drugs properly and have no resistance to these drugs, still have low amounts of virus detectable in their blood.
- Trial name
- NCT02354209
- Where
- 3 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- St Stephens Aids Trust
COPD
A Translational Study for Prediction of Biomarkers and Identification of Phenotype and Endotype of COPD and Pre-COPD Outcomes in Chinese Population
This is an observational study into more comprehensive understanding, including the trajectories of lung function decline, inflammatory/immunological mechanisms on pre-COPD or PRISm, clinical outcomes and relevant endotypes on…
- Trial name
- NCT06724848
- Where
- 14 sites in China
- Volunteers
- 850 people
- Sponsor
- AstraZeneca
Mental Health Disorders, Substance Use Disorders
Supporting Treatment Access and Recovery Through Linkage and Support
This 3-year Hybrid Type 1 study will randomize 208 people with co-occurring substance use and mental health disorders (COD) referred from the Worcester Hub.
- Trial name
- STAR-LS (NCT05713695)
- Testing
- Full MISSION, Linkage Only Delivered by a Peer Specialist
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- University of Massachusetts, Worcester
Metastatic Renal Cell Carcinoma, Kidney Neoplasm
Individualized Treatment Strategy for Patients With Metastatic Non-clear Cell Renal Cell Carcinoma
The purpose of the open-label INDIGO-study is to examine whether a first line individualized treatment strategy based on DNA and RNA analyses from the patient's tumor is feasible.
- Conditions
- Metastatic Renal Cell Carcinoma, Kidney Neoplasm, Urologic Neoplasms, Urogenital Neoplasms
- Trial name
- INDIGO (NCT04644432)
- Testing
- Medication (A specification is listed under each arm), Patient reported outcomes measurement
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Herlev and Gentofte Hospital
Gamification in Health Education, Health Education
Study on the Effect of a Gamified Health Education Programme on Primary School Children
This randomised study evaluates the effectiveness of Health Education through a Gamified Health Programme on diet, sedentary behaviour and daily physical activity in primary school children.
- Trial name
- BELLOTEX-SALUD (NCT07276412)
- Testing
- Intervention - A, Intervention - B, Intervention - C
- Where
- Spain
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Universidad de Extremadura
Tuberculosis, Pulmonary
Cost-effectiveness of Two Forms of DOTS in a Demonstration Area of the DOTS Strategy in Colombia
Tuberculosis ( TB ) remains a major global public health problems and actions to ensure the diagnosis and complete treatment of all cases is the priority for the control of this disease.
- Trial name
- DOTS (NCT01945905)
- Testing
- Intramural, Extramural
- Where
- Colombia
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Fundación FES
Fibromyalgia (FM)
Dietary Strategies for the Treatment of Fibromyalgia in Overweight and Obese Patients
Spontaneous, non-sponsored, interventional, controlled, randomized, parallel-arm clinical study. Primary objective To assess the impact of specific dietary approaches (ketogenic diet, Mediterranean diet, or Mediterranean diet…
- Trial name
- FIBRODIET (NCT07517757)
- Testing
- Very Low-Calorie Ketogenic Diet, Mediterranean diet, Mediterranean diet enriched by GABA-producing probiotic
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Universita degli Studi di Genova
Breast Cancer
Evaluating an Endocrine Therapy Dose-frequency Escalation Strategy and Its Effects on Tolerability and Compliance
The goal of this randomized, pragmatic clinical trial is to evaluate an endocrine therapy dose-frequency escalation strategy and its effects on tolerability and compliance.
- Trial name
- REaCT-TEMPO (NCT05754528)
- Testing
- Standard of care administration of Endocrine therapy, Dose-frequency escalation administration of Endocrine therapy
- Where
- 2 sites in Canada
- Volunteers
- 240 people
- Sponsor
- Ottawa Hospital Research Institute
HCV, HEPATITIS C VIRUS CHRONIC INFECTION
Scaling Up Point-of-Care Hepatitis C Testing and Treatment in Canada
The SCALE-POCT study is a national initiative designed to provide robust evidence for scaling up point-of-care hepatitis C testing for key populations.
- Trial name
- SCALE POCT (NCT07095192)
- Testing
- Preimplementation of HCV Point of care testing
- Where
- 12 sites in Canada
- Volunteers
- 300 people
- Sponsor
- McGill University
Coronary Heart Disease, Congestive Heart Failure
Standard Drug Therapy vs. Implanted Defibrillator for Primary Prevention of Sudden Cardiac Death
Recent ACC/AHA/ESC guidelines recommend prophylactic ICD implantation in most patients with coronary heart disease and LVEF < 40%.
- Conditions
- Coronary Heart Disease, Congestive Heart Failure, Ventricular Dysfunction, Low Cardiac Output
- Trial name
- SMART-ICD (NCT00524862)
- Testing
- Optimized medical therapy, Implantable Cardioverter Defibrillator
- Where
- 10 sites in Canada
- Volunteers
- 5,000 people
- Sponsor
- Unity Health Toronto
HIV, HIV Infections
The First Failure Study
The purpose of this study is to look at two different antiretroviral treatment options in individuals who are about to commence their second antiretroviral treatment.
- Trial name
- FAST (NCT01118871)
- Testing
- Darunavir, Ritonavir, Truvada, Darunavir, Ritonavir and Etravirine
- Where
- United Kingdom
- Volunteers
- 3 people
- Sponsor
- Imperial College London
Breast Cancer, Cancer
Randomized Trial Standard of Care Vascular Access Strategies for (Neo)Adjuvant Trastuzumab-based Breast Cancer Treatment.
In the REaCT-Vascular Access Trastuzumab study (REaCT-VA), the investigator will use a novel method to allow comparisons of established standard of care vascular access strategies using the "integrated consent model" as part of a…
- Trial name
- OTT 15-06 (NCT02632435)
- Testing
- PICC, PORT
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- Ottawa Hospital Research Institute
Peripheral Arterial Disease
Genotype-guided Strategy for Antithrombotic Treatment in Peripheral Arterial Disease.
Rationale: Peripheral arterial disease (PAD) is a common presentation of atherosclerosis. For the prevention of adverse events related to arterial thrombosis in PAD patients, clopidogrel is recommended.
- Trial name
- GENPAD (NCT04619927)
- Testing
- Direct CYP2C19 genotyping, CYP2C19 genotyping at the end of the study, Poor metabolisers
- Where
- 11 sites in Netherlands
- Volunteers
- 2,276 people
- Sponsor
- Radboud University Medical Center
Chronic Kidney Diseases
Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) in Chronic Kidney Disease (CKD)
30 patients will participate in a prospective randomized clinical trial to test the safety, tolerability and efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) for autonomic nervous system (ANS) dysfunction in…
- Trial name
- NCT06927024
- Testing
- Active taVNS
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Ischemic Stroke
Different Treatment Strategies on Prognosis of Acute Ischemic Stroke(AISDTS)
AISDTS is a prospective registry study, in which clinical information, examination and imaging data of patients with acute ischemic stroke receiving different treatment strategies were collected, grouped and statistically…
- Trial name
- NCT05410457
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Neoplasms, Cancer
Omics of Cancer: OncoGenomics
Background: Cancer is a leading cause of death in the United States. Researchers want to know more about how cancer develops and grows. They want to understand more about cancers that run in families.
- Trial name
- NCT05431439
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Superficial Esophageal Cancers
Status of Superficial Esophageal Cancers Treated by Endoscopy "OESOFARE"
In 2013, esophageal cancer was the 9th cause of cancer in the world and the 6th in terms of cancer mortality. The prognosis of this cancer varies according to geographical areas, but in Europe and the USA, the 5-year survival…
- Trial name
- OESOFARE (NCT03674801)
- Where
- France
- Volunteers
- 151 people
- Sponsor
- Nantes University Hospital
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