Clinical trials: Third Molar Extraction
Impacted Third Molar Tooth
Impact of Antibiotic Treatment and Extraction on the Oral Micro Biome
This is a prospective, longitudinal, observational, cohort study investigating young adults undergoing surgical extraction of a wisdom tooth with and without antibiotics post-operatively.
- Trial name
- NCT02951676
- Testing
- Extraction
- Where
- China
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Preventing Postextraction Complication
Controlling Post-extraction Complications of Impacted Mandibular Third Molar
Impacted mandibular 3rd molar will be extracted in all patients, then patients will be divided, according to material placed in extraction socket into 3 groups: control, hyaluronic acid and honey.
- Trial name
- NCT04816253
- Testing
- Normal saline, Hyaluronic acid, Methylprednisolone
- Where
- Saudi Arabia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Pain, Post-Operative Pain
Ibuprofen Extended-Release Dental Pain Study
The purpose of this study is to evaluate the efficacy and safety of multiple doses of Ibuprofen 600 mg Extended-Release Tablets in a study of dental pain following extraction of third molar teeth.
- Conditions
- Pain, Post-Operative Pain, Third Molar Extraction
- Trial name
- NCT00707057
- Testing
- Ibuprofen 600 mg Extended-Release Tablets
- Where
- United States
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- SCOLR Pharma, Inc.
Periodontal; Lesion, Periodontal Pocket
Prevention of Mandibular Third Molar Extraction- Associated Periodontal Defects Using Platelet-Rich Fibrin
The extraction of deep impacted mandibular third molar may cause periodontal defects at the distal root of the second molar. The aim of this study was to evaluate the ability of platelet-rich fibrin (PRF) in preventing…
- Conditions
- Periodontal; Lesion, Periodontal Pocket, Molar, Third
- Trial name
- NCT04033744
- Testing
- extraction of mandibular third molar
- Where
- Italy
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Naples
Dental Anxiety
Evaluation on the Anxiety of Third Molar Extraction
This study was performed on 66 patients who were admitted for third molar extraction under local anesthesia. The patients were divided into three groups: group 1 with verbal information, group 2 with written information, and…
- Trial name
- NCT03838081
- Testing
- Spielberger State Anxiety Inventory (STAI-S),, Dental Fear Scale (DFS), Modified Dental Anxiety Scale (MDAS)
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Ankara University
Wound Healing, Tooth Extraction Site Healing
Effect of Injectable Platelet Rich Fibrin (i-PRF) on Extraction Socket Healing: A Split-Mouth Randomized Study.
The aim of this study is to compare extraction socket healing (SH) following surgical extraction of lower third molars (LTMs) with and without the application of injectable platelet rich fibrine (i-PRF).
- Trial name
- (i-PRF) (NCT07257328)
- Testing
- Surgical extraction of lower third molars.
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Alveolar Bone Grafting, Bone Regeneration Following Wisdom Teeth Extraction
Autogenous Tooth Bone Graft for Alveolar Socket Preservation
The purpose of this clinical experiment is to assess how well autogenous tooth bone grafting preserves the alveolar socket after surgical tooth extraction.
- Conditions
- Alveolar Bone Grafting, Bone Regeneration Following Wisdom Teeth Extraction, Tooth Extraction Site Healing
- Trial name
- ATBG (NCT07267637)
- Testing
- "Autogenous Tooth Bone Graft"
- Where
- Yemen
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Haifaa Mohammed Al-hussini
Healthy
Study to Evaluate Efficacy and Safety of IW-6118 in Patients Undergoing Third Molar Extraction
The purpose of this study is to assess the safety of IW-6118 when administered as a single oral dose to patients undergoing third molar extraction. Efficacy will be assessed in an exploratory manner.
- Trial name
- NCT01107236
- Testing
- IW-6118, Naproxen Sodium
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ironwood Pharmaceuticals, Inc.
Impacted Third Molar Tooth
Effect of Using Irrigations at Different Temperatures on Postoperative Period During the Extraction of Impacted Mandibular Molars
An Evaluation of the Effect of Using Irrigations at Different Temperatures on Pain, Edema, and Trismus During the Extraction of Bilateral Impacted Mandibular Third Molars: A Randomized Split-Mouth Clinical Trial
- Trial name
- NCT06020053
- Testing
- saline irrigation at various temperatures (4°C, 25°C)
- Where
- Turkey (Türkiye)
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Firat University
Alveolar Osteitis
Comparative Efficacy of Amoxicillin, Metronidazole, and Chlorhexidine in Preventing Alveolar Osteitis
This study will compare the effectiveness of amoxicillin, metronidazole, and chlorhexidine in preventing alveolar osteitis (dry socket) following lower third molar extraction.
- Trial name
- NCT07833176
- Testing
- Amoxicillin, Metronidazole, Chlorhexidine
- Where
- Pakistan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Khyber Medical University Peshawar
Pre-emptive Analgesia in Different Psycho-emotional Status Patients
Pre-emptive Analgesia Effect in Different Psycho-emotional Status Patients During Lower Third Molar Surgical Extractions
To increase the effectiveness of pain control, it is recommended to use drugs before the pain onset, therefore the pre-emptive analgesia method is considered as a method, which allows decreasing the post-operative pain to…
- Trial name
- NCT04202224
- Testing
- Ibuprofen 400 mg and Acetaminophen 500 mg, Glucose, No drug
- Where
- Lithuania
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Wisdom Tooth, Socket Preservation
Soft and Hard Tissue Healing Following Alveolar Ridge Preservation of Mandibular Third Molar Extraction Socket Filled With Auto Tooth Bone Graft or Alloplastic Graft
This study compared two bone graft materials: 1. Auto Tooth Bone (ATB) (made from the patient's own extracted tooth) and 2. EthOss® a synthetic alternative.
- Trial name
- AutoToothGraft (NCT07723183)
- Testing
- auto tooth graft material
- Where
- Malaysia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Inflammation, Pain, Postoperative
Use of Corticosteroids in Third Molar Surgery
Surgical extraction of retained lower third molars is associated with the development of postoperative complications, including inflammation, trismus and postoperative pain, that lead to a decrease in patients' quality of life.
- Conditions
- Inflammation, Pain, Postoperative, Trismus
- Trial name
- NCT05752305
- Testing
- Dexamethasone 4 Mg/mL Injectable Solution, MethylPREDNISolone 40 Mg/mL Injectable Suspension
- Where
- Spain
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Dental Pain
Safety and Efficacy Study of XPF-001 to Treat Pain Following Wisdom Tooth Extraction
The purpose of this trial is to determine if XPF-001 is effective for the treatment of pain following third-molar/wisdom tooth extraction.
- Trial name
- NCT00954356
- Testing
- XPF-001
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Xenon Pharmaceuticals Inc.
Alveolar Osteitis
The Effect of Post-extraction Collagen Sponge Application on Alveolar Osteitis
The goal of this randomized controlled trial is to compare pain, mouth opening, and alveolar osteitis following surgical extraction of bilateral symmetrical impacted lower third molars using two types of wound closures.
- Trial name
- NCT05850650
- Testing
- Application of a collagen sponge after surgical extraction of impacted 3rd molar, No collagen sponge application after surgical extraction of impacted 3rd molar
- Where
- Saudi Arabia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Riyadh Colleges of Dentistry and Pharmacy
Impacted Third Molar Tooth
Epidemiological Study on the Surgical Removal of Third Molars
The aim of this study is to get a clear view on current practice of surgical third molar removal in Belgium and the association with morbidity and complications.
- Trial name
- NCT02481700
- Testing
- Third molar removal
- Volunteers
- 6,010 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pain
Study Testing Ketamine Sublingual Wafer After Wisdom Tooth Extraction
The purpose of the study is to test two different doses of ketamine sub-lingual (under the tongue) wafer against placebo to see how effective the medication is to treat moderate to severe pain after wisdom tooth extraction.
- Trial name
- NCT02356965
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- iX Biopharma Ltd.
Molar, Third, Wisdom Teeth
Effect of Hilotherm Therapy on Post-operative Pain and Swelling Following Surgical Wisdom Tooth Removal
This study evaluates the efficacy of Hilotherm therapy on the incidence of swelling and pain following the surgical removal of lower wisdom teeth.
- Trial name
- NCT02284841
- Testing
- Hilotherm cooling face mask
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Post Operative Pain
Double-Blinded Randomized Controlled Study Investigating the Efficacy of Exparel (Liposomal Bupivacaine) for Postoperative Pain Relief in Mandibular Third Molar Extractions
The most prevalent complaint after third molar extractions is pain. There have been many modalities and regimens developed to manage post-operative pain, such as modifications in surgical techniques, locally-applied medicaments…
- Trial name
- NCT05374499
- Testing
- Liposomal bupivacaine, 0.5% bupivacaine with 1:100,000 epinephrine
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Dry Socket, Postoperative Infections
The Effect of Chlorhexidine + Hyaluronic Acid on Postoperative Wound Healing After Lower Third Molar Removal
Our aim is to evaluate chlorhexidine-hyaluronic acid containing gel on postoperative wound healing regarding impacted lower third molar surgery.
- Trial name
- NCT07044219
- Testing
- Third molar surgery
- Where
- Hungary
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Pecs