Clinical trials: Thyroid Cancers
Intraoperative Parathyroid Scores System
Clinical Utility of Intraoperative Parathyroid Scores System in Thyroidectomy
Ready to establish the Intraoperative Parathyroid Scores System (IPSS) for thyroidectomy and study the clinical value of Intraoperative Parathyroid Scores System for thyroidectomy.
- Trial name
- IPSS (NCT03172312)
- Testing
- Different range of thyroid surgery
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Fujian Medical University
Medullary Thyroid Cancer
An Initial Study of Lithium in Patients With Medullary Thyroid Cancer
Primary objective is to evaluate the tumor response rate of patients with MTC treated with Lithium carbonate
- Trial name
- NCT00582712
- Testing
- Lithium carbonate
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Intraoperative Parathyroid Scores System
Extended Application of Intraoperative Parathyroid Scores System(IPSS) in Thyroidectomy
after established the Intraoperative Parathyroid Scores System (IPSS) for thyroidectomy we further extented the clinical value of Intraoperative Parathyroid Scores System in Treatment decisions of calcium treatment time and…
- Trial name
- IPSS (NCT03191344)
- Testing
- with IPSS
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Fujian Medical University
Hypothyroidism, Complications
Post-radiation Hypothyroidism After IMRT for Nasopharyngeal Carcinoma
The investigators evaluate if there are radiation dosimetric parameters for the prediction of biochemical and clinical hypothyroidism after intensity-modulated radiation therapy (IMRT) for non-metastatic nasopharyngeal carcinoma…
- Trial name
- NCT02689609
- Testing
- Intensity-modulated radiation therapy
- Volunteers
- 149 people
- Sponsor
- The University of Hong Kong
Metastatic Thyroid Cancer
Enhancing Radioiodine Incorporation Into Radio Iodine Refractory Thyroid Cancers With MAPK Inhibition
This is a prospective interventional trial that aims to restore iodine incorporation in tumoral lesions of patients with unresectable, radioiodine-refractory thyroid cancer.
- Trial name
- ERRITI (NCT04619316)
- Testing
- Trametinib 2 MG [Mekinist], Trametinib 2 MG [Mekinist] and Dabrafenib 75 MG (2-0-2) [Tafinlar]
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- University Hospital, Essen
Thyroid Nodule
Prediction of Thyroid Cancer From Ultrasonographic Characteristics of Thyroid Nodules
The aim of this study is to identify which ultrasonographic feature or a combination of features is the best predictor of thyroid cancer in thyroid nodules.
- Trial name
- NCT00571090
- Testing
- Thyroid ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 735 people
- Sponsor
- Istanbul Science University
Medullary Thyroid Cancer
SOM230 Alone or in Combination With RAD001 in Patients With Medullary Thyroid Cancer
A mono centre study to evaluate the efficacy of SOM230 in patients with progressive metastatic or postoperative persistent medullary thyroid cancer.
- Trial name
- NCT01625520
- Testing
- SOM230 alone or in combination with RAD001.
- Where
- Italy
- Volunteers
- 19 people
- Sponsor
- Federico II University
Brain Cancer, Thyroid Cancer
Cancer and Other Disease Risks in U.S. Nuclear Medicine Technologists
Background: The field of nuclear medicine has changed a lot in the past decades. Technology has gotten better, so patients are exposed to less radiation. But now workers are doing procedures more often and using lead aprons less.
- Conditions
- Brain Cancer, Thyroid Cancer, Circulatory Disease, Breast Cancer
- Trial name
- NCT02911155
- Where
- United States
- Volunteers
- 229 people
- Sponsor
- National Cancer Institute (NCI)
Thyroid Nodule
Laser Ablation Versus Radiofrequency Ablation for Thyroid Nodules
The purpose of this study is to prospectively compare percutaneous radiofrequency ablation (RFA) versus percutaneous laser ablation (LA) for the treatment of solid thyroid nodules.
- Trial name
- LARA (NCT02714946)
- Testing
- Percutaneous Laser Ablation, Percutaneous Radiofrequency Ablation
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Campus Bio-Medico University
Thyroid Gland Anaplastic Carcinoma, Poorly Differentiated Thyroid Carcinoma
[177Lu]Lu-AKIR001 First-in-human Study
The goal of this clinical trial is to evaluate the safety and tolerability of increasing doses of [177Lu]Lu-AKIR001, both in relation to tolerable activity of lutetium-177 and the absorbed protein mass dose of AKIR-001 in…
- Conditions
- Thyroid Gland Anaplastic Carcinoma, Poorly Differentiated Thyroid Carcinoma, Cancer Head and Neck, Cervix Carcinoma
- Trial name
- AKIR001 (NCT06639191)
- Testing
- [177Lu]Lu-AKIR001
- Where
- Sweden
- Volunteers
- 15 people
- Sponsor
- Karolinska University Hospital
Thyroid Cancer
Gemcitabine - Oxaliplatin for Advanced Refractory Thyroid Cancer Patients: a Phase II Study
Radioiodine refractory differentiated thyroid cancer is a rare tumor and therapeutic options are limited in this setting. Molecular targeted therapies have recently been developed for progressive disease and demonstrated clinical…
- Trial name
- THYGEMOX (NCT02472080)
- Testing
- gemcitabine -oxaliplatine combination
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Thyroid Cancer
Molecular Testing to Direct Extent of Initial Thyroid Surgery
The research study consists of the participant agreeing to 1) the use of preoperative molecular testing (ThyroSeq) to guide extent of initial surgery and 2) the prospective collection of medical record data related to treatment…
- Trial name
- NCT02947035
- Testing
- Thyroid lobectomy, Total thyroidectomy with CCND
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Pittsburgh
Thyroid Cancer, Surgery
The Importance of Thymus Anatomy to the Radical Resection of Thyroid Cancer Surgery and the Protection of Parathyroid Function
Thyroid cancer is one of the most common endocrine malignancies. In the past three decades, the incidence rate of thyroid cancer has continued to rise rapidly in many countries and regions around the world.
- Trial name
- NCT06851260
- Testing
- Fine-dissection of the thymus
- Volunteers
- 5 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Goiter
Immediate Postoperative Course of Patients With Mini Video Assisted Total Thyroidectomy (miVAT) Versus Classic Total Thyroidectomy (cTT)
Protocol Synopsis Protocol title: Immediate postoperative course of patients with mini Video Assisted Thyroidectomy (miVAT) versus classic Thyroidectomy (cTT) Purpose: Comparison of the immediate postoperative course and…
- Trial name
- NCT00692835
- Testing
- Total Thyroidectomy (Mini Video Assisted Thyroidectomy), Total Thyroidectomy (Classic Thyroidectomy)
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Aristotle University Of Thessaloniki
Thyroid Cancer
The Use of 124-I-PET/CT Whole Body and Lesional Dosimetry in Differentiated Thyroid Cancer
Study rationale High risk patients with differentiated thyroid cancer (DTC) require therapy with 131 I under thyroid stimulating hormone (TSH) stimulation.
- Trial name
- NCT03841617
- Testing
- Thyrogen, I-131, I-124
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Tumor, Solid Tumor
ImmunoPET Targeting Trophoblast Cell-Surface Antigen 2 (Trop-2) in Thyroid Cancer
In this study, we comprehensively evaluated the clinical utility of Trop2 PET/CT (68Ga-MY6349 PET/CT) imaging for detecting recurrent and metastatic thyroid cancer, and the results were compared with those of 18F-FDG PET/CT.
- Conditions
- Tumor, Solid Tumor, Thyroid Cancer, Positron-Emission Tomography
- Trial name
- NCT06465017
- Testing
- standard-of-care imaging (18F-FDG PET/CT), 68Ga-MY6349 PET/CT
- Where
- China
- Volunteers
- 149 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Thyroid Neoplasm, Cough
Comparison of the Coughing Frequency of Remimazolam Total Intravenous Anesthesia Versus Inhalational Anesthesia
This study is a randomized controlled trial. Adult patients undergoing thyroidectomy under general anesthesia at Severance Hospital and Yonsei Cancer Center are included in tis study.
- Trial name
- NCT06275425
- Testing
- Total intravenous anesthesia with Byfavo, Inhalation anesthesia with Sevoflurane
- Where
- South Korea
- Volunteers
- 106 people
- Sponsor
- Yonsei University
Thyroid Cancer
Development and Application of an AI Chatbot for Perioperative Health Education in Thyroid Cancer Patients
The goal of this clinical trial is to evaluate the usefulness and effectiveness of a newly developed artificial intelligence (AI) chatbot for health education in thyroid cancer patients during the period around their surgery (the…
- Trial name
- NCT07634978
- Testing
- Routine Perioperative Health Education, Coze-Based AI Chatbot Health Education
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Differentiated Thyroid Cancer (DTC)
Study of Efficacy and Safety of Dabrafenib in Combination With Trametinib in Previously Treated Patients With Metastatic, Radio-active Iodine Refractory BRAF V600E Mutation Positive Differentiated Thyroid Cancer
The purpose of this study is to assess the efficacy and safety of dabrafenib in combination with trametinib for treating adult patients with locally advanced or metastatic Differentiated Thyroid Cancer (DTC) harboring the…
- Trial name
- NCT04940052
- Testing
- Dabrafenib, Trametinib
- Where
- 41 sites in United States, Argentina and 9 more
- Volunteers
- 153 people
- Sponsor
- Novartis Pharmaceuticals
Breast Cancer, Stomach Neoplasms
Immunohistochemical & Immunoblot Analysis of NIS (Na+/I-Symporter) in Archival & Frozen Tissue Sample
The goal of this study is to study NIS expression in benign and malignant breast and thyroid samples using archival formalin-fixed paraffin-embedded tissue sections.
- Conditions
- Breast Cancer, Stomach Neoplasms, Salivary Gland Neoplasms, Thyroid Cancer
- Trial name
- NCT00568438
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- Stanford University
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