Clinical trials: Tibial Fracture
Fracture Femur, Fracture Tibia
Standard Versus Short Course Prophylactic Antibiotic in Femur and Tibia Shaft Fractures Managed With Intramedullary Interlocking Nail
Long-bone fractures, particularly of femur and tibia, are common following fall injury and road traffic accidents.1,2 The standard treatment is "intramedullary nailing," where a metal rod is inserted into the center of the bone…
- Conditions
- Fracture Femur, Fracture Tibia, Surgical Site Infection (SSI), Antibiotic
- Trial name
- NCT07554079
- Testing
- Short Course Antibiotics, Standard Course Antibiotics
- Where
- Nepal
- Volunteers
- 56 people
- Sponsor
- Kathmandu University School of Medical Sciences
Tibial Fractures, Open Fracture of Tibia
Intramedullary Nailing Versus External Fixation in Open Tibia Fractures in Tanzania
The investigators propose to undertake a randomized, controlled trial which will generate Level 1 evidence concerning optimal fixation methods for the treatment of severe open tibia fractures in Dar es Salaam, Tanzania.
- Conditions
- Tibial Fractures, Open Fracture of Tibia, Trauma
- Trial name
- NCT03861624
- Testing
- Intramedullary nailing with standard SIGN nail, External Fixation with uniplanar Dispofix external fixator
- Volunteers
- 240 people
- Sponsor
- University of California, San Francisco
Tibia Fracture, Knee Pain Chronic
Knee Pain After Intramedullary Nailing in the Tibia
The primary objective of this study is to evaluate the long-term outcome after inserting an intramedullary nail in patients with a tibial shaft fracture using an injury-specific questionnaire.
- Trial name
- NCT03649360
- Where
- Denmark
- Volunteers
- 223 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Tibial Fracture
Tibial IMN Vs. Tibial Micromotion IMN
Our null hypothesis is that micromotion tibial intramedullary fixation (IMFN) does not impact union or complication rates when compared to standard of care treatment with non-micromotion tibial nail fixation.
- Trial name
- NCT06976801
- Testing
- Intramedullary tibial Nail, Intermedullary nail
- Where
- United States
- Volunteers
- 372 people
- Sponsor
- University of Chicago
Open tíbia Fracture With Sub-segmental Bone Loss
Calcium Sulfate Spacer in Open Tibia Fractures
Investigators will compare antibiotic impregnated Calcium sulfate versus PMMA versus nothing in these sub-segmental bone defects.
- Trial name
- NCT03042546
- Testing
- Calcium Sulfate, PMMA, No treatment
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Washington
Tibial Fractures
Study Evaluating InductOs in Diaphyseal Tibia Fractures
Demonstrate a larger proportion of subjects with healed fractures among subjects treated with InductOs and reamed, locked intramedullary nailing compared to subjects treated with reamed, locked intramedullary nailing alone.
- Trial name
- NCT00161616
- Testing
- InductOs
- Where
- 27 sites in Belgium, Finland and 10 more
- Volunteers
- 277 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Tibial Fractures
Bone Healing Accelerant Versus Standard of Care for Open Tibia Fractures
This clinical study is being conducted to demonstrate the safety and effectiveness of the Bone Healing Accelerant (BHA) product when applied to tibia (leg bone) fractures with an external wound or skin break (also called open…
- Trial name
- NCT03826784
- Testing
- BHA
- Where
- United States
- Sponsor
- Carmell Therapeutics Corporation
Closed Fracture, Open Fracture
Efficacy of DBM on Fractures of the Shinbone (Tibia)
The Tibia bone (shinbone) is located in the leg, itis the most frequently fractured bone in the body and has very poor blood supply because it is surrounded by skin and fat instead of muscle like the thighbone causing healing…
- Trial name
- NCT00299052
- Testing
- Grafton DBM, Reamings
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Emory University
Arthritis, Femoroacetabular Impingement
Conjoint Analysis of Patient Preferences in Joint Interventions
This study is an observational study to test and validate a questionnaire and statistical model used to determine patient preferences regarding treatment for any one of 11 musculoskeletal conditions: hip arthritis, knee…
- Conditions
- Arthritis, Femoroacetabular Impingement, Osteochondritis Dissecans, Hip Fractures
- Trial name
- NCT02664337
- Testing
- Decision tool, Standard treatment information
- Where
- United States
- Volunteers
- 2,310 people
- Sponsor
- Duke University
Fracture Healing
Study of Romosozumab (AMG 785) in Tibial Diaphyseal Fractures Status Post Intramedullary Nailing
The primary objective of this study is to investigate the effect of romosozumab compared with placebo on time to radiographic healing of fresh tibial diaphyseal fractures (fractures in the midsection of the shinbone).
- Trial name
- STARTT (NCT00907296)
- Testing
- Romosozumab
- Where
- 103 sites in United States, Australia and 21 more
- Volunteers
- 402 people
- Sponsor
- Amgen
Tibia Fracture
Ilizarov Frame or Uni Planar External Fixator in the Cost-conscious Era
Tibial shaft fracture is a common injury worldwide. Their treatment, prognosis, and outcome are determined by the mechanism of injury, presence of communition, soft tissue injury and displacement.
- Trial name
- NCT03936972
- Testing
- ilizarov circular frame and uni-planarexternal fixator
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Tibial Fractures
A Post-Market Clinical Evaluation of the Treatment of Tibia Fractures With the T2 Alpha Tibia Nailing System
This investigation is a prospective, multi-center clinical investigation. It is anticipated that a total of 80 subjects will be enrolled.
- Trial name
- NCT04015167
- Testing
- T2 Alpha Tibia Nailing System
- Where
- 4 sites in United States
- Volunteers
- 103 people
- Sponsor
- Stryker Trauma and Extremities
Tibial Fractures
Compartmental Overpressures Associated to Reamed Intramedullary Nails
The purpose of this study is to determine the effect of reamed intramedullary nails in tibial shaft fractures (as a standard treatment), in raising intracompartmental pressures and therefore determine if they are a risk factor…
- Trial name
- NCT00842101
- Testing
- Quick Pressure Monitor
- Where
- Andorra
- Volunteers
- 80 people
- Sponsor
- University of Andorra
Tibial Shaft Fracture, Intramedullary Nail
RCT - Suprapatellar Approach Versus Lateral Parapatellar Approach in Tibial Shaft Fracture
This study aims to compare 2 surgical techniques for tibial shaft nailing (suprapatellar approach vs extra-articular lateral parapatellar approach). following peri-operative and postoperative outcomes
- Trial name
- ELPP (NCT07657559)
- Testing
- suprapatellar approach, extra-articular lateral parapatellar approach
- Volunteers
- 40 people
- Sponsor
- Queen Savang Vadhana Memorial Hospital, Thailand
Post-traumatic; Arthrosis, Tibial Fractures
Does Joint Lavage Reduce Intraarticular Inflammation in High-energy Tibial Pilon Fractures?
High-energy tibial pilon fractures have historically been associated with poor outcomes largely due to the elevated risk of severe post-traumatic arthritis.
- Conditions
- Post-traumatic; Arthrosis, Tibial Fractures, Post-Traumatic Osteoarthritis of Ankle
- Trial name
- NCT05652881
- Testing
- Joint Lavage
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Fracture Open Tibia
Gentamicin Open Tibia Study
Local application of antibiotics directly to the traumatic wound is a promising treatment for the prevention of infection after open tibia fractures, which are a significant source of disease burden globally, particularly in…
- Trial name
- GO-Tibia (NCT05157126)
- Testing
- Gentamicin, normal Saline
- Where
- Tanzania
- Volunteers
- 890 people
- Sponsor
- University of California, San Francisco
Tibial Fractures, Pain
Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures: A Pragmatic, Randomized Controlled Trial
Two arm, pragmatic, randomized controlled multicenter Phase III noninferiority trial evaluating the efficacy of standard pain management without NSAIDs (Group 1) vs.
- Trial name
- NSAID (NCT07006675)
- Testing
- 600 mg Ibuprofen
- Where
- 14 sites in United States, Canada
- Volunteers
- 1,000 people
- Sponsor
- Major Extremity Trauma Research Consortium
Surgical Wound Infection
Clinical Assessment of Next Science Solution on Gustilo and Anderson Type II and IIIA or IIIB Tibial Fractures
This is a prospective, randomized, controlled, double-blinded clinical feasibility study of subjects that are being treated for Gustilo and Anderson Type II or IIIA or IIIB Tibial Fractures
- Trial name
- NCT04906642
- Testing
- Next Science, Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Next Science TM
Non-union Diaphysary Tibial Fractures
A Prospective Randomized Controlled Trial on the Use of Bone Morphogenetic 7 (BMP-7) (OP-1®) and Demineralized Bone Matrix in Tibial Non-union
The researchers propose a prospective, randomised partially-blinded study to investigate the clinical and radiological outcome, effect on quality of life and socio-economic impact of non-union of diaphysary tibial fractures…
- Trial name
- NCT00551941
- Testing
- BMP-7 in adjunct to fresh frozen allograft, allograft together with DBM
- Where
- 2 sites in Belgium
- Volunteers
- 2 people
- Sponsor
- University Hospital, Ghent
Tibial Plateau Fractures
Genicular Nerve Block After Open Reduction Internal Fixation of Tibial Plateau
The investigators are conducting this research study to find better ways of treating pain following knee surgery. There is a standard (accepted) approach, which involves injection of numbing medication into the area around the…
- Trial name
- NCT06639503
- Testing
- Bupivacain
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Chicago