Clinical trials: Time
Healthy
Continuous vs. Intermittent Rt-fMRI Neurofeedback Training of the Anterior Insula
The main aim of this study is to compare the efficacy of intermittent with continuous real-time functional magnetic resonance imaging (fMRI) neurofeedback on anterior insula regulation and associated behavioral changes.
- Trial name
- NCT07389486
- Testing
- real-time fMRI neurofeedback training procedure
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Emergencies
Improvement of Ambulance Response Times in Karachi, Pakistan
The investigators hypothesize that spatial analysis of the location data of ambulance calls can improve prehospital care provided by Aman Foundation in Karachi, Pakistan by decreasing ambulance response times for high acuity…
- Trial name
- NCT02743169
- Testing
- Spatially-Optimized
- Where
- Pakistan
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Hypertension, Pulmonary
A Study to Assess the Efficacy and Safety of 20, 40, and 80mg of Sildenafil Three Times a Day in the Treatment of Pulmonary Arterial Hypertension
To evaluate the effect of three doses of oral sildenafil (20, 40 and 80 mg three times a day [TID]) on exercise capacity, as measured by the 6-Minute Walk test, as well as the safety and tolerability, after 12 weeks of treatment…
- Trial name
- NCT00644605
- Testing
- sildenafil
- Where
- 68 sites in United States, Australia and 21 more
- Volunteers
- 275 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Age-related Cognitive Decline
Cognitive Engagement and Aging Mind
The purpose of this research is to examine whether and to what extent training of different types of cognitive engagement will improve performance on fluid cognitive abilities that typically decline with age.
- Trial name
- NCT05924490
- Testing
- Real-time strategy-based videogame training, Semantic Knowledge training
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas
Menopause
Eating Chocolate at the Right Time Benefits the Circadiam Sytem and Metabolic Efficiency.
The purpose of this investigation is to test the hypothesis that in humans, eating a relatively big amount of chocolate at the wrong time (bedtime) may disrupt our circadian system (change the circadian phase), while taking this…
- Trial name
- ONTIME-CHOC (NCT03949803)
- Testing
- Chocolate 100gr
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia
Lung Nodule, Lung Mass
Cone Beam CT Guided Robotic Navigational Bronchoscopy
Navigational bronchoscopy (NB) is used to access peripheral and central parenchymal lung lesions via endobronchial and transbronchial approach.
- Conditions
- Lung Nodule, Lung Mass, Lung Cancer
- Trial name
- CBCTRNB (NCT05358041)
- Testing
- Robotic Bronchoscopy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Columbus Regional Health
Pulmonary Arterial Hypertension
Retrospective Chart Review of First-time Opsumit® (Macitentan) Users in the United States
The Opsumit Users registry (OPUS; NCT02126943) was developed to characterize the safety profile of Opsumit and to describe clinical characteristics and outcomes of patients newly treated with Opsumit in the post-marketing…
- Trial name
- OrPHeUS (NCT03197688)
- Testing
- Notapplicable
- Where
- 106 sites in United States, Puerto Rico
- Volunteers
- 2,200 people
- Sponsor
- Actelion
Lung Cancer
Soblidotin in Treating Patients With Progressive Locally Advanced or Metastatic Non-Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy such as soblidotin use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00061854
- Testing
- soblidotin
- Where
- 3 sites in United States
- Sponsor
- Daiichi Sankyo
Glioblastoma Multiforme, Anaplastic Astrocytoma
Study of a Retroviral Replicating Vector Given Intravenously to Patients Undergoing Surgery for Recurrent Brain Tumor
This is a multicenter study evaluating the safety and tolerability of Toca 511 administered intravenously to patients with recurrent or progressive Grade III or Grade IV Gliomas who have elected to undergo surgical removal of…
- Conditions
- Glioblastoma Multiforme, Anaplastic Astrocytoma, Anaplastic Oligodendroglioma, Anaplastic Oligoastrocytoma
- Trial name
- NCT01985256
- Testing
- Toca 511, Toca FC
- Where
- 6 sites in United States
- Volunteers
- 17 people
- Sponsor
- Tocagen Inc.
Behaviors, Health
Evaluating an Innovative HIV Self-testing Service With Counseling Provided by a Chatbot
A parallel-group non-inferiority randomized controlled trial will then be conducted to evaluate the performance of HIVST-Chatbot.
- Trial name
- NCT05796622
- Testing
- HIVST-Chatbot (HIV self-testing services with counseling provided by a Chatbot), HIVST-OIC (HIV self-testing services with counseling provided by administrators)
- Where
- Hong Kong
- Volunteers
- 564 people
- Sponsor
- Chinese University of Hong Kong
Breast Cancer, Rehabilitation
Real-time Interactive Digital Healthcare System in Post Operation Patients With Breast Cancer; Pilot Study
This study aims to examine the effect of hospital-home linkage short-term rehabilitation therapy using real-time interactive digital healthcare system (Uincare Homeplus) in post-operative patients with breast cancer.
- Trial name
- NCT04152590
- Testing
- Uincare
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- JongIn Lee
Insulin Resistance
Free Fatty Acid Induced Insulin Resistance
This study aims to explore time-dependent effects of lipid infusion an intramyocellular lipid metabolites and the induction of impaired insulin signaling.
- Trial name
- FFAIR (NCT01229059)
- Testing
- Lipovenös lipid infusion
- Where
- Germany
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- German Diabetes Center
Premature (Early) Ejaculation
On-demand Silodosin 4mg vs Dapoxetine 60mg in Treatment of Primary Premature Ejaculation
Both Silodosin 4 mg and Dapoxetine 60 mg significantly improved IELT and sexual function scores in primary PE patients. However, Silodosin exhibited a more favorable tolerability profile with fewer side effects, making it a…
- Trial name
- NCT07081659
- Testing
- sildosin 4mg, dapoxetine 60mg
- Where
- Egypt
- Volunteers
- 95 people
- Sponsor
- Benha University
Regional Block for Pain Control, Supraclavicular Block
Duration of Analgesic Effect for Ultrasound Guided Supraclavicular Blocks With the Addition of Buprenorphine to Local Anesthetic Solution
The patients included will be those who have already agreed to have a brachial plexus nerve block for surgery. A flip of the coin will decide who gets and additive called buprenorphine in their block or not.
- Conditions
- Regional Block for Pain Control, Supraclavicular Block, Ultrasound Guided Block, Block Additive
- Trial name
- NCT01583179
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Wisconsin, Madison
Warts
An up to Twelve Week Safety and Efficacy Study With a Topical Gel to Treat Common Warts in Pediatric Subjects
The primary purpose of this study is to evaluate the effectiveness in pediatric subjects of three different strengths of resiquimod gel applied to common wart(s) three times a week for up to twelve weeks.
- Trial name
- NCT00116662
- Testing
- Resiquimod
- Where
- 10 sites in United States
- Volunteers
- 84 people
- Sponsor
- Graceway Pharmaceuticals, LLC
COVID-19
Short-time Intervention in Post-Covid Syndrome Syndrome (SIPCOV): A Pragmatic Randomised Controlled Trial
The present study is a 2-arm pragmatic randomised controlled trial (RCT) in which 310 patients who suffer from post-Covid syndrome are randomised to either a short-time outpatient-based rehabilitation program (the intervention)…
- Trial name
- SIPCOV (NCT05196451)
- Testing
- Rehabilitation based on CBT principles
- Where
- Norway
- Volunteers
- 314 people
- Sponsor
- University Hospital, Akershus
Food Selection
Pilot Study Using a Wireless Motility Capsule
Research suggests dietary fiber may decrease transit time through the gastrointestinal tract. Research studies traditionally use radio-opaque markers to determine gastric emptying, colonic transit, and whole gut transit time.
- Trial name
- NCT01102894
- Testing
- SmartPill
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Muscle Fatigue
Post-Fatigue Vibration: Impact on Grip and Reaction Time
This study aims to investigate the acute effects of local vibration applied after induced fatigue of the wrist flexor muscles on grip strength and upper extremity reaction time.
- Trial name
- NCT06949566
- Testing
- 100 Hz Local Vibration, 50 Hz Local Vibration
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Bitlis Eren University
Peripheral Perfusion
Assessment of Peripheral Perfusion in the Critically Ill Patient
The purpose of this study is to evaluate PPI as a surrogate for clinical signs of peripheral perfusion in patients in septic shock and after cardiac surgery.
- Trial name
- CRTPPI (NCT02771002)
- Testing
- Peripheral Perfusion index by Carescape Patientenmonitor
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Polycythemia Vera (PV), JAK2 Mutation
A Study of Ropeg-Interferon in People With Polycythemia Vera
The researchers are doing this study to find out whether it is practical (feasible) to stop treatment with ropeg-interferon (ropeg-INF) for some people with polycythemia vera (PV) with a change (mutation) in theJa nus kinase 2…
- Trial name
- NCT07886801
- Testing
- Ropeginterferon
- Where
- 7 sites in United States
- Volunteers
- 55 people
- Sponsor
- Memorial Sloan Kettering Cancer Center