Clinical trials: Tissue Grafts
Diabetic Foot Ulcer
A Study Measuring the Effectiveness of Combined Modulated Ultrasound and Electric Current Stimulation as an Adjunctive Treatment in Treating Diabetic Foot Ulcers
The study aims to investigate if combined modulated ultrasound and electric current stimulation (CUSECS) is an effective adjunctive treatment to use to treat diabetic foot ulcers when compared against usual care.
- Trial name
- NCT03458286
- Testing
- BRH-A2 wound healing device
- Volunteers
- 50 people
- Sponsor
- Royal College of Surgeons, Ireland
Socket Preservation
Clinical and Radiographic of the Effect of Socket Preservation Using the Roll Pedicle Connective Tissue Graft With Bovine Bone: A Case Series Trial.
After tooth extraction, the residual alveolar ridge generally provides limited bone volume because of ongoing, progressive bone resorption.
- Trial name
- NCT05255341
- Testing
- roll pedicle connective tissue graft with bovine bone
- Where
- Egypt
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Cairo University
Recession
Surgical Management of Interdental Papilla Recession With Advanced Platelet Rich Fibrin or Connective Tissue Graft
deficient interdental papillae witt be surgically reconstructed. in one group, connective tissue graft (SCTG) will be used for papillae augmentation, while in the other group, advanced platelet rich fibrin (A-PRF).
- Trial name
- NCT05031169
- Testing
- interdental papilla surgical reconstructiion
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Cairo University
Adult Periodontitis
Clinical Trials of Regeneration for Periodontal Tissue
Adult periodontitis is a chronic infective disease affecting the periodontium. Periodontitis induce the destruction of attachment apparatus of teeth, resulting in periodontal pocket formation and teeth loss.
- Trial name
- NCT00221130
- Testing
- surgical operation of cell transplantation
- Where
- Japan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Patients With at Least Single Missing Anterior Tooth, Thin Gingival Biotype
Clinical Evaluation of Platelet Rich Fibrin Versus Subepithelial Connective Tissue Graft for Soft Tissue Augmentation
Soft tissue biotype is a critical factor for success of implant in the esthetic zone . Different soft tissue augmentation techniques have been employed to increase soft tissue thickness such as: autogenous grafts, allografts…
- Trial name
- NCT03219944
- Testing
- Platelet Rich Fibrin, sub epithelial connective tissue graft
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Cairo University
Peri-Implantitis
The Adjunctive Effect of Soft Tissue Augmentation Procedures of Moderate-severe Peri-implantitis
The key objective of the study is to compare the effects of soft tissue augmentation using a volume stable collagen matrix or autogenous connective tissue graft or no soft tissue augmentation in addition to bone…
- Trial name
- NCT05415111
- Testing
- Subepithelial connective tissue, Volume stable Collagen Matrix, No soft tissue augmentation
- Where
- 3 sites in Germany, Singapore and 1 more
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Nadja Naenni
Thin Peri-implant Mucosal Phenotype
Peri-implant Soft Tissue Augmentation Using Microneedling With i-PRF vs. Connective Tissue Graft
This randomized controlled clinical trial aims to evaluate a minimally invasive technique for peri-implant soft tissue augmentation using microneedling combined with injectable platelet-rich fibrin (i-PRF) compared with the…
- Trial name
- NCT07667855
- Testing
- Connective Tissue Graft (CTG), Microneedling with Injectable Platelet-Rich Fibrin (MN+i-PRF)
- Where
- Lebanon
- Volunteers
- 24 people
- Sponsor
- Beirut Arab University
Keratinized Tissue Augmentation Around Dental Implants
Keratinized Tissue Augmentation Using Augmented Gingival Matrix Compared to Free Gingival Graft Around Implants
This is a 12-month, randomized, examiner-blinded, controlled, two-arm, parallel-group, single-site clinical trial comparing a biocompatible tissue graft (Augmented Gingival Matrix barrier) with a free gingival graft (FGG) to…
- Trial name
- NCT07863882
- Testing
- Augmented Gingival Matrix graft, Free Gingival Graft
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The Forsyth Institute
Diabetes Mellitus Foot Ulcer
Platelet Rich Plasma and Autologous Fat Graft for Diabetic Ulcer
Conventional management of diabetic ulcers is associated with slow healing, high costs and repeated trips to clinic. Stem cells contained in fat grafts can differentiate into pro-healing cells and release growth factors with…
- Trial name
- NCT03085550
- Testing
- Fat grafting, Fat grafting + platelet rich plasma
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University College, London
Acute Biphenotypic Leukemia, Acute Leukemia
Depletion of CD45RA Positive Naive T Cells for the Prevention of Graft Versus Host Disease in Older Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Acute Leukemia or Myelodysplastic Syndrome
This phase II trial tests how well removing CD45RA positive naive T cells works to prevent graft versus host disease in older patients undergoing standard of care allogeneic hematopoietic stem cell transplantation for the…
- Conditions
- Acute Biphenotypic Leukemia, Acute Leukemia, Acute Leukemia of Ambiguous Lineage, Acute Lymphoblastic Leukemia
- Trial name
- NCT07819396
- Testing
- Allogeneic CD34+-enriched and CD45RA-depleted PBSCs, Biospecimen Collection, Bone Marrow Aspiration
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Fred Hutchinson Cancer Center
Skin Tumor
Negative-pressure Wound Therapy on Full-thickness Skin Grafts of the Lower Leg
This randomized controlled non-sponsored trial on 60 patients evaluates if a portable negative-pressure device improves graft-take and decrease the risk of surgical complications for skin-cancer surgeries below the knee.
- Trial name
- NCT05451680
- Testing
- Negative pressure device, Conventional care
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- Helsinki University Central Hospital
Inadequately Attached Gingiva
Augmentation of Keratinized Tissue Around Dental Implant With a Xenogeneic Collagen Matrix and the Free Gingival Graft
The purpose of this study is to compare the clinical effects of combined application of combined application of a xenogeneic collagen matrix and the free gingival graft in augmentation of keratinized tissue around dental implant…
- Trial name
- NCT05273476
- Testing
- apically repositioned flap+ xenogeneic collagen matrix +free gingival graft
- Where
- China
- Volunteers
- 13 people
- Sponsor
- The Dental Hospital of Zhejiang University School of Medicine
Congenital Pseudarthrosis of Tibia
NVD-003 in the Treatment of Congenital Pseudarthrosis of the Tibia
A single arm, multi-country, multi-center study in pediatric patients, suffering from congenital pseudarthrosis of the tibia (CPT), treated during the primary surgical intervention with NVD-003, an autologous 3D scaffold free…
- Trial name
- NCT05693558
- Testing
- NVD-003, an autologous 3D scaffold free osteogenic graft
- Where
- 2 sites in United States, Belgium
- Volunteers
- 4 people
- Sponsor
- Novadip Biosciences
Periodontal Diseases, Regeneration
A Clinical Study of Connective Tissue Graft and Enamel Matrix Derivative in the Treatment of Intrabony Periodontal Defects
This clinical study aims to evaluate the effectiveness of periodontal regenerative surgery using the connective tissue graft (CTG) wall technique combined with enamel matrix derivative (EMD) in patients who have intrabony…
- Trial name
- CTG + EMD (NCT07233733)
- Testing
- Connective Tissue Graft (CTG) Wall Technique, Minimally Invasive Flap Design, Root Surface Preparation and Debridement
- Where
- Vietnam
- Volunteers
- 17 people
- Sponsor
- Phạm Đình Thiên Khải
Psoriasis
Study to Evaluate Efficacy and Safety of MP1032 in Patients With Chronic Plaque Psoriasis
The primary objective of this trial is to evaluate the clinical efficacy and safety of two oral doses of MP1032 (150 mg bid and 300 mg bid) when taken for 12 weeks by patients with moderate-to-severe chronic plaque psoriasis.
- Trial name
- NCT03706209
- Testing
- MP1032
- Where
- 19 sites in Germany, Poland
- Volunteers
- 155 people
- Sponsor
- MetrioPharm AG
Gingival Recession, Palate; Wound
Comparison of Graft Quality and Patient Morbidity Following Palatal Harvesting.
The purpose of this study is to compare four different connective tissue graft harvesting technique in terms of graft quality and patient post-operative morbidity
- Trial name
- NCT03584906
- Testing
- DGG Harvesting approach, ET harvesting approach, TDT harvesting approach
- Where
- 2 sites in Italy
- Volunteers
- 60 people
- Sponsor
- University of Milan
Wound of Skin, Burns
Microscopic Skin Tissue Column Grafting Technique Using the Autologous Regeneration of Tissue System
This study evaluates Microscopic Skin Tissue Column (MSTC) grafting technique using the Autologous Regeneration Tissue (ART) System in the treatment of skin loss.
- Trial name
- NCT05324514
- Testing
- Split-thickness skin grafting, High density microscopic skin tissue column grafting, Low density microscopic skin tissue column grafting
- Volunteers
- 40 people
- Sponsor
- The Metis Foundation
Gingival Recession, Localized, Keratinized Tissue
Er,Cr:YSGG Laser for Deepithelialization in Gingival Recession.
Abstract: Introduction: The deepithelialized free gingival graft (DGG) technique provides high-quality connective tissue grafts (CTGs) with predictable outcomes for recession cov-erage.
- Conditions
- Gingival Recession, Localized, Keratinized Tissue, Gingival Thickness, Pocket Depth
- Trial name
- NCT07064304
- Testing
- Laser Deepithelialization of Free Gingival Graft, Scalpel Deepithelialization of Free Gingival Graft
- Where
- Poland
- Volunteers
- 9 people
- Sponsor
- Wroclaw Medical University
Scar
Tissue-engineered Skin Graft Repair of Autologous Scar Dermal Scaffolds
Hypertrophic scar is an inevitable outcome of wound repair. It affects the appearance and some scar contracture often leads to joint dysfunction.Patients have low quality of life, long treatment cycle, heavy social burden and…
- Trial name
- NCT04389164
- Testing
- Tissue-engineered skin grafts of autologous scar dermal scaffolds
- Where
- China
- Volunteers
- 226 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Kidney Failure, Chronic, Kidney Transplantation
Drone Transport of Deceased-Donor Kidney Grafts Between Two French Hospitals Before Transplantation: a Pilot Safety Study
Cold ischemia time, the period during which a donated kidney is kept cold outside the body between its removal from the donor and its transplantation into the recipient, is one of the main modifiable factors influencing how…
- Conditions
- Kidney Failure, Chronic, Kidney Transplantation, Delayed Graft Function, Cold Ischemia
- Trial name
- RAfALREIN (NCT07851571)
- Testing
- Kidney graft transport by autonomous unmanned aircraft (drone) between the procurement and transplantation centres
- Volunteers
- 5 people
- Sponsor
- Nantes University Hospital