Clinical trials: Tissue Transplantation
Immediate Dental Implants
Evaluation of Immediate Implant Placement Using Dual Zone Approach Versus Connective Tissue Graft
Tooth extraction is followed by ridge alteration and soft tissue collapse and recession. Different strategies were proposed to limit this collapse however, the ability of these techniques to mimic the original soft tissue level…
- Trial name
- NCT05776498
- Testing
- immediate implant placement with particulate bone graft using the dual zone technique., immediate implant placement with connective tissue grafting
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Gingival Recession, Localized
Er,Cr:YSGG Laser For Recipient Bed Bio-modification And Connective Tissue Harvesting in Treatment of Gingival Recession
A clinical and radiographic evaluation of using Erbium, Chromium, Scandium, Gallium and Garnet (Er,Cr:YSGG) laser in recipient site bio-modification and de-epithelialized connective tissue graft harvesting compared to…
- Trial name
- NCT03200392
- Testing
- laser root surface conditioning & laser DGG harvesting, laser root surface conditioning & blade DGG harvesting, blade DGG harvesting
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Misr International University
Implant Complication
Vertical Soft Tissue Augmentation With CTG vs ADM
The study aims at comparing two different approaches for vertical soft tissue augmentation at implant sites exhibiting soft tissue dehiscences: autogenous connective tissue graft vs acellular dermal matrix + enamel matrix…
- Trial name
- NCT05729607
- Testing
- Vertical soft tissue augmentation
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Harvard Medical School (HMS and HSDM)
Ulcer, Skin Ulcer
Epidermal Grafting in Wound Healing
Split thickness skin grafting is the normal standard of care for wound closure. However, this is an invasive procedure and associated with pain also there can be additional donor site morbidity.
- Conditions
- Ulcer, Skin Ulcer, Wounds and Injuries
- Trial name
- EPIGRAAFT (NCT02535481)
- Testing
- Epidermal grafting, Split thickness skin grafting
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University College, London
Gingival Recession
Amnion Chorion Membrane in Comparison to Subepithelial Connective Tissue Graft in Gingival Recession Coverage
The present randomized, controlled, parallel-grouped trial included twenty patients (aged 20 to 54 years) suffering from Miller's class I or II gingival recession.
- Trial name
- NCT02656732
- Testing
- amnion chorion allograft membrane, coronally advanced flap with the subepithelial connective tissue graft
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hopeless Tooth in Esthetic Zone, Loss of Soft and Hard Tissue Around Implant
Peri-implant Tissue Changes Using Dual Zone Concept With Connective Tissue Graft Versus Concentrated Growth Factor
Tooth extraction not only alters the bony architecture of the alveolar ridge, but it also has an impact on the surrounding soft tissues.
- Conditions
- Hopeless Tooth in Esthetic Zone, Loss of Soft and Hard Tissue Around Implant, Immediate Implant Placement
- Trial name
- NCT06728696
- Testing
- Immediate implant with with dual zone technique using concentrated growth factor graft., Immediate implant with dual zone technique using connective tissue graft.
- Where
- Egypt
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Recession, Gingival
Clinical Evaluation of Laterally Closed Tunnel Technique Versus Coronally Advanced Flap Combined With Connective Tissue Graft for the Treatment of Isolated RT2 Gingival Recession
The aim of this study is to evaluate reduction of recession depth using lateral closed tunnel technique versus CAF technique using connective tissue graft in single RT2 gingival recession cases.
- Trial name
- NCT05823415
- Testing
- Laterally Closed Tunnel with CTG, CAF with CTG
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Gingival Recession, Generalized
Comparison Between Connective Graft and Xenogeneic Matrix, in Patients With Multiple Gingival Recessions
Subepithelial connective tissue graft (SCTG) is considered the gold standard for root coverage treatment. However, it is associated with postoperative morbidity, limited amount of donor tissue, and longer surgical time.
- Trial name
- NCT03207984
- Testing
- Root coverage surgery
- Where
- Brazil
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Mucogingival Defects, Pontic Site Development
Pontic Site Development With or Without Fixed Partial Denture
This study aims to evaluate the effectiveness of soft tissue augmentation using connective tissue graft (CTG) in pontic site defects.
- Conditions
- Mucogingival Defects, Pontic Site Development, Keratinized Tissue Deficiency, Connective Tissue Graft
- Trial name
- Pontic Site (NCT07535060)
- Testing
- Connective Tissue Graft (CTG)
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Connective Tissue, Gingiva
Comparison of Free Gingival Graft and Linear Incision for Connective Tissue
A randomized controlled non-inferiority trial will be conducted with 24 individuals aged 18 or older, who are periodontally healthy and require root coverage in bilateral multiple RT1-type recessions involving at least two teeth…
- Conditions
- Connective Tissue, Gingiva, Gingival Recession, Humans
- Trial name
- NCT06365983
- Testing
- Connective Tissue with Free Gingival Graft, Connective Tissue with Linear Incision
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Socket Preservation
Clinical and Radiographic of the Effect of Socket Preservation Using the Roll Pedicle Connective Tissue Graft With Bovine Bone: A Case Series Trial.
After tooth extraction, the residual alveolar ridge generally provides limited bone volume because of ongoing, progressive bone resorption.
- Trial name
- NCT05255341
- Testing
- roll pedicle connective tissue graft with bovine bone
- Where
- Egypt
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Cairo University
Acellular Dermal Matrix, Bone Grafting
Evaluating the Barrier Function, Regenerative Capacity, and Soft Tissue Outcomes of Acellular Dermal Matrix
This investigator-initiated study will compare ADM and resorbable cross-linked collagen membrane barriers for guided bone regeneration at atrophic lateral ridge augmentation sites.
- Conditions
- Acellular Dermal Matrix, Bone Grafting, Soft Tissue Grafting
- Trial name
- NCT07613047
- Testing
- Guided Bone Regeneration with ADM (AlloDerm) as a barrier, Guided Bone Regeneration with Resorbable Crosslinked Collagen Matrix (Mem-Lok) as a barrier
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Acute Biphenotypic Leukemia, Acute Leukemia
Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant
This phase II trial studies how well naive T-cell depletion works in preventing chronic graft-versus-host disease in children and young adults with blood cancers undergoing donor stem cell transplant.
- Conditions
- Acute Biphenotypic Leukemia, Acute Leukemia, Acute Leukemia of Ambiguous Lineage, Acute Lymphoblastic Leukemia
- Trial name
- NCT03779854
- Testing
- Total-Body Irradiation, Thiotepa, Fludarabine
- Where
- 9 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Horizontally Deficient Alveolar Ridges, Hard and Soft Tissue Augmentation During Delayed Implant Placement
Effectiveness of Subepithelial Connective Tissue Graft as an Autogenous Barrier Membrane for Hard and Soft Tissue Augmentation in Horizontally Deficient Ridges During Delayed Implant Placement
This study evaluates the clinical effectiveness of using a patient's own subepithelial connective tissue graft as a natural barrier membrane during simultaneous hard and soft tissue augmentation in areas of the jawbone with…
- Trial name
- CBCT-GBR-SECTG (NCT07861724)
- Testing
- Subepithelial Connective Tissue Graft as an Autogenous Barrier Membrane for Hard and Soft Tissue Augmentation in Horizontally Deficient Ridges during delayed implant placement
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pontic Site Augmentation, Connective Tissue Graft
Clinical and Volumetric Changes Following Single Pontic Site Development Using Multilayered Platelet Rich Fibrin Versus Connective Tissue Grafting in the Maxillary Esthetic Zone
In clinical practice most patients' first concern is esthetics, soft tissue grafting is becoming routine in clinical practice to make up for the deficiency in supra-crestal tissue dimension that typically follows tooth loss.
- Trial name
- NCT06926452
- Testing
- Pontic site augmentation with sub-epithelial connective tissue graft., Pontic site augmenation using multi-layered platelet rich fibrin
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Gingival Recession
Morbidity and Coverage Outcome With Connective Tissue Graft Used With Coronally Advanced Flap and Tunneling Technique
The aim of this randomized-controlled clinical trial is to compare the patient morbidity and root coverage outcomes of a sub-epithelial connective tissue (SeCTG) used in combination with a coronally advanced flap (CAF) and tunnel…
- Trial name
- NCT02269748
- Testing
- Tunnel technique with subepithelial connective tissue, Coronally advanced flap, Analgesic Therapy
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Padova, School of Dental Medicine
Recession, Gingival
Palatal Volumetric Change Analysis Following Connective Tissue Graft With and Without Donor Site Augmentation
The goal of this randomized clinical trial is to compare whether soft tissue augmentation placed in the donor site following a gum graft harvesting leads to volumetric changes compared to non-augmented sites in the palate.
- Trial name
- NCT05961566
- Testing
- Use of collagen matrix after subepithelial connective tissue graft harvest
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hailey Bivens
Gingival Recession
Platelet-Rich Fibrin Prepared With Titanium in the Treatment of Multiple Gingival Recessions
The aim of this study was to treat the areas with Miller Class I bilateral multiple gingival recession in the maxillary teeth using the Titanium Platelet-Rich Fibrin (T-PRF), an autogenous biomaterial applied in combination with…
- Trial name
- NCT05270941
- Testing
- COMPARISON OF PLATELET-RICH FIBRIN PREPARED WITH TITANIUM AND SUBEPITHELIAL CONNECTIVE TISSUE GRAFT
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
To Evaluate the Efficacy of Platelet-rich Fibrin in Papilla Reconstruction, To Evaluate the Efficacy of Connective Tissue Graft in Papilla Reconstruction
Comparison of the Efficacy of Platelet-rich Fibrin and Connective Tissue Graft in Interdental Papilla Reconstruction
Aim: To evaluate the efficacy of platelet-rich fibrin (PRF) or connective tissue graft (CTG) in papilla reconstruction (PR) with semilunar incision (SI) technique.
- Trial name
- NCT05207696
- Testing
- retrospective data analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Gingival Recession, Generalized, Graft Reaction
The Healing of Soft Tissue Augmentation by Acellular Dermal Matrix and Autogenous Subepithelial Connective Tissue Graft
The study team proposes to prospectively compare the healing outcomes of autogenous soft tissue connective tissue graft (CTG) and Acellular dermis matrix (ADM) in a split-mouth design study for patients requiring modification of…
- Trial name
- NCT03954028
- Testing
- Gingival Punch Biopsy after healing of Gingival Soft Tissue Augmentation
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida