Clinical trials: Tolerance of the Liver
Non-Alcoholic Fatty Liver Disease
Effects of TOTUM-448 on Liver Fat Content, Cardiometabolic Risk Factors and Gut Microbiota Among Participants with MASLD
This clinical trial aims to investigate the effects of TOTUM-448, a mix of 5 plant extracts and choline, consumed at the daily regimen of two times per day, on liver fat content, cardiometabolic risk factors and gut microbiota…
- Trial name
- CARDIO-LIVER (NCT06704321)
- Testing
- TOTUM-448
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Valbiotis
Impaired Fasting Glucose, Pre Diabetes
Dietary Interventions in Prediabetes
Assessment of glucose metabolism and liver fat after 12 week dietary intervention in pre diabetes subjects. Subjects will be randomized to either high fat (olive oil supplemented),high carb/high fiber (beans supplemented) and…
- Conditions
- Impaired Fasting Glucose, Pre Diabetes, Liver Fat
- Trial name
- NCT01729078
- Testing
- Dietary intervention
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Mayo Clinic
Tolerance of the Liver
Pringle Time Exceeding 120 Min in Liver Resection
Intermittent Pringle's maneuver is widely used to limit blood loss during hepatectomy, without an established time-limit. However, many authors claims its danger for patients' outcome.
- Trial name
- NCT01237002
- Where
- Italy
- Volunteers
- 189 people
- Sponsor
- University of Milan
Metastases, Neoplasm, Colorectal Neoplasms
Magnetic-Targeted Doxorubicin in Treating Patients With Cancer Metastatic to the Liver
MTC-DOX is Doxorubicin or DOX, a chemotherapy drug, that is adsorbed, or made to "stick", to magnetic beads (MTCs). MTCs are tiny, microscopic particles of iron and carbon.
- Conditions
- Metastases, Neoplasm, Colorectal Neoplasms, Esophageal Neoplasms, Stomach Neoplasms
- Trial name
- NCT00041808
- Testing
- MTC-DOX for Injection, Chemotherapy
- Where
- 4 sites in United States, Germany
- Volunteers
- 20 people
- Sponsor
- FeRx
HepatoCellular Carcinoma
The Impact on Therapeutic Effect and Tolerance of Treatment for Patients With Hepatocellular Carcinoma in Transcatheter Arterial Chemoembolization (TACE) of Dexamethasone Application: A Random, Double-blind, Controlled, Clinical Trial.
The current random, double-blind, controlled, clinical trial was designed to evaluate the impact on therapeutic effect and tolerance of treatment for patients with hepatocelluclar carcinoma in transcatheter arterial…
- Trial name
- NCT02987907
- Testing
- Dexamethasone, Normal Saline
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Sun Yat-sen University
Type 2 Diabetes Mellitus, Obesity
The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes
This research study is being performed to begin to determine the effectiveness of two dominant bariatric surgery procedures versus an intensive lifestyle intervention to induce weight loss in patients and promote improvements in…
- Trial name
- TRIABETES (NCT01047735)
- Testing
- Roux-en-Y Gastric Bypass Surgery, Laparoscopic Adjustable Gastric Banding, Lifestyle Weight Loss Intervention
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Pittsburgh
Gastrointestinal Tolerance, Liver Function
A Clinical Trial to Evaluate the Chronic Safety and Tolerance of Turmipure Gold™ in Healthy Subjects
The aim of this study is to evaluate the safety and tolerance of Turmipure Gold™ product during a chronic consumption of 5 weeks in healthy subjects.
- Conditions
- Gastrointestinal Tolerance, Liver Function, Kidney Function
- Trial name
- TURBIO-GOLD (NCT03945149)
- Testing
- Turmipure Gold™
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Givaudan France Naturals
Hepatitis C
A Pilot Study Evaluating Safety of Sitagliptin Combined With Peg-IFN Alfa-2a + Ribavirin in Chronic Hepatitis C Patients
Hepatitis C infection is a major public health problem with nearly 175 million infected individuals worldwide. Although cure is possible, only 20-40% of patients spontaneously resolve infection and 40-80% of chronically infected…
- Trial name
- NCT01567540
- Testing
- Sitagliptin
- Where
- 4 sites in France
- Volunteers
- 3 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Severe Pediatric Obesity (BMI > 97° pc -According to Centers for Disease Control and Prevention BMI Charts-), Altered Liver Function Tests
Obalon in Children With Severe Obesity
The ongoing global rise in the prevalence of overweight and obesity among all ages and among all ethnic groups, figures into a real epidemic phenomenon.
- Conditions
- Severe Pediatric Obesity (BMI > 97° pc -According to Centers for Disease Control and Prevention BMI Charts-), Altered Liver Function Tests, Glycemic Intolerance
- Trial name
- Obalon (NCT02137330)
- Testing
- Swallowable Obalon® Gastric Balloon
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Liver Transplantation
Assessment Of the Safety and Benefit of Prospective Immunosuppressive Drug Withdrawal in Liver Transplantation and Prediction of Operational Tolerance
In liver transplantation up to 20% of recipients can completely discontinue immunosuppressive therapy maintaining normal graft function, and are conventionally considered as operationally tolerant.
- Trial name
- NCT00647283
- Testing
- Gradual immunosuppression drug withdrawal
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Hospital Clinic of Barcelona
Patient With Hepatic Metastasis
CoSeal in Liver and Biliary Surgery in Prevention of Denovo Hepatic Adhesion
Study of phase II: Clinical study national, exploratory, multicentric, prospective, randomized, as a double blind man evaluating the effectiveness and the tolerance of the treatment by a surgical gel of sealing containing…
- Trial name
- COLIBIS (NCT01121601)
- Testing
- hepatic surgery of resection
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Impaired Glucose Tolerance, Pre-diabetes
Study to Investigate the Pathophysiology of Type 2 Diabetes in Youth
The purpose of the study is to determine the role of beta-cell function and insulin resistance in the development of impaired glucose tolerance (IGT) and type 2 diabetes in children and adolescents who have an increased risk of…
- Conditions
- Impaired Glucose Tolerance, Pre-diabetes, Childhood Obesity, Insulin Resistance
- Trial name
- NCT00536250
- Where
- United States
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Yale University
Non-Alcoholic Fatty Liver Disease, Insulin Resistance
The Effect of Curcumin on Liver Fat Content in Obese Subjects
The majority of obese have non-alcoholic fatty liver disease (NALFD). Currently, no pharmacological agents are licenced for the prevention or treatment of NAFLD, and weight loss, notoriously difficult to obtain (and specially to…
- Conditions
- Non-Alcoholic Fatty Liver Disease, Insulin Resistance, Glucose Tolerance Impaired, Obesity, Abdominal
- Trial name
- NCT03864783
- Testing
- Curcumin (Meriva®)
- Where
- Denmark
- Volunteers
- 39 people
- Sponsor
- Steno Diabetes Center Copenhagen
Hepatocellular Carcinoma
Phase Ib/2, Multicenter, Dose Escalation Study of DCR-MYC in Patients With Hepatocellular Carcinoma
The purpose of this study is to assess the safety and tolerability of the investigational anticancer drug DCR-MYC. DCR-MYC is a novel synthetic double-stranded RNA in a stable lipid particle suspension that targets the oncogene…
- Trial name
- NCT02314052
- Testing
- DCR-MYC
- Where
- 6 sites in United States, Singapore and 1 more
- Volunteers
- 21 people
- Sponsor
- Dicerna Pharmaceuticals, Inc., a Novo Nordisk company
Glucose Metabolism Disorders
Cirrhosis-Diabetes
Glucose metabolism disorders (GMD) can be present in an overt and a subclinical way. They have negative impact in survival of patients with liver cirrhosis (LC).
- Trial name
- CH-DM (NCT01396954)
- Volunteers
- 130 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Hepatocellular Carcinoma
Neoadjuvant Hypofractionated Stereotactic Body Radiation Therapy Prior to Surgery for Hepatocellular Carcinoma: a Feasibility Study.
Hepatocellular carcinoma (HCC) is the fifth more common cancer in the world, with high mortality rates, due to the low number of patients who are eligible for therapy with curative intent, like surgical resection.
- Trial name
- KARCHER-1 (NCT04587739)
- Testing
- Surgery with Neoadjuvant stereotactic body radiation therapy
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Lille
Hepatocellular Carcinoma
A Phase I Clinical Study on a New Oral Pentamidine Formulation in Hepatocellular Carcinoma
The purpose of this study is to investigate on the Hepatic Uptake, Pharmacokinetics, Safety and Tolerance of a New Oral Pentamidine Formulation in Hepatocellular Carcinoma Subjects Undergoing Thermal Ablation
- Trial name
- NCT02210182
- Testing
- Oral Pentamidine
- Where
- 3 sites in Canada
- Volunteers
- 29 people
- Sponsor
- Oncozyme Pharma Inc.
Liver Transplantation, Liver Transplantation in Long-term
Immunosuppressant Withdrawal Based on Parenchymal Chimerism in the Liver Transplantation
The goal of this clinical trial is to learn whether liver parenchyma chimerism can represent a chievement of operational tolerance in liver transplantation recipients.
- Trial name
- NCT07735650
- Testing
- liver biopsy, Immunosuppression withdrawal, Immunosuppression minimization
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung Memorial Hospital
Living-donor Liver Transplantation
Induction of Transplant Tolerance in LDLT Via iTS
The purpose of this clinical trial is to examine the immunotolerance-inducing ability (effectiveness) of induced inhibitory T cells JB-101 in patients with living-donor liver transplantation using "whether or not operational…
- Trial name
- NCT04950842
- Testing
- JB-101
- Where
- 5 sites in Japan
- Volunteers
- 10 people
- Sponsor
- Juntendo University
Chronic Hepatitis B
Clinical Study to Evaluate the Safety, Tolerance and Pharmacokinetic Characteristics of Single Administration of HRS-5635 Injection in Chinese Healthy Subjects and the Safety, Tolerance, Pharmacokinetics and Antiviral Effect of Multiple Administration in Patients With Chronic Hepatitis B
The study is being conducted to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of HRS-5635 in healthy adults and chronic hepatitis B. To explore the reasonable dosage of HRS-5635.
- Trial name
- NCT05808374
- Testing
- HRS-5635
- Where
- China
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.