Clinical trials: Tooth Defect
Molar Incisor Hypomineralisation
Correlation Between Colour and Hypersensitivity of First Permanent Molars With Molar Incisor Hypomineralisation (MIH)
Cheese molars (MIH: molar incisor hypomineralisation) can be recognized not only by their colour abnormalities but also by their hypersensitivity.
- Trial name
- NCT07727044
- Where
- Switzerland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Basel
Fuchs' Endothelial Dystrophy, Pseudophakic Bullous Keratopathy
The Effect Of Preoperative Parameters On Success After DMEK Surgery
The aim of this study is to evaluate the effect of preoperative parameters on surgical results in Descemet Membrane Endothelial Keratoplasty (DMEK) surgery.
- Conditions
- Fuchs' Endothelial Dystrophy, Pseudophakic Bullous Keratopathy, Descemet's Membrane; Defect, Herpetic Keratitis
- Trial name
- NCT04420429
- Testing
- Descemet membrane endothelial keratoplasty (DMEK)
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Beyoglu Eye Research and Education Hospital
Bone Loss, Occlusion
Comparative Clinical and Radiographical Evaluation of Treatment of Angular Bone Defect Related to Over Erupted Tooth Using GTR Followed by Orthodontic Intrusion Versus Orthodontic Intrusion Followed by GTR
Occlusal prematurity leading to loss of vertical stopping points between teeth can lead to teeth over eruption creating abnormal contact area which favors food accumulation and plaque retention.
- Trial name
- NCT05371418
- Testing
- surgical (guided tissue regeneration), orthodontic intrusion followed by guided tissue regeneration GTR
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Tanta University
Gingival Recession, Connective Tissue Defect
A Novel Volume Stable Matrix for Gingival Recession Coverage at Teeth
Periodontal health and preservation of the dentition without tooth loss are important quality of life components and should be safeguarded in order to provide optimal function and esthetics.
- Trial name
- FibroGide (NCT07437417)
- Testing
- Volume stable collagen matrix, Control
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Bern
Wound Heal
Effect of A-PRF After Removal of Wisdom Teeth
To evaluate the healing effect of advanced platelet-rich fibrin (blood clot charged with growth factors) taken from the patient own blood on the extraction site.
- Trial name
- A-PRF (NCT03703479)
- Testing
- autologous blood clot made from the patient own clot without any additive
- Where
- Saudi Arabia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Prosthetic Tissue Defect, Dental Prosthesis Complication
Study of Periodontal Tissues in Fixed Prostheses on Natural Teeth
When the tooth is severely compromised, it needs a prosthetic crown. The tooth is prepared to allow the housing of the prosthetic crown without difficulty.
- Conditions
- Prosthetic Tissue Defect, Dental Prosthesis Complication, Dental Prosthesis Failure, Tissue Injury
- Trial name
- NCT04151316
- Testing
- crown preparation, vertical preparation, horizontal preparation
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Università Vita-Salute San Raffaele
Molar Incisor Hypomineralisation, Enamel Breakdown
Correlation Between Colour of Defect and Enamel Breakdown in First Permanent Molars With Molar Incisor Hypomineralisation (MIH)
Cheese molars (MIH) can be recognized not only by their colour abnormalities but also by the enamel breakdown. Clinical management of those teeth may become challenging by the chronic hypersensitivity, that makes various steps…
- Conditions
- Molar Incisor Hypomineralisation, Enamel Breakdown, Colour of Defect
- Trial name
- MIH (NCT07727200)
- Where
- Switzerland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Basel
Periodontitis, Tooth Migration
Timing of Orthodontic Therapy and Regenerative Periodontal Surgery in Advanced Periodontitis Patients With Pathologic Tooth Migration
Pathologic tooth migration (PTM) is a common complication of advanced periodontitis and often motivation for patients to seek orthodontic therapy.
- Conditions
- Periodontitis, Tooth Migration, Intrabony Periodontal Defect
- Trial name
- NCT02761668
- Testing
- ParS+Ortho 4W, ParS+Ortho 6M
- Where
- 2 sites in Germany, Spain
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Sphingosine Phosphate Lyase Insufficiency Syndrome (SPLIS)
Natural History of Sphingosine Phosphate Lyase Insufficiency Syndrome (SPLIS)
This is a prospective longitudinal natural history study with a retrospective cross-sectional arm aimed at determining the natural history of sphingosine phosphate lyase insufficiency syndrome (SPLIS), a recently recognized…
- Trial name
- SPLIS-HIS (NCT06669949)
- Testing
- no intervention
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of California, San Francisco
Dental Caries Secondary to Acquired Defects of Tooth Structure
10-years Clinical Trial of Sealed of Margin Failures
Assess the effectiveness of sealing localized marginal defects of amalgam restorations that were initially scheduled for replacement of restorations.
- Trial name
- Sealant (NCT02075801)
- Testing
- Sealing of amalgam margin defects
- Where
- Chile
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Chile
Tooth Loss, Peri-implant Mucosa Defect
Comparison of Two Different Surgical Approaches To Increase Peri-Implant Mucosa Thickness
The purpose of this non-inferiority trial is to determine the clinical efficacy of acellular dermal matrix (ADM) in the augmentation of the gum around dental implants as compared to an autologous gum graft (sCTG) obtained from…
- Trial name
- NCT02450383
- Testing
- Acellular Dermal Matrix, Autologous subepithelial connective tissue graft
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Tooth Defect
Occlusal Contact Trueness Affected by Six Chairside CAD/CAM Ceramic Materials
The aim of this clinic self-control study was to evaluate the trueness of occlusal contact affected by six ceramic materials during chairside fabricating process and offer recommendations for occlusal offset according to…
- Trial name
- NCT05346744
- Testing
- Chairside CAD/CAM ceramic materials for dental restoration
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University
Malocclusion, Temporomandibular Disorder
Postural Assessment in Patients With Malocclusions
This observational cross-sectional study aims to investigate the association between skeletal malocclusions and body posture using three-dimensional postural analysis.
- Conditions
- Malocclusion, Temporomandibular Disorder, Postural; Defect
- Trial name
- NCT07664059
- Testing
- Lateral teleradiography, Temporomandibular assessment with Helkimo Index, Three-dimensional postural assessment
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Andrea Scribante
Chemotherapy Effect, Dental Caries
Prevalence of Long-term Dental Effects of Chemotherapy in Childhood Cancer Survivors Diagnosed With Cancer Before the Age of 10
To date, there are no methods for assessing the risk of oral developmental defects that could predict long-term adverse effects in childhood cancer survivors.
- Conditions
- Chemotherapy Effect, Dental Caries, Malocclusion, Childhood Cancer
- Trial name
- NCT06517927
- Testing
- Clinical and radiographic dental examination
- Where
- Belgium
- Volunteers
- 142 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Root Canal Infection, Tooth Defect
Clinical Trial of Modified Endocrown and Personalized Post-core and Crown for Large-area Tooth Defects After Root Canal Treatment
This study intends to adopt a multicenter, randomized controlled, single-blind, non-inferiority clinical trial design. 246 premolars that meet the inclusion criteria after complete root canal treatment will be selected from the…
- Conditions
- Root Canal Infection, Tooth Defect, Post and Core Technique
- Trial name
- NCT07206108
- Testing
- modified endocrown
- Where
- China
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Tooth Loss in the Esthetic Zone Requiring Immediate Implant Placement, Guided Immediate Implant Placement
Silicate β-TCP vs Extended Sticky Bone for Peri-Implant Jumping Gap in Guided Immediate Implants: RCT
This randomized clinical trial compares three peri-implant jumping gap management approaches following fully guided immediate implant placement in the maxillary esthetic zone.
- Conditions
- Tooth Loss in the Esthetic Zone Requiring Immediate Implant Placement, Guided Immediate Implant Placement, Bone Grafting, Customized Healing Abutment
- Trial name
- JUMP-ESTHETIC (NCT07700706)
- Testing
- No Grafting, Silicate-Added β-TCP Putty, Extended Sticky Bone
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Mansoura University
Tooth Defect
Clinical Evaluation of AI-Generated Dental Crowns
This clinical research validates a fully automatic AI algorithm for dental crown design using GANs trained on University of Hong Kong 3D prosthesis data and AI-powered FEA for stress correction, overcoming CAD/CAM limitations…
- Trial name
- NCT07562607
- Testing
- Conventional CAD/CAM Dental Crowns, AI-Designed Dental Crowns
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- The University of Hong Kong
Peri-Implantitis and Peri-implant Mucositis
Risk Assessment of Proximal Contact Loss Between Implant-supported Prostheses and Adjacent Teeth.
In this study, we collected and analysed the review results of 100 patients over 18 years of age who received implant fixed restorations in the Department of Stomatology of the First Hospital of Nanjing, China.
- Trial name
- NCT06475313
- Testing
- plaque index assessment, periodontal probing, Bleeding on probing (BOP), Prosthetic adjacency check, initial occlusal contact, maximum occlusal contact, and filling of the cusps.
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Dentition Defect, Healing Abutment
Feasibility Study on the Application of Bionic Healing Abutments in Implant Impressions
The bionic healing abutment of the group's previous research results has both soft tissue shaping and impression taking functions, realizing the advantages of no need to dismantle the impression, simplifying clinical operation…
- Trial name
- NCT07514585
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Fujian Medical University
Alveolar Bone Loss, Alveolar Ridge Resorption After Extraction
THBC/CGF for Alveolar Bone Regeneration: A Real-World Study
This study aims to combine real-world research with relevant bone repair materials and techniques to improve alveolar bone resorption in extraction sockets following impacted wisdom tooth removal, while achieving effective bone…
- Conditions
- Alveolar Bone Loss, Alveolar Ridge Resorption After Extraction, Tooth, Impacted
- Trial name
- NCT07779421
- Testing
- Temperature-sensitive hydroxybutyl chitosan-loaded concentrated growth factor, Temperature-sensitive hydroxybutyl chitosan, Autologous Concentrated Growth Factor
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Stomatological Hospital Affiliated with Fujian Medical University