Clinical trials: Total Knee Replacement Surgeries
Epidural; Analgesia, Local Infiltration
Comparison of Epidural Analgesia With Intra-Articular Infiltration Analgesia
The results of combining infiltrative analgesia applied by orthopedists with epidural analgesia applied by anesthesiologists after knee replacement surgery will be compared.
- Trial name
- NCT06872528
- Testing
- Recording the amount of medication and the number of complications according to observational follow-up
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Namik Kemal University
Knee Osteoarthritis
Personalized Approach to Robotic Total Knee Arthroplasty
For the first time in Russia, it is planned to introduce a system of personalized preoperative planning, applying the concept of kinematic alignment in robotic knee arthroplasty.
- Trial name
- NCT05750784
- Testing
- Total knee arthroplasty using the active robotic surgical system
- Where
- Russia
- Volunteers
- 150 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Arthroplasty; Replacement; Knee, Radiotherapy; Image-Guided
Surgical Outcomes of the Accelerometer-based Navigation System for Total Knee Arthroplasty
Osteoarthritis (OA) is a very common condition in the elderly population. Treatment for end-stage OA is total knee Replacement (TKR)
- Trial name
- NCT04037228
- Testing
- KneeAlign 2 system (OrthAlign Inc, Aliso Viejo, California)
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Arthroplasty, Replacement, Knee, Surgery, Computer-Assisted
Navigated Versus Convention Total Knee Arthroplasty
The aim of this single blinded randomised control trial study was to assess the accuracy of implantation of components and the clinical outcome and complications with the iNAV electromagnetic navigation system compared with…
- Trial name
- iNAV (NCT05325060)
- Testing
- Electromagnetically navigated total knee arthroplasty, Conventional total knee arthroplasty
- Volunteers
- 200 people
- Sponsor
- NHS Greater Glasgow and Clyde
Osteoarthritis
Guided Imagery Response in Total Knee Replacement
The purpose of this mixed methods pilot study is to produce preliminary data for a randomized, placebo-controlled trial testing a biobehavioral model of the effects of guided imagery on outcomes of total knee replacement surgery.
- Trial name
- NCT01491750
- Testing
- GUIDED IMAGERY
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Kent State University
Arthroplasty, Replacement, Knee
Silkeborg Knee Replacement Cohort Study
In this cohort study, we will investigate short and long term outcomes after knee replacement surgery and identify preoperative and early postoperative factors associated with long term outcome.
- Trial name
- NCT03411083
- Testing
- Total or unicompartmental knee replacement
- Where
- Denmark
- Volunteers
- 1,225 people
- Sponsor
- Central Jutland Regional Hospital
Joint Replacement Surgery
Reversal of Spinal Anesthesia Residual Motor Block Via Intrathecal Catheter
The purpose of this study is to determine the feasibility of administering a predetermined amount of normal saline into the intrathecal or subarachnoid space via a small spinal catheter to reduce or eliminate the effects of…
- Trial name
- IT-Cath (NCT07404982)
- Testing
- Normal Saline 10 mL Injection
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Beth Israel Deaconess Medical Center
Prehabilitation, Preoperative Care
Preoperative Optimization Before Total Hip or Knee Replacement Surgery
Preoperative Optimisation prior to Hip and Knee Arthroplasty (PrOpE) Many patients scheduled for planned hip or knee replacement surgery have health conditions that may affect recovery, such as reduced physical fitness…
- Trial name
- PrOpE (NCT07394582)
- Testing
- Prehabilitation
- Where
- Austria
- Volunteers
- 180 people
- Sponsor
- Medical University Innsbruck
Osteoarthritis, Total Knee Arthroplasty
Tourniquet and Quadricepsforce
The purpose for this study is to investigate the quadriceps (thigh) function preoperatively and 48 hours postoperatively during knee arthroplasty (total replacement of the knee joint) in a randomised study with or without the use…
- Trial name
- NCT01808859
- Testing
- Tourniquet
- Where
- Sweden
- Volunteers
- 64 people
- Sponsor
- Region Skane
Total Knee Arthroplasty (TKA), Total Knee Arthroplasty \(TKA\)
Suzetrigine in TKA
Total knee replacements are among the most common and painful orthopedic procedures performed worldwide, often requiring intensive analgesia to support early ambulation and recovery.
- Conditions
- Total Knee Arthroplasty (TKA), Total Knee Arthroplasty \(TKA\), Total Knee Replacement, Total Knee Replacement Surgery
- Trial name
- NCT07864896
- Testing
- Suzetrigine
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Postoperative Pain, Anxiety
The Effect of Coaching Strategy on Some Patient Outcomes After Total Knee Arthroplasty Surgery
Total knee arthroplasty (TKA); It is frequently applied to adults, especially those over the age of 55. Total knee arthroplasty surgery is among the surgeries with a high satisfaction rate for the patient, although complications…
- Conditions
- Postoperative Pain, Anxiety, Self Efficacy, Patient Satisfaction
- Trial name
- NCT04683588
- Testing
- Nursing Coaching
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Primary Osteoarthritis Patients Scheduled for Total Knee Replacement Surgery
First-in-human Single Ascending Dose Study of LNA043 in Patients Scheduled for Total Knee Replacement
This study is designed to evaluate the safety and tolerability of ascending single doses of LNA043 given intra-articularly into the human knee joint prior to its removal at total knee replacement surgery.
- Trial name
- NCT02491281
- Testing
- LNA043
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Novartis Pharmaceuticals
Osteo Arthritis Knee
Surgical Excision of the Fat Pad
Introduction: The infrapatellar fat pad (Hoffa's fat pad) is a structure which is located intra-articularly. Its function is not well known.
- Trial name
- NCT04503512
- Testing
- removal of fat pad, non removal of fat pad
- Where
- United Kingdom
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Osteoarthritis
Study to Assess Exactech's Guided Personalized Surgery eGPS® in Total Knee Arthroplasty
Study to collect outcomes data for patients who are undergoing an Exactech Optetrak® primary total knee replacement using the Exactech Guided Personalized Surgery (eGPS®) manufactured or distributed by (Exactech, Gainesville…
- Trial name
- NCT02962362
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Exactech
Arthritis, Arthritis (Knee)
Kinematic Alignment in Total Knee Arthroplasty - a Double-blind Randomised Controlled Trial Between Robotic and Caliper-based Techniques
Knee replacement surgery is a surgery designed to treat severe arthritis of the knee. However, as many as 20% of patients are not satisfied with the results of their surgery.
- Conditions
- Arthritis, Arthritis (Knee), Osteoarthritis, Osteoarthritis Knee Pain
- Trial name
- NCT06709703
- Testing
- Kinematic aligned total knee replacement
- Volunteers
- 200 people
- Sponsor
- Université de Sherbrooke
Osteoarthritis, Knee
Assessment With Gait Analysis of Robotic Total Knee Arthroplasty Using Inverse Kinematic Alignment
Postoperative function and patient satisfaction are becoming increasingly relevant in patients after knee arthroplasty surgery. Despite adequate preoperative planning, improved surgical techniques and rehabilitation protocols…
- Trial name
- RATKA-CBO (NCT04912973)
- Testing
- Robotically Assisted Total Knee Arthroplasty - Knee Replacement
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Philip Winnock de Grave, MD
Total Knee Anthroplasty, Knee Osteoarthritis
IPACK vs Adductor Magnus Plane Block Added to Adductor Canal Block for Total Knee Arthroplasty
Total knee arthroplasty (TKA) is among the most frequently performed surgical procedures for degenerative joint diseases, including advanced knee osteoarthritis, rheumatoid arthritis, and post-traumatic arthritis.
- Conditions
- Total Knee Anthroplasty, Knee Osteoarthritis, Postoperative Pain Management
- Trial name
- NCT07643883
- Testing
- ACB+IPACK, ACB+AMM
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Pain, Total Knee Replacement
Analysis of Postoperative Analgesic of Different Nerve Blocks for Total Knee Replacement Surgery
This study is a retrospective analysis using the accumulated clinical database from 2017/09-2023/12 to analyze patients who underwent total knee arthroplasty and received nerve blocks.
- Conditions
- Pain, Total Knee Replacement, Motor Function
- Trial name
- NCT06521619
- Testing
- Femoral and sciatic nerve blocks
- Where
- Taiwan
- Volunteers
- 126 people
- Sponsor
- Fu Jen Catholic University Hospital
Staphylococcal Infections
StaphVAX Immunogenicity and Safety in Orthopaedic Joint Surgery
Staphylococcus aureus (S. aureus) is the most common pathogen encountered in infections associated with orthopedic surgery. StaphVAX® is a bivalent S.
- Trial name
- NCT00211965
- Testing
- S. aureus Types 5 and 8 Capsular Polysaccharide Conjugate
- Where
- United Kingdom
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Nabi Biopharmaceuticals
Osteoarthritis, Knee
Kinematics After Total Knee Arthroplasty
The purpose of this study is to evaluate and compare implant kinematics of conventional mechanically aligned and anatomically aligned total knee arthroplasties (TKA) at 1 year post-operatively.
- Trial name
- NCT03093077
- Testing
- DePuy ATTUNE total knee arthroplasty system
- Where
- United States
- Sponsor
- Kristin Zhao, PhD