Clinical trials: Total Knee Replacements
Osteoarthritis, Knee
Clinical Outcomes With Omni Apex Ultracongruent Knee System
A prospective, matched case comparison of total knee arthroplasty with the OMNI Apex Ultracongruent vs. Triathlon® CS tibial insert vs. the Triathlon® PS tibial insert.
- Trial name
- NCT01367938
- Testing
- OMNI Apex Ultracongruent Knee Device
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Spokane Joint Replacement Center
Osteoarthritis
Patient Controlled Epidural Analgesia Versus Local Infiltration Analgesia Following Knee Arthroplasty
The purpose of this study was to determine if the method of peri-operative analgesia used following total Knee Replacement surgery affected the progress towards rehabilitation goals and to determine whether the analgesia had any…
- Trial name
- NCT02478372
- Testing
- Patient Controlled Epidural (PCEA), Local Infiltration Analgesia (LIA)
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Golden Jubilee National Hospital
Osteoarthritis
Comparing Fixed-bearing Versus Mobile-bearing Prosthesis in Total Knee Arthroplasty: A Prospective Randomized Trial
The purpose of this study is to determine which prosthesis is better in total knee arthroplasty
- Trial name
- NCT01312532
- Testing
- fixed-bearing (P.F.C.® Sigma), mobile-bearing (P.F.C.® Sigma)
- Where
- Iran
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Arthroplasty, Replacement, Knee, Arthroplasty, Replacement, Hip
Sleep Patterns After Total Joint Replacement Surgery
The purpose of this study is to determine sleep patterns and sleep quality following total joint arthroplasty, in order to understand when patients should expect to return to baseline or improved sleep following total joint…
- Trial name
- NCT04896892
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Arthroplasty, Replacement, Knee, Nerve Block
Epidural Catheter With or Without Adductor Canal Nerve Block for Postoperative Analgesia Following Total Knee Arthroplasty
The purpose of this study is to further investigate the efficacy of adductor canal nerve blocks for pain management after total knee replacement.
- Trial name
- NCT02121392
- Testing
- Adductor Canal Nerve Block Catheter, Bupivacaine
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Osteoarthritis, Knee
Topical Tranexamic Acid and Floseal® in Total Knee Arthroplasty
Our purpose of this study is to conduct a prospective randomized controlled trial to investigate the blood-conservation effect of this two topical hemostatic agents in primary TKA procedures in patients with a risk of…
- Trial name
- NCT02865174
- Testing
- Topical tranexamic acid, Floseal®, Enoxaparin
- Where
- Taiwan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Osteoarthritis
Assessment of Conventional and Patient-specific Instrumentation in Total Knee Arthroplasty
This study will use a special type of x-ray called radiostereometric analysis (RSA) imaging to determine whether patient-specific instrumentation for total knee arthroplasty (replacement) has an effect on implant loosening…
- Trial name
- NCT02230215
- Testing
- Total Knee Arthroplasty with use of Visionaire Patient-Specific Instrumentation
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Osteoarthritis, Knee
Parabens Flocculation on the Anti Inflammatory Effects of Corticosteroid Injections for Total Knee Arthroplasty
The purpose of this study is to identify whether corticosteroid use with anesthetics containing preservatives (parabens) reduces clinical effectiveness of the anti-inflammatory agent Up to 100 patients, both male and female…
- Trial name
- 5160373 (NCT03445611)
- Testing
- corticosteroid solution with lidocaine containing parabens., corticosteroid solution with lidocaine containing no paraben
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Loma Linda University
Osteoarthritis, Knee
Clinical Outcomes of MP Persona vs. Persona Knee-PS
Knee osteoarthritis (OA) is a highly prevalent condition that results in substantial pain and loss of function. The end stage treatment for knee OA is total knee arthroplasty (TKA), a common and safe procedure typically performed…
- Trial name
- MP-Persona (NCT03681977)
- Testing
- Zimmer MP Persona, Zimmer Persona Knee-PS
- Where
- 3 sites in Canada
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Lady Davis Institute
Knee Osteoarthritis
Comparison of Postoperative Pain Score Between Perioperative Intravenous Ketamine and Placebo in Patients Undergoing Unilateral Total Knee Arthroplasty Under General Anesthesia
The goal of this clinical trial is to compare postoperative pain score between perioperative intravenous ketamine and placebo in patients undergoing unilateral total knee arthroplasty under general anesthesia.
- Trial name
- NCT06267638
- Testing
- Ketamine group
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Thailand
Anesthesia, Orthopedic Surgery
Does Midazolam Cause Effective Anterograde Amnesia in Orthopedic Surgeries?
Spinal anesthesia is one of the commonest choices of anesthesia for infraumbilical surgeries.The use of sedation has markedly increased patients' comfort and acceptance towards spinal anesthesia.
- Trial name
- NCT04232150
- Testing
- single-dose midazolam for sedation under spinal anesthesia., Double-dose midazolam for sedation under spinal anesthesia., spinal anesthesia with no sedation.
- Where
- Jordan
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- University of Jordan
Osteoarthritis, Knee
Comparison of Mobile-Bearing and Fixed-Bearing All-Polyethylene Tibia Total Knee Designs
This study will be designed to compare prospectively, in a randomized fashion, the clinical, functional, and radiographic results of a nonmodular (all-polyethylene tibi/AP) fixed-bearing posterior cruciate substituting design…
- Trial name
- NCT00894361
- Testing
- TKA surgery with the rotating platform mobile-bearing knee design, TKA surgery with the all-polyethylene tibia knee design
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Total Knee Anthroplasty, Knee Osteoarthritis
IPACK vs Adductor Magnus Plane Block Added to Adductor Canal Block for Total Knee Arthroplasty
Total knee arthroplasty (TKA) is among the most frequently performed surgical procedures for degenerative joint diseases, including advanced knee osteoarthritis, rheumatoid arthritis, and post-traumatic arthritis.
- Conditions
- Total Knee Anthroplasty, Knee Osteoarthritis, Postoperative Pain Management
- Trial name
- NCT07643883
- Testing
- ACB+IPACK, ACB+AMM
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Postoperative Delirium
Dexmetomedine for Post Operative Delirium in Elderly Patients Undergoing Elective Total Knee Replacement Under Spinal Anesthesia
Postoperative delirium is a geriatric syndrome occurring after anesthesia and surgery which manifests as acute alterations in mental status, involving changes in cognition, attention, and levels of consciousness that tend to…
- Trial name
- NCT05707741
- Testing
- dexmetomedine infusion
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Total Knee Replacement
Prediction of Leg Length Discrepancy After Unilateral Total Knee Replacement in Varus Deformity
To What degree total knee replacement (TKA) affects leg length discrepancy in patients with varus deformity? Varus deformity, the most commonly encountered deformity in patients undergoing TKA is associated with limb alignment…
- Trial name
- NCT03502382
- Testing
- x-ray
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Arthroplasty, Replacement
TKA Melatonin and Sleep Quality
This randomized controlled trial (RCT) will compare the effects of melatonin vs. placebo in patients undergoing primary total knee arthroplasty (TKA). This RCT aims to study the effects melatonin has on sleep quality after TKA.
- Conditions
- Arthroplasty, Replacement, Knee, Sleep Initiation and Maintenance Disorders
- Trial name
- NCT05332717
- Testing
- Melatonin 5 mg
- Where
- United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Pain Monitoring, Pain Assessment
Intraoperative Analgesia Based on ANI
Osteoarthritis of the knee joint is common and total knee arthroplasty (TKA) is performed in patients with advanced joint degeneration, no response to conservative treatments, severe pain and joint instability.
- Conditions
- Pain Monitoring, Pain Assessment, Opioid Consumption
- Trial name
- NCT06236035
- Testing
- Analgesia nociception index
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
Postoperative Pain, Analgesia
Evaluation of Dexketoprofen in Total Knee Arthroplasty
Pain is a global public health issue and represents the most common reason for both physician consultation and hospital admissions. Dexketoprofen is a new NSAID treating acute postoperative pain.
- Trial name
- NCT04161690
- Testing
- Dexketoprofen Trometamol, Ropivacaine Hydrochloride 7.5 MG/ML
- Where
- Greece
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- KAT General Hospital
Knee Osteoarthritis, Blood Loss
Extended Postoperative Oral Tranexamic Acid in Knee Replacement
A comparison of outcomes between use of oral tranexamic acid as compared to oral placebo in the first days after total knee replacement will be made to determine impact on clinical indications and patient reported outcomes.
- Conditions
- Knee Osteoarthritis, Blood Loss, Pain, Postoperative
- Trial name
- NCT05099276
- Testing
- Tranexamic Acid Pill
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Campbell Clinic
Total Knee Arthroplasty
Bupivacaine Liposome Suspension Versus a Concentrated Multi Drug Periarticular Injection
Despite a robust multimodal pain management regimen, patients undergoing total knee arthroplasty (TKA) continue to report low satisfaction with postoperative pain management.
- Trial name
- NCT02299349
- Testing
- bupivacaine liposome suspension, concentrated multi drug Ketorlac, Morphine PF, Epinephrine, Ropivicaine, 0.9% NaCL
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- TriHealth Inc.