Clinical trials: Trabeculectomy
Advanced Glaucoma, Failed Trabeculectomies
Imaging Ahmed Glaucoma Tubes With a Pericardial Graft and Tissue Glue or Partial-Thickness Scleral Flap and Sutures
When implanting an Ahmed glaucoma tube, a scleral flap is usually created to cover the tube, and the conjunctiva is stitched back in place with nylon 10-0 sutures.
- Trial name
- NCT00453024
- Testing
- Pericardial graft & tissue glue, scleral flap & sutures
- Where
- Singapore
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Glaucoma
Effect of SLT Location on Treatment Outcomes
Selective Laser Trabeculoplasty (SLT) is a glaucoma treatment that has been shown to effectively lower intraocular pressure by increasing aqueous outflow through macrophage recruitment.
- Trial name
- SLOS (NCT03164941)
- Testing
- Selective Laser Trabeculoplasty
- Where
- Canada
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Healthcare Hamilton
Intraocular Pressure
Evaluation of Comfort With Xibrom (Bromfenac Ophthalmic Solution)0.09% and Nevanac (Nepafenac Ophthalmic Suspension) 0.1% Following Selective Laser Trabeculoplasty (SLT)
The objective of this study is to evaluate and compare the comfort of bromfenac or nepafenac following SLT.
- Trial name
- NCT00828477
- Testing
- Xibrom, Nevanac
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Bp Consulting, Inc
Glaucoma Following Surgery
DEXTENZA for the Treatment of Pain and Inflammation Following Surgical Trabeculectomy and Ahmed Valve Procedures
This is a prospective, comparative, open-label, single-center, randomized, investigator-sponsored clinical study and seeks to investigate clinical outcomes with standard of care and high dose DEXTENZA treatment compared to…
- Trial name
- DEXTenSiVe (NCT05116345)
- Testing
- DEXTENZA, Topical Dexamethasone
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Brian Jerkins, MD
Open Angle Glaucoma
Different Glaucoma Treatments Effect on Intraocular Pressure Fluctuation With Postural Change in Eyes With Open-angle Glaucoma
The purpose of this study is to investigate the effect of trabeculectomy, glaucoma drainage devices, cyclophotocoagulation and ocular hypotensive eye-drops on IOP elevation with postural change from the sitting to supine…
- Trial name
- NCT02868502
- Testing
- Goldmann tonometer, Pneumatonometer, Tonopen XL
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
OCTA
Conjunctival Vascularity Changes Usnig OCTA After Trabeculectomy
Reduce the trauma and the time taken for patient rehabilitation. The prevailing trend is to perform a mitomycin- C (MMC)-augmented trabeculectomy and trabeculectomy with ologen implants in a trial to decrease bleb failure as a…
- Trial name
- NCT04493073
- Testing
- Trabectulectomy, Mitomycin, Ologen Collagen Implant
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Asmaa Ahmed Ali Youssif
Glaucoma Open-Angle Primary, Glaucoma
Comparing Preoperative Injection of Mitomycin-C vs. Intraoperative Injection of Mitomycin-C vs. Topical Application of Mitomycin-C (Conventional Use) in Trabeculectomy
In this Pilot explorative study, the investigators are going to estimate and compare the outcomes of three different delivery methods of MMC for Trabeculectomy: a subconjunctival injection of MMC 0.002% at the site of future…
- Conditions
- Glaucoma Open-Angle Primary, Glaucoma, Open Angle Glaucoma, Glaucoma, Open-Angle
- Trial name
- NCT03875911
- Testing
- Mitomycin C
- Where
- 4 sites in United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Steroid-Induced Glaucoma
Management Steroid Induced Glaucoma
Purpose: To assess the safety and efficacy of Viscotrabeculotomy Versus trabeculectomy with MMC for the management of medically uncontrolled steroid induced glaucoma.
- Trial name
- NCT04673201
- Testing
- Viscotrabeculotomy Versus trabeculectomy with "MMC"
- Where
- Egypt
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Glaucoma
Effectiveness of a Procedure for Previously Failed Glaucoma Surgery
Transconjunctival mitomycin-C in needle bleb revision may be an effective procedure to treat cases with a previously failed trabeculectomy. We will investigate approximately 100 consecutive cases with follow up of up to 9 years.
- Trial name
- NCT00347789
- Testing
- Glaucoma surgery- Bleb revision
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Glaucoma Research & Education Group
Open Angle Glaucoma
Micropulse Laser Trabeculoplasty (MLT) Versus Selective Laser Trabeculoplasty (SLT) for Treatment of Open Angle Glaucoma
The purpose of this study is to evaluate the effectiveness of a new laser (called Micropulse Laser Trabeculoplasty or MLT) in the treatment of glaucoma compared to the conventional laser presently used which is called selective…
- Trial name
- NCT01956942
- Testing
- Micropulse Laser Trabeculoplasty, Selective Laser Trabeculoplasty
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- David Belyea
Pigmentary Glaucoma, Primary Open Angle Glaucoma
Autoimmune Dysregulation in Pigmentary Glaucoma
Based on these recent observations and findings in this new animal model of pigmentary glaucoma in the DBA/2J mouse, we propose that immune system abnormalities in the anterior chamber may play a possible role in the development…
- Conditions
- Pigmentary Glaucoma, Primary Open Angle Glaucoma, Cataract
- Trial name
- NCT00280345
- Testing
- Trabeculectomy, Trabeculectomy and cataract surgery, Cataract surgery
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Open Angle Glaucoma, Ocular Hypertension
PSLT Compared to Prostaglandin Analogue Eye Drops
This study aims to compare the efficacy of PSLT and the topical use of prostaglandin-like hypotensive eye drops in the treatment of ocular hypertensive or glaucomatous patients in decreasing intraocular pressure and measuring…
- Trial name
- NCT05241938
- Testing
- PSLT, Prostaglandin analogue eye drops
- Where
- Brazil
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Primary Open Angle Glaucoma, Pseudoexfoliation Glaucoma
Anti-inflammatory Therapy Following Selective Laser Trabeculoplasty
The type of anti-inflammatory medication used post selective laser trabeculoplasty (SLT) may have an impact on the intra-ocular pressure (IOP) lowering effect of SLT.
- Trial name
- NCT00485108
- Testing
- prednisolone 1%, ketorolac 0.5%, Artificial Tears (Methyl cellulose drops)
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Queen's University
OAG - Open-Angle Glaucoma
Evaluation of the Compatibility of Different Eye Lid Retractors to the Direct Selective Laser Trabeculoplasty (DSLT) Procedure
Direct Selective Laser Trabeculoplasty (DSLT) is an emerging therapeutic technology to treat glaucoma. DSLT was previously tested in 2 clinical trials and demonstrated promising safety and efficacy results in reducing the…
- Trial name
- NCT05271734
- Testing
- Lid retractor placement
- Where
- Georgia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- BelkinVision
Glaucoma, Open-Angle
Trabeculectomy Versus 2-iStent and Prostaglandin Study
Investigators hypothesize that the synergistic action of iStent in increasing aqueous outflow through the trabecular meshwork and use of prostaglandin analog such as travoprost or latanoprost to increase uveoscleral outflow will…
- Trial name
- TIPS (NCT03274323)
- Testing
- iStent and travoprost or latanoprost, Trabeculectomy
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Primary Open Angle Glaucoma, Ocular Hypertension
The Efficacy of Selective Laser Trabeculoplasty
Selective laser trabeculoplasty (SLT) is a new method to reduce intraocular pressure in eyes with open angle glaucoma or ocular hypertension. SLT may also be effective for cases with previously failed ALT procedures.
- Conditions
- Primary Open Angle Glaucoma, Ocular Hypertension, Pseudo-Exfoliative Glaucoma, Pigment Dispersion Glaucoma
- Trial name
- NCT00347893
- Testing
- Selective laser trabeculoplasty
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Glaucoma Research & Education Group
Glaucoma, Filtering Bleb
Bleb Vascularity and the Outcomes After Trabeculectomy
1. Study objective: To evaluate the relationship between filtering bleb vascularity and the surgical outcomes after trabeculectomy 2.
- Trial name
- NCT04552314
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Medical University of Lublin
Glaucoma, Inflammatory Response
Impact Post-operative Treatment on Intraocular Pressure Post-SLT on Patients With Primary Open-angle Glaucoma
The present study's main objective is to assess if there is a significant difference between either of the treatments frequently used in post-op, namely a topic cortisone-based treatment, an non-steroidal anti-inflammatory drug…
- Trial name
- SLT (NCT01058278)
- Testing
- Selective Laser trabeculoplasty
- Where
- Canada
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Glaucoma
Benchmarking Management of Glaucoma Using the Diopsys VEP/PERG Protocols.
Establish electrophysiological benchmarks, using the Diopsys Visual Evoked Potential/ Pattern ERG (VEP/PERG) protocols of populations with Glaucoma following: 1) Baseline VEP/ERG prior to treatment; and 2) VEP/PERG after…
- Trial name
- NCT02594280
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Diopsys, Inc.