Clinical trials: Tranexamic Acid
Fibroid Uterus, Abnormal Uterine Bleeding
Prophylactic Tranexamic Acid During Minimally Invasive Myomectomies
This is a Double-blinded randomized placebo-controlled trial based at Eastern Virginia Medical School. Subjects who are identified in clinic having menorrhagia or abnormal Uterine bleeding (AUB) due to uterine fibroids and meet…
- Conditions
- Fibroid Uterus, Abnormal Uterine Bleeding, Myoma;Uterus
- Trial name
- NCT04311073
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Eastern Virginia Medical School
Hematoma, Seroma
Tranexamic Acid for Bleeding in Breast Surgery
Bleeding is an important consideration in breast surgeries that involve large resections of soft tissues in the breast. Inappropriate bleeding during or after surgery, can lead to uncomfortable fluid buildup in the breasts known…
- Trial name
- TABBS (NCT02615366)
- Testing
- Tranexamic Acid
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Tranexamic Acid, Orthognathic Surgery
The Effects of Tranexamic Acid on Blood Loss During Orthognathic Surgery
This study seeks to answer the question: Does a single pre-operative dose of tranexamic acid have a statistically significant reduction in blood loss during orthognathic surgery? If it does, this drug may begin to be used…
- Trial name
- TXA-OMFS (NCT03433144)
- Testing
- Tranexamic Acid Injectable Solution
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nick Emanuele
Obstetrical Hemorrhage
Can we Use Intravenous Injection of Tranexamic Acid in Routine Practice With Active Management of the Third Stage of Labor?
Obstetrical hemorrhage accounts for nearly one quarter of all maternal deaths worldwide and was the most common cause of maternal death in the Turkey [1,2].
- Trial name
- NCT01338454
- Testing
- transamin
- Where
- Turkey (Türkiye)
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Erzincan Military Hospital
Facial Filler Injections, Hyaluronic Acid
Effect of TXA on Reducing Bruising After Filler Injection
The goal of this clinical trial is to look at the effect tranexamic acid (TXA) may have on reducing bruising, swelling, and pain after facial filler injection.
- Conditions
- Facial Filler Injections, Hyaluronic Acid, Tranexamic Acid
- Trial name
- NCT06665594
- Testing
- Hyaluronic Acid (HA), Tranexamic Acid (TXA)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Postpartum Hemorrhage
Tranexamic Acid Pharmacokinetics During Postpartum Hemorrhage
Postpartum hemorrhage (PPH) accounts for 20-25 percent of maternal deaths worldwide. Tranexamic Acid (TXA) is an antifibrinolytic agent that has been shown to reduce the estimated blood loss after delivery and is recommended by…
- Trial name
- NCT03863964
- Testing
- blood test
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Knee Osteoarthritis, Blood Loss
Use of Tranexamic Acid in the Total Knee Arthroplasty.
Tranexamic acid is a medication used to treat or prevent excessive blood loss during surgery. Previous studies have shown tranexamic acid (TXA) reduces blood loss and post-operative blood transfusion rate without significant…
- Conditions
- Knee Osteoarthritis, Blood Loss, Blood Transfusion
- Trial name
- NCT05919615
- Testing
- Tranexamic Acid 100 MG/ML, Normal saline
- Where
- Syria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Damascus University
Arthroplasty, Replacement, Hip
Tranexamic Acid Study
The purpose of this study is to determine if tranexamic acid significantly reduces blood loss and blood transfusion in revision total hip replacement. Tranexamic acid is a drug that helps to reduce blood loss during surgery.
- Trial name
- NCT00375440
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Pain, Postoperative, Bruising
Use of Tranexamic Acid in Blepharoplasties
The goal of this investigation is to assess whether or not there is a significant difference in the presence and/or degree of post-operative ecchymosis, pain, and edema between groups of patients undergoing upper lid…
- Trial name
- NCT04724772
- Testing
- Tranexamic acid injection
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwestern University
Cesarean Section Complications
Topical Tranexamic Acid Plus Bilateral Uterine Artery Ligation During Cesarean Delivery
Placenta previa (PP) is an obstetric condition that is closely linked with massive obstetric hemorrhage with a varied incidence about once in every 200 live births.
- Trial name
- NCT03741075
- Testing
- BUA, topical tranexamic acid
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aswan University Hospital
Hypotension During Surgery, Blood Loss, Surgical
Reducing Hypotensive Anesthesia Use With TXA During Orthognathic Surgery
This prospective study will analyze the need for deliberate hypotensive anesthesia (DHA) during orthognathic surgery when tranexamic acid (TXA) is administered.
- Trial name
- NCT05474027
- Testing
- Avoidance of Deliberate Hypotensive Anesthesia, TRANEXAMIC ACID 1 G in 10 mL INTRAVENOUS INJECTION, SOLUTION
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Postpartum Hemorrhage
Prevention of Postpartum Hemorrhage With TXA
Hemorrhage remains the leading cause of maternal death worldwide. Tranexamic acid has been shown to reduce rates of hemorrhage when given prophylactically prior to cesarean delivery.
- Trial name
- TXA (NCT03326596)
- Testing
- Tranexamic Acid 1000 mg/10ml normal saline infusion
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Arthritis of Hip
Goal-directed vs Preemptive Tranexamic Acid Administration in Total Hip Arthroplasty
The present study is a multi-center randomized prospective placebo-controlled non-inferiority trial. The study's primary objective is to compare the amounts of postoperative bleeding using two different TXA administration…
- Trial name
- NCT05956769
- Testing
- Tranexamic Acid, thromboelastography
- Where
- 2 sites in South Korea
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Konkuk University Medical Center
Osteoarthritis, Intraoperative Bleeding
Weighted Versus Uniform Dose of Tranexamic Acid in Patients Undergoing Primary, Knee Arthroplasty
Hypotheses: Primary - A weighted dose of 20 mg/kg of tranexamic acid will be more efficacious than a single uniform dose of 1 gram in primary total knee arthroplasty (TKA) cases.
- Trial name
- NCT01651806
- Testing
- Tranexamic Acid standard dose, Females Tranexamic Acid weighted dose, Females receiving a uniform dose of TA
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Knee Osteoarthritis, Blood Loss
Extended Postoperative Oral Tranexamic Acid in Knee Replacement
A comparison of outcomes between use of oral tranexamic acid as compared to oral placebo in the first days after total knee replacement will be made to determine impact on clinical indications and patient reported outcomes.
- Conditions
- Knee Osteoarthritis, Blood Loss, Pain, Postoperative
- Trial name
- NCT05099276
- Testing
- Tranexamic Acid Pill
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Campbell Clinic
Blood Loss After a Total Hip Replacement
Evaluating the Effectiveness of Intramuscular Versus Intravenous Tranexamic Acid for Minimizing Blood Loss After Total Hip Arthroplasty: A Randomized Controlled Trial
Intramuscular vs. Intravenous Tranexamic Acid for Total Hip Arthroplasty
- Trial name
- NCT07817537
- Testing
- Tranexamic Acid (TXA) intarmuscular, Tranexamic Acid (TXA) intravenous
- Where
- Egypt
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Hemorrhage of Cesarean Section and/or Perineal Wound, Postpartum Hemorrhage
Role of Tranexamic Acid Versus Uterine Cooling at Caesarean Section
This study aims to compare role of a prophylactic predefined intravenous Tranexamic Acid dose versus intraoperative Uterine Cooling in reducing blood loss and incidence of postpartum hemorrhage at secondary CS.
- Conditions
- Hemorrhage of Cesarean Section and/or Perineal Wound, Postpartum Hemorrhage, Uterine Atony
- Trial name
- NCT02780245
- Testing
- Tranexamic Acid, Intraoperative Uterine Cooling
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Talkha Central Hospital
Tranexamic Acid, Blood Loss, Surgical
Intravenous vs. Topical Tranexamic Acid in Revision THA (VITALITY-X)
The objective of this study is to evaluate and compare the effects of intravenous and topical administration of tranexamic acid during revision hip arthroplasty on blood loss, allogenic blood transfusion rates, length of hospital…
- Conditions
- Tranexamic Acid, Blood Loss, Surgical, Arthroplasty, Replacement, Hip
- Trial name
- VITALITY-X (NCT02938962)
- Testing
- Tranexamic Acid
- Where
- Canada
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Blood Loss, Surgical, Blood Loss, Postoperative
Comparative Study Between Oxytocin Versus Tranexamic Acid and Ethamsylate
Comparative Study Between Oxytocin Versus Tranexamic Acid and Ethamsylate, Pre-operative Administration.
- Trial name
- NCT04656067
- Testing
- Oxytocin ,Tranexamic acid and Ethamsylate
- Where
- Egypt
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Egymedicalpedia
Placenta Previa
Blood Loss During Cesarean Delivery in Placenta Previa Patients
To compare the efficacy and safety profile of intravenous tranexamic acid versus intrauterine misoprostol in reducing the blood loss during and after cesarean delivery in pregnant women diagnosed with placenta previa
- Trial name
- NCT05340205
- Testing
- Tranexamic acid, Misoprostol, Oxytocin
- Where
- Egypt
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Cairo University