Clinical trials: Transfusions
The Focus is on the Detection of the Consequences of Autologous Blood Transfusion in Healthy Volunteers
Biological Parameters Changes After Autologous Blood Transfusion of Red Blood Cells (200 ml) in Healthy Volunteers.
The purpose of this study is to evaluate if differences between samples of subjects obtained before autologous blood transfusion or samples of non-transfused subjects and samples of subjects after autologous blood transfusion can…
- Trial name
- AUTOT-SPORT (NCT03889834)
- Testing
- Autologous Blood Transfusion, No transfusion
- Where
- France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Fetal Anemia as Antepartum Condition (Diagnosis), Rh Incompatible Blood Transfusion Nos
Cardiac Functions as a New Method for Evaluation of Fetal Anemia Pre and Post Intrauterine Fetal Blood Transfusion
INTRODUCTION Circulatory changes associated with fetal anemia have an important role in maintaining sufficient tissue oxygenation. With fetal anemia, hyperdynamic circulation and increased cardiac output occurred.
- Trial name
- NCT03169907
- Testing
- Mid trimesteric fetal ultrasonography
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Research Centre, Egypt
Osteoarthritis, Intraoperative Bleeding
Use of a Novel Fibrin Sealant in Total Knee Arthroplasty
Applying a fibrin spray, after knee device implantation, will help in reducing patient blood loss and decrease the drop in both hemoglobin and hematocrit levels.
- Trial name
- NCT01656759
- Testing
- Evicel Fibrin Spray
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Thalassemia, Brain Function (Measured by ERP Level)
A Case Control Study to Evaluate the Cognitive and Brain Function of β-thalassemia Patients.
β-thalassemia syndromes are a group of hereditary disorders characterized by a genetic deficiency in the synthesis of beta-globin chains.
- Trial name
- NCT01935661
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Blood Donation, Blood Transfusion
Donor Lifestyle and Nutritional Status, Blood Component Quality, and Patient Safety (ESENCIA)
The goal of this observational study is to evaluate how blood donors' lifestyle and nutritional status influence the quality of packed red blood cells (pRBCs) during storage and their impact on patient safety in transfused…
- Trial name
- ESENCIA (NCT07558369)
- Where
- Mexico
- Volunteers
- 1,014 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Perinatologia
End Stage Liver DIsease, Liver Transplantation
Effect of Transfusion of Plasma on Endothelial During Liver Transplantation
To study the effects of plasma transfusionon during liver transplantation on endothelial condition and short-term outcome in patients with end-stage liver disease.
- Trial name
- NCT04107883
- Testing
- fresh frozen plasma, blood sample
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beijing Chao Yang Hospital
Trauma, Acute Hemorrhage
Evaluation of a Transfusion Therapy Using Whole Blood in the Management of Coagulopathy in Patients With Acute Traumatic Hemorrhage
The prognosis of traumatized hemorrhages is correlated with the nature of transfusion therapy: a 50% reduction in mortality for an early and massive supply of plasma, and 20% for an early and massive supply of platelets.
- Conditions
- Trauma, Acute Hemorrhage, Coagulopathy
- Trial name
- T-STORHM (NCT04431999)
- Testing
- Whole blood transfusion, Fractionated blood products transfusion
- Where
- 6 sites in France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Healthy
Feasibility Study of Mirasol-Treated Whole Blood Red Cell Recovery and Survival
Feasibility trial to evaluate recovery and survival of red blood cells (RBCs) from Mirasol-treated whole blood
- Trial name
- IMPROVE (NCT00742001)
- Testing
- Mirasol System for Whole Blood.
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Terumo BCTbio
Degenerative Joint Disease, Osteoarthritis
Epsilon Aminocaproic Acid (EACA) for the Reduction of Blood Loss in Total Hip Arthroplasty (THA)
You are being asked to take part in this research study because you are scheduled to have total hip replacement (arthroplasty) surgery.
- Trial name
- NCT01391182
- Testing
- EACA
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Twin Pregnancy, Antepartum Condition or Complication, Twin to Twin Transfusion as Antepartum Condition
Multicenter Prospective Cohort Study of Twin Maternal-Child Dyads in China
Multicenter Prospective Cohort Study of Twin Maternal-Child Dyads in China (ChiTwiMC) is supported by National Key Research and Development Program of China - Reproductive Health and Women's and Children's Health Protection…
- Conditions
- Twin Pregnancy, Antepartum Condition or Complication, Twin to Twin Transfusion as Antepartum Condition, Pre-Term, Pre-Eclampsia
- Trial name
- ChiTwiMC (NCT06414655)
- Where
- 11 sites in China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Twin Twin Transfusion Syndrome
Sequential vs. Standard Laser Treatment of Twin-twin Transfusion Syndrome
The investigators hypothesize that treatment of twin-twin transfusion syndrome (TTTS) using sequential laser photocoagulation of communicating vessels (SQLPCV) over the predominant method, selective laser photocoagulation of…
- Trial name
- NCT02122328
- Testing
- Sequential laser photocoagulation of communicating vessels., Selective laser photocoagulation of communicating vessels
- Where
- United States
- Volunteers
- 642 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Blood Loss, Surgical, Transfusion
Blood Loss Evaluation Using a Novel Device
The study´s aim is to evaluate the clinical applicability of the Feature Extraction Technology (FET) during a simulated blood loss scenario.
- Conditions
- Blood Loss, Surgical, Transfusion, Patient Blood Management
- Trial name
- NCT04245995
- Testing
- Feature Extraction Technology
- Where
- Germany
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Graft Versus Host Disease, Hyperkalemia
Irradiated Blood Versus Non Irradiated Blood Transfusions in Craniosynostosis Repair
Blood transfusions are required for patients undergoing a craniosynostosis repair due to the significant amount of blood loss. Irradiated or non-irradiated transfusions have many risks involved including elevated potassium levels…
- Conditions
- Graft Versus Host Disease, Hyperkalemia, Craniectomy, Synostectomy
- Trial name
- NCT02483702
- Testing
- Irradiated Blood Transfusions, Non-Irradiated Blood Transfusions
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Valley Anesthesiology Consultants
Anemia
Transfusion of Biotinylated Red Blood Cells
The purpose of this research is to study how red blood cells (RBCs) survive in a person's circulation, and how that survival may be different in red blood cells that are donated and stored prior to being transfused.
- Trial name
- b-RBCs (NCT02757898)
- Testing
- Biotin-Labeled Red Blood Cells (RBCs)
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Emory University
Twin Pregnancy, Monochorionic, Pregnancy Followed
Ductus Venosus Doppler at 16 Weeks in Monochorial Pregnancy
Studies shows that the realization of the Ductus venosus Doppler may improve the screening of the twin-twin transfusion syndrome.
- Trial name
- DVSTT (NCT03579069)
- Testing
- Ductus venosus Doppler
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Hypovolemic Shock, Hemorrhagic Shock
Sternal Intraosseous Transfusion of Autologous Whole Blood: A Comparison of Flow Rates and Degree of Hemolysis
In this study the impact of two CE marked and FDA approved sternal needles in comparison to intravenous access on the flow-rate of autologous reinfusion of whole blood and the possible hemolysis of red cells post-transfusion in a…
- Trial name
- NCT02924792
- Testing
- Reinfusion - Sternal IO needle, Reinfusion - Intravenous needle
- Where
- Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Infant, Newborn, Infant, Low Birth Weight
The Effects of Erythropoietin (EPO) on the Transfusion Requirements of Very Low Birth Weight Infants
This study tested the safety and efficacy of transfusing erythropoietin (Epo) and iron in infants of <1,250g birth weight. For infants 401-1,000g birth weight, we tested whether early erythropoietin (Epo) and iron therapy would…
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- EPO (NCT01203514)
- Testing
- Erythropoietin
- Where
- 9 sites in United States
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Blood Transfusion
Developing, Implementing and Evaluating Effective Community-facility Interactions to Improve Blood Availability and Transfusion in Three Distinct County Settings in Kenya
The strategy of the CoBAnK study is to establish and enable the function of Community-Facility Transfusion Committees (CFTCs) incorporating diverse representation involving hospital, community, and county leadership, to improve…
- Trial name
- CoBAnK (NCT06142825)
- Testing
- Community-Facility Transfusion Committee (CFTC)
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Hematologic Diseases
Clinical Study of Combined Platelet Transfusion
Platelet transfusion is an irreplaceable and important treatment method for clinical prevention and treatment of thrombocytopenia or platelet dysfunction.
- Trial name
- NCT06613425
- Testing
- Combined platelets
- Where
- China
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- The General Hospital of Western Theater Command
Twin to Twin Transfusion Syndrome
Fetoscopic Selective Laser Photocoagulation in Twin-Twin Transfusion Syndrome
This is a study to compare two treatments (amnioreduction vs. selective fetoscopic laser photocoagulation [SFLP]) in patients with severe twin to twin transfusion syndrome.
- Trial name
- NCT00345852
- Testing
- Fetoscopic Selective Laser Photocoagulation
- Where
- 12 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)