Clinical trials: Transfusions
Anemia, Sickle Cell
Quality of Life of Children With Sickle Cell Disease Who Are Getting Chronic Transfusions With a Lifeport
This study is being done to see what impact having a Lifeport device has on quality of life for children with sickle cell who are getting chronic transfusions, from the child's perspective.
- Trial name
- NCT00246077
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Children's Mercy Hospital Kansas City
Oxidative Stress in Neonates, Near Infrared Spectroscopy
Transfusion-Related Changes in Oxidative Stress Biomarkers in Neonates
Reactive oxygen species (ROS), which include peroxides, are generated in the human body as by-products of cellular metabolism. In small amounts, they fulfill important physiological functions.
- Conditions
- Oxidative Stress in Neonates, Near Infrared Spectroscopy, Fetal Hemoglobin, Erythrocyte Transfusion
- Trial name
- NEO-REDOX (NCT07672275)
- Testing
- Peroxide analysis-TOC Omnignostica Forschungs GmbH, Near Infrared Imaging
- Where
- Austria
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Postoperative Anemia
A New Approach to a Personalized Patient Blood Management Program (pPBM) in Total Hip Arthroplasty (THA)
The study evaluates the patient related risk and predictive factors concerning perioperative homologous blood cell transfusion (erythrocyte concentrate ) in THA patients in one EndoCert max-certified orthopedic hospital in…
- Trial name
- NCT02519088
- Where
- Germany
- Volunteers
- 477 people
- Sponsor
- Krankenhaus der Barmherzigen Brüder Trier
Transfusion Related Complication, Liver Transplant
Utilization of Donor Whole Blood for Blood Transfusion in Deceased Donor Liver Transplantation
We will study 40 matched patients. 20 patients will receive leukoreduced whole blood from the solid organ donor. These 20 patients will be compared to 20 historical matched controls with regards to allogenic blood product usage…
- Trial name
- NCT04383756
- Testing
- Donor Blood, Banked Blood
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Sickle Cell Disease
Ph I/II Study of Allogeneic SCT for Clinically Aggressive Sickle Cell Disease (SCD)
The investigators propose to determine the engraftment and transplant related morbidity and mortality after a non-myeloablative allogeneic hematopoietic stem cell transplant protocol using immune- suppressive agents and low-dose…
- Trial name
- NCT01499888
- Testing
- Allogeneic Non-Myeloablative Stem Cell Transplantation, Alemtuzumab, Sirolimus
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Illinois Chicago
Anemia, Blood Transfusion
Evaluation of Alternative Transfusion Triggers in Hemodynamically Stable, Non-Ventilated Cancer Patients
This is a prospective, single-center observational study conducted at the Kazakh Institute of Oncology and Radiology. The study included 107 clinically stable adult patients with cancer who required red blood cell transfusion…
- Conditions
- Anemia, Blood Transfusion, Cancer, Hemoglobin
- Trial name
- NCT06952361
- Testing
- Red blood cell transfusion
- Where
- Kazakhstan
- Volunteers
- 107 people
- Sponsor
- Ardak Arynov
Myelodysplastic Syndromes
Study to Evaluate Imetelstat (GRN163L) in Participants With International Prognostic Scoring System (IPSS) Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS)
The purpose of this study is to evaluate the efficacy and safety of imetelstat sodium in transfusion-dependent participants with low or intermediate-1 risk myelodysplastic syndrome (MDS) that is relapsed/refractory to…
- Trial name
- NCT02598661
- Testing
- Imetelstat Sodium
- Where
- 126 sites in United States, Belgium and 15 more
- Volunteers
- 289 people
- Sponsor
- Geron Corporation
Transfusion Dependent Beta-thalassemia
Effects of Hydroxyurea and Metformin in Transfusion Dependent Beta-Thalassemia
This clinical trial aims to evaluate and compare the effects and safety of hydroxyurea and metformin in transfusion-dependent beta-thalassemia major and correlate responders/non-responders with the single nucleotide polymorphism…
- Trial name
- NCT06606886
- Testing
- Tablet Metformin (Group A), Tablet Hydroxyurea (Group B)
- Where
- Pakistan
- Volunteers
- 96 people
- Sponsor
- Bahria University
Β-thalassemia
Evaluating Safety and Efficacy of Lentiviral-transduced CD34+ HSCs in Β-thalassaemia Patients.
This is a single-arm, open label, multi-center, single-dose Phase 1 clinical trial in subjects with transfusion dependent β-thalassaemia.
- Trial name
- NCT06655662
- Testing
- β-globin restored autologous hematopoietic stem cells
- Where
- 3 sites in China
- Volunteers
- 8 people
- Sponsor
- Shenzhen Hemogen
Perioperative Anemia
Effect of Perioperative Roxadustat in Elective Lumbar Interbody Fusion Surgery.
The goal of this clinical trial is to assess whether Roxadustat can reduce perioperative blood transfusions in patients with anemia undergoing elective lumbar interbody fusion surgery.
- Trial name
- PRELIFS (NCT06772272)
- Testing
- Roxadustat
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hepatitis, Viral, Human, Blood Transfusion
Risk of Post Transfusion Hepatitis C Virus Infection
To determine the risk of transfusion-transmitted hepatitis C virus (HCV) in cardiac surgery patients before and after donor screening for anti-HCV and surrogate markers of non-A, non-B hepatitis (NANBH).
- Conditions
- Hepatitis, Viral, Human, Blood Transfusion, Blood Donors
- Trial name
- NCT00005339
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Blood Transfusion; Hemoglobinemia, Hypoxia
The Role of Central Venous Oxygen Saturation (ScvO2) as an Indicator of Blood Transfusion in the Critically Ill
Transfusion of red blood cells is an everyday practice in critical care with the primary aim of restoring adequate tissue oxygenation.
- Conditions
- Blood Transfusion; Hemoglobinemia, Hypoxia, Anemia
- Trial name
- NCT03138200
- Testing
- Blood transfusion
- Where
- 2 sites in Hungary
- Volunteers
- 160 people
- Sponsor
- Szeged University
Anemia, Multiple Myeloma
The Effect of Epoetin Alfa on the Anemia of Patients With Multiple Myeloma
The purpose of this study is to evaluate the safety and effectiveness of epoetin alfa versus placebo in reducing the transfusion requirements in anemic patients with multiple myeloma, and to investigate the quality-of-life…
- Trial name
- NCT00270101
- Testing
- epoetin alfa
- Volunteers
- 156 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Acute Coronary Syndrome, Anemia
Red Blood Cell Transfusion in Patients With Coronary Artery Disease (CAD)
Patients with a low blood count (anemia) with stable or unstable coronary artery disease consistently show worse clinical outcomes.
- Trial name
- NCT01504945
- Testing
- RBC transfusion, Normal saline infusion
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Beth Israel Deaconess Medical Center
Bleeding, Transfusion Related Complication
Use of Transexamic Acid in Hip Replacement
Studies have shown that tranexamic acid reduces blood loss and transfusion need in patients undergoing total hip arthroplasty. However, no to date, no study has been large enough to determine definitively whether the drug is safe…
- Trial name
- NCT02587845
- Testing
- Tranexamic Acid (IV), Tranexamic Acid (Topical)
- Where
- South Korea
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Cardiac Arrest
Packed Red Blood Cell Transfusion During Cardiac Arrest
The purpose of this pilot interventional study is to collect preliminary data on administering packed red blood cell (PRBC) during cardiac arrest (CA).
- Trial name
- NCT06462027
- Testing
- Packed Red Blood Cells (1 unit), Packed Red Blood Cells (2 units), Saline
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Extracorporeal Membrane Oxygenation Complication, Transfusion Related Complication
PRospective Multicenter Observational Study on Transfusion Practice in Vv-ECMO Patients: The PROTECMO Study
Background: Over the past decade, the use of extracorporeal membrane oxygenation (ECMO) for respiratory support in adults has increased.
- Conditions
- Extracorporeal Membrane Oxygenation Complication, Transfusion Related Complication, Hemorrhage, Anticoagulant-induced Bleeding
- Trial name
- PROTECMO (NCT03815773)
- Where
- Italy
- Volunteers
- 656 people
- Sponsor
- The Mediterranean Institute for Transplantation and Advanced Specialized Therapies
Hematologic Neoplasms, Bleeding
Bleeding In Thrombocytopenia Explained
Multicenter case cohort study investigating clinical risk factors for clinically relevant bleeding in hemato-oncology patients, as well as bleeding related biomarkers during intensive treatment.
- Conditions
- Hematologic Neoplasms, Bleeding, Hemorrhage, Platelet Transfusion
- Trial name
- BITE (NCT03505086)
- Testing
- Blood withdrawal, Questionnaire for former bleeding events
- Where
- Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Sanquin-LUMC J.J van Rood Center for Clinical Transfusion Research
Cerebral Palsy
Safety and Effectiveness of Cord Blood Stem Cell Infusion for the Treatment of Cerebral Palsy in Children
The purpose of this study is to test the safety and effectiveness of a cord blood infusion in children who have motor disability due to cerebral palsy (CP).
- Trial name
- NCT01072370
- Testing
- Cord Blood Infusion
- Where
- United States
- Sponsor
- Augusta University
Transfusion-dependent Beta-Thalassemia
Gene-Modified Stem Cell Therapy for Subjects With Transfusion-dependent Beta-thalassemia
This is a prospective, dual-centre, single dose, Phase IIb, single arm, open label study. The proposed clinical trial involves a single infusion of autologous HSPCs genetically modified with the GLOBE lentiviral vector, using an…
- Trial name
- NCT07680803
- Testing
- FT007
- Where
- 2 sites in Italy
- Volunteers
- 9 people
- Sponsor
- Fondazione Telethon
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