Clinical trials: Transplantation, Liver
Hepatocellular Carcinoma, Liver Transplantation
Liver Transplantation With ADV-TK Gene Therapy Improves Survival in Patients With Advanced Hepatocellular Carcinoma
Previous rather poor results in liver transplantation (LT) of patients with advanced hepatocellular carcinoma (HCC) have made the application of LT very limited in treatment of HCC.
- Trial name
- NCT00300521
- Testing
- ADV-TK (adenovirus-thymidine kinase enzyme) gene therapy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Beijing Chao Yang Hospital
Liver Transplant, Organ Perfusion
NRP vs DHOPE vs COR-NMP in ECD-DCD Donation
There is still a discrepancy between the number of liver transplant candidates and the availability of liver grafts, resulting in waiting list mortality.
- Conditions
- Liver Transplant, Organ Perfusion, Complication of Surgical Procedure
- Trial name
- NCT05327478
- Testing
- NRP, DHOPE, COR-NMP
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Erasmus Medical Center
Hepatopulmonary Syndrome
Pilot Study of Pentoxifylline for Hepatopulmonary Syndrome
The Hepatopulmonary syndrome (HPS) results from intrapulmonary microvascular dilatation that impairs arterial oxygenation in the setting of cirrhosis or portal hypertension.
- Trial name
- NCT00593658
- Testing
- pentoxifylline
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Alabama at Birmingham
HIV Infection, Liver Failure
Raltegravir in Patients With End Stage Liver Disease and in Transplant Recipients
This phase I/II, multi-center study is designed to determine the pharmacokinetic profile of Raltegravir in patients with end stage liver disease and to assess drug-drug interaction when Raltegravir is combined with…
- Conditions
- HIV Infection, Liver Failure, Evidence of Liver Transplantation
- Trial name
- LIVERAL (NCT01022476)
- Testing
- Raltegravir potassium
- Where
- France
- Volunteers
- 14 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Tissue and Organ Harvesting, Liver Transplantation
Evaluation of Liver Grafts With FibroScan® Before Organ Retrieval in Patients With Brain Death
According to the French Biomedicine Agency annual report on retrieval activities and transplants, 1,164 liver transplants were performed in 2011 and 1,161 in 2012.
- Conditions
- Tissue and Organ Harvesting, Liver Transplantation, Brain Death
- Trial name
- FIBROSCAME (NCT02460250)
- Testing
- Fibroscan
- Where
- 19 sites in France
- Volunteers
- 740 people
- Sponsor
- University Hospital, Limoges
Patients Waiting for a Liver Transplant.
Assessment of the Prevalence of Lysosomal Acid Lipase Deficiency in Patients Waiting for a Liver Transplant.
Lysosomal Acid Lipase (LAL) deficiency is a rare, autosomal recessive storage disease linked to decrease enzymatic activity of LAL, responsible for intracellular accumulation of cholesterol esters and triglycerides.
- Trial name
- LALTH-1 (NCT02852304)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
End-stage Liver Disease (ESLD), Acute Liver Failure
Establishing a Reference Framework for Outcomes After Machine-Preserved Liver Transplantation in Europe
Machine perfusion (MP) has become routine clinical practice in liver transplantation. However, as the field has matured, direct randomized comparisons between distinct MP modalities have become increasingly impractical, given…
- Conditions
- End-stage Liver Disease (ESLD), Acute Liver Failure, Liver Cirrhosis, Liver Transplantation
- Trial name
- REFRAME-MP (NCT07585890)
- Testing
- Endischemic hypothermic oxygenated machine perfusion (any device), Endischemic (back-to-base) normothermic machine perfusion (any device), Continuous (device-to-donor) normothermic machine perfusion (any device)
- Where
- 38 sites in Austria, Belgium and 8 more
- Volunteers
- 10,000 people
- Sponsor
- University Medical Center Groningen
Alpha-1-antitrypsin Deficiency, Emphysema
Development of a Prediction Score for the Occurrence of Death or Lung Transplantation in Patients With Emphysema Secondary to Alpha-1-anti-tripsin Deficiency
Emphysema linked to alpha-1-antitrypsin deficiency (DAAT): towards a better prediction of risks Emphysema caused by alpha-1-antitrypsin deficiency (DAAT) is a rare genetic disorder that can lead to serious complications, such as…
- Conditions
- Alpha-1-antitrypsin Deficiency, Emphysema, Artificial Intelligence (AI), Predictive Learning Models
- Trial name
- FLARE (NCT07715617)
- Where
- 4 sites in France
- Volunteers
- 230 people
- Sponsor
- University Hospital, Bordeaux
Liver Cirrhosis, Liver Disease Chronic
Assessing EUS and Percutaneous Untargeted Liver Biopsy Quality
This prospective, single-center study evaluates and compares the tissue sample quality and patient comfort of different liver biopsy methods.
- Conditions
- Liver Cirrhosis, Liver Disease Chronic, Liver Transplant
- Trial name
- EUS-PERC (NCT07701031)
- Testing
- EUS Liver biopsy 19G FNA, EUS LB 19G FNB, EUS LB 22G FNB
- Where
- Germany
- Volunteers
- 146 people
- Sponsor
- University Hospital Muenster
Iron Overload, Hemosiderosis
Impact of Iron Overload on the Incidence of Liver Complications in Long-Term Survivors (≥10 Years) of Allogeneic Hematopoietic Stem-Cell Transplantation.
This single-center, non interventional cohort study investigates whether chronic iron overload influences the incidence of liver complications in adults who are at least 10 years beyond allogeneic hematopoietic stem cell…
- Conditions
- Iron Overload, Hemosiderosis, Liver Diseases, Hematopoietic Stem Cell Transplantation (HSCT)
- Trial name
- AlloFer (NCT07028112)
- Testing
- Cohort
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Liver Disease and Cirrhosis, Liver Transplant; Complications
Magnetic Resonance Cholangiopancreatography in Living Liver Donors and Its Relationship With Post Operative Recipient Biliary Complications
Living donor liver transplantation is widely accepted as an life-saving treatment for patients with end-stage liver diseases. Careful donor selection is essential to maximize the success and minimize the risk of postoperative…
- Conditions
- Chronic Liver Disease and Cirrhosis, Liver Transplant; Complications, Donor Hepatectomy
- Trial name
- NCT07715500
- Testing
- Magnetic Resonance Cholangiopancreatography
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Hepatitis C
A Study of the Use of Hepatitis C Positive Donors for Hepatitis C Negative Lung Transplant Recipients With Post-transplant Treatment With Mavyret
Patients who are Hepatitis C Negative (HCV negative) and are on the waiting list for a lung transplant at NYULH who consent to participate in this study will receive a lung transplant from a deceased donor that is HCV positive.
- Trial name
- NCT03523871
- Testing
- Mavyret
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Liver Transplantation
Nebulized Salbutamol Facilitate Management of Hyperkalemia Postreperfusion During Liver Transplantation
The therapeutic effect of nebulized salbutamol on hyperkalemia during reperfusion in liver transplantation patients. Secondary research objectives: To observe the results of blood gas analysis, changes in urinary potassium and…
- Trial name
- NCT05589441
- Testing
- salbutamol, Insulin
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Chronic Hepatitis C, Evidence of Liver Transplantation
Switch From Tacrolimus to Cyclosporin in the Treatment of Recurrent Hepatitis C After Liver Transplantation
In France, 50% of hepatitis C virus carriers develop chronic clinical hepatitis, which may lead to cirrhosis and liver transplantation.
- Trial name
- NCT00375895
- Testing
- ciclosporin
- Where
- 13 sites in France
- Volunteers
- 11 people
- Sponsor
- Rennes University Hospital
Liver Transplantation, Surgical Site Infection
Surgical Site Infections After Liver Transplantation Based on Perioperative Antibiotics
This study will be to prospectively determine differences in Surgical Site Infection (SSI) if a prolonged course of post-operative antibiotics are used following liver transplantation.
- Trial name
- NCT02717273
- Testing
- standard, extended, liver transplant
- Volunteers
- 102 people
- Sponsor
- University of Virginia
Liver Transplant; Complications, Perioperative/Postoperative Complications
Impact of Age and BMI on Liver Transplant Outcomes
Prospectively enrolled retrospective chart review and Liver Transplant database review to determine the modifiable and nonmodifiable risk factors specifically relating to Living Donor Liver Transplants.
- Trial name
- NCT04853641
- Testing
- Cadaveric, Living Donor
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- University of Pittsburgh
Infection
Prediction Value of PANX1 in Infection Post Liver Transplantation
The purpose of this study is to determine prediction value of PANX1 expression in infection post liver transplantation.
- Trial name
- NCT02693639
- Volunteers
- 200 people
- Sponsor
- Lin Zhong
Chronic Liver Disease and Cirrhosis
Influence of Donor and Recipient Genetic Polymorphisms on Graft Steatosis After Liver Transplant
MASH (Metabolic Dysfunction-associated Steatohepatitis) is among the most common indications for liver transplantation.The metabolic syndrome persists after liver transplant and is often further exacerbated among MAFLD patients…
- Trial name
- NCT07685353
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Transplantation
Efficacy of Everolimus in Combination With Tacrolimus in Liver Transplant Recipients
This trial evaluated the efficacy and safety of Everolimus in combination with tacrolimus versus a standard immunosuppressive regimen concerning kidney function in liver transplant recipients.
- Trial name
- HEPHAISTOS (NCT01551212)
- Testing
- Everolimus, Tacrolimus, Corticosteroids
- Where
- 15 sites in Germany
- Volunteers
- 339 people
- Sponsor
- Novartis Pharmaceuticals
Sinusoidal Obstruction Syndrome, Complications of Bone Marrow Transplant
Using Ultrasound Elastography to Predict Development of SOS
Sinusoidal obstruction syndrome (SOS) is a potentially fatal hepatic veno-occlusive disease-affecting children following bone marrow transplantation (BMT).
- Trial name
- NCT02483481
- Testing
- shear wave ultrasound elastography
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Children's Mercy Hospital Kansas City
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