Clinical trials: Transplantation, Liver
Liver Transplantation
Data Collection Study From Donors and Recipients to Optimize Donor-recipient Matching in Liver Transplantation
A major limitation of liver transplantation is organ shortage. To avoid exposing patients to death on the waiting list, organs are used that would have been discarded few years ago.
- Trial name
- OPTIMATCH-LT (NCT03371264)
- Volunteers
- 9,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Transplantation
Study to Assess the Effect of Intravenous Supplementation of Omega-3 Fatty Acids on Outcome of Recipients in Living Donor Liver Transplantation
In this study, the investigators aim to analyse the effect of Omega 3 fatty acid supplementation on recipients undergoing living donor liver transplantation.
- Trial name
- NCT04030065
- Testing
- Omega 3 fatty acid
- Where
- India
- Volunteers
- 124 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Transplantation
Interest of an Early Rehabilitation Program in Liver Transplant Surgery
Monocentric, prospective study to evaluate 10 liver transplanted patients
- Trial name
- RAC-TH (NCT03976765)
- Testing
- Rehabilitation program
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Rennes University Hospital
Liver Transplant Failure
Liver Graft Viability Assessment During Normothermic Regional Perfusion
With the increasing shortage of available donor organs, liver transplantation from donation after circulatory death (DCD) has been established in many countries to offer a therapeutic strategy for patients with end-stage liver…
- Trial name
- MAASTR3BOLOMIC (NCT05361044)
- Testing
- Blood samples Donnor
- Where
- 4 sites in France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon
Liver Cirrhosis
Allogenic Bone Marrow Stem Cells Transplantation in Patients With Liver Cirrhosis
The objective of this study is to evaluate the therapeutic efficacy of allogenic bone marrow stem cells (BMSCs) transplantation in patients with liver cirrhosis.
- Trial name
- NCT01223664
- Testing
- Allogenic bone marrow stem cells transplantation, Conserved therapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Sun Yat-sen University
Non-alcoholic Fatty Liver Disease, Evidence of Liver Transplantation
Quantifying Steatosis in Liver Transplant Donors
Non-alcoholic fatty liver disease is the most common chronic liver disease in Hong Kong. Its presence among donors of living donor liver transplants could affect the outcomes of recipients of liver transplantation.
- Trial name
- NCT02579408
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- The University of Hong Kong
End Stage Liver Diseases
Analysis of Respiratory System Mechanics and Inflammatory Response During Orthotopic Liver Transplantation (SPPLIT Trial)
During orthotopic liver transplantation (OLT), respiratory system function may be severely impaired for several reasons including anaesthesia effects, hyperdynamic volume state with fluid overload and ischemia reperfusion injury.
- Trial name
- SPPLIT (NCT02119585)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Turin, Italy
Transfusion Related Complication, Liver Transplant
Utilization of Donor Whole Blood for Blood Transfusion in Deceased Donor Liver Transplantation
We will study 40 matched patients. 20 patients will receive leukoreduced whole blood from the solid organ donor. These 20 patients will be compared to 20 historical matched controls with regards to allogenic blood product usage…
- Trial name
- NCT04383756
- Testing
- Donor Blood, Banked Blood
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Liver Transplant Rejection, Immunosuppression
Immune Tolerance and Alloreactivity in Liver Transplant Recipients on Different Monotherapy Immunosuppressive Agents
This study is being done with the purpose of trying to understand if and why transplant recipients may develop tolerance to their transplanted organ.
- Trial name
- NCT01678937
- Testing
- Blood Draw - Rapamycin, Blood Draw from Control Subjects, Blood Draw - CyA
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Transplantation
Hepatitis E Virus Infection in Pediatric Transplantation, a Prevalence Study
Hepatitis E virus (HEV) is an emerging disease. The genotype 1 and 2 are predominant in Asia and Africa, and are responsible for recurrent epidemics.
- Trial name
- HEV (NCT02809885)
- Testing
- Hepatitis E serology
- Where
- France
- Volunteers
- 226 people
- Sponsor
- Hospices Civils de Lyon
Liver Transplantation
Study to Evaluate Pharmacokinetic and Bioavailability of Envarsus® vs. Advagraf® in Liver Transplant Recipients
Single centre, open-label, randomized, controlled, cross over study to evaluate the pharmacokinetic and bioavailability of Envarsus® in comparison to Advagraf® in de novo liver transplant recipients
- Trial name
- NCT03241043
- Testing
- Treatment 2 weeks Envarsus followed by 2 weeks Advagraf, Treatment 2 weeks Advagraf followed by 2 weeks Envarsus
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Liver Transplant, Post Transplant Diabetes
Liver Transplant CGM
This investigator initiated study aims to describe continuous glucose monitoring (CGM) based glycemic metrics after discharge from liver transplant and assess relationship with glycemic metrics and liver transplant outcomes.
- Conditions
- Liver Transplant, Post Transplant Diabetes, Type 2 Diabetes
- Trial name
- NCT07216508
- Testing
- Libre 3+
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Liver Transplantation
INTERNATIONAL SURVEY ON COMPLEXITY IN LIVER TRANSPLANTATION
The aim of this study is to perform an online survey to assess the perception of international liver transplant surgeons regarding the complexity and surgical difficulty in liver transplantation and to develop a complexity score…
- Trial name
- NCT04348721
- Testing
- online survey
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Pitié-Salpêtrière Hospital
Cirrhosis, Hepatitis C
Adult-to-Adult Living Donor Liver Transplantation Study
There are two principal purposes of this study: 1) to determine whether it is more beneficial for a liver transplant recipient candidate to pursue a living donor liver transplant (LDLT) or wait for a deceased donor liver…
- Conditions
- Cirrhosis, Hepatitis C, Hepatocellular Carcinoma
- Trial name
- A2ALL-1 (NCT00096733)
- Where
- 9 sites in United States
- Volunteers
- 2,470 people
- Sponsor
- Arbor Research Collaborative for Health
Biliary Atresia Intrahepatic Syndromic Form
Effects of Intraoperative Normal Saline vs Lactated Ringer on Outcomes in Pediatric Liver Transplantation
Lactated Ringer(LR) has been extensively used to maintain and replace intravascular volume in a variety of anesthetic procedures.
- Trial name
- NCT03563378
- Testing
- Lactated Ringer, Normal saline
- Where
- China
- Volunteers
- 200 people
- Sponsor
- RenJi Hospital
Orthotopic Liver Transplant
Everolimus Post Orthotopic Liver Transplant
The purpose of this study is to evaluate the efficacy of an everolimus conversion (EVR) protocol as compared to the standard tacrolimus (TAC) based protocol in liver transplant recipients, as determined by renal function…
- Trial name
- NCT01998789
- Testing
- Everolimus, Standard Tacrolimus
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Tomoaki Kato
Liver Transplant Failure
Plasmatic Factor V as a Predictor of Graft Dysfunction After Liver Transplantation
Factor V is a coagulation cofactor that is primarily produced by the liver. Previous data has suggested a correlation between factor V levels and graft dysfunction.
- Trial name
- NCT03396016
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- University Health Network, Toronto
Recurrent Hepatocellular Carcinoma, Stage III Hepatocellular Carcinoma AJCC v8
Lenvatinib for the Treatment of Recurrent Hepatocellular Carcinoma After Liver Transplant
This phase II trial evaluates lenvatinib for the treatment of hepatocellular carcinoma (HCC) that has come back (recurrent) after a liver transplant.
- Conditions
- Recurrent Hepatocellular Carcinoma, Stage III Hepatocellular Carcinoma AJCC v8, Stage IIIA Hepatocellular Carcinoma AJCC v8, Stage IIIB Hepatocellular Carcinoma AJCC v8
- Trial name
- NCT05103904
- Testing
- Laboratory Biomarker Analysis, Lenvatinib
- Where
- 3 sites in United States
- Volunteers
- 3 people
- Sponsor
- Emory University
Liver Disease
Study Comparing in Livertransplantation Recipients With Tacrolimus Alone Versus Tacrolimus&Sirolimus
In this study we compare long term renal function in liver transplantation recipients treated with standard dose extended-release tacrolimus alone and recipients treated with a combination of low dose extended-release tacrolimus…
- Trial name
- NCT01958190
- Testing
- Tacrolimus and Sirolimus, Tacrolimus
- Where
- 3 sites in Netherlands
- Volunteers
- 196 people
- Sponsor
- Foundation for Liver Research
Pediatric Liver Transplanted Recipients
Health Advocate for Children After Liver Transplant
The HEAL-Tx is a 90-day intervention, in which a Health Advocate works with eligible families to identify and apply for community-based resources, alert healthcare providers to challenges the family is encountering, and guide…
- Trial name
- HEAL-Tx:RCT (NCT07279350)
- Testing
- Health advocate, Enhanced Control
- Where
- 2 sites in United States
- Volunteers
- 108 people
- Sponsor
- University of California, San Francisco
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