Clinical trials: Transplantation, Liver
Liver Transplant Rejection, Immunosuppression
Immune Tolerance and Alloreactivity in Liver Transplant Recipients on Different Monotherapy Immunosuppressive Agents
This study is being done with the purpose of trying to understand if and why transplant recipients may develop tolerance to their transplanted organ.
- Trial name
- NCT01678937
- Testing
- Blood Draw - Rapamycin, Blood Draw from Control Subjects, Blood Draw - CyA
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Iron Overload
Risk Factors and Measures to Prevent Liver and Pancreas Complications in Pediatric Patients After HSCT
Hematopoietic Stem Cell Transplantation (HSCT) is currently a standard procedure for a wide range of blood-oncological diseases and genetic disorders.
- Trial name
- NCT04423237
- Testing
- Deferasirox
- Where
- Italy
- Volunteers
- 39 people
- Sponsor
- University of Pisa
Liver Transplant; Complications, Physical Inactivity
Preoperative Prehabilitation in Patients Planned for Liver Transplantation
The objective of this study is to determine the feasibility and effectiveness of a home-based multimodal prehabilitation program in patients anticipated to be waitlisted for LT.
- Trial name
- PRELIVERT (NCT06808945)
- Testing
- Prehabilitation program
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Erasmus Medical Center
Acute Lung Injury
Anesthetic Methods and Liver Transplantation
Postoperative pulmonary complications are not uncommon after liver transplantation. They can not only prolong the stay in intensive care unit and in hospital but also increase the morbidity and mortality rate.
- Trial name
- NCT01936545
- Testing
- propofol during liver transplantation., Desflurane during liver transplantation.
- Where
- Taiwan
- Volunteers
- 144 people
- Sponsor
- National Taiwan University Hospital
Motor Activity
Adapted Physical Activity Effect on Aerobic Function and in Patients in Pre Liver Transplantation
Physical exercise has been identified as a major beneficial factor in the management of patients suffering from many chronic diseases especially cancer and in the context of cardiac or pulmonary transplantation.
- Trial name
- FAPA (NCT02567591)
- Testing
- Physical activity
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Limoges
Transplant Complication
Using Transcriptional Assessment of Immune Response to Assess Immunosuppression After Liver Transplantation
To develop a prospective quantitative liver allograft monitoring protocol and retrospectively validate the use of Phenotypic personalized medicine (PPM) in immunosuppression dosing in liver transplant recipients.
- Trial name
- TGI (NCT06063213)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Florida
Living Donor Liver Transplantation
The Regenerative Capacity of the Donor Liver After Living Donor Liver Transplantation: an Ambidirectional Cohort Study
Rationale: Living donor liver transplantation (LDLT) offers a promising solution to the organ shortage. During living liver donation, a substantial portion of the donor's liver is resected.
- Trial name
- LRLDLT (NCT07329296)
- Testing
- Living liver donation
- Where
- Netherlands
- Volunteers
- 90 people
- Sponsor
- Erasmus Medical Center
Liver Transplant Infection
Application of Nanopore Adaptive Sequencing
Infection post liver transplantation is an important factor in the death in patients. The traditional method of diagnosing infection post liver transplantation is laboratory tests.
- Trial name
- NCT06542042
- Testing
- NAS, NGS and Laboratory tests
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shenzhen Third People's Hospital
Graft Rejection, Heart Transplantation
Diagnostic Validity of [18F]FSPG PET for the Assessment of Acute Rejection After Heart or Liver Transplantation
The a series of clinical studies of [18F]FSPG PET/CT showed that [18F]FSPG is safe and promising PET tracer for detecting inflammation with favorable biodistribution and pharmacokinetics in patients.
- Conditions
- Graft Rejection, Heart Transplantation, Liver Transplantation
- Trial name
- NCT04488094
- Testing
- [18F]FSPG
- Where
- South Korea
- Volunteers
- 7 people
- Sponsor
- Asan Medical Center
Liver Transplant
Albumin, Total and Free Fraction of Mycophenolic Acid, and Measurement of IMPDH Activity in Liver Transplants.
In this study we aim to investigate to what extent the serum albumin concentration in liver transplant patients treated with mycophenolic acid (MPA) affect the free fraction of MPA.
- Trial name
- Albumix (NCT00995956)
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Oslo University Hospital
Decompensated Cirrhosis
Efficacy of High Dose Albumin Therapy in Improving Liver Transplant-free Survival in Patients With Acute Decompensation of Cirrhosis
Research Objectives- We hypothesized high-dose 25% albumin would be superior to standard medical treatment in improving 3-month mortality in patients with acute decompensation of cirrhosis by improving the systemic hemodynamics…
- Trial name
- NCT05956197
- Testing
- No intervention
- Where
- India
- Volunteers
- 55 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Reperfusion Injury, Liver Injury
Study to Evaluate if Inhaled Nitric Oxide Improves Liver Function After Transplantation
This blinded, placebo-controlled study will administer inhaled nitric oxide to patients undergoing liver transplantation. The purpose of the study is to test if inhaled nitric oxide prevents liver injury associated with the…
- Trial name
- NCT00582010
- Testing
- inhaled nitric oxide, nitrogen gas
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of Alabama at Birmingham
Portosystemic Shunt
To Compare the Outcome of Temporary Portocaval Shunt During Recipient Hepatectomy Versus No Shunt in Adult Elective Live Donor Liver Transplantation.
Temporary portocaval Shunt during recipient hepatectomy improves intra operative parameters and morbidity in LDLT recipients
- Trial name
- NCT05385120
- Testing
- Temporary Portocaval Shunt
- Volunteers
- 40 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Cholangiocarcinoma, Intrahepatic
Liver Transplant for Stable, Advanced Intrahepatic Cholangiocarcinoma
Diagnosis of intrahepatic cholangiocarcinoma (iCCA) is an increasingly common form of primary liver cancer, but patients with this diagnosis are not currently eligible for LT.
- Trial name
- NCT04195503
- Testing
- Liver Transplantation
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University Health Network, Toronto
Liver Transplant, Liver Steatosis
Controlled Attenuation Parameter (CAP) in Liver Allografts
The primary aim is to determine the accuracy of CAP in the quantification of liver steatosis using liver biopsies as reference. Secondarily, investigators will correlate transient elastography (TE) and CAP results, analyze…
- Conditions
- Liver Transplant, Liver Steatosis, Liver Disease, Primary Non-function
- Trial name
- NCT02798861
- Testing
- Fibroscan 402/530
- Where
- 3 sites in United States
- Volunteers
- 160 people
- Sponsor
- Andres Duarte-Rojo
Ischemia Reperfusion Injury
Tacrolimus During the Implantation and the Effect on Ischemia-reperfusion Injury in Liver Transplantation
The evaluation of the efficacy of an intraportal infusion with Tacrolimus, at the time of liver graft implantation, compared to a control group without immunosuppressive intraportal infusion (Placebo: Saline solution 0.9%) with…
- Trial name
- TAC-Infusion (NCT00609388)
- Testing
- Tacrolimus, Saline solution 0.9% (250mL)
- Where
- Austria
- Volunteers
- 26 people
- Sponsor
- Medical University of Vienna
Liver Transplant
Early Nutritional Intervention in Patients Undergoing Liver Transplantation
The main goal of this clinical study is to assess the feasibility of a 12-week oral nutritional supplementation post-liver transplantation (LT).
- Trial name
- NutLT (NCT07168369)
- Testing
- protein and energy-rich supplement
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Mediastinal Cancer, Metastatic Cancer
Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
- Conditions
- Mediastinal Cancer, Metastatic Cancer, Testicular Germ Cell Tumor
- Trial name
- NCT00003941
- Testing
- bleomycin sulfate, filgrastim, cisplatin
- Where
- 37 sites in Austria, Belgium and 10 more
- Volunteers
- 222 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Weight Gain
Impact of a LCD on Metabolic Inflexibility and Cardiovascular Risk in Liver Transplant Patients
This study is looking to see how a 6-month low carbohydrate diet can affect the body's ability to use energy in addition to the affects it has on the heart and blood vessel health.
- Trial name
- NCT04145427
- Testing
- Control, LCD
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Virginia Commonwealth University
Liver Transplant, Liver Cancer, Immunosuppressant
Analysis of Clinical Outcomes and Complications in Patients Received Liver Transplantation: A Retrospective Study
Liver transplantation is the last-line method for liver failure. Thomas Starzl completed the first liver transplant in 1967, liver transplantation is developing rapidly.
- Trial name
- NCT05587556
- Where
- Taiwan
- Volunteers
- 1,400 people
- Sponsor
- China Medical University Hospital
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