Clinical trials: Transplantation Lung
Respiratory Distress Syndrome, Adult, Bronchiolitis Obliterans
Etanercept for Non-Infectious Lung Injury Following Bone Marrow Transplantation
The purpose of this study is to determine the effects of etanercept, and define the toxicity, when administered to patients with acute non-infectious lung injury (idiopathic pneumonia syndrome, IPS) and with subacute pulmonary…
- Conditions
- Respiratory Distress Syndrome, Adult, Bronchiolitis Obliterans, Pneumonia
- Trial name
- NCT00029328
- Testing
- etanercept
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- FDA Office of Orphan Products Development
Lung Transplant; Complications
Management of Cytomegalovirus (CMV) Infection in Lung Transplant Recipients (LTR)
Background: Lung transplant recipients (LTR) have the highest risk of CMV infection. CMV pneumonitis, lymphocytic bronchitis, and detection of CMV DNA in bronchoalveolar lavage fluid are independent risk factors for the…
- Trial name
- NCT04377139
- Testing
- Prophylaxis, Preemptive
- Volunteers
- 1,500 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Portopulmonary Hypertension, Pulmonary Arterial Hypertension
A Study to Assess the Safety and Efficacy of Treprostinil to Facilitate Liver Transplantation in Patients With Portopulmonary Hypertension
This was a multicenter, prospective, observational, open-label study. Patients meeting inclusion/exclusion criteria received treatment with treprostinil as recommended by their treating physicians and were followed according to…
- Conditions
- Portopulmonary Hypertension, Pulmonary Arterial Hypertension, Pulmonary Hypertension
- Trial name
- NCT01028651
- Testing
- Treprostinil
- Where
- 4 sites in United States
- Volunteers
- 13 people
- Sponsor
- United Therapeutics
Lung Transplantation
Prediction Model for Postoperative AKI in Patients Undergoing Lung Transplantation Using Machine Learning
Since 1963, lung transplantation progress has surged due to immunosuppressive agent advancements. In 2004, 1,815 global lung transplantations were reported.
- Trial name
- NCT06218745
- Testing
- General anesthesia
- Where
- South Korea
- Volunteers
- 214 people
- Sponsor
- Pusan National University Yangsan Hospital
Hematopoietic Stem Cell Transplantation, Hematologic Malignancy
The Association of Microbiota Composition With cGVHD After Allo-HSCT
Previous studies had found that the microbe in intestinal after allogeneic hematopoietic cell transplantation(allo-HSCT) were closely associated with overall survival and post-transplantation complications, especially graft…
- Conditions
- Hematopoietic Stem Cell Transplantation, Hematologic Malignancy, Chronic Graft-versus-host-disease, Complication
- Trial name
- NCT05355675
- Testing
- blood sample, stool sample
- Where
- 10 sites in China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
GVHD (Acute or Chronic), Acute Myeloid or Lymphoblastic Leukemia (AML or ALL)
Phase I Study of Milatuzumab for Graft Versus Host Disease
This study will assess the safety and tolerability of milatuzumab (IMMU-115) when added to a standard regimen to prevent Graft vs. Host Disease (GVHD) in patients with hematologic malignancies undergoing stem cell transplant.
- Conditions
- GVHD (Acute or Chronic), Acute Myeloid or Lymphoblastic Leukemia (AML or ALL), Myelodysplastic Syndrome, Chronic Myelogenous Leukemia (CML)
- Trial name
- NCT01663766
- Testing
- milatuzumab
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Gilead Sciences
Steroid-refractory Bronchiolitis Obliterans
A Phase II Trial on Treatment of Steroid-refractory Bronchiolitis Obliterans With Interferon Gamma 1b After Allogeneic SCT
Improvement of quality of life in patients with BO and establishment of a new third line therapy
- Trial name
- IFN_BOSZT_01 (NCT01639261)
- Testing
- Interferon gamma 1b
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University Hospital Regensburg
Lung Transplantation, Fungal Infections
Pharmacokinetic Profile of Inhaled Liposomal Amphotericin B in Lung Transplant Recipients - Ambisome Study
The purpose of this study is to determine the steady state concentrations of inhaled liposomal amphotericin B (Ambisome®) in lung transplant recipients via aerosolized nebulization.
- Trial name
- NCT00177710
- Testing
- Amphotericin B
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Pittsburgh
Stem Cell Transplant Complications, Pulmonary Complication
Change in Management Following Bronchoscopy in Hematopoietic Stem Cell Transplant Patients With Pulmonary Infiltrates
Hematopoietic stem cell transplant (HSCT) is a modality that is increasingly utilized to treat various haematological disorders with a varying degree of success.
- Trial name
- NCT04998903
- Testing
- Fiberoptic Bronchoscopy
- Where
- Saudi Arabia
- Volunteers
- 51 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Solid Organ Transplantation, Pregnancy
Long-term Follow-up of the Offspring Born to Mothers With a Solid Organ Transplant, Transplantlines Next Generation
Background Pregnancy after all types of solid organ transplantation (SOT) is possible, although these have higher risk of pregnancy complications for mother and child, such as preeclampsia and preterm birth.
- Conditions
- Solid Organ Transplantation, Pregnancy, Long-term Follow-up, Kidney Transplant
- Trial name
- NCT07291258
- Where
- Netherlands
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Vaccine Response Impaired, Respiratory Syncytial Virus Infections
RSV Vaccine in Transplant Recipients
Adjuvant, non-live RSV vaccine will be administered to adult lung and allogeneic hematopoietic stem cell transplant recipients. The safety and immunogenicity of this intervention will be studied.
- Conditions
- Vaccine Response Impaired, Respiratory Syncytial Virus Infections, Immune Suppression
- Trial name
- RSVax (NCT06593210)
- Testing
- Adjuvant, non-live RSV vaccine
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Varicella Zoster Vaccine
Safety and Immunogenicity of Non-live, Recombinant Subunit Herpes Zoster Vaccine Before and After Lung Transplantation
The investigators plan to study the immunogenicity of the vaccine before and after lung transplantation. Patients (at least 50 years old) before and after lung transplantation will be enrolled.
- Trial name
- NCT03493776
- Testing
- VZV subunit vaccine
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Deepali Kumar
Kidney Transplant, Familial Hypercholesterolaemia
Cardiovascular Risk in Children With Chronic Conditions Study
Children living with chronic health conditions face a higher risk of developing cardiovascular diseases than their peers, largely due to the accelerated aging of the heart and blood vessels.
- Conditions
- Kidney Transplant, Familial Hypercholesterolaemia, Type 1 Diabetes Mellitus (T1DM), Type 2 Diabetes Mellitus (T2DM)
- Trial name
- CR3C (NCT07086989)
- Where
- 3 sites in Hungary
- Volunteers
- 300 people
- Sponsor
- Semmelweis University
Kidney Failure, Chronic, Transplantation
Fibrosis in Renal Allografts
This prospective, randomized study, comparing sirolimus to cyclosporine in renal transplant recipients, has two major objectives: 1.
- Conditions
- Kidney Failure, Chronic, Transplantation, Immunosuppression, Interstitial Fibrosis
- Trial name
- NCT00493194
- Testing
- sirolimus, cyclosporine, daclizumab
- Where
- 3 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital, Antwerp
Cystic Fibrosis
Lung Transplant READY Pilot Study
Lung transplant is an option for treating end-stage lung disease in cystic fibrosis (CF). More than half of people with CF who die without a lung transplant were never referred for consideration.
- Trial name
- NCT05135156
- Testing
- Investigator-designed lung transplant education resource (Research Intervention), Publicly available transplant education resource (Attention Control)
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Washington
Complication of Transplanted Lung
Safety Study of Aztreonam Lysine for Inhalation (AZLI) in the Treatment of Early Bronchiolitis Obliterans Syndrome (BOS)
This study is a pilot two- center study to determine if aztreonam lysine for inhalation AZLI can be safely and self-administered in lung transplant recipients with newly diagnosed bronchiolitis obliterans syndrome, grade 1 (BOS)…
- Trial name
- AZLI (NCT01469364)
- Testing
- Aztreonam Lysine for Inhalation (AZLI), Status Post Lung Transplant
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Duke University
Lung Transplant; Pain
Impact of a Multidisciplinary Protocol of Respiratory Kinesitherapy and Active Music Therapy on Anxiety, Depression and Pain in Lung Transplant Patients
Transplantation remains the last resort to prolong life when the patient reaches the stage of terminal respiratory failure. Lung transplantation improves survival and quality of life compared to medical treatment, at acceptable…
- Trial name
- PPKRMA (NCT05219292)
- Testing
- Active music therapy, Questionnaires
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Hospices Civils de Lyon
Lung Transplant, Hepatitis B
Utilization of Hepatitis B Virus NAT+ Donors for Hepatitis B Vaccinated Lung Transplant Candidates
The objective of this study is to determine the safety and efficacy of transplanting lungs from hepatitis B virus (HBV) nucleic acid test positive (NAT+) donors into HBV vaccinated HBV surface antibody positive (sAb+) lung…
- Trial name
- INHIBITOR (NCT05404919)
- Testing
- Hepatitis B Immune Globulin and entecavir, tenofovir disoproxil, or tenofovir alafenamide
- Where
- United States
- Sponsor
- University of Pennsylvania
Hip Fractures, Lower Extremity Fracture
Can Mobility Technicians Provide Value to Hospitalized Patients?
The specific aim of this study is to determine the impact of the addition of a dedicated mobility technician to the care team on specialty specific outcomes for patients recovering from surgical treatment for a hip or lower…
- Conditions
- Hip Fractures, Lower Extremity Fracture, Lung Transplant
- Trial name
- NCT03874767
- Testing
- Patient Mobility
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Immunocompromised Patients
Immunogenicity and Safety of Two Respiratory Syncytial Virus Vaccine Strategies in Lung and Allogeneic Haematopoietic Stem Cell Transplant Recipients.
Respiratory syncytial virus (RSV) is a major cause of acute respiratory infections (ARIs), which occur in seasonal outbreaks. Among the adult population, immunocompromised individuals, particularly lung transplant recipients and…
- Trial name
- RSVAxID (NCT07863401)
- Testing
- RSVpreF3-AS01, RSVpreF3
- Where
- 16 sites in France
- Volunteers
- 400 people
- Sponsor
- Hospices Civils de Lyon