Clinical trials: Trauma ICU Patients
COVID-19, Endothelial Dysfunction
The Glycocalyx in COVID-19 Patients. A Pilot Study
The damage of the endothelial glycocalyx is based on microvascular endothelial dysfunction and typical for critical clinical conditions like sepsis, trauma, bleeding, shock, as well as ARDS.
- Conditions
- COVID-19, Endothelial Dysfunction, Coagulation Disorder
- Trial name
- Glycovid-19 (NCT05137249)
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Corneal Diseases
Ocular Surface Disorders in Patients in Intensive Care Units, a Comparative Study of Three Preventive Approaches
60% of the patients hospitalized in intensive care and sedated suffer from insufficient inferior eyelid occlusion. Thus, they are at risk for corneal damage (estimated risk 20% to 57%).
- Trial name
- OCUREA2 (NCT02348242)
- Testing
- Aqueous Gel, Eyelid Occlusion Dressing, Artificial Tears
- Where
- France
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Communication Barriers
Understanding Communication Barriers in Acute Care: A Mixed-Methods Needs Assessment Among Healthcare Providers Caring for Non-Verbal Patients With Spinal Cord Injury and Tracheostomy in the ICU
Communication impairment is common among critically ill patients who are mechanically ventilated, have tracheostomies, or have neurological injuries such as spinal cord injury.
- Trial name
- NCT07796035
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Trauma ICU Patients, Endothelial Injury
Inflammation Severity and miRNA-126 in Trauma
Trauma triggers a complex immune response intended to eliminate danger signals and restore physiological balance. Early post-traumatic inflammation is primarily initiated by damage-associated molecular patterns (DAMPs) and…
- Trial name
- NCT07291908
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Melike Cengiz
COVID-19, Stress Disorders, Post-Traumatic
Psychological Impact of Medical Evacuations on Families of Patients Admitted to Intensive Care Unit for Severe COVID-19
At the "Métropole Savoie" hospital, to deal with the daily influx of severe patients during the second wave of COVID-19, 23 patients had to be transferred away from their home city and far from their families as part of a medical…
- Trial name
- IPES-CoV (NCT05421182)
- Testing
- Revised Impact of Event Scale, Hospital Anxiety and Depression scale, 36-Item Short Form Survey
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Metropole Savoie
Post Traumatic Stress Disorder PTSD
Effectiveness of Informational and Educational Tools to Improve the Experience of Relatives of ICU Patients. RELIEF, a Platform Trial
The admission of a patient to an intensive care unit (ICU) is associated with high levels of acute stress, anxiety, and depression among relatives, as well as extreme emotions such as fear, guilt, distress, and helplessness.
- Trial name
- RELIEF (NCT06851884)
- Testing
- Standard of Care (SOC), Video capsules, Cartoon
- Volunteers
- 562 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Transfusion-Related Acute Lung Injury, ARDS, Human
Comparison of the Proteome in ICU Patients in Search for TRALI Biomarkers: A Case-control Study Using Both Retrospective and Prospective Samples
Transfusion-related acute lung injury (TRALI) is a severe complication of blood transfusions. After a transfusion, TRALI develops in 0.08-15% of cases depending on the characteristics of the studied population.
- Trial name
- CURIE (NCT06444750)
- Testing
- Blood sample collection
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
ICU, Trauma Injury
Current Situation and Analysis of ICU Management for Severe Trauma Patients in China
Over the past 10 years, there has not been a consensus on ICU nursing management based on the concept of injury control. Case management for patients with serious trauma continues to be initiated in general services and after…
- Conditions
- ICU, Trauma Injury, ICU Acquired Weakness
- Trial name
- NJJLISTP (NCT04944537)
- Testing
- No Intervention
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lulu Gu
Respiratory Failure, SARS-CoV 2
Stress Related Disorders in Family Members of COVID-19 Patients Admitted to the ICU
Coronavirus disease 2019 (COVID-19) is a novel infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
- Conditions
- Respiratory Failure, SARS-CoV 2, Corona Virus Infection, Post Intensive Care Unit Syndrome
- Trial name
- NCT04476914
- Where
- 9 sites in United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Pressure Injury, Risk Assessment
Positioning Duration and Pressure Injury Risk
This research aims to investigate the effect of positioning times on the risk of pressure injury in critically ill patients.
- Trial name
- PIP-ICU (NCT07355439)
- Testing
- Position Change - 1 Hour, Position Change - 2 Hours
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- SEMA ŞAHİNER
Cardiac Arrest, Post Traumatic Stress Syndrome
Family-Authored ICU Diaries to Reduce Fear in Patients Experiencing a Cardiac Arrest (FAID Fear)
The present study will: Aim 1: Enroll 15 family members of CA patients to (a) pilot recruitment procedures, (b) estimate retention, and (c) assess acceptability of study procedures.
- Trial name
- FAID Fear (NCT05144477)
- Testing
- FAID Fear Intervention
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Columbia University
Trauma
Effect of Family Member's Massage Therapy on the Vital Signs and Glasgow Coma Scale Score
The effect of family member's massage therapy on the Vital signs and Glasgow Coma Scale Score of hospitalized patients in Intensive Care Unit: A Triple-blinded Randomized controlled Clinical Trial Study
- Trial name
- NCT01909882
- Testing
- Massage therapy
- Where
- Iran
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Baqiyatallah Medical Sciences University
Acute Kidney Injury
Controlled Trial to Demonstrate a Reduction in the Number of Oliguria Events in Patients Being Managed in a Critical Care Unit, Following Cardiac Surgery, When a Novel Oliguria Prediction Tool (STABILITY UO) is Used to Identify Patients at Risk, Compared to Standard of Care.
Acute kidney injury (AKI) is experienced by 12% of patients following surgery and in up to 50% of patients following cardiac surgery.
- Trial name
- NCT05001503
- Testing
- Stability UO
- Where
- United Kingdom
- Volunteers
- 362 people, healthy volunteers welcome
- Sponsor
- Rinicare Ltd
Acute Kidney Injury
Role of Some Biochemical Indices for Prediction of Acute Kidney Injury in Intensive Care Unit Patients in Upper Egypt
1. We will investigate the relation between the triglyceride-glucose index and the development of AKI in ICU. 2. To detect whether the TGI is a predictor of poor outcome (requirement of renal replacement therapy, or 14-day…
- Trial name
- NCT06791200
- Testing
- biochemical indices
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Diabetic Ketoacidosis, Heart Disease, Ischemic
Effectiveness of Music Intervention on Anxiety and Physiological Responses in Critical Ill Patient
Music intervention is a non-pharmacological and effective intervention that can alleviate anxiety and agitation in patients undergoing weaning.
- Conditions
- Diabetic Ketoacidosis, Heart Disease, Ischemic, Stroke, GastroIntestinal Bleeding
- Trial name
- NCT04977011
- Testing
- relaxing music
- Where
- Taiwan
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Min-Sheng General Hospital
Acute Stress Disorder, Anxiety
GASA-CIR Trail (Guidance and the Symptoms of Acute Stress and Anxiety in Critically Ill Patients Relatives in Intensive Care Unit)
A randomized clinical trial 1:1 among relatives of patients admitted to an intensive care unit, the intervention group will be composed by family members who receive a printed brochure and will be encouraged to visit a website…
- Conditions
- Acute Stress Disorder, Anxiety, Depression
- Trial name
- GASA-CIR (NCT03812458)
- Testing
- website and brochure
- Where
- Brazil
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Augmented Renal Clearance, Critical Illness
Incidence and Associated Risk Factors of ARC in the Trauma Critically Ill Older Than 50 Years Old
This single-center prospective cohort study conducted at the adult trauma ICU of the Montreal General Hospital (MGH) affiliated with the McGill University Health Centre (MUHC) aims to determine the incidence and associated risk…
- Conditions
- Augmented Renal Clearance, Critical Illness, Polytrauma, Traumatic Brain Injury
- Trial name
- NCT04766944
- Testing
- No intervention
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Limb Fracture
Impact of Continuous Regional Analgesia in Severe Trauma Patients
Regional analgesia, based on its physiological effects and efficacy, is used for optimal perioperative pain relief. However, for acute pain in multiple trauma patients in a critical condition, it has not been prospectively…
- Trial name
- ALRréa (NCT04546503)
- Testing
- Continuous Regional analgesia, Control Group
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Traumatic Brain Injury, Multiple Trauma
Evolution of Oropharyngeal and Rectal Microbiota After Severe Traumatic Brain Injury
Modifications of the human gut microbiota have been associated with different pathological conditions such as obesity, inflammatory bowel diseases and neurodegenerative diseases.
- Trial name
- BBAX (NCT03965611)
- Testing
- Oropharyngeal swab, Rectal swab, Disability rating scale (DRS-F)
- Where
- France
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Kidney Injury, Chronic Kidney Insufficiency
Comparison of Two Different External Clearance Markers - Mannitol and Iohexol for Measuring Glomerular Filtration Rate
GFR is the best parameter of the real kidney function. Measurements, however are time-consuming and have limited capacity. Patients treated in the intensive care units often have more than one organ-insufficiency and acute kidney…
- Trial name
- GFR (NCT06238310)
- Testing
- Comparison of two external marker substance for measuring glomerular filtration rate
- Where
- Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Katalin Kiss