Clinical trials: Traumatic Brain Injury (TBI)
Traumatic Brain Injury
Rapid MRI for Assessing Functional Abilities and Predicting TBI Outcomes
Our project aims to develop a rapidly acquired and communicated MRI assessment and report that incorporates functional and structural imaging to convey information about functional neurological insults following traumatic brain…
- Trial name
- NCT06454591
- Where
- 2 sites in Canada
- Volunteers
- 300 people
- Sponsor
- D.J Cook
Concussion (Diagnosis), Concussion, Mild Traumatic Brain Injury
Multidimensional Sleep Health Intervention to Optimize Concussion Recovery
Following adolescent concussion, poor sleep health is common and relates to the development of persisting post-concussion symptoms, and uninjured adolescents (independent of concussion) also commonly experience sleep…
- Conditions
- Concussion (Diagnosis), Concussion, Mild Traumatic Brain Injury, Treatment, Sleep Health
- Trial name
- SCORE (NCT07082218)
- Testing
- Sleep Intervention
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Colorado, Denver
Brain Injuries, Traumatic
Traumatic Brain Injury Positive Strategies
This study evaluates the effectiveness of The Traumatic Brain Injury Positive Strategies (TIPS) program, a comprehensive educational and training resource to help families improve their knowledge and skills in supporting a child…
- Trial name
- TIPS (NCT03867968)
- Testing
- TIPS Intervention, Control
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Traumatic Brain Injury, Mild Traumatic Brain Injury
Score Predicting Lesion Development on CT Following Mild TBI
Mild traumatic brain injury (mTBI) is one of the most common reasons behind emergency department (ED) visits. A small portion of mTBI patients will develop an intracranial lesion that might require neurosurgical intervention.
- Trial name
- SELECT-TBI (NCT04995068)
- Testing
- Head CT to determine presence of traumatic intracranial lesion
- Where
- Sweden
- Volunteers
- 20,000 people
- Sponsor
- Karolinska Institutet
Concussion
Recent Experiences With Concussions
College athletes will be recruited to complete a voluntary online survey that will take approximately 10 minutes. In this survey, they will answer a series of questions related to the concussion symptoms they have experienced in…
- Trial name
- NCT02626650
- Testing
- Symptom elicitiation
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Brain Concussion
ImPACT Normative Extension
The researchers want to find out more about a standalone software application, ImPACT Online and how it relates to other commonly used tests of memory, attention and reaction time.
- Trial name
- NCT03180905
- Testing
- ImPACT Online/Paper Pencil Tests, ImPACT Online
- Where
- 3 sites in United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- ImPACT Applications, Inc.
Concussion, Mild Traumatic Brain Injury
Cognitive-Communication Screening and Early Therapy for Adults With Mild TBI
Approximately 15-20% of patients diagnosed with a concussion/mild traumatic brain injury (mTBI) have persistent symptoms that continue up to six months or longer.
- Conditions
- Concussion, Mild Traumatic Brain Injury, Cognitive Communication Disorder
- Trial name
- NCT03230656
- Testing
- Early cognitive-communication therapy
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Northern Arizona University
Mild Traumatic Brain Injury
PROtein S100B for Mild Trauma of the HEad in Emergency Patients
Brain injury is a frequent purpose for consultation in emergency services. Management of brain injury is time and resource consuming, combining clinical monitoring and imaging.
- Trial name
- PROMETHEE (NCT03313505)
- Testing
- S100B protein dosage, Brain CT scan
- Where
- 15 sites in France, Monaco
- Volunteers
- 787 people
- Sponsor
- Centre Hospitalier Princesse Grace
Traumatic Brain Injury
Improving Executive Functioning After Traumatic Brain Injury (TBI): A Trial of the "Short Term Executive Plus" Program
The purpose of this study is to determine the efficacy of an intensive short term cognitive rehabilitation program aimed towards improving executive functioning in individuals with traumatic brain injury (TBI).
- Trial name
- STEP (NCT00627237)
- Testing
- Immediate Start, Waitlist
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Traumatic Brain Injury, Subdural Hematoma
Hypernatremia for the Prevention and Treatment of Cerebral Edema in Traumatic Brain Injury
Cerebral edema is seen heterogenous group of neurological disease states that mainly fall under the categories of metabolic, infectious, neoplasia, cerebrovascular, and traumatic brain injury disease states.
- Conditions
- Traumatic Brain Injury, Subdural Hematoma, Cerebral Contusion, Head Injury
- Trial name
- NCT01605357
- Testing
- Induced, sustained hypernatremia using hypertonic saline, Standard of care (hypertonic saline and mannitol; serum sodium)
- Sponsor
- Massachusetts General Hospital
Traumatic Brain Injury, Intracranial Hemorrhages
Improving Diagnosis and Prediction of Outcome in Patients With Severe Disorders of Consciousness
Patients with acute severe brain injury are usually admitted to the Intensive Care Unit. A substantial proportion of these patients will have disorders of consciousness (DOC) after interruption of sedation.
- Conditions
- Traumatic Brain Injury, Intracranial Hemorrhages, Subarachnoid Hemorrhage, Meningitis
- Trial name
- IMPROVE-DOC (NCT06283901)
- Where
- 5 sites in Netherlands
- Volunteers
- 160 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Traumatic Brain Injury
Mannitol vs HS to Treat ICHT After Severe TBI : Comparison on PtiO2 and Microdialysis Values
The purpose of this study is to determine whether hypertonic saline is as much effective as mannitol to treat intracranial hypertension after traumatic brain injury and has at least the same effects on PtiO2 and cerebral…
- Trial name
- NCT01028339
- Testing
- Hypertonic saline, Mannitol
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Direction Centrale du Service de Santé des Armées
Cerebrovascular Accident, Traumatic Brain Injury
Telerehabilitation for the Hand and Arm After Stroke and Traumatic Brain Injury
The goal of this project is to develop a low-cost, user-friendly, portable telerehabilitation system for physical therapy of the upper limb after stroke or traumatic brain injury.
- Trial name
- NCT00295399
- Testing
- The Jerusalem Telerehabilitation System
- Where
- 2 sites in Israel
- Sponsor
- Ono Academic College
Brain Injury, Brain Tumor Adult
Development and Implementation of an Intervention Enhancing Involvement of Relatives to Patients With Acquired Brain Injury or Malignant Brain Tumour
Caring for a loved one with a serious illness like acquired brain injury (ABI) or primary malignant brain tumors (PMBT) can be a challenging and burdensome experience, often affecting the well-being and quality of life of…
- Conditions
- Brain Injury, Brain Tumor Adult, Traumatic Brain Injury, Glioblastoma
- Trial name
- NCT06796335
- Testing
- RIGht
- Where
- Denmark
- Volunteers
- 35 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Head Injury Trauma
Decompressive Craniectomy Following Trauma
A prospective clinical trial on trauma patients with increased intracranial pressure(ICP) applied for decompressive craniectomy to lower ICP
- Trial name
- NCT04574349
- Testing
- Decompressive craniectomy
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Assiut University
Mild Traumatic Brain Injury, Concussion, Mild
Feasibility of a Cognitive Intervention for Youth Post Concussion
The purpose of this study is to evaluate the feasibility and effects of a cognitive intervention for youth following concussion
- Trial name
- NCT03195738
- Testing
- Cognitive Orientation to Occupational Performance (CO-OP)
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Pain, Chronic Pain
Chronic Pain After Combat-Related Traumatic Brain Injury (cTBI-Pain Study) A Prospective Cohort Study of Pain Chronification After Combat-Related Traumatic Brain Injury
Combat-related traumatic brain injury (cTBI), particularly blast-related injury, is frequently associated with the development of persistent and disabling chronic pain.
- Conditions
- Pain, Chronic Pain, Chronic Pain Due to Injury
- Trial name
- TBI-Pain (NCT07424248)
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
Head Injuries With Non Missile Penetrating Objjects
Non-missile Penetrating Head Trauma,Cases Registry in Sohag University Hospital
A retrospective study was done in Neurosurgery trauma unit, Sohag University. Eighteen patients reported with different mechanisms of trauma. All patients clinically tested involving neurological evaluation.
- Trial name
- trauma (NCT03768778)
- Testing
- Debridement and dural repair
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Sohag University
Traumatic Brain Injury
Neurofeedback-enhanced Mindfulness Meditation in Traumatic Brain Injury
Spaulding Rehabilitation Hospital is conducting a research study evaluating the effectiveness of the brain-training product, MUSE, an EEG-guided neurofeedback device designed to assist in cultivating a relaxed, attentive state of…
- Trial name
- NCT02615535
- Testing
- EEG neurofeedback-assisted meditation, Non-EEG feedback-assisted meditation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Spaulding Rehabilitation Hospital
Traumatic Brain Injury
Validation of the Scandinavian Guidelines for Management of TBI in Adults
Traumatic brain injuries (TBI) are one of the most common reasons for patients to attend the emergency department (ED). 90% of patients with TBI are defined as mild TBI (mTBI).
- Trial name
- NCT03280485
- Testing
- no intervention
- Where
- Sweden
- Volunteers
- 3,000 people
- Sponsor
- Halmstad County Hospital
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