Clinical trials: Treatment Failure
Bradycardia, Heart Failure
ECG Belt to Assess Electrical Synchronization
The objective of the study is to assess the utility of ECG Belt to understand the conduction and ECG characteristics of Left Bundle Branch Pacing (LBBAP) and His-Optimized Cardiac Resynchronization Therapy (HOT-CRT) and compare…
- Trial name
- NCT04583709
- Testing
- ECG Belt
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Pugazhendhi Vijayaraman
Prostatic Neoplasms, Prostate Cancer
Imaging Studies to Check the Local Response of Prostate Cancer to Radiation Therapy
Background: Radiation is a common treatment for prostate cancer. It helps damage tumor cells and causes them to die. Radiation can be effective, but some tumors may be harder to treat with radiation or even with surgery.
- Trial name
- NCT01834001
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Cancer Institute (NCI)
Heart Failure With Reduced Ejection Fraction
Changes in Intrathoracic Impedance During Sacubitril/Valsartan Treatment
The CHILISALT Study aimed to explore the effect of angiotensin-neprilysin inhibition on intrathoracic impedance and -derived fluid index in HFrEF patients who had a device for cardiac resynchronization therapy and/or an…
- Trial name
- CHILISALT (NCT03359967)
- Testing
- Entresto tablet
- Volunteers
- 24 people
- Sponsor
- Central Hospital, Izmir
End Stage Renal Disease
Study to Evaluate the Safety of Chronic Administration of Simulect to Subjects Receiving a First Kidney Transplant
The study is undertaken to explore the safety of using Simulect at monthly dose intervals to reduce the need of high dose/level CNI's such as Prograf.
- Trial name
- Simulect (NCT00928811)
- Testing
- basiliximab
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Drexel University College of Medicine
Acute Hypoxemic Respiratory Failure
Benefits of Optiflow® Device for Preoxygenation Before Intubation in Acute Hypoxemic Respiratory Failure : The PREOXYFLOW Study
Oro-tracheal intubation in intensive unit care(ICU) in acute hypoxemic respiratory failure after crash induction remains a critical event.
- Trial name
- PREOXYFLOW (NCT01747109)
- Testing
- PREOXYFLOW, STANDARD FACE MASK
- Where
- 6 sites in France
- Volunteers
- 122 people
- Sponsor
- Nantes University Hospital
HIV Infections
Prospective Evaluation of Anti-retroviral Combinations for Treatment Naive, HIV Infected Persons in Resource-limited Settings
This study compared 3 different three-drug combinations in HIV infected individuals starting their first HIV treatment regimens.
- Trial name
- PEARLS (NCT00084136)
- Testing
- Atazanavir, Didanosine (enteric-coated), Efavirenz
- Where
- 42 sites in United States, Brazil and 7 more
- Volunteers
- 1,571 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Heart Failure, Congestive
Efficacy and Safety of Relaxin for the Treatment of Acute Heart Failure
Different doses of relaxin will be compared to placebo to determine efficacy and safety for the treatment of patients hospitalized with acute heart failure
- Trial name
- RELAX-AHF (NCT00520806)
- Testing
- Relaxin
- Where
- 3 sites in United States, Israel
- Volunteers
- 1,161 people
- Sponsor
- Corthera, Inc.(formerly BAS Medical, Inc.), a member of the Novartis group of companies
Coronary Heart Disease, Heart Failure
Cardiovascular Diseases in HIV-infected Patients HIV-HEART Study: 7.5 Years Follow-up
Since the introduction of antiretroviral therapy life expectancy of HIV-infected persons is rising. Different cohorts are observing an increased risk for cardiovascular diseases in this aging HIV-infected population.
- Conditions
- Coronary Heart Disease, Heart Failure, HIV, AIDS
- Trial name
- NCT01667068
- Testing
- Comprehensive non invasive cardiovascular examination
- Where
- 6 sites in Germany
- Volunteers
- 1,481 people
- Sponsor
- University Hospital, Essen
Sepsis
Efficacy & Safety of Resatorvid in Adults With Severe Sepsis
The purpose of this study is to determine the optimal dose of Resatorvid for reducing 28-day all-cause mortality in subjects with severe sepsis.
- Trial name
- NCT00143611
- Testing
- Resatorvid
- Where
- 144 sites in United States, Australia and 15 more
- Volunteers
- 277 people
- Sponsor
- Takeda
Metastatic Breast Cancer
Nab-paclitaxel in Metastatic Breast Cancer Patients Failing Solvent Based Taxane (Tiffany)
Nab-paclitaxel has demonstrated to be an active agent in breast cancer and probably a less toxic alternative to solvent based taxanes. It is indicated in metastatic breast cancer after failure of anthracyclines.
- Trial name
- NCT01416558
- Testing
- Nab-Paclitaxel
- Where
- Germany
- Volunteers
- 66 people
- Sponsor
- GBG Forschungs GmbH
Aplastic Anemia
Combination of Thrombopoietin Mimetic and Immunosuppressive Therapy in Aplastic Anaemia
To the investigator's Knowledge this is the first study that will assess Treatment with thrombopoietin Mimetic plus immunosuppressiveTherapy in Egyptian Patients with Aplastic Anaemia. Aim of the work : 1.
- Trial name
- NCT03896971
- Testing
- Combination of thrombopoietin mimetic and cyclosporin A
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Safaa AA Khaled
Acute Heart Failure
Acute Heart Failure Patients With High Copeptin Treated With Tolvaptan Targets Increased AVP Activation for Treatment (ACTIVATE)
Patients being hospitalized for acute heart failure and already receiving standard therapy will be randomized to receive either tolvaptan or placebo, based on the level of copeptin measured in their bloodstream.
- Trial name
- ACTIVATE (NCT01733134)
- Testing
- Tolvaptan
- Sponsor
- Maisel, Alan, M.D.
Chronic Renal Failure
The Effect of Steroid Pulse Therapy for the Reduction of Acute Rejection Episode in Subclinical Borderline Changes
Several studies have shown that about 30% of transplanted kidneys with stable function present with tubule-interstitial mononuclear cell infiltration in protocol biopsies and therefore meet criteria for acute rejection.
- Trial name
- NCT02664493
- Testing
- Methylprednisolone
- Where
- South Korea
- Volunteers
- 154 people
- Sponsor
- Samsung Medical Center
Overactive Bladder
Risk Factors for Treatment Failure in Women With Detrusor Overactivity Receiving Combined Pharmacotherapy
This study evaluated the outcomes of women with detrusor overactivity treated with combined pharmacotherapy to identify risk factors for treatment failure.
- Trial name
- NCT07337252
- Testing
- Combined pharmacotherapy
- Where
- Taiwan
- Volunteers
- 61 people
- Sponsor
- Mackay Memorial Hospital
Cirrhosis, Hepatic Encephalopathy
VE303 for Treatment of Hepatic Encephalopathy (HE)
This research is studying the use of a new drug to learn about its safety and efficacy as a treatment for hepatic encephalopathy.
- Trial name
- NCT04899115
- Testing
- VE303, oral vancomycin
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Patricia Bloom
Acute Respiratory Distress Syndrome, Critical Illness
Acetaminophen and Ascorbate in Sepsis: Targeted Therapy to Enhance Recovery
Prospective multi-center phase 2b randomized placebo-controlled double-blinded interventional platform trial of two different pharmacologic therapies (intravenous Vitamin C or intravenous Acetaminophen) for patients with…
- Conditions
- Acute Respiratory Distress Syndrome, Critical Illness, Respiratory Failure, Sepsis
- Trial name
- ASTER (NCT04291508)
- Testing
- Intravenous Acetaminophen (room temperature), Intravenous Vitamin C (refrigerated), 5% Dextrose (room temperature)
- Where
- 41 sites in United States
- Volunteers
- 488 people
- Sponsor
- Massachusetts General Hospital
Chronic Kidney Failure, HIV Infection
Kidney Transplant for HIV-Infected Patients in Renal Failure
This study will examine the safety and effectiveness of renal (kidney) transplantation for HIV-infected patients with end-stage renal disease (kidney failure).
- Trial name
- NCT00009009
- Testing
- immunosuppressive regimen designed to complement HAART
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Heart Failure
Drug Management in Heart Failure
Aim of the proposal is to create an interactive AI-based multicentre prospective database to provide information on how to improve the QoC for pts with HF.This will provide detailed information on pts characteristics,treatment…
- Trial name
- DRUM-HF (NCT06915584)
- Where
- Italy
- Volunteers
- 450 people
- Sponsor
- IRCCS San Raffaele Roma
Pediatric Dental General Anesthesia, Restoration
Clinical Performance and Failure Rates of Restorations Following Pediatric Dental Rehabilitation Under General Anesthesia
Full-mouth dental rehabilitation under general anesthesia (GA) is frequently required for young children with extensive dental caries, behavioral challenges, or special healthcare needs.
- Conditions
- Pediatric Dental General Anesthesia, Restoration, Clinical Performance, Full Mouth Rehabilitation
- Trial name
- NCT07827833
- Testing
- Routine Restorative Materials and Treatment Methods
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Tanta University
Heart Failure
Multicenter Study of Family Nursing to Treat Heart Failure
The purpose of this study is to determine whether Family Focused Nursing are effective in the treatment of heart failure outpatients with respect to health-related quality of life.
- Trial name
- NCT01378247
- Testing
- Family Focused Nursing
- Where
- 3 sites in Denmark
- Volunteers
- 468 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
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