Clinical trials: Treatment Resistant Obsessive Compulsive Disorder
Obsessive-Compulsive Disorder
Effectiveness of Deep Brain Stimulation for Treating People With Treatment Resistant Obsessive-Compulsive Disorder
This study will evaluate the safety and effectiveness of deep brain stimulation in treating people with severe and otherwise treatment-resistant obsessive-compulsive disorder.
- Trial name
- NCT00640133
- Testing
- Active DBS
- Where
- 9 sites in United States
- Volunteers
- 27 people
- Sponsor
- Butler Hospital
Obsessive-Compulsive Disorder, OCD
pBFS Guided rTMS Therapy for Treatment-resistant Obsessive-Compulsive Disorder
The investigators aim to evaluate the safety and efficacy of pBFS-guided rTMS therapy targeting DLPFC for patients with treatment-resistant Obsessive-Compulsive Disorder.
- Trial name
- NCT05964049
- Testing
- active rTMS treatment
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Changping Laboratory
Obsessive-Compulsive Disorder
A Study of Pregabalin (Lyrica) Augmentation in Serotonin Reuptake Inhibitor-Refractory Obsessive Compulsive Disorder
This study will examine the efficacy of pregabalin (Lyrica) added to SRI treatment in OCD for individuals who have not responded or only partially responded to an adequate trial of SRI.
- Trial name
- NCT00994786
- Testing
- pregabalin
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- McMaster University
Obsessive-Compulsive Disorder
Deep Brain Stimulation and Obsessive-compulsive Disorder
Obsessive-compulsive disorder (OCD) is a relatively common psychiatric condition, which is classically treated by antidepressant medications in combination with psychotherapies.
- Trial name
- STOC2 (NCT01329133)
- Testing
- Deep Brain Stimulation (DBS)
- Where
- 14 sites in France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Bordeaux
OCD
Cerebral and Cognitive Markers of Treatment Resistance in Obsessive Compulsive Disorder
This study aims to define individual profiles of treatment resistants in order to find indicators and predictors of the therapeutic response.
- Trial name
- 3TOC (NCT05843604)
- Testing
- Functional MRI
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Henri Laborit
Obsessive-Compulsive Disorder
European Study of Quality of Life in Resistant OCD Patients Treated by STN DBS
Obsessive-Compulsive Disorder (OCD) is among the most disabling psychiatric disorders as more than 40% of patients are resistant to the standard pharmacological and psychotherapy approaches and about 10% show severe disability…
- Trial name
- EQOLOC (NCT02844049)
- Testing
- Deep Brain Stimulation
- Where
- 8 sites in France, Germany and 2 more
- Volunteers
- 60 people
- Sponsor
- University Hospital, Grenoble
Obsessive - Compulsive Disorder
tDCS and Symptom Provocation in Treatment-Resistant OCD
The goal of this clinical trial is to learn if symptom provocation before transcranial Direct Current Stimulation (tDCS) in Obsessive-Compulsive Disorder (OCD) patients.
- Trial name
- PPS-TDCSTOC (NCT07429500)
- Testing
- tDCS session, symptom provocation
- Where
- 6 sites in France
- Volunteers
- 178 people
- Sponsor
- Centre Hospitalier Henri Laborit
Obsessive-Compulsive Disorder
tDCS as an add-on Treatment in SSRI-resistant OCD
The purpose of this study is to determine whether tDCS is effective as an add-on treatment in SSRI-resistant patients with obsessive and compulsive disorder
- Trial name
- TDCSTOC (NCT02407288)
- Testing
- transcranial dirrect current stimulation
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Hôpital le Vinatier
Obsessive-Compulsive Disorder (OCD)
DBS for Treatment-resistant Obsessive-compulsive Disorder
The primary purpose of this study is to investigate the effect of deep brain stimulation (DBS) implantation targeting the anteromedial region of subthalamic nucleus (amSTN), or nucleus accumbens (NAc), or bed nucleus of the stria…
- Trial name
- NCT06360991
- Testing
- Deep brain stimulation (DBS)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xuanwu Hospital, Beijing
Obsessive-Compulsive Disorder (OCD)
DBS for Obsessive-Compulsive Disorder
There are two primary approaches to the treatment of OCD, pharmacotherapy and cognitive behavior therapy (CBT). Lack of therapeutic success with one approach leads to trials of the alternative approach or a combination of the…
- Trial name
- DBS (NCT02773082)
- Testing
- Reclaim™ DBS Therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Northwell Health
Obsessive-Compulsive Disorder
Feasibility, Clinical Effects, and Safety of Psilocybin-assisted Psychotherapy for Treatment-resistant OCD
Psilocybin, the chemical component of "magic mushrooms", has been administered with psychotherapy in several randomized clinical trials (RCTs) showing large and sustained antidepressant effects.
- Trial name
- PAP-OCD (NCT06299319)
- Testing
- Psilocybin
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Centre for Addiction and Mental Health
Obsessive-Compulsive Disorder, OCD
pBFS Guided High-dose rTMS Therapy for Treatment-Resistant Obsessive-Compulsive Disorder
The research aims to evaluate the safety and efficacy of pBFS-guided High-dose rTMS therapy targeting preSMA for patients with treatment-resistant Obsessive-Compulsive Disorder.
- Trial name
- NCT05964062
- Testing
- active rTMS treatment
- Volunteers
- 30 people
- Sponsor
- Changping Laboratory
1 Hz Real rTMS to the Pre-SMA, 1 Hz Sham rTMS to the Pre-SMA
TMS for Exposure Therapy Resistant OCD
TETRO is a multi-center placebo-controlled double-blind randomized controlled trial with an intervention phase of 5-7 weeks and a follow-up phase of 12 months in 250 adult (18 years and older) OCD patients who show…
- Trial name
- TETRO (NCT05331937)
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- 8 sites in Netherlands
- Volunteers
- 250 people
- Sponsor
- Amsterdam UMC, location VUmc
Obsessive-Compulsive Disorder
Development of Adaptive Deep Brain Stimulation for OCD
This research study is for participants that have been diagnosed with intractable Obsessive -compulsive disorder (OCD). OCD is a persistent and oftentimes disabling disorder marked by unwanted and distressing thoughts…
- Trial name
- Phase Ib (NCT04281134)
- Testing
- Summit RC+S System, One Month Blinded Discontinuation Period:
- Where
- 3 sites in United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Obsessive Compulsive Disorder (OCD)
Examining the Feasibility and Acceptability of Good Quality Intensive CBT for OCD and Good Quality Weekly CBT for OCD
The purpose of this study is to examine how feasible and acceptable it is to deliver a talking treatment called Cognitive Behavioural Therapy (CBT) in two different formats for people who have had treatment for OCD in the past…
- Trial name
- NCT02216981
- Testing
- Cognitive Behavioural Therapy (CBT)
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Bath
Obsessive Compulsive Disorder
Ondansetron in Treatment Resistant Obsessive Compulsive Disorder (OCD)
Given that 5-HT3 receptors are indirect inhibitors of cortico-mesolimbic DA release, the 5-HT3 receptor antagonist ondansetron augmentation might potentially have efficacy in the treatment of resistant Obsessive Comulsive…
- Trial name
- NCT00796497
- Testing
- ondansetron
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- Institute of Neuroscience, Florence, Italy
Patient Diagnosed With OCD and Resistant to SSRI Treatment, Failed SSRI Over 12 Weeks at Appropriate Doses
Study to Evaluate the Effect of AFQ056 in Obsessive Compulsive Disorder (OCD) Patients Resistant to Selective Serotonin Reuptake Inhibitor (SSRI) Therapy
The purpose of this study is to determine whether AFQ056 as an add on therapy to SSRIs can have beneficial effects by reducing the total score of Y-BOCS (Yale and Brown Obsessive Compulsive Scale) in OCD patients resistant to…
- Trial name
- NCT01813019
- Testing
- AFQ056
- Where
- 15 sites in United States, Bulgaria and 3 more
- Volunteers
- 50 people
- Sponsor
- Novartis Pharmaceuticals
Obsessive-Compulsive Disorder
Development of Adaptive Deep Brain Stimulation for OCD (Phase 1a)
This research study is for participants that have been diagnosed with intractable Obsessive -compulsive disorder (OCD). OCD is a persistent and oftentimes disabling disorder marked by unwanted and distressing thoughts…
- Trial name
- NCT03457675
- Testing
- Activa PC+S DBS implant for OCD, One Month Blinded Discontinuation Period
- Where
- 3 sites in United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Obsessive-Compulsive Disorder
Memantine Augmentation in Treatment-Resistant Adults With Obsessive-Compulsive Disorder
Obsessive-compulsive disorder (OCD) is a common psychiatric illness that affects up to 2-3% of the population. People with OCD experience anxiety-provoking, intrusive thoughts, known as obsessions, and feel compelled to perform…
- Trial name
- NCT00956085
- Testing
- Memantine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- New York State Psychiatric Institute
Obsessive-compulsive Disorders and Symptoms
tDCS Stimulation to Treat Patients With Severe and Resistant Obsessive Compulsive Disorder-Pilot Study
The purpose is to show that bifocal tDCS with an anodal stimulation on the orbitofrontal cortex and cathodic stimulation on supplementary motor areas is an effective treatment for patients with resistant and severe obsessive…
- Trial name
- tDCS-TOC (NCT03284671)
- Testing
- bifocal stimulation with tDCS
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Henri Laborit