Clinical trials: Treatment of Periodontitis
Periodontitis, Periodontitis Stage I
Hypochlorous Acid in Non-Surgical Periodontal Therapy
Periodontitis is a chronic inflammatory disease associated with dental plaque and characterized by the progressive destruction of the tooth-supporting tissues.
- Conditions
- Periodontitis, Periodontitis Stage I, Periodontitis Stage II
- Trial name
- NCT07712627
- Testing
- Hypochlorous Acid Application, Scaling and Root Planing (SRP) with Purified Water
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Ataturk University
Periodontal Diseases
TREM-1 Pathway in Predicting Treatment Outcomes in Periodontitis
This study investigated modulations in salivary triggering receptor expressed on myeloid cells (TREM)-1, peptidoglycan recognition protein 1 (PGLYRP1) and interleukin (IL)-1β levels between healthy, gingivitis and periodontitis…
- Trial name
- NCT06715176
- Testing
- Clinical periodontal measurements at baseline (T0), Saliva collection at baseline (T0), Scaling and root planing
- Where
- Turkey (Türkiye)
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Periodontitis Chronic Generalized Severe
Contribution of an Antiviral Drug (Valaciclovir) in the Treatment of Generalized Periodontitis (Stage III or IV and Grade A, B or C): Prospective, Randomized and Double Blind Clinical Trial
Periodontitis is an inflammatory pathology that destroys periodontitis and causes tooth loosening. Its high incidence, combined with very high oral and systemic morbidity, places this pathology at the heart of global public…
- Trial name
- HERPARO (NCT05902208)
- Testing
- Antiviral treatment with conventional non-surgical treatment
- Where
- 3 sites in France
- Volunteers
- 142 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Periodontitis, Periodontal Debridement
A Non-inferiority Study of Laser Combined With Ultrasonic Debridement Therapy (LCUDT) Versus Manual Combined With Ultrasonic Debridement Therapy (MCUDT) in the Treatment of Periodontitis
The rate of periodontal health among adults and the elderly in China is less than 10%, with the prevalence of severe periodontitis reaching 30.6% in those aged 35 and above.
- Trial name
- NCT07487285
- Testing
- Experimental: Laser Combined with Ultrasonic Debridement Therapy, Active Comparator: Manual Combined with Ultrasonic Debridement Therapy
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Residual Disease, Aggressive Periodontitis
Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive Periodontitis
The aim of this randomized controlled clinical trial of superiority will be to evaluate the effect of 3 g of omega-3 polyunsaturated fatty acids and 100 mg of aspirin daily supplementation over a period of 180 days as adjunct to…
- Trial name
- NCT03093207
- Testing
- Open flap debridement, Omega-3 polyunsaturated fatty acids, Aspirin
- Where
- Brazil
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Anesthesia
Effect of Ibuprofen Sustained Release on Intraoperative and Postoperative Pain in Mandibular Molars
The study is conducted to evaluate the effect of Ibuprofen sustained release premedication on the success of buccal infiltration anaesthesia, intaroperative pain and post operative pain in mandibular molars with symptomatic…
- Trial name
- NCT05053009
- Testing
- Brufen Retard
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Cairo University
Cardiovascular Risk Markers, Chronic Periodontitis
Non-surgical Peridontal Treatment on Cardiovascular Risk Markers
The study evaluates the influence of non-surgical mechanical periodontal treatment in patients with severe chronic periodontitis on inflammatory markers related to risk for cardiovascular diseases
- Trial name
- NCT04540328
- Testing
- Non-surgical periodontal treatment
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Periodontitis, Stage III Periodontitis
Ozone Therapy After Open Flap Debridement in Periodontitis
Periodontitis is a chronic inflammatory disease characterized by the destruction of supporting periodontal tissues. Open flap debridement (OFD) is a commonly used surgical approach for the treatment of deep periodontal pockets…
- Trial name
- OFD-OZONE (NCT07551297)
- Testing
- Open Flap Debridement, Ozone Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Alparslan Dilsiz
Periodontitis, Intrabony Periodontal Defect
MIST Versus M-MIST for the Treatment of Intrabony Defects
This is a 12-month longitudinal, double-blind, parallel-design randomized controlled clinical trial involving surgical therapeutic intervention (Phase 4).
- Conditions
- Periodontitis, Intrabony Periodontal Defect, Periodontitis, Chronic
- Trial name
- NCT06058923
- Testing
- M-MIST, MIST
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Periodontitis, Intrabony Periodontal Defect
Treatment of Intrabony Defects With Injectable Platelet-Rich Fibrin and Xenogenic Grafts
The use of injectable platelet-rich fibrin (i-PRF) in both surgical and non-surgical dental treatments has become increasingly widespread.
- Conditions
- Periodontitis, Intrabony Periodontal Defect, Periodontal Diseases, Periodontal Defect
- Trial name
- NCT07146776
- Testing
- open flap debridement with I-prf and xenogeneic graft, open flap debridement with saline and xenogenic graft
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Single-visit, Periapical Periodontitis
Postoperative Pain and Success of Single-Visit Root Canal Treatment Using Different Root Canal Sealers in Asymptomatic Teeth
This study evaluates the postoperative pain and long-term clinical and radiographic success of single-visit primary root canal treatment in asymptomatic teeth with periapical lesions.
- Trial name
- NCT07868315
- Testing
- One-Fill, TotalFill, AH Plus + Single Cone
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Istanbul Medipol University Hospital
Periodontitis
Treatment of Periodontal Intrabony Defects Using Autologous Platelet Rich Fibrin vs Titanium Platelet Rich Fibrin
Background: To compare the effectiveness of open flap debridement (OFD) alone and OFD along with either Autologous Platelet Rich Fibrin (PRF) or Titanium Platelet Rich Fibrin (TPRF) in the treatment of intrabony defects (IBDs).
- Trial name
- NCT02512952
- Testing
- Open flap debridement (OFD), OFD with Platelet rich fibrin (PRF), OFD with Titanium Platelet rich fibrin (TPRF)
- Where
- 2 sites in India
- Volunteers
- 38 people
- Sponsor
- Government Dental College and Research Institute, Bangalore
Advanced Periodontitis, Stage III Periodontitis
Treatment of Periodontitis by Tulsi Gel
This study will be carried out to compare between the effect of 4%Tulsi gel and 1%Chlorohexidine gel as locally administered agents in the treatment of advanced periodontitis.
- Conditions
- Advanced Periodontitis, Stage III Periodontitis, Stage IV Periodontitis
- Trial name
- NCT06675578
- Testing
- Tulsi gel, Chlorhexidine gel
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Al-Azhar University
Periodontitis
Effect of Probiotics as Supplement to Non-surgical Periodontal Treatment
The present study is a double-blinded randomized clinical trial with a duration of 12 weeks.
- Trial name
- NCT05518747
- Testing
- Probiotic
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- University of Copenhagen
Periodontitis
Air Polishing for Pain and Compliance in Supportive Periodontal Therapy
Supportive periodontal therapy (SPT) is essential for maintaining periodontal stability and preventing disease recurrence in patients who have been successfully treated for periodontitis.
- Trial name
- NCT07837947
- Testing
- Trehalose Air-Polishing, Ultrasonic Instrumentation
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Octavi Camps-Font
Renal Insufficiency Chronic, Chronic Periodontitis
Effect on Teeth and Gum Cleaning in Patients With Gum and Kidney Disease
The main aim and objective of this study was to evaluate the effects of Non- surgical periodontal therapy on the subgingival microbiota and biochemical parameters in patients with chronic kidney disease and chronic periodontitis.
- Trial name
- ETGPGK (NCT02901743)
- Testing
- Scaling and Root planing
- Volunteers
- 40 people
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Periodontitis, Diabete Mellitus
Omega-3 Pufa and Aspirin as Adjunctive Therapy in Treatment of Smoker Patients With Stage Iii Periodontitis
Background: Smoking reduces the effect of non-surgical periodontal therapy, a host modulation regimen consisting of omega-3 polyunsaturated fatty acids (ω-3 PUFA) supplementation with low-dose aspirin (ASA) with or without…
- Trial name
- NCT07385300
- Testing
- Omega-3 PUFA and Aspirin as adjunctive therapy to (SRP), Omega-3 PUFA and Aspirin and doxycycline as adjunctive therapy to (SRP), scaling and root planning (SRP)
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Alexandria University
Periodontitis
Use of Laser Assisted New Attachment Procedure and Low Level Laser Therapy for Periodontitis Patients
In this study, it is evaluated the effects of laser assisted new attachment procedure (LANAP) and low level laser therapy (LLLT) and on clinical, biochemical and radiographic parameters in addition to non-surgical periodontal…
- Trial name
- LANAP LLLT (NCT04694222)
- Testing
- Nd:YAG laser
- Where
- Turkey (Türkiye)
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Periodontitis
Evaluation of the Effects of Immune Cells on Periodontal Healing
Periodontitis is an inflammatory disease with an infectious character, where, as the result of the host response to a dysbiotic microflora, attachment and bone loss occur.
- Trial name
- EMTA (NCT04792372)
- Testing
- Initial periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Biruni University
Chronic Periodontitis
Effect of Periodontal Treatment on Salivary Biomarkers
The investigators plan to recruit 40 healthy patients referred to the unit of Periodontology, diagnosed with generalized moderate - severe chronic periodontitis.
- Trial name
- NCT02159781
- Testing
- periodontal treatment - scaling and root planning
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Baruch Padeh Medical Center, Poriya
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