Clinical trials: Troponin T
Acute Coronary Syndrome
Comparison Between the New Highly Sensitive Troponin T and the Conventional Troponin T Test in Elderly Patients
The planned cohort study shall clarify whether the use of biomarkers leads to improved diagnostic assessment of elderly patients.
- Trial name
- BOSCH2 (NCT01370382)
- Where
- Germany
- Volunteers
- 180 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Acute Coronary Syndrome, Angina Pectoris
Mersey Acute Coronary Syndrome Rule-Out Using High Sensitive Troponin
The aim of this observational study is twofold. The primary hypothesis being tested is that initial(first) high sensitivity Tn <5ng/l (limit of detection) combined with an ECG with no ischaemic changes is superior as an…
- Conditions
- Acute Coronary Syndrome, Angina Pectoris, Cardiovascular Diseases, Chest Pain
- Trial name
- MACROS (NCT02581540)
- Volunteers
- 3,054 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Myocardial Infarction, Cardiac Arrest
Troponin-T for Detection of Perioperative Cardiovascular Events
We will conduct a prospective cohort study evaluating the incidence of and optimal risk estimation model for major perioperative cardiovascular events in consecutive patients undergoing noncardiac surgery at the 'Herlev…
- Trial name
- VISION-pilot (NCT00443989)
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hypothermia, Perioperative
Prevalence Survey in France of Unintentional Perioperative Hypothermia and Its Impact on Two Outcomes
The primary objectives of the study are to perform a survey on the clinical management of unintentional hypothermia during surgery in France. to assess the impact of perioperative hypothermia on anemia and myocardial injury.
- Trial name
- HYPOTHERMIE (NCT02790086)
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Société Française d'Anesthésie et de Réanimation
Acute Myocardial Infarction
Using Higher Cut-off Values to Diagnose Acute Myocardial Infarction in Patients With Elevated Hs-cTnT Concentrations
High-sensitive cardiac troponin T (hs-cTnT) is a cornerstone for diagnosing acute myocardial infarction (AMI). However, it is often challenging to diagnose AMI in patients with elevated hs-cTnT before a rise or fall of hs-cTnT…
- Trial name
- NCT06059079
- Testing
- No Intervention
- Where
- China
- Volunteers
- 80,000 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Pancreas Disease, Troponin T
Cardiac Cycle Efficiency and Postoperative Troponin
Knowing how intraoperative anesthesia management and cardiac cycle monitoring affect postoperative cardiac outcomes in patients undergoing pancreatic surgery can help develop a protocol for future cases.
- Conditions
- Pancreas Disease, Troponin T, Hemodynamic Monitoring, MINS
- Trial name
- NCT07778914
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Istanbul Saglik Bilimleri University
Myocardial Ischemia, Myocardial Injury
Perioperative Myocardial Ischemia: Troponin Monitoring,Cost-effectiveness, Insights Into Pathophysiology
Background: Despite preoperative screening, technical improvements and increased patient monitoring, perioperative myocardial infarction (PMI) remains the first cause of morbidity and mortality within 30 days after surgery.
- Conditions
- Myocardial Ischemia, Myocardial Injury, Morality
- Trial name
- PMI (NCT03438448)
- Testing
- High sensitive Troponin T monitoring
- Where
- Spain
- Volunteers
- 1,510 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Coronary Artery Disease
HsTnT in Stable Coronary Artery Disease
Coronary artery disease (CAD) is one of the leading causes of morbidity and mortality worldwide. Life threatening manifestations such as acute myocardial infarction (AMI) and sudden cardiac death are the most important causes of…
- Trial name
- NCT01954303
- Testing
- Progress of CHD
- Volunteers
- 965 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Peripheral Arterial Occlusive Disease
Troponin T as Risk Stratification Tool in Peripheral Arterial Occlusive Disease
Study hypothesis: elevated Troponin T is a marker of increased mortality in patients with peripheral arterial occlusive disease (PAOD).
- Trial name
- NCT01087385
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- University Heart Center Freiburg - Bad Krozingen
Heart Failure
Age Gender Left Ventricular Mass and Cardiac Troponin T
The purpose of this study is to determine the influence of functional or anatomic cardiac parameters, age and gender on high sensitivity cTnT (TnThs) levels in healthy individuals.
- Trial name
- NCT01100710
- Where
- Germany
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Major Adverse Cardiovascular Events, Troponin T
Pre-discharge vs. Early Post-discharge Stress Testing and GRACE Score for Safe Discharge of ACS-patients With a Negative Hs-troponin T Result
New high-sensitivity cardiac troponin (hs-cTn) assays allow earlier detection of acute myocardial infarction (AMI). Furthermore, elevated values were associated with an increased risk of recurrent AMI or death.
- Conditions
- Major Adverse Cardiovascular Events, Troponin T, GRACE Score
- Trial name
- NCT02072538
- Where
- Germany
- Sponsor
- University Hospital Heidelberg
Myocardial Injury After Noncardiac Surgery (MINS)
Myocardial Injury After Transurethral Resection
This prospective observational study aims to determine the incidence of myocardial injury after noncardiac surgery (MINS) in adult patients undergoing elective transurethral resection of the prostate (TURP) or transurethral…
- Trial name
- TUR-MINS (NCT07900035)
- Where
- Turkey (Türkiye)
- Volunteers
- 89 people
- Sponsor
- Haseki Training and Research Hospital
Thoracic Anesthesia, One Lung Ventillation (OLV)
Association Between One Lung Ventilation and Myocardial Injury Markers (Troponin T and I) in Thoracic Surgical Procedures (OLVTIS)
This prospective single-group cohort study aims to investigate the association between the One-Lung Ventilation (OLV) technique and myocardial injury, as measured by postoperative Troponin T and Troponin I levels, in patients…
- Trial name
- OLVTIS (NCT07302243)
- Where
- Indonesia
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Universitas Jenderal Soedirman
Heart Attack, Chest Pain
T-MACS Decision Aid: a Randomized, Controlled Point of Care Trial
The aim of the study is to establish whether the safety of the T-MACS decision aid to immediately 'rule out' acute coronary syndromes with one blood sample for the cardiac damage marker troponin, is non-inferior to an approach…
- Conditions
- Heart Attack, Chest Pain, Acute Coronary Syndrome
- Trial name
- NCT04313465
- Testing
- Immediate discharge
- Where
- United Kingdom
- Sponsor
- Manchester University NHS Foundation Trust
Cardiotoxicity, Breast Cancer
Dietary Restriction to Prevent Cardiotoxicity in Breast Cancer Patients
The goal of this clinical trial is to compare a dietary intervention with a regular diet in patients with early breast cancer undergoing anthracycline based chemotherapy.
- Trial name
- PROTECT-COR (NCT06622954)
- Testing
- Protein- and Calorie restriction
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- Erasmus Medical Center
Newborn; Newborn, Transient
Variations of High Sensitivity Troponin T in Neonates
Troponin T-us is a cardiac marker for myocardial infarction. Its use in neonates is increasing, yet normal values are still to be determined for the latest generation of tests, such as High sensitivity cardiac troponin T test.
- Trial name
- TnTc-us (NCT02880098)
- Testing
- Troponin T blood level
- Where
- France
- Volunteers
- 497 people, healthy volunteers welcome
- Sponsor
- Hôpital NOVO
Biomarkers
DIGIPREDICT-Physio-DE
The study aims to investigate short-term physiological and biochemical inflammatory and cardiocirculatory biomarker kinetics in heart failure patients, using the DIGIPREDICT Physiopatch device - an investigational device that…
- Trial name
- NCT05886569
- Testing
- DIGIPREDICT Physiopatech
- Volunteers
- 20 people
- Sponsor
- Charite University, Berlin, Germany
Heart Failure, Coronary Artery Disease
The Usefulness of Growth Differentiation Factor 15 (GDF-15) for Risk Stratification in Cardiac Surgery
Growth determination factor 15 (GDF-15) and high sensitive troponin-t (hsTnT) are emerging humoral markers for risk stratification in clinically stable heart failure patients and in patients with stable coronary artery disease.
- Trial name
- NCT01166360
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- University of Luebeck
Chest Pain, Acute Coronary Syndrome
The Pre-hospital Evaluation of Sensitive Troponin (PRESTO) Study
The aim of the study is to assess whether a decision aid that is currently used in hospitals across Greater Manchester to determine how likely it is that a patient has a serious heart problem is still accurate in the pre-hospital…
- Conditions
- Chest Pain, Acute Coronary Syndrome, Heart Attack
- Trial name
- NCT03561051
- Where
- 13 sites in United Kingdom
- Volunteers
- 700 people
- Sponsor
- Manchester University NHS Foundation Trust
Troponin T
Hs-Troponin T Kinetics in Patients Treated With MCO Membranes Compared to High-flux, Low-flux Membranes and HDF
In this study, 24 prevalent hemodialysis patients will undergo four regular hemodialysis sessions during which four different treatments will be performed.
- Trial name
- NCT05439681
- Testing
- Theranova 400, FX 10, FX CorDiax 800
- Where
- Austria
- Volunteers
- 22 people
- Sponsor
- Medical University of Graz