Clinical trials: Type I Diabetes Mellitus
Diabetes, Diabetes Mellitus, Type 1
Paediatric Subjects - Special Survey
This study is conducted in Japan. The aim of this study is to collect safety and efficacy data when using insulin aspart in children with diabetes under normal clinical practice conditions.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT01538576
- Testing
- insulin aspart
- Where
- Japan
- Volunteers
- 71 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes Mellitus
Hypoglycemia Fear Affect Autonomic Function, Physical Activity, and Exercise Capacity in Type I Diabetes
This cross-sectional study aims to investigate whether fear of hypoglycemia affects autonomic function, physical activity levels, and exercise capacity in children and adolescents with T1DM.
- Trial name
- HypoFear-T1DM (NCT07527676)
- Testing
- No intervention (observational study)
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people
- Sponsor
- Ordu University
Type 2 Diabetes, Emotions
Boosting Emotions & Happiness in Outpatients Living With Diabetes: Phase I
The focus of this study is to examine the feasibility, acceptability, and preliminary impact of a customized, combined positive psychology and motivational interviewing (PP-MI) health behavior intervention in a group of patients…
- Conditions
- Type 2 Diabetes, Emotions, Patient Compliance
- Trial name
- BEHOLD-16 (NCT03001999)
- Testing
- PP-MI health behavior intervention
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Massachusetts General Hospital
Diabetes Mellitus, Type 1
Steno Tech Explore: A Study of Insulin Pump Users With Type 1 Diabetes
The present study is part of an overarching study being conducted in Denmark at Steno Diabetes Center Copenhagen (SDCC) and Nordsjællands Hospital Hillerød (NOH), Steno Tech, that aims to develop and ultimately, in a randomized…
- Trial name
- NCT04311164
- Testing
- Questionnaire-based survey, No intervention given.
- Where
- 2 sites in Denmark
- Volunteers
- 770 people
- Sponsor
- Steno Diabetes Center Copenhagen
Diabete Type 1, Ketoacidosis, Diabetic
Hemoglobin Levels and Resolution Time of Diabetic Ketoacidosis in Pediatric Patients
This retrospective observational cohort study aims to evaluate the association between hemoglobin levels and the time to resolution of diabetic ketoacidosis (DKA) in pediatric patients.
- Conditions
- Diabete Type 1, Ketoacidosis, Diabetic, Pediatrics, Child
- Trial name
- NCT07377604
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Aydin Adnan Menderes University
Type 2 Diabetes Mellitus
A Clinical Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ZYD1, Following Subcutaneous Administration in Healthy Volunteers
ZYD1 is a novel GLP-1 receptor agonist. The ZYD1 exhibits increased stability to proteolytic cleavage, especially against dipeptidyl peptidase-4 (DPP-IV). ZYD1 is a potent antidiabetic agent without gastrointestinal side-effects.
- Trial name
- ZYD1 (NCT01972893)
- Testing
- ZYD1
- Where
- India
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Zydus Lifesciences Limited
Diabetes
The Effect of Gastric Emptying on Blood Glucose Profile of Type 1 Diabetes Mellitus and Its Therapeutic Strategies
Establish a cohort study to describe the characteristics of gastric emptying in patients with type 1 diabetes, and adjust the timing of insulin injection during meals to improve blood glucose fluctuations according to the speed…
- Trial name
- NCT06173934
- Testing
- insulin injection 15 minutes before meals, Insulin injection 15 minutes after eating
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Type 1 Diabetes Mellitus
Screening of Subjects With Type I Diabetes to Determine Eligibility for Islet Transplantation
Protocol to screen potential subjects for islet transplantation
- Trial name
- NCT02004964
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Rodolfo Alejandro
Type 1 Diabetes, Insulin Pump Therapy
Impact of Hybrid Closed Loop Systems in People With Type I Diabetes
Type 1 diabetes requires people with type 1 diabetes to constantly monitor their blood glucose and adjust their insulin doses to try and keep glucose levels in range.
- Conditions
- Type 1 Diabetes, Insulin Pump Therapy, Patient Reported Outcomes
- Trial name
- ProHCL (NCT05348499)
- Testing
- Questionnaire/Interview
- Where
- United Kingdom
- Volunteers
- 350 people
- Sponsor
- University of Leicester
Diabetes Type 2, Obesity
I-care: Stimulating Self-management in Patients With Type 2-diabetes
The overall objective of this pilot study is to develop a cost-effective treatment methodology delivered outside of traditional clinical setting, and based on modern technology for patients with diabetes type 2 also suffering…
- Trial name
- I-care (NCT01297049)
- Testing
- Cognitive behavior therapy (CBT)
- Where
- Norway
- Volunteers
- 15 people
- Sponsor
- Oslo Metropolitan University
Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
Plasma Dihydroceramides Are Associated With Hepatic Steatosis in Type 1 and Type 2 Diabetes
Sphingolipids are associated with metabolic diseases. Distribution of plasma sphingolipids in type 1 and type 2 diabetes has never been studied.
- Trial name
- CERADIAB (NCT03447964)
- Testing
- dosing of sphingolipids
- Where
- France
- Volunteers
- 128 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Diabetes Mellitus, Type 1
A Study in Adults With Type 1 Diabetes
The purpose of this study is to compare the effectiveness and safety of LY2963016 versus Lantus when taken once daily in combination with insulin lispro before meals three times a day.
- Trial name
- ELEMENT 1 (NCT01421147)
- Testing
- LY2963016, Lantus, Insulin Lispro
- Where
- 52 sites in United States, Belgium and 7 more
- Volunteers
- 536 people
- Sponsor
- Eli Lilly and Company
Type 1 Diabetes (T1D), Diabetes Secondary to Pancreatitis
Digital Mindfulness for Young Adults With Type 1 Diabetes
The purpose of this research study is to test a mindfulness app called Calm Health among young adults with type 1 diabetes or other absolute insulin deficiency diabetes.
- Trial name
- NCT07062887
- Testing
- Mindfulness app
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Osteoarthritis of Knee
Clinical Trial to Evaluate Safety and Efficacy of MesoCellA-Ortho Tissue-Engineered Advanced Therapy Product in Patients With Osteoarthrosis and Civilisation Diseases
The aim of the study is to evaluate safety, tolerability and clinical efficacy of a newly developed MesoCellA-Ortho tissue-engineered advanced therapy medicinal product in adult patients suffering with osteoarthritis and…
- Trial name
- BioMiStem-CT (NCT05081921)
- Testing
- MesoCellA-Ortho administration, HA administration
- Where
- Poland
- Volunteers
- 192 people
- Sponsor
- Jagiellonian University
Diabetes Mellitus, Type 1
Automated Insulin Delivery for Type 1 Diabetes - Beyond Glucose Metrics
The goal of this clinical trial is to determine if transitioning to automated insulin delivery (AID) systems, can improve objectively measured sleep quality and quantity and alleviate cardiovascular risk factors in both children…
- Trial name
- AID-BEYOND (NCT06469593)
- Testing
- Automated insuling delivery system
- Where
- 3 sites in Denmark
- Volunteers
- 200 people
- Sponsor
- Steno Diabetes Center Copenhagen
Diabetic Nephropathy
Effect of Pyridorin in Patients With Diabetic Nephropathy
The primary objective of the study is to evaluate the safety, tolerability and efficacy of Pyridorin (pyridoxamine dihydrochloride) up to 250 mg given orally twice daily in patients with diabetic kidney disease.
- Trial name
- NCT00320021
- Testing
- Pyridorin (pyridoxamine dihydrochloride)
- Volunteers
- 80 people
- Sponsor
- BioStratum
Type 1 Diabetes Mellitus
Islet Transplantation Using Abatacept
Islet transplantation in type 1 diabetics with hypoglycemic unawareness using abatacept as a part of a novel calcineurin-inhibitor-sparing immunosuppressive regimen.
- Trial name
- NCT00276250
- Testing
- Efalizumab, Abatacept, Belatacept
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Emory University
Type 1 Diabetes
Registry for Stage 2 Type 1 Diabetes
Stage 2 Type 1 Diabates (T1D) is an early stage of T1D characterized by dysglycemia but not yet leading to clinical symptoms. Progression of the disease to Stage 3 (clinical T1D), leads to overt hyperglycemia requiring eventually…
- Trial name
- NCT06481904
- Testing
- TZIELD (teplizumab-mzwv)
- Where
- 37 sites in United States
- Volunteers
- 200 people
- Sponsor
- Sanofi
Diabetes Mellitus Type 1
Comparison of Basal (Fasting) Glycemic Control in Type 1 Diabetic Patients With CSII Achieved by the Circadian Slide Ruler Scale or Flat Basal Rate
This is a pilot trial to establish study procedures that allow comparison of various starting basal rate profiles used in Continuous Subcutaneous Insulin Infusion (CSII).
- Trial name
- NCT00569452
- Testing
- Accu-Chek Spirit Insulin Pump
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- Hoffmann-La Roche
Caffeine and Carbohydrate, Carbohydrate Only
Caffeine Ingestion to Counter the Exercise-mediated Fall in Glycaemia in Type 1 Diabetes
This project will aim to investigate the clinical efficacy and metabolic effects of a pre-exercise dose of caffeine with a low (10g) dose of carbohydrate (CAF+lowCHO) without modification of insulin degludec on exercise…
- Conditions
- Caffeine and Carbohydrate, Carbohydrate Only, Placebo
- Trial name
- DE-CAF (NCT04671043)
- Testing
- Caffeine and glucose, Glucose alone
- Where
- Switzerland
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
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