Clinical trials: Unipolar Disorder
Major Depression, Bipolar Disorder
Triiodothyronine (T3) Supplementation in the Treatment of Bipolar and Unipolar Depression.
The purpose of this project is to determine whether concurrent treatment of patients with major depression (unipolar or bipolar) with triiodothyronine (T3) and sertraline, will lead to a stronger and/or more rapid antidepressant…
- Conditions
- Major Depression, Bipolar Disorder, Unipolar Depression
- Trial name
- NCT00158990
- Testing
- triiodothyronine, sertraline
- Where
- 2 sites in United States, Israel
- Volunteers
- 220 people
- Sponsor
- Hadassah Medical Organization
Unipolar Depression, Bipolar Depression
The Antidepressant Efficacy of the Anticholinergic Scopolamine
A previous study showed that the intravenous administration of scopolamine produces antidepressant effects. This study is designed to determine if other routes of administration of scopolamine produce antidepressant effects.
- Trial name
- NCT00369915
- Testing
- Scopolamine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- National Institute of Mental Health (NIMH)
Osteoarthritis
Intraarticular Pulse Radiofrequency to Treat Chronic Knee Pain
The purpose of this study is to determine whether bipolar intraarticular pulsed radiofrequency method has a superiority to unipolar mode in the treatment of chronic knee pain.
- Trial name
- NCT02141529
- Testing
- Unipolar pulsed radiofrequency thermocoagulation, Bipolar pulsed radiofrequency thermocoagulation
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Cukurova University
Bipolar Disorder, Depression
Early Detection and Prevention of Mood Disorders in Children of Parents With Bipolar Disorder
This study will develop strategies for early detection and prevention of mood disorders and associated impairment in adolescent children of parents with bipolar disorder.
- Trial name
- NCT00338806
- Testing
- Interpersonal psychotherapy for prevention with adolescents, Educational clinical monitoring
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- New York State Psychiatric Institute
Unipolar Depression
Transcranial Magnetic Treatment (TMS) in Unipolar Depression
Repetitive Transcranial Magnetic Stimulation (rTMS) can improve mood and decrease sadness in patients with depression. In this study, the investigators seek to increase their understanding about how rTMS improves depression, and…
- Trial name
- NCT00186784
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Depression, Unipolar, Bipolar Disorder
Exercise for Depression
A randomized single-blinded prospective study to evaluate the efficacy of an individualized supervised 8-week exercise program in subjects with moderate to severe depressive episodes compared to treatment-as-usual
- Trial name
- EXDEP (NCT02874833)
- Testing
- Exercise
- Where
- 2 sites in Germany
- Volunteers
- 20 people
- Sponsor
- Johannes Gutenberg University Mainz
Depression, Unipolar, Anxiety Disorder Social
Trans-diagnostic Group CBT vs. Standard Group CBT for Depression, Social Anxiety and Agoraphobia/Panic Disorder
Transdiagnostic Cognitive Behavior Therapy (CBT) delivered in the individual format, have been proven just as effective as traditional diagnosis specific CBT manuals.
- Conditions
- Depression, Unipolar, Anxiety Disorder Social, Panic Disorder
- Trial name
- TRACT-RCT (NCT02954731)
- Testing
- UP-CBT, Standard-CBT
- Where
- 4 sites in Denmark
- Volunteers
- 292 people
- Sponsor
- Psychiatric Research Unit, Region Zealand, Denmark
Unipolar Depression, Treatment Resistant Depression
Home-administered tDCS for Treatment of Depression
This study will determine the safety and efficacy of home administered tDCS in adults with unipolar depression. The device used to administer tDCS will be the Soterix Medical 1X1 mini-CT.
- Trial name
- NCT04781127
- Testing
- Soterix Medical mini-CT tDCS stimulator
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Soterix Medical
Major Depression
Serum Markers as a Bioassay for Unipolar Depression
The goal of the study is to validate a biomarker assay for unipolar depression based on serum proteins involved in inflammation, metabolism, and stress response.
- Trial name
- NCT00825799
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Steward St. Elizabeth's Medical Center of Boston, Inc.
Depressive Disorder, Depression
The Role of Inflammatory Processes in Development and Treatment of Depression
The study investigates the influence of inflammatory processes on the development and the course of uni- and bipolar depression.
- Conditions
- Depressive Disorder, Depression, Inflammation
- Trial name
- INFLAME-D (NCT03920475)
- Testing
- Sertraline or venlafaxine, Immune parameters
- Volunteers
- 104 people
- Sponsor
- Kliniken Essen-Mitte
Major Depressive Disorder, Depression
Nitrous Oxide- Suicidal Ideation
Most clinical major depression responds to standard treatments (medication and psychotherapy); however, a significant subset of depressed patients (15-20%) do not respond to these treatments and are referred to as…
- Conditions
- Major Depressive Disorder, Depression, Mood Disorders, Suicidal Ideation
- Trial name
- NCT03736538
- Testing
- Nitrous Oxide
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Washington University School of Medicine
Major Depressive Disorder, Depression
Combinatorial Pharmacogenomics Testing in Treatment-Naïve Major Depressive Disorder
This study aims to determine whether the GeneSight Psychotropic test can result in better treatment outcomes for patients with treatment-naive major depressive disorder
- Conditions
- Major Depressive Disorder, Depression, Depressive Disorder, Depressive Episode
- Trial name
- NCT03537547
- Testing
- GeneSight Psychotropic test, FDA-approved antidepressant or antipsychotic treatment
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Washington University School of Medicine
Depression
Sleep Deprivation Plus Paroxetine for Treating Major Depression in Elderly Individuals
This study will determine the effectiveness of total sleep deprivation (TSD) for one night plus paroxetine versus either TSD plus placebo or paroxetine alone in inducing rapid symptom resolution of major depression in the elderly.
- Trial name
- NCT00178035
- Testing
- paroxetine, One night of Total Sleep Deprivation
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- University of Pittsburgh
Unipolar Depression
Thinking Healthy Program - Peer Delivered (Pakistan)
The rates of perinatal depression in South Asian women are reported to be amongst the highest in the world, ranging from 18%-30% in urban areas and 28%-36% in rural areas.
- Trial name
- THPP-P (NCT02111915)
- Testing
- THPP-P, EUC
- Where
- Pakistan
- Volunteers
- 560 people
- Sponsor
- University of Liverpool
Depressive Disorder, Depression, Unipolar
Safety, Tolerability and Antidepressant Effects of DMT in Patients With Depression
This study aims to evaluate the acute and subacute effects of an inhaled N, N-Dimethyltryptamine (DMT) in patients with partial response in depression.
- Trial name
- NCT06094907
- Testing
- N,N-Dimethyltryptamine
- Where
- Brazil
- Volunteers
- 14 people
- Sponsor
- Universidade Federal do Rio Grande do Norte
Depression, Unipolar
Intermittent Theta-burst Stimulation for Major Depression: an Intensity-response Study
The United States Food and Drug Administration (FDA) approved intermittent theta-burst stimulation (iTBS) in 2018 as a form of repetitive transcranial magnetic stimulation (rTMS).
- Trial name
- NCT06392867
- Testing
- intermittent theta-burst stimulation (iTBS)
- Where
- Hong Kong
- Volunteers
- 246 people
- Sponsor
- The Hong Kong Polytechnic University
Unipolar Depression
Open Study Assessing the Feasibility of Minocycline in Patients With Unipolar Depression
A single center, open label study assessing the feasibility, safety and therapeutic effect of Minocycline in adult patients with diagnosis of unipolar depression.
- Trial name
- NCT01574742
- Testing
- Minocycline
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Shalvata Mental Health Center
Major Depressive Disorder, Depression, Unipolar
Low-Dose Naltrexone (LDN) for Depression Relapse and Recurrence
The purpose of this pilot study is to determine if taking a low dose of naltrexone in addition to an antidepressant medication can help treat relapse or recurrence in people with Major Depressive Disorder (MDD). The U.S.
- Conditions
- Major Depressive Disorder, Depression, Unipolar, Recurrence, Relapse
- Trial name
- NCT01874951
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Massachusetts General Hospital
Atrial Fibrillation (AF)
Local Potential Measurement In PFA: A Pilot Study
This is a pilot study to collect unipolar signal data during a pulsed field ablation study for the treatment of atrial fibrillation and to test the performance of an algorithm designed to measure the local potential of the…
- Trial name
- NCT06877156
- Where
- Croatia
- Volunteers
- 9 people
- Sponsor
- CathVision ApS
Depression, Bipolar, Depression, Unipolar
Chronobiology and Depression: Circadian Analytics as a Biomarker for Depressive Subtypes
An objective measure of treatment response could be a valuable new tool in the armamentarium of depression management, and this holds true for stimulation-based and pharmacological therapies alike.
- Conditions
- Depression, Bipolar, Depression, Unipolar, Healthy
- Trial name
- NCT03538275
- Testing
- Monitoring test
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medibio Limited