Clinical trials: Vagal Nerve Stimulation
Stress, Psychological, Sleep
Stress and Sleep Study
This between-subject, longitudinal pilot study in healthy college students aims to explore the acceptability and preliminary outcomes of two novel and complementary interventions that may improve stress and sleep: transcutaneous…
- Conditions
- Stress, Psychological, Sleep, Transcutaneous Electric Nerve Stimulation, Vagus Nerve Stimulation
- Trial name
- NCT05218109
- Testing
- tVNS, Mindfulness, Number Puzzle
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Florida
Vagus Nerve Stimulation
Multi-device Testing for Autonomic Nervous System Stimulation
The Vagus nerve (VN) serve as an "unconscious inner brain" that integrates messages from the body and provides metabolic homeostatic regulation to various organs.In this study the investigators want to compare different ways to…
- Trial name
- NCT04341649
- Testing
- Manual Head Massage, BREO Helmet Massager, Low Laser Therapy (LLT)
- Where
- China
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Gastroparesis
Vagal Nerve Stimulation for Gastroparesis
This study is investigating a new form of treatment for a digestive disorder called gastroparesis. Gastroparesis is thought to be caused by a mix of inflammation and neural dysfunction.
- Trial name
- VNS (NCT03120325)
- Testing
- Vagal Nerve Stimulation
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Stanford University
Inflammation
Effects of Transvenous Vagus Nerve Stimulation on Immune Response: a Pilot Study
The purpose of this study is to assess the effect of transvenous vagus nerve stimulation (tVNS) on the immune response. In the human endotoxemia model, intravenously administered endotoxin (lipopolysaccharide [LPS]) elicits a…
- Trial name
- NoSIRS (NCT01944228)
- Testing
- Vagal Nerve Stimulation
- Where
- Netherlands
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
U-VNS, Sham U-VNS
Blinding and Adverse Effects of Ultrasonic Vagus Nerve Stimulation (U-VNS)
The vagus nerve is a large nerve that runs from the gut to the brain. It consists of two main sections, left and right, and comprises a series of branches. One of these branches runs through the ear.
- Trial name
- BLAST (NCT07091812)
- Testing
- Ultrasound Vagus Nerve Stimulation (U-VNS)
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Balanced, Aging
Non-Invasive Vagus Nerve Stimulation Combine Postural Training in the Elderly
This three-year research proposal aims to enhance postural control in older adults using non-invasive vagus nerve stimulation (nVNS).
- Trial name
- NCT06768112
- Testing
- Non-Invasive Vagus Nerve Stimulation, balance training, Mini-Mental State Examination
- Where
- Taiwan
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Anxiety, Distress, Emotional
Effect of (TaVNS) on Anxiety and Brain Function in Distressed Health Care Workers
The purpose of this research is to measure alterations in anxiety and brain activity associated with the use of an approved health device called Transauricular Vagal Nerve Stimulation (TaVNS) in distressed persons who work in a…
- Conditions
- Anxiety, Distress, Emotional, Effects of Vibration, Healthy
- Trial name
- fMRIVNS (NCT05132881)
- Testing
- Neuvana 2.0 Transcutaneous Auricular Vagal Nerve Stimulation (TaVNS), Waitlist Control, Healthy Controls: Substudy Group III
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Healthy Volunteers
Non-Invasive Transcutaneous Auricular Vagus Nerve Stimulation Applied at Different Durations in Healthy Adults
This randomized, participant-blinded, sham-controlled interventional study aims to compare the acute effects of non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) applied at different durations on autonomic…
- Trial name
- taVNS-DUR (NCT07532005)
- Testing
- Active taVNS
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Sinop University
Pain, Acute
Antinociceptive Effect of Transauricular Electrical Vagal Nerve Stimulation
This investigation is going to study whether electrical tVNS applied at the cymba of auricular conchae reduces central sensitization of experimentally induced pain in comparison with electrical sham stimulation applied at the…
- Trial name
- TVNS_TSP (NCT04448990)
- Testing
- TENS eco 2 Transauricular vagal nerve stimulation
- Where
- Germany
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Healthy Volunteers
Stimulating Compassion UsingTranscutaneous Vagus Nerve Stimulation
This experimental proof-of-concept study in healthy volunteers investigates whether a specific form of self-relating, namely, self-compassion, can be controlled through non-invasive stimulation of the vagus nerve.
- Trial name
- NCT05441774
- Testing
- Active transcutaneous vagus nerve stimulation, Active self-compassion imagery
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University College, London
Opioid-use Disorder, Opioid Withdrawal
Novel Earpiece for Transcutaneous Auricular Neurostimulation (tAN) for Symptoms of Opioid Withdrawal
The objective of this study is to evaluate whether tAN via the tragus (vagal) and auriculotemporal (trigeminal) nerve pathways results in a clinically meaningful reduction in opioid withdrawal symptoms.
- Trial name
- NCT04731935
- Testing
- Sparrow Therapy System
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Spark Biomedical, Inc.
Parkinson Disease
Research on the Brain Mechanism of taVNS in Regulating PD Motor Symptoms
This study is a double blind comparative study exploring the neural underpinnings of taVNS modulating PD motor deficits. We hypothesize that taVNS might improve PD motor deficits by regulating the balance between excitation and…
- Trial name
- NCT06409338
- Testing
- Transcutaneous auricular vagus nerve stimulation (active）
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Myocardial Injury
Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Myocardial Injury in Elderly Patients Undergoing Thoracoscopic Surgery: a Prospective, Randomized Controlled Study
This research group plans to design a prospective, double-blind, randomized controlled study to explore the effect of taVNS on hs-cTnT in elderly patients undergoing thoracoscopic surgery, and to evaluate the effect on…
- Trial name
- NCT06759818
- Testing
- transcutaneous vagus nerve stimulation
- Where
- China
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital of Jiaxing University
Degenerative Cervical Myelopathy
Vagus Nerve Stimulation for Myelopathy
The objective of this study is to generate preliminary data to establish the feasibility and effectiveness of transauricular vagus nerve stimulation (taVNS) to improve post-operative outcomes of moderate to severe degenerative…
- Trial name
- NCT07660250
- Testing
- Vagus nerve stimulation (taVNS)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Alzheimer Disease, Aging
Vagus Nerve Stimulation to Enhance Memory in Aging
The aim of this study is to determine whether non-invasive vagus nerve stimulation enhances memory formation in cognitively healthy older adults and whether the effects of stimulation depend on gut and brain health.
- Trial name
- VNS (NCT07214194)
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Stanford University
Healthy Volunteers
Different Frequency Applications of Transcutaneous Auricular Vagus Nerve Stimulation in Healthy Individuals
This randomized, participant-blinded, sham-controlled crossover study aims to investigate the acute effects of different frequency applications of transcutaneous auricular vagus nerve stimulation (taVNS) on autonomic…
- Trial name
- taVNS-FREQ (NCT07526402)
- Testing
- taVNS 10 Hz, taVNS 25 Hz, taVNS 50 Hz
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Sinop University
Premature Ejaculation
Vagus Nerve Stimulation in Premature Ejaculation
Introduction: Premature ejaculation (PE), one of the most common sexual dysfunctions in men, negatively affects sexual function and quality of life.
- Trial name
- NCT07300774
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Healthy Volunteers
Using a Transcutaneous Electrical Auricular Stimulator to Harness the Cholinergic Anti-Inflammatory Pathway
Persistent chronic inflammation is an important underlying event in multiple diseases including rheumatoid arthritis, inflammatory bowel diseases and type 2 diabetes.
- Trial name
- TEACAP (NCT02910973)
- Testing
- Vagus Nerve Stimulation
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Cognitive Assessment, Cognition
Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Cognitive Performance and Sex Differences
This study investigates the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on cognitive performance in healthy adults.
- Conditions
- Cognitive Assessment, Cognition, taVNS, Vagus Nerve Stimulation
- Trial name
- NCT07256080
- Testing
- Active taVNS
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Heart Failure With Preserved Ejection Fraction, Heart Failure With Midrange Ejection Fraction
Transcutaneous Vagus Nerve Stimulation in Heart Failure
Several studies have shown that alterations in autonomic nervous system function are implicated in the onset and progression of numerous cardiovascular diseases.
- Trial name
- TRANSFER (NCT05789147)
- Testing
- Active tVNS
- Where
- Italy
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA