Clinical trials: Variability
Overweight, Pre Diabetes
DPP4 Activity, Microvascular Reactivity and Inflammation
Dipeptidyl peptidase 4 (DPP4) is a serine exopeptidase able to inactivate various oligopeptides involved in inflammation, immunity and vascular function.
- Conditions
- Overweight, Pre Diabetes, Diabetes Mellitus Type 2 Without Complication
- Trial name
- DPP4 (NCT03178019)
- Testing
- Laser-Doppler methods
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
NAD
Method Optimization for the Quantification of the NAD
Method optimization for the quantification of the NAD metabolome in human whole blood, and evaluation of baseline inter and intra-subject variability.
- Trial name
- NCT05561712
- Testing
- Laboratory method validation
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Vagus Nerve Stimulation, Autonomic Nervous System
Frequency-Dependent Effects of Auricular Vagus Nerve Stimulation on Autonomic and Cardiovascular Parameters
This randomized, sham-controlled, crossover study investigates the acute autonomic effects of transcutaneous cervical vagus nerve stimulation (tcVNS) applied at five different frequencies (0 Hz/sham, 10 Hz, 25 Hz, 50 Hz, 100 Hz)…
- Conditions
- Vagus Nerve Stimulation, Autonomic Nervous System, Heart Rate, Blood Pressure
- Trial name
- AVNS-DRC (NCT07274332)
- Testing
- Pulsetto FIT™ - tcVNS 10 Hz, Pulsetto FIT™ - tcVNS 25 Hz, Pulsetto FIT™ - tcVNS 50 Hz
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- SEFA HAKTAN HATIK
Heart Rate Variability
Effects of Repetitive Transcranial Magnetic Stimulation on Heart Rate Variability
Repetitive transcranial magnetic stimulation is a non-invasive neuromodulation technique used to treat different neuropsychiatric disorders, such as, depression, neuropathic pain, fibromyalgia and obsessive-compulsive disorder.
- Trial name
- TMSXHRV (NCT03739489)
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Behavior, Social, Autonomic Imbalance
Coping Strategies and Responsiveness to a Brief Online Intervention During COVID-19 Pandemic
The present study investigates the efficacy of a brief and cost-effective video-intervention that combines bottom-up elements of deep breathing and third-wave cognitive behavioral therapy techniques (i.e., mindfulness and…
- Trial name
- NCT04382560
- Testing
- Deep Breathing training, Compassion focused intervention
- Where
- Italy
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Parma
Warm Footbath, Cardiovascular System
Temperature-dependent Changes in Cardiovascular Parameters During Warm Water Footbaths in Healthy Women
A study to explore whether different temperatures of warm water footbaths have different effects on the cardiovascular system, the autonomic nervous system and the general well-being of healthy women.
- Conditions
- Warm Footbath, Cardiovascular System, Autonomic Nervous System
- Trial name
- NCT04579497
- Testing
- 38°C warm water footbath, 40°C warm water footbath, 42°C warm water footbath
- Where
- Germany
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- ARCIM Institute Academic Research in Complementary and Integrative Medicine
Atrial Fibrillation, Stroke
Wearable ECG for AF Screening and Stroke Risk Assessment
This study aims to evaluate the application of wearable ECG garments in atrial fibrillation (AF) screening and stroke risk assessment.
- Trial name
- NCT06907264
- Testing
- Wearable ECG Garment for Continuous Atrial Fibrillation Screening and Stroke Risk Assessment
- Where
- 2 sites in China
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Personalized Nutrition
N=1 Trials of Individual Variability in Post-prandial Glycemic Responses to Diets of Varying Macronutrient Composition
The key objective of this study is to identify the most suitable diet (i.e. high protein, high fat, low GI, high GI) for an individual.
- Trial name
- NCT05402085
- Testing
- High Protein Diet, High Fat Diet, High Carbohydrate-Low Glycemic Index Diet
- Where
- Singapore
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Elderly Subjects, Respiration Exercises
Effects of Respiratory Yoga Training on Heart Rate Variability and Baroreflex of Healthy Elderly Subjects
The decreases of physiological capacities which take place with senescence include diminishing respiratory capacity as well as a reduction of heart rate variability and baroreflex sensibility.
- Trial name
- NCT00969345
- Testing
- Stretching Exercises, Respiratory Exercises conducted twice a day for 10 minutes
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Apnea, Circulatory; Change
Plethysmography Curve Variability Depending on the Breath Cycle
The aim of the study is to analyze the variability of plethysmography curve depending on the breath cycle (respiratory rate and tidal volume).
- Conditions
- Apnea, Circulatory; Change, Respiration
- Trial name
- NCT05302219
- Testing
- Respiratory rate, Tidal volume, Apnea
- Where
- Czechia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Czech Technical University in Prague
Fall, Gait, Unsteady
Non-invasive Brain Stimulation to Improve Unsteady Gait in Older Adults (StimGait)
Walking is a complex and continuous task that entails repetitive motions of the body. Relatively high gait variability sensitively predicts falls and cognitive decline in older adults.
- Conditions
- Fall, Gait, Unsteady, Mobility Limitation
- Trial name
- NCT06008431
- Testing
- Transcranial direct current stimulation (tDCS) (active)
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Hebrew SeniorLife
Healthy Subjects
Microvascular Sex and Age-related Day-to-day Variability in Healthy Subjects
The goal of this observational study is to learn more about the microcirculation in the skin by examining sex and age-related day-to-day variability in healthy subjects.
- Trial name
- NCT06009939
- Testing
- Occlusion of the circulation in the arm and foot
- Where
- Sweden
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Vårdcentralen Åby
Depressive Disorder, Major
Probiotics and the Gut Brain Axis- Do Probiotics Interact With the Vagal Nerve?
The purpose of this study is to investigate the effects of a multispecies probiotic on the function of the vagal nerve in patients with major depression and healthy participants in a single-center, randomized, placebo-controlled…
- Trial name
- ProBIO-HRV (NCT04772664)
- Testing
- Multispecies-Probiotic
- Where
- Austria
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Autonomic Dysfunction
Cardiac Autonomic Modulation in Older Hypertensive Individuals Submitted to Different Types of Physical Training
Sixty-one sedentary older hypertensive individuals were randomized to four groups: continuous aerobic training (CA), interval aerobic training (IA), resistance training (R), and control (C) group.
- Trial name
- NCT05135247
- Testing
- Exercise
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Stress, Stress, Psychological
The Effect of SKY Breath Meditation on Health and Well-being
The goal of this pilot SKY (Sudarshan Kriya Yoga) Breath Meditation study is to establish feasibility and acceptability of the intervention; and investigate preliminary effectiveness of the intervention at the DNA methylation…
- Conditions
- Stress, Stress, Psychological, Stress, Physiological, Anxiety
- Trial name
- NCT05523414
- Testing
- SKY
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Psychological Trauma
A Couples' Intervention Protocol for PTSD
Posttraumatic stress disorder (PTSD) is a multifaceted disorder resulting from intense and/or life-threatening trauma. PTSD sequelae often have a ripple effect on close others, including spouses and children.
- Trial name
- NCT05045859
- Testing
- CBCT for PTSD
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Bar-Ilan University, Israel
Pain
Patient and Provider Confidence and Satisfaction With the Clinical Use of CYP Genetic Variability
This study utilizes the Medication DNA Insight™ tests for pain and mental health medications. We are testing the pain and mental health medications commonly used in pain treatment.
- Trial name
- Genomics (NCT02568618)
- Testing
- Pain Medication DNA Insight (TM) test
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Defense and Veterans Center for Integrative Pain Management
Cerebral Hypoxia
The Effects of Hypobaria vs Hypoxia on Cerebral Functions.
The investigators will investigate the effect of hypobaria and hypoxia on physiological responses such as: oxygen saturation, heart rate, cerebral blood flow, cerebral oxygenation, brain's activity and concentration performance.
- Trial name
- Hypoxia (NCT03303118)
- Testing
- Hypoxia
- Where
- Switzerland
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Fliegerärztliches Institut
Autonomic Neuropathy
A Comparison Between Pupillometry, Heart Rate Variability and Metaiodobenzylguanidine Scintigraphy for the Diagnosis of Early Diabetic Autonomic Neuropathy in Type 1 Diabetes
This study will examine if one of the following methods: pupillometry, spectral analysis of heart rate variability and metaiodobenzylguanidine scintigraphy, is more capable to detect early diabetic autonomic neuropathy in…
- Trial name
- NCT01822431
- Testing
- metaiodobenzylguanidine scintigraphy
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- AHEPA University Hospital
Healthy Young Adults, Physical Activity Levels
Differences in Autonomic Recovery Between Physically Active and Inactive Women Following an Automated Massage Chair Intervention
The goal of this study is to investigate whether an automated massage chair can improve the body's recovery system in healthy young women (aged 19-26 years) who are either physically active or inactive.
- Conditions
- Healthy Young Adults, Physical Activity Levels, Inactive People
- Trial name
- NCT07529678
- Testing
- Massage chair
- Where
- Malaysia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia