Clinical trials: Variability
Physical Fitness
BPIT 5-Week Multi-Site Study: Movement Efficiency, Mobility & Neuromuscular Adaptation
This prospective, multi-site, single-arm interventional study evaluates the 5-Line Principle of Balanced Progressive Intensity Training (BPIT) over 5 weeks in healthy adults aged 18-65 years.
- Trial name
- BPIT_5LINE_369 (NCT07256717)
- Testing
- Balanced Progressive Intensity Training (BPIT) 5-Line Method
- Where
- 10 sites in United States, India
- Volunteers
- 369 people, healthy volunteers welcome
- Sponsor
- MMSx Authority Institute for Movement Mechanics & Biomechanics Research Inc.
Respiratory Failure
Comparative Effects of Variable Pressure Support, NAVA and PAV
Experimental animal data suggest that increasing breathing pattern variability in mechanical ventilation could be beneficial. Variable ventilation can be induced through the following modes: Neurally Adjust Ventilatory Assist…
- Trial name
- NCT02499276
- Testing
- PSV, NAVA, PAV, Variable-PSV
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil
HRV, Psychological Adaptation
Weight Cut Stress: the Hidden Struggle Beyond Fight Day
This study investigated the effects of rapid weight-cutting on stress in elite kickboxers by analyzing Heart Rate Variability (HRV) and subjective stress levels using a Visual Analog Scale (VAS).
- Trial name
- NCT06860204
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Erzurum Technical University
Obstructive Hypertrophic Cardiomyopathy (oHCM)
Biological Collection for the Purpose of Exploring Genetic and Clinical-biological Factors Associated With Variability in Response to Mavacamten in the Treatment of Obstructive Hypertrophic Cardiomyopathy
The European Medicines Agency has required pre-treatment genotyping of CYP2C19 to determine the initial and maximum dosage, in order to avoid overexposure to mavacamten associated with a decrease in ventricular ejection fraction…
- Trial name
- MAVA PG (NCT07439952)
- Where
- 3 sites in France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Non Valvular Atrial Fibrillation
Apixaban Versus Rivaroxaban in Non Valvular Atrial Fibrillation
The investigators will first measure the maximum concentration (after 2 hours of intake) and the residual concentration (just before the next intake) after at least 15 consecutive days of treatment.
- Trial name
- APIXA-Xa (NCT06862726)
- Testing
- Anti Xa dosage, Dosage of PT-INR
- Where
- Tunisia
- Volunteers
- 120 people
- Sponsor
- Les Laboratoires des Médicaments Stériles
Diabetes Mellitus, Type 2
Insulin Glargine U300 vs Insulin Degludec U100 in Impact on the Glycaemic and Cardiovascular Factors
To compare the impact of insulin degludec (IDeg-100) and insulin glargine U300 (IGlar-300) on cardiovascular risk parameters - glycaemic variability (GV), oxidative stress, arterial stiffness and lipid parameters - in insulin…
- Trial name
- NCT04692415
- Testing
- Degludec, Glargine U300
- Where
- Croatia
- Volunteers
- 25 people
- Sponsor
- University of Split, School of Medicine
Decisional Variability by Presentation Methods for Consensus
Protocol Lab for Online Trials-Delphi
The Protocol Lab for Online Trials-Delphi (PLOT-D) module will use an online three-round Delphi combined with Participatory action research to inform the development of a multi-use protocol template to use in writing protocols…
- Trial name
- PLOT-D (NCT03498690)
- Testing
- Integrative, Role specific, Consecutive
- Where
- United Kingdom
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- ThinkWell
Mood Disorder, Mania
Assessment of Cardiac Autonomic Behavior in Patients With Mood Disorders
The purpose of this study is to characterize the behavior of cardiac patients with Mood Disorders and its clinical course, interpreting the results from a theoretical framework of Chaos Theory and Complexity Theory and Systems as…
- Conditions
- Mood Disorder, Mania, Depression
- Trial name
- NCT01272518
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Sao Jose do Rio Preto Medical School
Arteriosclerosis Obliterans
Preoperative Heart Rate Variability and Baroreflex Sensitivity in ASO Patients During Various Sleep Stages
The goal of this study is to evaluate the possible preoperative predictive value of altered heart rate variability (HRV) and baroreflex sensitivity in different sleep stages for postoperative adverse cardiac events (i.e.
- Trial name
- Barosleep (NCT00712946)
- Where
- Finland
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Metabolic Disease, Diabetes
Dietary Protein Sources and Glycemic Variability
This goal of trial is to evaluate the effects of plant-based vs. animal-based diets on glycemic variability in overweight or obese adults through a 3-week dietary intervention.
- Conditions
- Metabolic Disease, Diabetes, Overweight, Obesity
- Trial name
- ProG (NCT06525441)
- Testing
- Plant-based Diet, Animal-based Diet
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial People's Hospital
Neuroplasticity in Motor Learning
Neuroplasticity in Motor Learning in Young Adults Under Variable and Constant Practice Conditions
The project aims at providing a better understanding of motor skill acquisition and learning processes. The primary objectives of the study are to determine how practice conditions, i.e., variable and constant practice…
- Trial name
- NMLPC (NCT04921072)
- Testing
- Constant practice conditions, Variable practice conditions
- Where
- Czechia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Substance-Related Disorders
Resonance Breathing Intervention Opioid Use Disorder
This study aims to assess the feasibility of an intervention for the management of craving, stress, anxiety, and depression among people who use opioids via a resonance breathing smartphone app.
- Trial name
- NCT05830773
- Testing
- Resonance Breathing Exercises
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Healthy
Renal Magnetic Resonance (MR) Elastography in Healthy Volunteers
MR Elastography is a new technique aimed at non-invasively measuring the stiffness of tissues. It has recently given interesting results in the assessment of liver fibrosis. The objectives of the current study are: 1.
- Trial name
- MRE_Rénale (NCT00876629)
- Testing
- Pneumatic Driver
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Diabetes
Pharmacodynamic and Pharmacokinetic Variability of a Basal Insulin (0000-168)
The purpose of this study is to evaluate whether the within-subject variation in duration of action and time-action profile of glargine measured by isoglycemic clamp will be below prespecified levels.
- Trial name
- NCT01152242
- Testing
- Isoglycemic Clamp, Comparator: insulin glargine
- Volunteers
- 36 people
- Sponsor
- Merck Sharp & Dohme LLC
Child Development, Early Child Development
Intergenerational Risk and Resilience of Rohingya in Displacement
The iRRRd study is an ongoing prospective longitudinal prenatal birth cohort study based in Cox's Bazar, Bangladesh. Between February 2023 and March 2024, 2,888 pregnant women were enrolled (approximately 80% Rohingya refugees…
- Conditions
- Child Development, Early Child Development, Mental Health, PTSD - Post Traumatic Stress Disorder
- Trial name
- iRRRd (NCT07758283)
- Where
- Bangladesh
- Volunteers
- 2,200 people
- Sponsor
- New York University
Clozapine-induced Sinustachycardia
Treating Clozapine-induced Sinustachycardia With Bisoprolol
Clozapine-induced sinustachycardia occurs in 25% of patients treated with clozapine and sustained sinustachycardia might be a risk factor for dilated cardiomyopathy.
- Trial name
- Biscloz (NCT00882856)
- Testing
- Bisoprolol
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- University of Aarhus
Cardiac Arrest, Fear
The Care After Life-threatening Medical Events Study
This study tests the feasibility of a home-based heart rate variability biofeedback (HRVB) intervention in survivors of cardiac arrest (CA).
- Trial name
- CALME (NCT04589559)
- Testing
- Heart Rate Variability Biofeedback Training
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Columbia University
Stress, Acute Stress
Neurophysiological and Autonomic Responses to Acute Physical and Emotional Stress: An EEG Study
This study aims to investigate neurophysiological, autonomic, and subjective responses to different acute physical and emotional stress-inducing conditions using a within-subject repeated-measures design.
- Trial name
- NCT07781670
- Testing
- Cold Pressor Test, Negative Autobiographical Memory Recall, Affective Picture-Viewing Task
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pavia
Spastic Cerebral Palsy
Repeatability of Gait Deviations in Children With Cerebral Palsy
Three-dimensional gait analysis (3DGA) is the 'gold standard' for measurement and description of gait. Gait variability can arise from intrinsic and extrinsic factors and may vary between walking conditions.
- Trial name
- NCT06355869
- Testing
- repeated 3D gait-analysis
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Congenital Bleeding Disorder, Haemophilia A
Intra-subject Variability Following Administrations of Activated Recombinant Human Factor VII in Haemophilia Patients in a Non-bleeding State
This trial is conducted in Asia and Europe. The aim of this trial is to evaluate the intra-subject variability of thromboelastographic parameters (TEG® and ROTEM®) following two administrations of activated recombinant human…
- Conditions
- Congenital Bleeding Disorder, Haemophilia A, Haemophilia B
- Trial name
- NCT01562457
- Testing
- activated recombinant human factor VII
- Where
- 3 sites in France, Germany and 1 more
- Volunteers
- 30 people
- Sponsor
- Novo Nordisk A/S
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