Clinical trials: Vascular Aging
Aging, Fragility
Ischemic Conditioning to Promote Microvascular Resiliency in Frail Individuals
The goal of this clinical trial is to see how small blood vessels respond to the stress of high intensity exercise, and if a safe and simple intervention called ischemic conditioning can protect blood vessels from the stress of…
- Conditions
- Aging, Fragility, Endothelial Dysfunction
- Trial name
- NCT05808686
- Testing
- Ischemic Conditioning
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Transgender, Gender Identity
Effects of Aging and Gender-Affirming Hormone Therapy on Vascular Endothelial Function and Metabolic Profiles in Transgender Women
This study will examine markers of vascular endothelial function (vascular health) and metabolic profiles in younger versus older transgender women (people who were assigned male at birth but whose gender identity is female).
- Conditions
- Transgender, Gender Identity, Vascular Stiffness, Vascular Inflammation
- Trial name
- NCT04066283
- Testing
- No intervention
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Elderly, Sedentary
Mechanisms and Functional Outcomes of Exercise Progression Models in the Elderly
The aim of this study is to devise a sufficiently high intensity training program that provided an optimal stimulus to remove the peripheral factors known to reduce functional capacity, and can be cardiovascular and…
- Trial name
- FIT (NCT01899586)
- Testing
- Regional Specific Training Stimulus (RSTS), Aerobic Exercise Regimen (AE)
- Where
- 2 sites in United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Duke University
Hypertension, Aging
Nicotinamide Riboside for Treating Elevated Systolic Blood Pressure and Arterial Stiffness in Middle-aged and Older Adults
Aging is the primary risk factor for cardiovascular diseases (CVD), the number one cause of death in developed societies. Systolic blood pressure (SBP) increase with age and is a key intermediary factor linking aging to increased…
- Trial name
- NCT03821623
- Testing
- Nicotinamide riboside
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Douglas Seals
Heart Failure With Normal Ejection Fraction
The Heart Failure With Preserved Ejection Fraction (HFpEF) Pathophysiology Study.
The study addresses the hypothesis that a gradual build-up in arterial resistance and microvascular endothelial dysfunction due to common comorbidities such as hypertension and diabetes mellitus, on top of age related vascular…
- Trial name
- IDENTIFY-HF (NCT03186833)
- Testing
- no intervention
- Where
- United Kingdom
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Aging
Chronic Passive Heating in Healthy Older Adults
Aging is associated with a decline in cardiovascular health, cognitive function and losses in muscle strength, with half or more of those over age 65 suffering from two or more comorbidities (e.g., heart disease, type 2…
- Trial name
- NCT05618197
- Testing
- Passive heating
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Portsmouth
Persistent COVID-19, Quality of Life
Vascular Structure, Vascular Function and Vascular Aging in Adults Diagnosed With Persistent COVID
The ICOPER study aims to analyze the structure, vascular function, vascular aging and determining factors in 300 adults diagnosed with Persistent Covid in the field of Primary Health Care.
- Conditions
- Persistent COVID-19, Quality of Life, Lifestyles, Arterial Stiffness
- Trial name
- ICOPER (NCT05819840)
- Where
- Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Investigacion y Formacion en Ciencias de la Salud
Hot Weather; Adverse Effect, Healthy
Characterization of Myocardial Blood Flow During Heat Exposure
The purpose of this study is to determine the increase in myocardial blood flow during heat exposure and how this response is affected by age and coronary artery disease.
- Conditions
- Hot Weather; Adverse Effect, Healthy, Coronary Artery Disease, Aging
- Trial name
- PET-Heat (NCT04549974)
- Testing
- Heat exposure
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Montreal Heart Institute
Vascular Endothelium, Microvascular Circulation
Healthy Age-dependent Reference Values for Microvascular Structure and Function
The greatest challenge in our ageing society are cardiovascular diseases such as stroke, heart attack, peripheral artery disease of the legs with non-healing wounds (ulcers), or diabetes.
- Conditions
- Vascular Endothelium, Microvascular Circulation, Arterial Stiffness, Healthy Ageing
- Trial name
- NCT04897191
- Testing
- Age
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Healthy Young, Healthy Aging
Reactive Balance Training for Fall Prevention
The objective of this pilot study is to evaluate and compare the effect of three different perturbation based training devices on the reactive balance control among healthy young adults, healthy older adults, and neurologically…
- Conditions
- Healthy Young, Healthy Aging, Stroke
- Trial name
- NCT04205279
- Testing
- Experimental: Treadmill training, Experimental: Overground training, Experimental: Surefooted training
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Healthy, Ageing
Can Cocoa Flavanols Protect Endothelial Function During Prolonged Sitting in Healthy Older Adults?
Sitting time is high in older adults and has been shown to temporarily impair endothelial function and blood pressure. Flavanols, plant-derived compounds, acutely enhance endothelial function and reduce Blood pressure in older…
- Trial name
- NCT07265869
- Testing
- High-flavanol cocoa powder, Low-flavanol cocoa powder
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Aging
The Effect of NAD Supplementation on Brain Vascular Health in Aging
Daily consumption of one of the forms of Vitamin B3, the Nicotinamide Riboside (NR), energizes the body and combats cellular aging. This study is designed to test whether NR can also improve brain health and memory.
- Trial name
- NCT05483465
- Testing
- Nicotinamide riboside
- Where
- United States
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Cardiovascular Diseases, Inflammation
Impact of T Cells on Age-related Vascular Dysfunction: A Translational Approach
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States and other industrialized societies, and advanced age is the major risk factor for development of CVD.
- Conditions
- Cardiovascular Diseases, Inflammation, Aging
- Trial name
- NCT04344873
- Testing
- Abatacept 10 mg/kg
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Utah
Aging, Brain Metabolic Disorder
Monitoring of Brain Metabolites Using Proton and Deuterium MR Techniques
MR pulse for whole brain optimal Deuterium (2H) Metabolic Imaging and EPSI (echo planar spectroscopic imaging) based SLOW-edited 1H-MRSI will be developed and optimized for use at an UHF scanner at 7 Tesla.
- Conditions
- Aging, Brain Metabolic Disorder, Carotid Stenosis, Alzheimer Disease
- Trial name
- SIGNATURES2023 (NCT06705010)
- Testing
- Application of new pulse sequence package SIGNATURES2023 to healthy controls, Application of new pulse sequence package SIGNATURES2023 to 4 groups of patients (pilot)
- Where
- Switzerland
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cardiovascular Disease, Aging
Effects of Age and Exercise on Blood Pressure Regulation
The purpose of this study is to investigate the effects of age, exercise and cardiovascular disease on blood pressure.
- Trial name
- NCT00319397
- Testing
- Exercise-Training Program
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Physical Inactivity, Aging
The Effects of 8 Weeks Post Exercise Hot Water Immersion on Vascular and Cardiometabolic Health in Physically Inactive Middle-aged Adults
This research project aims to determine whether post exercise hot water immersion can improve vascular and cardiometabolic health to a greater extent than post exercise thermoneutral water immersion in healthy middle-aged adults.
- Trial name
- NCT05409404
- Testing
- Aerobic exercise + hot water immersion, Aerobic exercise + thermoneutral water immersion
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Coventry University
Alzheimer Disease, Dementia
Accelerated Non-Atherosclerotic Brain Arterial Aging Relationship to Alzheimer's Disease
The aging of the United States (US) population will lead to a steep rise in Alzheimer disease (AD). There is an urgent need for novel therapies that may tackle this looming societal problem.
- Trial name
- NCT04510168
- Testing
- 11C-ER176, [F-18]MK-6240, Florbetaben
- Where
- United States
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Jose Gutierrez, MD, MPH
HIV, Cardiovascular Disease
Ugandan Non-Communicable Diseases and Aging Cohort
Longitudinal cohort study of older-aged people living with HIV infection in southwestern Uganda and age and gender-matched HIV uninfected controls with the primary aim of measuring the epidemiology of cardiovascular and pulmonary…
- Conditions
- HIV, Cardiovascular Disease, Chronic Obstructive Pulmonary Disease, Atherosclerosis
- Trial name
- UGANDAC (NCT02445079)
- Testing
- This is an observational study only
- Where
- Uganda
- Volunteers
- 309 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Abdominal Obesity, Metabolic Syndrome
WAVE Study- Walking and Aging in VErona Study
Monocentric unblinded two parallel-group randomized controlled trial to evaluate the effect of diet with or without Nordic Walking on weight loss, physical performance and cardiovascular risk factors in overweight and obese…
- Conditions
- Abdominal Obesity, Metabolic Syndrome, Disability Physical, Sarcopenic Obesity
- Trial name
- WAVE (NCT03212391)
- Testing
- Diet, Walking, Nordic Walking
- Where
- Italy
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Healthy Aging, Vascular Dilation
Effects of a Supplement to Target Ageing Mechanisms on Vascular Function (STAMINA)
In the ageing society, extending the healthy lifespan is a major challenge and a healthy diet may play an import role in maintaining health throughout life.
- Trial name
- STAMINA (NCT06145087)
- Testing
- "NOVOS Core" supplement
- Where
- United Kingdom
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Surrey