Clinical trials: Vascular Neurocognitive Disorder
Cerebrovascular Disease
Multi-Modality Imaging Standard Cohort Of Cerebrovascular Disease
The aim of this study is to establish a multi-center and multi-modality imaging standard cohort of cerebrovascular disease, analyze the potential mechanisms affecting the prognosis of cerebrovascular disease based on a variety of…
- Trial name
- NCT06925178
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Ischemic Stroke, Transient Ischemic Attack (TIA)
Ambulatory Stroke Unit Treatment for Elderly Patients
ARTIFICE is a prospective, multicenter, randomized, controlled, exploratory non-inferiority trial evaluating whether an ambulatory stroke unit model (aSU) is non-inferior to conventional inpatient stroke unit care (SU) in…
- Conditions
- Ischemic Stroke, Transient Ischemic Attack (TIA), Retinal Ischemia
- Trial name
- ARTIFICE (NCT07420374)
- Testing
- Ambulatory Stroke Unit Care, Conventional Stroke Unit Care
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- University Hospital Heidelberg
Genetic Predisposition, Paraganglioma
Using the EHR to Advance Genomic Medicine Across a Diverse Health System
Given the expansion of indications for genetic testing and our understanding of conditions for which the results change medical management, it is imperative to consider novel ways to deliver care beyond the traditional genetic…
- Conditions
- Genetic Predisposition, Paraganglioma, Pheochromocytoma, ALS
- Trial name
- NCT06377033
- Testing
- Behavioral nudge
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Pennsylvania
Mild Cognitive Impairment
Study on Ginkgo Biolba Extract Fifty and Mild Cognitive Impairment Associated With CSVD
This study aimed to explore the efficacy and safety of Ginkgo Biolba Extract fifty in treating mild cognitive impairment associated with cerebral small vessel disease (CSVD).
- Trial name
- GRACE (NCT06495476)
- Testing
- Ginkgo biloba extract 50 dropping pills, Ginkgo biloba extract Ginkgo biloba extract 50 Drops simulant
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Beijing Tiantan Hospital
Dementia, Dementia, Vascular
Factors Associated With Mortality, Morbidity and Prognosis in Dementia Patients
Dementia; It is a chronic syndrome characterized by a general and progressive deterioration in cognition, including memory, orientation, language, and comprehension.
- Conditions
- Dementia, Dementia, Vascular, Dementia With Lewy Bodies, Dementia of Alzheimer Type
- Trial name
- NCT05052450
- Testing
- Observational
- Volunteers
- 1,000 people
- Sponsor
- Gulhane Training and Research Hospital
Hypotension, Cognitive Impairment
Comparing Fluid Responsiveness Assessment Methods in Patients With Impaired Consciousness
Hypotension is a significant precursor to unfavorable clinical outcomes. To determine whether infusion therapy can positively impact the management of hypotension, several evaluative tests can be utilized.
- Trial name
- NCT06180902
- Testing
- Inferior vena cava's diameter ratio, Central venous pressure, Passive leg raising test
- Where
- Russia
- Volunteers
- 222 people
- Sponsor
- Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology
Alzheimer Disease, Cognitive Impairment
The Clinical Impact of the Novel Alzheimer's Blood-based Biomarkers
The goal of this observational study is to determine whether the early adoption of blood-based biomarkers for Alzheimer's disease is associated with an impact on etiological diagnosis, patient's management, emotional impact…
- Conditions
- Alzheimer Disease, Cognitive Impairment, Dementia, Neurodegenerative Diseases
- Trial name
- PLASMAR (NCT06246019)
- Testing
- Early adoption of blood-based biomarkers for Alzheimer's disease
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Hospital del Mar Research Institute (IMIM)
Neurologic Manifestations, Psychiatric Disorders
Cohort of Patients With Covid-19 Presenting Neurological or Psychiatric Disorders (CoCo-Neurosciences)
Covid-19 pandemic now affects more than two million people worldwide. The neurotropism of the virus is assumed by its frequent association with neurological symptoms (anosmia, ageusia, headaches) but the extent of the central or…
- Conditions
- Neurologic Manifestations, Psychiatric Disorders, COVID-19
- Trial name
- CoCo-Neuro (NCT04362930)
- Where
- France
- Volunteers
- 730 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stroke, Mild Cognitive Impairment
Investigating Neurocognitive, Motor and Biological Effects of MindLenses Professional in Neurological Diseases
This study aims to explore the effects of the treatment with MindLenses Professional device on cognitive and motor performances,as well as on the levels of a neurotrophic factor implied in brain plasticity, that is the brain…
- Trial name
- MindLensesN (NCT05826626)
- Testing
- MindLenses Professional, Conventional rehabilitation
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Stroke, Cognitive Decline
Association Between Blood Pressure and Risk of PSCI
This retrospective cohort study was designed to explore the relationship between blood pressure and cognitive impairment after stroke
- Conditions
- Stroke, Cognitive Decline, Blood Pressure
- Trial name
- NCT06730711
- Where
- China
- Volunteers
- 600 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Neurodegenerative Diseases, Alzheimer Disease
Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease - Retrospective Register Study
In this retrospective register study, clinically classified individuals with neurodegenerative disease from the years 2010-2021 will be verified from the clinical records from KUH and Oulu University Hospital (OUH).
- Conditions
- Neurodegenerative Diseases, Alzheimer Disease, Frontotemporal Dementia, Lewy Body Disease
- Trial name
- DEGERWD (NCT06209515)
- Where
- Finland
- Volunteers
- 61,292 people
- Sponsor
- Kuopio University Hospital
TBI (Traumatic Brain Injury), Stroke
Guided Training for People With Cognitive Impairment
Abstract Objective: Investigators examined the feasibility of applying a participation-focused strategy training intervention to community-dwelling adults with cognitive impairments following stroke and brain injury and evaluated…
- Conditions
- TBI (Traumatic Brain Injury), Stroke, Cognitive Impairment
- Trial name
- GTPCI (NCT03225768)
- Testing
- Guided Training
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Taipei Medical University WanFang Hospital
Stroke, Attention Disorder
Virtual-reality Exercises for Alleviating Attention Deficits in Patients With Acquired Brain Injury
Stroke is the leading cause of long-term disability with an increasing incidence, especially in young adults. Among the cognitive difficulties following brain damage, deficits in attention are frequent and pervasive, affecting…
- Trial name
- NCT05728840
- Testing
- Immersive virtual reality gamified cognitive activities, Double neuropsychological standard activities
- Where
- Switzerland
- Volunteers
- 135 people
- Sponsor
- Mindmaze SA
Vascular Dementia
The Clinical Trial of Chinese Herbal Medicine (SaiLuoTong) Capsule
As a traditional Chinese medicine compound, SaiLuoTong capsule is proven to have beneficial effects on learning and memory ability in animal models of vascular dementia (VaD).
- Trial name
- NCT03789760
- Testing
- SaiLuoTong capsule
- Where
- 29 sites in China
- Volunteers
- 493 people
- Sponsor
- Shineway Pharmaceutical Co.,Ltd
Alzheimer's Disease, Stroke
Safety Study of AVP-923 in the Treatment of IEED (Involuntary Emotional Expression Disorder) Also Known as Pseudobulbar Affect (Episodes of Uncontrolled Crying and/or Laughter)
The purpose of this study is to evaluate the long-term safety of AVP-923 in the treatment of Involuntary Emotional Expression Disorder (IEED) also known as Pseudobulbar Affect (episodes of uncontrolled crying and/or laughter).
- Conditions
- Alzheimer's Disease, Stroke, Parkinson's Disease, Traumatic Brain Injury
- Trial name
- NCT00056524
- Testing
- AVP-923
- Where
- 39 sites in United States
- Volunteers
- 600 people
- Sponsor
- Avanir Pharmaceuticals
Intracranial Meningioma
Cognition-preserving Brain Irradiation for Treating Patients With Intracranial Meningioma in the Era of Modern Radiotherapeutic Techniques Including Proton Beam Therapy - a Prospective Study Focusing on Radiological Outcomes and Neurocognitive Endpoints
【Background】For cranial-irradiation-naive patients with intracranial meningiomas at risk of local recurrence, the administration of conformal cranial radiotherapy can enhance tumor control in the current era of modern…
- Trial name
- NCT05832099
- Testing
- Radiation
- Where
- Taiwan
- Volunteers
- 74 people
- Sponsor
- Chang Gung Memorial Hospital
Cognitive Decline
Evaluating the Impact of Cerebral Ischemic And Degenerative Changes On Cognition
The purpose of this study is to evaluate whether or not cerebral atrophy scores obtained from a brain MRI can correlate with Cognitive Test results.
- Trial name
- NCT00704327
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Lahey Clinic
Hypertension
The Effect of Antihypertensive Medication Timing on Morbidity and Mortality
High blood pressure is common and its presence increases the risk of cardiovascular mortality and morbidity (most notably stroke, myocardial infarction, and congestive heart failure).
- Trial name
- NCT02990663
- Testing
- Use of blood pressure lowering medication at bedtime, Use of blood pressure lowering medication in the morning
- Where
- 5 sites in Canada
- Volunteers
- 3,357 people
- Sponsor
- University of Alberta
Cognitive Impairment, Estrogen Deficiency
Effects of Ovarian Hormone Suppression on Vascular and Cognitive Function
Complaints about memory and thinking are common in women as they go through menopause. The female hormone estrogen is important for both the health of both the brain and the blood vessels.
- Conditions
- Cognitive Impairment, Estrogen Deficiency, Menopause, Endothelial Dysfunction
- Trial name
- NCT03112226
- Testing
- GnRHant + E2
- Where
- 2 sites in United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Stroke, Cognitive Impairment
White Matter Connections and Memory: the STRATEGIC Study
In patients who have had a stroke, memory problems are common. Some patients with memory problems improve over the first year after stroke, but recovery is unpredictable.
- Conditions
- Stroke, Cognitive Impairment, Memory Impairment
- Trial name
- STRATEGIC (NCT03982147)
- Volunteers
- 193 people
- Sponsor
- King's College London