Clinical trials: Vascular Risk
Deep Vein Thrombosis
The STOP CLOT Pilot Study: Study of Low Molecular Weight Heparin in High Risk Cesarean Section
Venous thromboembolism (VTE) remains the most common cause of maternal death in the developed world. VTE includes two conditions, deep vein thrombosis (DVT) and pulmonary embolism (PE).
- Trial name
- NCT00225108
- Testing
- Tinzaparin
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Ottawa Hospital Research Institute
Chest Pain, Coronary Artery Disease
Risk Markers in the Acute Coronary Syndromes
The main aim of this trial is to assess the long-term prognostic value of different types of Factor XIIa in an unselected, single center series of 871 chest pain patients admitted to the emergency unit, employing blood samples…
- Conditions
- Chest Pain, Coronary Artery Disease, Unstable Angina Pectoris, Myocardial Infarction
- Trial name
- RACS (NCT00521976)
- Where
- Norway
- Volunteers
- 871 people
- Sponsor
- Helse Stavanger HF
Cardiovascular Diseases, Coronary Disease
Coronary Heart Disease Incidence: Depression & Inflammation Risk
To examine the associations among depression, inflammation, and coronary heart disease using an existing data base and associated plasma samples.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Depression
- Trial name
- NCT00241774
- Where
- United States
- Volunteers
- 3,227 people
- Sponsor
- Columbia University
Acute Heart Failure, Decompensated Heart Failure
Characterisation of phenotYpes in aCute Heart faiLure patiEnts
An observational cohort study to evaluate the benefit of functional parameters, radiomics and blood biomarkers to predict the outcome of patients with acute heart failure.
- Conditions
- Acute Heart Failure, Decompensated Heart Failure, Cardiogenic Shock
- Trial name
- CYCLE (NCT07508891)
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Diabetic Foot, Amputation
Predictors of Foot Amputation in Diabetic Foot Ulcers
Diabetes affects 463 million population of the world. Diabetic foot is one of the complications of uncontrolled diabetes which can lead to amputation in 5- 24% of non-healing diabetic foot ulcers.
- Conditions
- Diabetic Foot, Amputation, Antibiotic Resistant Strain, Diabetic Foot Ulcer
- Trial name
- NCT05551988
- Testing
- Retrospective observational study of diabetic foot ulcer
- Where
- Pakistan
- Volunteers
- 110 people
- Sponsor
- Bolan Medical Complex Hospital Quetta Pakistan
HIV (Human Immunodeficiency Virus), AIDS
Disease Evolution and Risk Factors of AIDS-related Prevalent Cancers
This study aims to investigate the disease progression trends and risk factors of common AIDS-related tumors, including Kaposi sarcoma, lymphoma, lung cancer, and et al., among people living with HIV.
- Conditions
- HIV (Human Immunodeficiency Virus), AIDS, Kaposi Sarcoma (KS), Lymphoma
- Trial name
- NCT07696169
- Volunteers
- 1,000 people
- Sponsor
- Shenzhen Third People's Hospital
Carotid Artery Disease
Stenting and Angioplasty With Protection in Patients at High Risk for Endarterectomy (SAPPHIRE)
The primary objective of this study is to compare the safety and effectiveness of the Cordis Nitinol Carotid Stent and Delivery Systems (5.5 F and 7 F) with the ANGIOGUARD XP distal protective device to CEA in the treatment of…
- Trial name
- NCT00231270
- Testing
- Cordis Nitinol Stent, PRECISE tapered stent, ANGIOGUARD XP Emboli Capture Guidewire (ECGW)
- Volunteers
- 1,300 people
- Sponsor
- Cordis US Corp.
Cardiac Arrest, Coronary Disease
An In-Hospital Family Member Cardiopulmonary Resuscitation (CPR) Education Program
Each year in the United States, 300,000 people suffer from a Cardiac Arrest (CA), and of them, there is a 90% mortality rate. Out-of-Hospital arrests, in particular, have a 1-5% survival to hospital discharge.
- Conditions
- Cardiac Arrest, Coronary Disease, Cardiovascular Risk Factors
- Trial name
- NCT01260441
- Testing
- CPR Training using the Family and Friends CPR Anytime VSI Kit
- Where
- 3 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Atrial Fibrillation, Stroke
Using Left Atrium Appendage Closure in NVAF Patients With High Risk of Ischemic Stroke
To evaluate the safety and efficacy of using Microport CardioAdvance Left Atrium Appendage Closure for preventing stroke in Non-valvular atrial fibrillation (NVAF) patients who have contraindications for long-term…
- Trial name
- SAFE-PROTECT (NCT04479722)
- Testing
- Left atrial appendage closure procedure
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Shanghai MicroPort Medical (Group) Co., Ltd.
Venous Thromboembolism
High-Risk Factors for VTE Death
Study population and characteristics This retrospective cohort study initially screened 105,168 consecutive hospitalized patients at Shihezi People's Hospital from February 2022 to June 2025.
- Trial name
- NCT07767279
- Testing
- comorbidity, Respiratory Failure, Sepsis
- Where
- China
- Volunteers
- 105,168 people
- Sponsor
- China International Neuroscience Institution
Hypertension, Cardiovascular Risk Factor
Primary Care Usage of Health Promoting Messages
This project aims to investigate the use of e-health to assist health personnel in primary health care to carry out preventive measures of cardiovascular disease.The primary objective of the study is to examine the impact of…
- Trial name
- PUSHME (NCT04407962)
- Testing
- SMS group
- Where
- 9 sites in Sweden
- Volunteers
- 400 people
- Sponsor
- Lund University
Coronary Artery Disease, Left Ventricular Dysfunction
DEfibrillators To REduce Risk by MagnetIc ResoNance Imaging Evaluation
This trial is a prospective, multi-center, randomized study of patients with coronary artery disease (CAD) and mild to moderate left ventricular (LV) dysfunction.
- Conditions
- Coronary Artery Disease, Left Ventricular Dysfunction, Sudden Cardiac Death
- Trial name
- DETERMINE (NCT00487279)
- Testing
- Defibrillator, Control
- Where
- 56 sites in United States
- Volunteers
- 81 people
- Sponsor
- Abbott Medical Devices
Brain and Central Nervous System Tumors, Thromboembolism
Risk Factors for Developing a Blood Clot in Patients Who Are Undergoing Cancer Treatment for Newly Diagnosed Gliomas
RATIONALE: Patients with gliomas may be at risk for developing blood clots. Learning about the risk factors for developing blood clots may help doctors plan better treatment for gliomas.
- Trial name
- NCT00253669
- Testing
- laboratory biomarker analysis, physiologic testing, management of therapy complications
- Where
- 9 sites in United States
- Volunteers
- 110 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Leiomyoma, Uterine, Thrombosis
Are Uterine Fibroids Pro-thrombotic?
This study will investigate whether the presence of uterine fibroids is independently associated with a laboratory defined pro-thrombotic phenotype. VTE is associated with significant mortality and morbidity.
- Trial name
- NCT05607602
- Testing
- Comparison of blood samples between the two groups
- Where
- United Kingdom
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Pre-Eclampsia, Hypertension in Pregnancy
Furosemide vs. Placebo for Severe Antepartum Hypertension
Primary objective: To determine whether the addition of intravenous furosemide with usual antihypertensives is associated with a reduction in mean systolic blood pressure from baseline compared to treatment with placebo plus…
- Conditions
- Pre-Eclampsia, Hypertension in Pregnancy, Pregnancy Complications, Hypertension, Pregnancy-Induced
- Trial name
- NCT04615624
- Testing
- Furosemide
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Melanie Maykin, MD
Coronary Artery Disease
Imaging and Omics for Cardiovascular Risk During NASA Deep Space Missions
The purpose of this study is to develop new approaches for screening astronauts for cardiovascular risk during deep space missions.
- Trial name
- NCT02465554
- Testing
- Myocardial contrast echocardiography
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Oregon Health and Science University
Chronic Myeloproliferative Disorders, Fever, Sweats, and Hot Flashes
Moxifloxacin Compared With Ciprofloxacin/Amoxicillin in Treating Fever and Neutropenia in Patients With Cancer
RATIONALE: Antibiotics such as amoxicillin, ciprofloxacin, and moxifloxacin may be effective in preventing or controlling fever and neutropenia in patients with cancer.
- Conditions
- Chronic Myeloproliferative Disorders, Fever, Sweats, and Hot Flashes, Infection, Leukemia
- Trial name
- NCT00062231
- Testing
- amoxicillin-clavulanate potassium, ciprofloxacin, moxifloxacin hydrochloride
- Where
- 23 sites in Belgium, France and 6 more
- Volunteers
- 351 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Microvascular Angina
The Impact of Cardiac Rehabilitation Participation on Cardiac Syndrome X
The study is designed to test the hypothesis that participation in a standard phase III group based cardiac rehabilitation programme will improve psychological morbidity, quality of life and cardiovascular risk factors, along…
- Trial name
- NCT00123617
- Testing
- Phase III group-based cardiac rehabilitation
- Where
- United Kingdom
- Volunteers
- 64 people
- Sponsor
- National Heart and Lung Institute
Venous Thromboembolism
Comparison of the Risk of Venous Thromboembolism (i.e., Blood Clots in the Veins) and Bleeding Events in a Population of Obese Patients Receiving Higher-Dose or Extended-Duration Versus Conventional-Dose or Conventional-Duration of Prophylaxis (i.e., Preventive Treatment) With Enoxaparin
In individuals with obesity, the optimal dosing and duration of venous thromboembolism (VTE) prophylaxis in settings representing acute medical illness or surgery is limited due to lack of randomized controlled trials (RCTs)…
- Trial name
- NCT05819125
- Where
- United States
- Volunteers
- 21,000 people
- Sponsor
- Sanofi
Cardiovascular Diseases, Heart Diseases
Apolipoprotein Polymorphisms and Risk of Coronary Heart Disease
To determine the relative risk in a defined population of angiographically demonstrated coronary artery disease due to genetic polymorphisms at the four apolipoprotein genomic regions.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Arteriosclerosis, Coronary Disease
- Trial name
- NCT00005225
- Sponsor
- University of Utah
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