Clinical trials: Venoarterial Extracorporeal Membrane Oxygenation
Extracorporeal Membrane Oxygenation, Cardio/Pulm: Heart Failure
Real-time Pressure Volume Loop Monitoring as a Guide for Enhanced Understanding of Changes in Elemental Cardiovascular Physiology During Therapeutic Strategies Aiming for Hemodynamic Optimization. Cohort I: Veno-arterial Extracorporeal Membrane Oxygenation (PLUTO-I)
Invasive pressure-volume (PV) loop measurements have the potential to confirm or refute earlier computer simulations and animal studies regarding changes in cardiovascular physiology induced by (veno-arterial) ECMO.
- Trial name
- PLUTO-I (NCT05909280)
- Testing
- Pressure-volume loop measurements
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Erasmus Medical Center
Cardiogenic Shock
A Study on the Effects of Left Ventricular Unloading in the Setting of VA ECMO Support
REMAP ECMO is a registry based platform in which multiple response adaptive randomized clinical trials (trial domains) will be embedded.
- Trial name
- REMAP ECMO (NCT05913622)
- Testing
- Intra-aortic balloon pump
- Where
- 14 sites in Belgium, Netherlands
- Volunteers
- 430 people
- Sponsor
- Erasmus Medical Center
Venoarterial Extracorporeal Membrane Oxygenation, Renal Replacement Therapy
Evaluation of Integrated Versus Parallel Connection for Renal Replacement Therapy in ECMO Patients
Extracorporeal membrane oxygenation (ECMO) is an extra-corporeal assistance used in case of respiratory or circulatory failure. In case of circulatory failure, ECMO is in the veno-arterial configuration (VA-ECMO).
- Conditions
- Venoarterial Extracorporeal Membrane Oxygenation, Renal Replacement Therapy, Acute Kidney Injury
- Trial name
- EPIC-ECMO (NCT06038162)
- Testing
- Parallel connection, Integrated connection
- Where
- 12 sites in France
- Volunteers
- 158 people
- Sponsor
- Hospices Civils de Lyon
ECMO
Early Intra-aortic Balloon Pump Use After Venoarterial Extracorporeal Membrane Oxygenation
The goal of this multicenter, randomized trial is to compare early early left ventricular unloading by Intra-aortic Balloon Pump (IABP) versus conventional approach in patients with cardiogenic shock (CS) undergoing venoarterial…
- Trial name
- EASE-ECMO (NCT06872021)
- Testing
- Early IABP use, Conventional approach
- Where
- China
- Volunteers
- 358 people
- Sponsor
- Beijing Anzhen Hospital
Cardiogenic Pulmonary Edema, Ventilator-Induced Lung Injury
Ultra Protective Ventilation During Venoarterial Extracorporeal Membrane Oxygenation (UPV-ECMO)
Mechanical ventilation, in spite of being a life-saving technique, can also induce lung injury (VILI) mediated by an inflammatory response, thus having a profound impact in the course of critically ill patients.
- Conditions
- Cardiogenic Pulmonary Edema, Ventilator-Induced Lung Injury, Extracorporeal Circulation; Complications
- Trial name
- UPV-ECMO (NCT03041428)
- Testing
- Ultraprotective ventilation
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundación para la Investigación Biosanitaria del Principado de Asturias
Shock, Cardiogenic, Cardiac Arrest
ECMO LEft Ventricle UNloading Strategy
The present study is an International multicentric prospective observational cohort study. This will be an international research campaign to prospectively collect and analyze clinical data of all VA ECLS patients admitted to…
- Conditions
- Shock, Cardiogenic, Cardiac Arrest, Extracorporeal Membrane Oxygenation Complication
- Trial name
- ECMOLENS (NCT06766006)
- Testing
- Venoarterial extracorporeal life support (VA ECLS) implant
- Where
- Netherlands
- Volunteers
- 500 people
- Sponsor
- Maastricht University Medical Center
VA-ECMO for Postcardiotomy Cardiogenic Shock
Timing of VA-ECMO Support During or After Cardiac Surgery
Some patients develop severe heart failure during or after cardiac surgery and require temporary support for circulation and oxygenation.
- Trial name
- NCT07873034
- Where
- Slovakia
- Volunteers
- 128 people
- Sponsor
- National Institute of Cardiovascular Diseases, Slovakia
Heparin-induced Thrombocytopenia
Prognosis Related to Induced Thrombopenia With Heparin Under Venoarterial ECMO in Reanimation
Thrombocytopenia is a frequent and serious adverse event in patients treated with veno-arterial extracorporeal membrane oxygenation (VA-ECMO) for refractory cardiogenic shock.
- Trial name
- TIH ECMO (NCT03979625)
- Testing
- Hospitalization for more than 3 days with high clinical suspicion of HIT and positive anti-PF4/heparin antibodies
- Volunteers
- 39 people
- Sponsor
- Central Hospital, Nancy, France
Cardiac Arrest, Cardiopulmonary Arrest
ECMELLA vs. ECMO on 30-day Mortality
This international, multicenter cohort study aims to investigate outcomes after treatment with extracorporeal cardiopulmonary resuscitation (eCPR) during cardiac arrest.
- Conditions
- Cardiac Arrest, Cardiopulmonary Arrest, Extracorporeal Membrane Oxygenation Complication, Cardiogenic Shock
- Trial name
- NCT05175898
- Testing
- VA-ECMO, ECMELLA
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Charite University, Berlin, Germany
Pulmonary Hypertension of the Newborn (PPHN)
Circulatory Changes During Venovenous (VV)- and Venoarterial (VA) Extracorporeal Membrane Oxygenation (ECMO)
Rationale: Persistent pulmonary hypertension of the newborn (PPHN) is a life threatening disease with a high mortality rate. Extracorporeal Membrane Oxygenation (ECMO) with veno-arterial (V-A) or veno-venous (V-V) cannulation can…
- Trial name
- ECMO (NCT00622492)
- Testing
- echocardiography Doppler sonography, blood and urine sampling
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Cardiogenic Shock, Renal Replacement Therapy
REnal reCOVery After ECMO for Cardiogenic Shock (RECOVECMO)
This retrospective study assesses long term renal outcome in patients having suffered medical or post cardiotomy refractory cardiogenic shock requiring renal replacement therapy (RRT) concomitant with veno-arterial extracorporeal…
- Conditions
- Cardiogenic Shock, Renal Replacement Therapy, Venoarterial Extracorporeal Membrane Oxygenation
- Trial name
- RECOVECMO (NCT05788211)
- Testing
- standard of care
- Where
- France
- Volunteers
- 93 people
- Sponsor
- University Hospital, Bordeaux
Shock, Cardiogenic, Cardiac Arrest
Hemodynamic Comparison of Peripheral and Central VA ECMO.
The goal of this clinical trial is to monitor hemodynamic differences between central veno-arterial extracorporeal membrane oxygenation (VA ECMO) and peripheral VA ECMO.
- Conditions
- Shock, Cardiogenic, Cardiac Arrest, Extracorporeal Circulation; Complications, Hemodynamics Instability
- Trial name
- RECOVERY (NCT05669183)
- Testing
- Veno-arterial extracorporeal membrane oxygenation
- Where
- China
- Volunteers
- 136 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Acute Kidney Injury
Renal Biomarkers to Predict Recovery Following Venoarterial Extracorporeal Membrane Oxygenation
The investigators objective is to assess the utility of renal biomarkers in predicting renal recovery following institution of Venoarterial Extracorporeal Membrane Oxygenation (VA-ECMO).
- Trial name
- NCT02978378
- Testing
- biomarker levels
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Milton S. Hershey Medical Center
Cardiogenic Shock
Early Insertion of Axillary Impella® With VA ECMO
Veno-arterial extra-corporeal membrane oxygenation (VA-ECMO) is used as a rescue strategy for patients in acute hemodynamic deterioration such as cardiogenic shock and cardiopulmonary arrest with severe pulmonary congestion.
- Trial name
- NCT04084015
- Testing
- Axillary Impella®
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Massachusetts General Hospital
Heart Failure, Respiratory Failure
Microcirculation in Venoarterial Extracorporeal Membrane Oxygenation Life Support
Extra-corporeal membrane oxygenation (ECMO) life support system can provide both cardiac and respiratory support to patients with heart and respiratory failure.
- Trial name
- NCT02393274
- Testing
- Extra-corporeal membrane oxygenation life support
- Where
- Taiwan
- Volunteers
- 48 people
- Sponsor
- National Taiwan University Hospital
Cardiogenic Shock
The Effects of oXiris in Cardiogenic Shock Requiring VA-ECMO
Cardiogenic shock (CS) defines a state of systemic hypo-perfusion leading to end-organ dysfunction related to cardiac pump failure and with mortality rates in the range of 27-50% according to recent reviews.
- Trial name
- CLEAN ECMO (NCT05642273)
- Testing
- oXiris membrane, Blood tests
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
Cardiogenic Shock
Passive Leg Raising for Predicting Fluid Responsiveness in VA-ECMO Assisted Patients
Peripheral Veno-Arterial Extra Corporeal Membrane Oxygenation (VA ECMO) is a temporary assistance that provides a mechanical circulatory support in patients victim of cardiogenic shock (CS) or refractory cardiac arrest.
- Trial name
- PARANOVA (NCT04984603)
- Testing
- PLR in patients under VA-ECMO
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Complication of Extracorporeal Membrane Oxygenation, Cerebral Microembolism
Cerebral Microemboli in Venoarterial ECMO Patients
Extracorporeal membrane oxygenation (ECMO) is progressively used in critically ill patients with cardiac or respiratory failure as a bridging option for potential organ recovery.
- Conditions
- Complication of Extracorporeal Membrane Oxygenation, Cerebral Microembolism, Cerebral Perfusion
- Trial name
- NCT02020759
- Testing
- Transcranial Doppler Ultrasound
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Extracorporeal Membrane Oxygenation Complication, Blood Cells Transfusion
Evaluation of the 1-year Prognosis of Patients Under Veno-arterial Extracorporeal Membrane Oxygenation for Cardiogenic Shock With Blood Transfusion Requirement
The primary objective of this work is to study the 1-year prognosis of patients who received Veno-arterial extracorporeal membrane oxygenation for cardiogenic shock with the need for blood transfusion.
- Conditions
- Extracorporeal Membrane Oxygenation Complication, Blood Cells Transfusion, Transfusion Related Complication
- Trial name
- HemoECMO (NCT05696210)
- Testing
- Transfusion rate of red blood cells
- Volunteers
- 110 people
- Sponsor
- Central Hospital, Nancy, France
Cardiogenic Shock, Cardiac Arrest
Outcomes of Patients With Venoarterial Extracorporeal Membrane Oxygenation
Venoarterial extracorporeal membrane oxygenation (VA ECMO)-also referred to as extracorporeal life support-is a form of temporary mechanical circulatory support and simultaneous extracorporeal gas exchange.
- Trial name
- NCT04039594
- Testing
- VA ECMO
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Beijing Anzhen Hospital