Clinical trials: Ventilated Patient in Intensive Care
Extubation Failure, Ventilated Patients
Factors Associated With Extubation Failure in Kanigara ICU (Intensive Care Unit) RSUPN Dr. Cipto Mangunkusumo
Extubation is the final stage after patients undergo weaning procedure from mechanical ventilation in the ICU. Extubation failure followed by reintubation is associated with worse patient outcomes, including prolonged length of…
- Trial name
- NCT07038291
- Testing
- Not applicable- observational study
- Where
- Indonesia
- Volunteers
- 156 people
- Sponsor
- Universitas Indonesia
Intensive Care Unit Acquired Weakness
Blood Flow Restriction Training for Mechanically Ventilated Patients With ICU-Acquired Weakness
Patients receiving mechanical ventilation in the intensive care unit (ICU) frequently develop ICU-acquired weakness - a condition marked by widespread muscle loss and weakness caused by prolonged bed rest, severe illness, and…
- Trial name
- BFRT-ICU (NCT07802743)
- Testing
- Blood flow restriction training, Standard ICU Care and Routine Rehabilitation
- Volunteers
- 120 people
- Sponsor
- Affiliated Hospital of Jining Medical University
Mechanically Ventilated Patients
Cough Assist Device in Mechanically Ventilated Patients
Aspiration of respiratory secretions is a frequently needed procedure in intubated patients . Cough is an important defence mechanism to clear mucus from the upper and lower airways .
- Trial name
- NCT05480371
- Testing
- Conventional tracheal suctioning, Mechanical insufflation/exsufflation
- Volunteers
- 200 people
- Sponsor
- Assiut University
Intensive Care Ventilation
Pressure Support Ventilation With the Anesthetic Conserving Device
Sevoflurane inhalational anesthetic has got pulmonary effects such as bronchodilatation. These effects could be of interest in intensive care patients ventilated in pressure support ventilation mode.
- Trial name
- NCT01017744
- Testing
- Anesthetic Conserving Device
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Clermont-Ferrand
Respiratory Failure
Effects of PBMT-sMF in Mechanically Ventilated Patients
The goal of this clinical trial is to evaluate the effectiveness of photobiomodulation therapy combined with static magnetic field (PBMT-sMF) in adult patients who require mechanical ventilation.
- Trial name
- NCT06454006
- Testing
- Active PBMT-sMF
- Where
- Brazil
- Volunteers
- 112 people
- Sponsor
- University of Nove de Julho
Pneumonia
Probiotic Enteral Administration in Mechanically Ventilated Patients
The objective of this study is to assess the effects of a daily enteral supplementation with probiotics within a population of critically ill, mechanically ventilated patients.
- Trial name
- NCT00122408
- Testing
- Ergyphilus
- Where
- 3 sites in France
- Volunteers
- 740 people
- Sponsor
- Central Hospital, Nancy, France
Mechanical Ventilation, Intensive Care (ICU)
Effects of PERMISSive Lung-protective Ventilation on Outcome in Critically Ill Invasively Ventilated Patients
RATIONALE Lung-protective ventilation using a lower respiratory rate (RR) is an appealing strategy to reduce ventilation intensity, which may require permissive hypercapnia.
- Trial name
- PERMISS pilot (NCT07077174)
- Testing
- Permissive lung-protective ventilation, Conventional lung-protective ventilation
- Where
- 5 sites in Netherlands, Spain
- Volunteers
- 56 people
- Sponsor
- Reinier de Graaf Groep
Dexmedetomidine, Ketamine
Safety and Efficacy of Esketamine Combined With Dexmedetomidine for Sedation of Mechanically Ventilated Patients
A prospective, randomized controlled study was conducted to compare the effects of esketamine combined with dexmedetomidine in the sedation and analgesia treatment of mechanically ventilated patients in the ICU on the time to…
- Conditions
- Dexmedetomidine, Ketamine, Analgesia, Intensive Care Units
- Trial name
- SEEDS (NCT05466708)
- Testing
- Esketamine combined with dexmedetomidine, Dexmedetomidine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Critical Illness, Malabsorption Syndromes
The Early Nasojejunal Tube to Meet Energy Requirements in Intensive Care (ENTERIC) Study
This is a multi-centre randomised controlled trial comparing early jejunal feeding (using a frictional nasojejunal [NJ] tube) and standard feeding in critical illness.
- Trial name
- ENTERIC (NCT00163813)
- Testing
- Early jejunal feeding (using frictional NJ tube), Standard feeding (using nasogastric [NG] tube)
- Where
- Australia
- Volunteers
- 180 people
- Sponsor
- Bayside Health
Critically Ill, Mechanical Ventilation
The TEAM Long-Term Cohort Study (A Sub-study of TEAM(III))
This study is a prospective cohort study to evaluate the long-term effects of early activity and mobilisation compared to standard care on disability, function and health status for patients at 1, 2 and 5 years after recruitment…
- Conditions
- Critically Ill, Mechanical Ventilation, Long Term Outcome
- Trial name
- NCT05298982
- Testing
- Early activity and Mobilisation Intervention
- Where
- 16 sites in Australia
- Volunteers
- 250 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Agitation
Acupuncture to Improve Comfort of Children on a Ventilator in the Intensive Care Unit
The purpose of this study is to determine whether acupuncture is effective at improving comfort in children on a ventilator in the intensive care unit.
- Trial name
- NCT01848158
- Testing
- acupuncture
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Seattle Children's Hospital
Weaning From Mechanical Ventilation
Assessment of Inspiratory Muscles Strength and Endurance Evolution on Difficult to Wean Patients in Intensive Care Unit
Ventilator-induced diaphragmatic dysfunction appears to contribute to slow weaning from mechanical ventilation. Several trials of inspiratory muscle training to facilitate weaning in intensive care have been performed, with…
- Trial name
- EFES (NCT03140267)
- Testing
- Difficult to wean patients
- Where
- 2 sites in France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Bordeaux
Intensive Care Unit Acquired Weakness
The Effect of Inspiratory Muscle Training on Diaphragmatic Function in Mechanically Ventilated Patients
In this study, the effect of inspiratory muscle training on diaphragmatic functions will be investigated radiologically in mechanically ventilated patients.
- Trial name
- NCT05303623
- Testing
- Conventional Physiotherapy, Conventional Physiotherapy+ inspiratory muscle training, inspiratory muscle training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul Demiroglu Bilim University
Sepsis
Efficacy and Safety of a Multicomponent Physical Therapy Program in Mechanically Ventilated Patient With Sepsis
Despite of a remarkable decrease in overall mortality has been achieved following the International Guidelines for Management of Sepsis and Septic Shock since 2004,the short-and long-term outcomes remain poor in critically ill…
- Trial name
- PTMVP (NCT03406494)
- Testing
- Early multicomponent physical therapy program
- Volunteers
- 800 people
- Sponsor
- Zhujiang Hospital
Neuromuscular Monitoring
Electromyography and Acceleromyography in Ventilated ICU Patients
In intensive care unit (ICU) patients who are mechanically ventilated for a longer period of time, there might be a difference in accuracy and performance of neuromuscular transmission monitoring [as measured by the train-of-four…
- Trial name
- NCT03778749
- Testing
- TOF measurements
- Where
- Belgium
- Volunteers
- 12 people
- Sponsor
- Onze Lieve Vrouw Hospital
Intensive Care Patients Invasively Ventilated
S4 :Trial Of Fully Closed-Loop Ventilation In ICU.
Preliminary study to compare IntelliVent-ASV to conventional modes used from intubation to extubation or death in ICU patients requiring mechanical ventilation measuring duration of mechanical ventilation in order to design a…
- Trial name
- S4 (NCT01781091)
- Testing
- INTELLIVENT ASV FULLY CLOSED-LOOP VENTILATION, Conventionals Modes
- Where
- 2 sites in France, Italy
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Early Mobility, Critically Ill
Early Mobilization in Ventilated SEpsis & Acute Respiratory Failure Study
Early mobilization in Ventilated sEpsis \& acute Respiratory failure Study: EVER Study
- Trial name
- EVER (NCT04582760)
- Testing
- early mobilization
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
Pain, Pediatric ALL
Validation of the ANI in Perpubescent Patients in Pediatric Intensive Care Unit.
The ANI monitor is a medical device allowing to measure the response of the autonomic nervous system to a painful stimulus. In the pediatric population under general anesthesia, the ANI score can detect failure of locoregional…
- Trial name
- ANI-EP (NCT04913038)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Lille
Mechanically Ventilated Patients
Prevention of Delirium in Intensive Care by Melatonin
This is a double-blind, randomized, placebo-controlled, Phase 2b/3 two-part adaptive clinical trial. The trial is designed to investigate the pharmacokinetics and the efficacy of multiple dosing regimens of melatonin and to…
- Trial name
- DEMEL (NCT03524937)
- Testing
- MELATONIN (HIGH DOSE), MELATONIN (LOW DOSE)
- Where
- France
- Volunteers
- 355 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Circulatory Failure, Critical Illness
Role of End-Tidal CO2 During Passive Leg Raising to Predict Fluid Responsiveness in ICU
This prospective observational study evaluates whether monitoring changes in exhaled carbon dioxide (End-Tidal CO2 or EtCO2) during a "Passive Leg Raising" (PLR) test can reliably predict fluid responsiveness in critically ill…
- Conditions
- Circulatory Failure, Critical Illness, Hypovolemia
- Trial name
- NCT07304648
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Izmir Katip Celebi University