Clinical trials: Ventilation Perfusion Mismatch
Respiratory Distress Syndrome, Adult, Ventilation Perfusion Mismatch
Comparison of Extra Vascular Lung Water Index in Covid-19 ARDS and "Typical"ARDS Patients
Covid-19 also primarily affects endothelium that line up the alveoli. The resulting hypoxemia may differ from "typical" Acute Respiratory Distress Syndrome (ARDS) due to maldistribution of perfusion related to the ventilation.
- Conditions
- Respiratory Distress Syndrome, Adult, Ventilation Perfusion Mismatch, Pulmonary Edema, Covid19
- Trial name
- NCT04508933
- Testing
- Extravascular Lung Water Index, Pulmonary Vascular Permeability Index
- Where
- Turkey (Türkiye)
- Sponsor
- Istanbul University - Cerrahpasa
ARDS (Acute Respiratory Distress Syndrome)
EIT Evaluation of the Impact of Inhaled Nitric Oxide on Ventilation/Perfusion Mismatch in ARDS Patients Receiving Noninvasive Respiratory Support
This study aimed to quantitatively evaluate the immediate effect of inhaled nitric oxide on the ventilation / perfusion ratio in ARDS patients receiving nasal high flow oxygen therapy or noninvasive ventilation using electrical…
- Trial name
- NCT07617298
- Testing
- Inhale different doses of nitric oxide
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Ming Zhong
Mechanical Ventilation, Ventilation Perfusion Mismatch
Post-hoc Analysis of Regional Pulmonary Perfusion and Hemodynamic Parameters Measured by Electrical Impedance Tomography
Define the capability and reliability of the PulmoVista® 500 (PV500) to detect changes in global and regional ventilation and perfusion.
- Trial name
- NCT04249414
- Testing
- PulmoVista 500
- Where
- Germany
- Volunteers
- 22 people
- Sponsor
- Drägerwerk AG & Co. KGaA
Lung Perfusion, Respiratory Physiology
Effects of Inspiratory vs Expiratory Breath-Hold on Lung Perfusion Measured by EIT Saline Indicator Method: A Self-Controlled Study
This study aims to compare lung perfusion distribution between inspiratory breath-hold and expiratory breath-hold phases using the saline indicator method combined with electrical impedance tomography (EIT).
- Conditions
- Lung Perfusion, Respiratory Physiology, Electrical Impedance Tomography, Ventilation-Perfusion Mismatch
- Trial name
- NCT07303972
- Testing
- Electrical Impedance Tomography Saline Indicator Procedure, Electrical Impedance Tomography Device
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
ARDS
V/Q Matching Variations With PEEP in ARDS According to Compliance-based Phenotypes (France)
This study aim to compare the effect of Positive End Expiratory Pressure (PEEP) on ventilation/perfusion mismatch in two phenotypes of patients with moderate-to-severe Acute Respiratory Distress Syndrome (ARDS), characterized by…
- Trial name
- MISMATCHED FR (NCT05578742)
- Testing
- PEEP increase, PEEP decrease
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Angers
Nitric Oxide, Acute Respiratory Distress Syndrome
Potential for Inhaled Nitric Oxide and Ventilation-Perfusion Mismatch by Electrical Impedance Tomography in the ARDS Patients With Lung Recruitment
In the recent years, the treatment of Acute Respiratory Distress Syndrome has been proved that lung recruitment re-opens the non-ventilated alveolar to improve ventilation, and inhaled Nitric Oxide dilates non-perfused pulmonary…
- Trial name
- NCT04776408
- Testing
- Lung recruitment combined inhaled Nitric oxide, Lung recruitment
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Far Eastern Memorial Hospital
Covid19, ARDS, Human
Nebulised Heparin to Reduce COVID-19 Induced Acute Lung Injury
The investigators present a randomised open label phase Ib/IIa trial of nebulised unfractionated heparin to evaluate the effect of nebulised unfractionated heparin on the procoagulant response in ICU patients with SARS-CoV-2…
- Conditions
- Covid19, ARDS, Human, Lung Injury, Acute, Ventilation Perfusion Mismatch
- Trial name
- CHARTER-Irl (NCT04511923)
- Testing
- Nebulised heparin
- Where
- Ireland
- Volunteers
- 40 people
- Sponsor
- University College Hospital Galway
Respiratory Insufficiency Syndrome of Newborn, Infant, Premature, Diseases
PEEP and V/Q Mismatch in Premature Infants
Positive end-expiratory pressure (PEEP) is used in premature infants receiving mechanical ventilation to maintain lungs open and facilitate gas exchange.
- Trial name
- NCT03109613
- Testing
- Positive end-expiratory pressure (PEEP)
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- Children's Hospital of Philadelphia
Bronchopulmonary Dysplasia, Pulmonary Hypertension Due to Lung Diseases and Hypoxia
Ventilator Pressure and Optimization of Compliance and Hemodynamics
In preterm infants < 34 weeks' gestation at birth receiving respiratory support with invasive positive pressure ventilation, the positive end-expiratory pressure (PEEP) of best compliance will increase the cardiac output and…
- Conditions
- Bronchopulmonary Dysplasia, Pulmonary Hypertension Due to Lung Diseases and Hypoxia, Extreme Prematurity, Ventilator Lung; Newborn
- Trial name
- VPOCH (NCT06512935)
- Testing
- Increase in the PEEP followed by decrease in the PEEP, Decrease in the PEEP followed by increase in the PEEP
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Alabama at Birmingham
Acute Respiratory Distress Syndrome, Coronavirus
Prone Position Improves End-Expiratory Lung Volumes in COVID-19 Acute Respiratory Distress Syndrome
Covid-19 associated Acute Respiratory Distress Syndrome (ARDS) may present with profound hypoxemia not fully explained with pulmonary infiltrates.
- Conditions
- Acute Respiratory Distress Syndrome, Coronavirus, Mechanical Ventilation Complication, Ventilation Perfusion Mismatch
- Trial name
- NCT04818164
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Istanbul University - Cerrahpasa
Anesthesia
A Unique Device for Independent Lung Ventilation
Adequate blood oxygenation and ventilation/perfusion matching should be the main goal of anaesthetic and intensive care management.
- Trial name
- NCT02786862
- Testing
- independent ventilation
- Volunteers
- 69 people
- Sponsor
- Medical University of Lublin
Acute Respiratory Distress Syndrome
Effect of Spontaneous Breathing in APRV Mode on Respiratory Physiology of ARDS Patients
This is a single-center, prospective, randomized, three-period crossover physiological study in adult patients with moderate-to-severe acute respiratory distress syndrome (ARDS, PaO₂/FiO₂ ≤150 mmHg).
- Trial name
- SBA-APRV (NCT07798154)
- Testing
- APRV ventilation with low-level spontaneous breathing, APRV ventilation with high-level spontaneous breathing, APRV ventilation with fully suppressed spontaneous breathing
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Ventilation Perfusion Mismatch
Effect of Alveolar Minute Ventilation on Respiratory Gas Heat Content
This is a single site, prospective, non-blinded, non-randomized, non-interventional study designed to evaluate the effect of changes in alveolar minute ventilation on the measurement of respiratory heat loss (enthalpy).
- Trial name
- NCT01943227
- Testing
- controlled positive pressure ventilation 9ml/kg tidal volume, controlled positive pressure ventilation 6ml/kg tidal volume
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Davis
ARDS
Gas Exchange and CT Effects of PEEP in ARDS
The study aims to investigate the association between effects of PEEP on gas exchange model parameters and CT scan results
- Trial name
- NCT04067154
- Testing
- ALPE
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Policlinico Hospital
Acute Respiratory Distress Syndrome, Ventilation Perfusion Mismatch
Vascular ARDS Recruitment After Inhaled Nitric Oxide
Acute respiratory distress syndrome (ARDS) is when a person's lungs become inflamed, which can be caused by infection, trauma, surgery, blood transfusion, or burn.
- Trial name
- NCT05801224
- Testing
- Nitric Oxide
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Massachusetts General Hospital
ARDS, Human
Effect of Electric Impedance Tomography-Guided PEEP Titration
Acute respiratory syndrome distress (ARDS) is a clinical common syndrome with high mortality. Mechanical ventilation (MV) is the cornerstone of management of ARDS but can lead to ventilator-induced lung injury.
- Trial name
- NCT05736185
- Testing
- PEEP selection
- Where
- China
- Volunteers
- 69 people
- Sponsor
- Southeast University, China
Pulmonary Embolism (Diagnosis), Venous Thromboembolism (VTE)
3D-EIT for Diagnosis and Monitoring of Pulmonary Embolism
This prospective observational study aims to validate three-dimensional electrical impedance tomography (3D-EIT) as a non-invasive bedside tool for the diagnosis and longitudinal monitoring of pulmonary embolism (PE).
- Trial name
- TIDE-PE (NCT07560293)
- Volunteers
- 115 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Critical Illness, Ventilation Perfusion Mismatch
Arterial and End-Tidal CO2 Gradient as a Mortality Predictor in Critical Care Patients
Scoring systems (SOFA, APACHE-II etc.) are used to estimate the mortality rates of patients treated in the intensive care unit. . In the scoring systems used, the disfunction level of the organs of the patients is measured.
- Conditions
- Critical Illness, Ventilation Perfusion Mismatch, Shock, Pulmonary Embolism
- Trial name
- NCT05341258
- Testing
- EtCO2, PaCO2
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Ventilation Perfusion Mismatch
Effect of Patient Position on Arterial, End-tidal and Transcutaneous Carbon Dioxide
Investigators evaluate the effect of patient position (Trendelenburg and reverse Trendelenburg) on arterial, end-tidal and transcutaneous carbon dioxide partial pressure in patients undergoing laparoscopic surgery.
- Trial name
- NCT03508791
- Testing
- Arterial carbon dioxide monitoring, End-tidal carbon dioxide monitoring, Transcutaneous carbon dioxide monitoring
- Volunteers
- 142 people
- Sponsor
- SMG-SNU Boramae Medical Center
Mechanical Ventilation Complication
Effect of Recruitment Maneuvers Plus Optimal PEEP Versus Optimal PEEP Alone in One Lung Ventilation
The intraoperative driving pressure (∆P) has been recently identified as the greater independent predictor of postoperative pulmonary complications after one lung ventilation (OLV).
- Trial name
- NCT03635281
- Testing
- Recruitment manoeuvers, incremental PEEP
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Università degli Studi di Ferrara