Clinical trials: Ventricular Dysfunction, Right
PreTerm Neonate, Pulmonary Hypertension of Newborn
Identification of the Risk of Remote Pulmonary Hypertension in Preterm Births.
This study aims to learn about the prevalence of pulmonary hypertension and right ventricular dysfunction in patients born prematurely, at birth and at a distance, and the association with the development of pulmonary…
- Conditions
- PreTerm Neonate, Pulmonary Hypertension of Newborn, Right Ventricular Dysfunction
- Trial name
- Iper-NeoRisk (NCT06800300)
- Where
- 2 sites in Italy
- Volunteers
- 51 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Cardiomyopathies, Dilated Cardiomyopathy
Pediatric Cardiomyopathy Mutation Analysis
The goal of this protocol is to obtain information from individuals with cardiomyopathy and from their families in order to elucidate the molecular genetics of this disorder.
- Conditions
- Cardiomyopathies, Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy, Restrictive Cardiomyopathy
- Trial name
- NCT02432092
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Indiana University
Acute Exacerbation of COPD, Acute Exacerbation of Bronchiectasis
Outcomes of RV Dysfunction in Acute Exacerbation of Chronic Respiratory Diseases
Observational study in patients with chronic respiratory diseases (chronic obstructive pulmonary diseases, bronchiectasis, interstitial lung diseases, neuromuscular diseases, obesity-hypoventilation syndrome...) admitted in…
- Conditions
- Acute Exacerbation of COPD, Acute Exacerbation of Bronchiectasis, Acute Exacerbation of Asthma, Interstitial Lung Disease
- Trial name
- DVD (NCT04098094)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil
Pulmonary Embolism, Right Ventricular Dysfunction
Augmented Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for PE
SONIC-PE is a multicenter, prospective, single-arm study of 10 patients with bilateral PE treated with ultrasound-facilitated, catheter-directed lower-dose fibrinolysis (total dose 8 mg tPA given as 2 mg/hour/catheter over 2…
- Conditions
- Pulmonary Embolism, Right Ventricular Dysfunction, Right Ventricular Failure
- Trial name
- SONIC-PE (NCT06310018)
- Testing
- Ultrasound-facilitated, catheter-directed lower-dose fibrinolysis, Tissue Plasminogen Activator
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brigham and Women's Hospital
Ventricular Dysfunction, Right, Hypoxia
Impact of Hypoxia on Resting and Exertional Right Ventricular Performance
The purpose of this study is to better understand how hypoxia (low oxygen) affects resting and exertional right ventricular function in healthy individuals.
- Trial name
- NCT05272514
- Testing
- Hypoxia
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Right Ventricular Dysfunction
Incidence, Impact and Mechanisms of Perioperative Right VEntricular Dysfunction (IMPRoVE)
A study to see how common right heart failure (right ventricular dysfunction) after major surgery is, and to investigate if right ventricular dysfunction causes worse patient outcomes after surgery.
- Trial name
- IMPRoVE (NCT05827315)
- Testing
- Echocardiography, T1 Cardiovascular Magnetic Resonance, Right heart catheterisation and coronary sinus blood sampling
- Where
- 3 sites in United Kingdom
- Volunteers
- 175 people
- Sponsor
- NHS National Waiting Times Centre Board
Right Heart Failure, Right Ventricular Dysfunction
PRediction of Early PostoperAtive Right vEntricular Failure in Mitral Valve Replacement/Repair Patients
The PREPARE-MVR (PRediction of Early PostoperAtive Right vEntricular failure in Mitral Valve Replacement/Repair patients) Study aims to evaluate those preoperative factors which can predict the early postoperative right…
- Conditions
- Right Heart Failure, Right Ventricular Dysfunction, Right Ventricular Failure, Mitral Valve Disease
- Trial name
- PREPARE-MVR (NCT03438825)
- Testing
- Mitral valve replacement/repair
- Where
- Hungary
- Volunteers
- 72 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Postoperative Complications, Heart Diseases
Detection of Right Ventricular Dysfunction by Portal Vein Doppler After Cardiac Surgery
Right ventricular (RV) failure after cardiac surgery is associated with morbidity and mortality, but is hard to diagnose with conventional echocardiographic means.
- Conditions
- Postoperative Complications, Heart Diseases, Heart Failure, Heart Valve Diseases
- Trial name
- DVDDP (NCT04890860)
- Testing
- cardiac surgery involving mitral or tricuspid valve repair procedure, with cardiopulmonary bypass
- Where
- France
- Volunteers
- 70 people
- Sponsor
- CMC Ambroise Paré
RV - Right Ventricular Abnormality, LV Dysfunction
Pediatric Ventricle Function Assessment Study
This study aims to develop a deep learning-based framework for right ventricular (RV) segmentation, prediction of RV fractional area change (FAC), and identification of pediatric RV dysfunction.
- Conditions
- RV - Right Ventricular Abnormality, LV Dysfunction, Pulmonary Hypertension, TOF
- Trial name
- NCT06739057
- Where
- United States
- Volunteers
- 3,993 people, healthy volunteers welcome
- Sponsor
- HBI Solutions Inc.
Sinus-node Dysfunction
Right Ventricular Outflow Tract Study
This is a prospective, randomized, double blinded, multi-center, controlled study to evaluate the clinical impact at 18 months after DDD implantation of alternative pacing site (RVOTs and RVA) and the different conduction path…
- Trial name
- RVOTCARE (NCT01294839)
- Testing
- Right ventricular lead location
- Where
- China
- Volunteers
- 380 people
- Sponsor
- Abbott Medical Devices
Tetralogy of Fallot, Heart Defects, Congenital
Right Ventricular Dysfunction in Tetralogy of Fallot: Inhibition of the Renin-angiotensin-aldosterone System
Rationale: The prevalence of adult patients with congenital heart disease (CHD) has steadily increased over the last decades, due to the advances in cardiac surgery.
- Conditions
- Tetralogy of Fallot, Heart Defects, Congenital, Ventricular Dysfunction, Right
- Trial name
- Redefine (NCT02010905)
- Testing
- Losartan
- Where
- 6 sites in Netherlands
- Volunteers
- 120 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Transposition of Great Arteries
Cardiovascular Magnetic Resonance in Adults With SysTemic Right Ventricle (STAR)
The main aim of the study is to explore HFs in SRV, comparing their magnitude and direction with that of subpulmonary RV and systemic LV.
- Trial name
- STAR (NCT05690854)
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Atrio-Ventricular Block
Right Ventricular Septal Pacing for the Prevention of Left Ventricular Dysfunction in Patients With Atrio-Ventricular Block
The aim of this study is to investigate the effects of the right ventricular septal pacing on left ventricular function compared with right ventricular apical pacing.
- Trial name
- NCT00709774
- Testing
- Pacemaker Implantation
- Volunteers
- 60 people
- Sponsor
- Osaka General Medical Center
Pulmonary Hypertension
Targeting Right Ventricle in Pulmonary Hypertension Gilead
This study is looking to see if giving ranolazine to subjects on stable pulmonary hypertension therapies but with right ventricular dysfunction (RVEF <45%) will improve their health by improving right ventricular (RV) function.
- Trial name
- NCT02829034
- Testing
- Ranolazine
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- University of Pennsylvania
Acute Pulmonary Embolism, Thromboembolism
SYMPHONY-PE Study for Treatment of Pulmonary Embolism
Evaluation of the Safety and Efficacy of the Symphony Thrombectomy System in the Treatment of Pulmonary Embolism
- Conditions
- Acute Pulmonary Embolism, Thromboembolism, Emboli, Pulmonary, Thrombosis
- Trial name
- NCT06062329
- Testing
- Symphony Thrombectomy System
- Where
- 19 sites in United States
- Volunteers
- 110 people
- Sponsor
- Imperative Care, Inc.
Heart Failure, Right Ventricular Dysfunction
Mitigating Post-Op RV Dysfunction After LVAD Implantation
This project evaluates right ventricle (RV) protective strategies after left ventricular assist device (LVAD) implantation.
- Conditions
- Heart Failure, Right Ventricular Dysfunction, Right Ventricular Failure
- Trial name
- NCT05758194
- Testing
- Standardized RV Management, Usual Care RV Management
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
Right Ventricular Dysfunction
Role of Echocardiography in the Assessment of Right Ventricular Function in the Pediatric Population With Valvular Pulmonary Stenosis.
Correct assessment of right ventricular function by transthoracic echocardiographic examination in pediatric patients with congenital valvular pulmonary stenosis after Percutaneous Balloon Pulmonary Valvuloplasty
- Trial name
- NCT04960085
- Testing
- echocardiography
- Volunteers
- 50 people
- Sponsor
- Assiut University
Heart Failure, Left Ventricular Systolic Dysfunction
Mechanisms and Innovations in Cardiac Resynchronisation Therapy
The aim of this study is to compare the effectiveness of multiple modalities of cardiac resynchronisation therapy using high precision acute electrical and haemodynamic measurements.These modalities include biventricular pacing…
- Conditions
- Heart Failure, Left Ventricular Systolic Dysfunction, Left Bundle-Branch Block, Right Bundle-Branch Block
- Trial name
- MIC (NCT04221763)
- Testing
- His-bundle pacing.
- Where
- United Kingdom
- Volunteers
- 47 people
- Sponsor
- Imperial College London
Right Ventricular Dysfunction
Right Heart International NETwork During Exercise in Different Clinical Conditions
The aim of this registry will be to compare the pathophysiological response of the morphology and function of the right heart and pulmonary circulation assessed with resting and stress-echocardiography in patients with various…
- Trial name
- RIGHT-Net (NCT03041337)
- Testing
- stress echocardiography
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera OO.RR. S. Giovanni di Dio e Ruggi D'Aragona
Postoperative Complications, Heart Failure
Association Between Portal Flow Pulsatility and Right Ventricular Dysfunction in the Postoperative Period of Cardiac Surgery
Right ventricular dysfunction (RVD) after cardiac surgery is associated with ischemia and myocardial injury. While echocardiographic measures like Tricuspid Annular Plane Systolic Excursion (TAPSE) are frequently used to assess…
- Trial name
- LIFESAVE (NCT06777355)
- Testing
- Transthoracic and Transesophageal echography within 24 hours post cardiac surgery
- Where
- France
- Volunteers
- 32 people
- Sponsor
- CMC Ambroise Paré